Neutrophil elastase in bronchiectasis

Abstract The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes a...
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Autor*in:	Andrea Gramegna [verfasserIn] Francesco Amati [verfasserIn] Leonardo Terranova [verfasserIn] Giovanni Sotgiu [verfasserIn] Paolo Tarsia [verfasserIn] Daniela Miglietta [verfasserIn] Maria Adelaide Calderazzo [verfasserIn] Stefano Aliberti [verfasserIn] Francesco Blasi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	Bronchiectasis Neutrophil elastase Protease Neutrophil elastase inhibitors Desmosine

Übergeordnetes Werk:	In: Respiratory Research - BMC, 2003, 18(2017), 1, Seite 13
Übergeordnetes Werk:	volume:18 ; year:2017 ; number:1 ; pages:13

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12931-017-0691-x

Katalog-ID:	DOAJ077300750

Internformat


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allfields	10.1186/s12931-017-0691-x doi (DE-627)DOAJ077300750 (DE-599)DOAJ3173e7f3be7a43019e71e315df706597 DE-627 ger DE-627 rakwb eng RC705-779 Andrea Gramegna verfasserin aut Neutrophil elastase in bronchiectasis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systematic search of scientific evidence was performed. Two investigators independently performed the search on PubMed and included studies published up to May 15, 2017 according to predefined criteria. A final pool of 31 studies was included in the systematic review, with a total of 2679 patients. For each paper data of interest were extracted and reported in table. In this review sputum NE has proved useful as an inflammatory marker both in stable state bronchiectasis and during exacerbations and local or systemic antibiotic treatment. NE has also been associated with risk of exacerbation, time to next exacerbation and all-cause mortality. This study reviews also the role of NE as a specific target of treatment in bronchiectasis. Inhibition of NE is at a very early stage and future interventional studies should evaluate safety and efficacy for new molecules and formulations. Bronchiectasis Neutrophil elastase Protease Neutrophil elastase inhibitors Desmosine Diseases of the respiratory system Francesco Amati verfasserin aut Leonardo Terranova verfasserin aut Giovanni Sotgiu verfasserin aut Paolo Tarsia verfasserin aut Daniela Miglietta verfasserin aut Maria Adelaide Calderazzo verfasserin aut Stefano Aliberti verfasserin aut Francesco Blasi verfasserin aut In Respiratory Research BMC, 2003 18(2017), 1, Seite 13 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:18 year:2017 number:1 pages:13 https://doi.org/10.1186/s12931-017-0691-x kostenfrei https://doaj.org/article/3173e7f3be7a43019e71e315df706597 kostenfrei http://link.springer.com/article/10.1186/s12931-017-0691-x kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 13
spelling	10.1186/s12931-017-0691-x doi (DE-627)DOAJ077300750 (DE-599)DOAJ3173e7f3be7a43019e71e315df706597 DE-627 ger DE-627 rakwb eng RC705-779 Andrea Gramegna verfasserin aut Neutrophil elastase in bronchiectasis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systematic search of scientific evidence was performed. Two investigators independently performed the search on PubMed and included studies published up to May 15, 2017 according to predefined criteria. A final pool of 31 studies was included in the systematic review, with a total of 2679 patients. For each paper data of interest were extracted and reported in table. In this review sputum NE has proved useful as an inflammatory marker both in stable state bronchiectasis and during exacerbations and local or systemic antibiotic treatment. NE has also been associated with risk of exacerbation, time to next exacerbation and all-cause mortality. This study reviews also the role of NE as a specific target of treatment in bronchiectasis. Inhibition of NE is at a very early stage and future interventional studies should evaluate safety and efficacy for new molecules and formulations. Bronchiectasis Neutrophil elastase Protease Neutrophil elastase inhibitors Desmosine Diseases of the respiratory system Francesco Amati verfasserin aut Leonardo Terranova verfasserin aut Giovanni Sotgiu verfasserin aut Paolo Tarsia verfasserin aut Daniela Miglietta verfasserin aut Maria Adelaide Calderazzo verfasserin aut Stefano Aliberti verfasserin aut Francesco Blasi verfasserin aut In Respiratory Research BMC, 2003 18(2017), 1, Seite 13 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:18 year:2017 number:1 pages:13 https://doi.org/10.1186/s12931-017-0691-x kostenfrei https://doaj.org/article/3173e7f3be7a43019e71e315df706597 kostenfrei http://link.springer.com/article/10.1186/s12931-017-0691-x kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 13
allfields_unstemmed	10.1186/s12931-017-0691-x doi (DE-627)DOAJ077300750 (DE-599)DOAJ3173e7f3be7a43019e71e315df706597 DE-627 ger DE-627 rakwb eng RC705-779 Andrea Gramegna verfasserin aut Neutrophil elastase in bronchiectasis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systematic search of scientific evidence was performed. Two investigators independently performed the search on PubMed and included studies published up to May 15, 2017 according to predefined criteria. A final pool of 31 studies was included in the systematic review, with a total of 2679 patients. For each paper data of interest were extracted and reported in table. In this review sputum NE has proved useful as an inflammatory marker both in stable state bronchiectasis and during exacerbations and local or systemic antibiotic treatment. NE has also been associated with risk of exacerbation, time to next exacerbation and all-cause mortality. This study reviews also the role of NE as a specific target of treatment in bronchiectasis. Inhibition of NE is at a very early stage and future interventional studies should evaluate safety and efficacy for new molecules and formulations. Bronchiectasis Neutrophil elastase Protease Neutrophil elastase inhibitors Desmosine Diseases of the respiratory system Francesco Amati verfasserin aut Leonardo Terranova verfasserin aut Giovanni Sotgiu verfasserin aut Paolo Tarsia verfasserin aut Daniela Miglietta verfasserin aut Maria Adelaide Calderazzo verfasserin aut Stefano Aliberti verfasserin aut Francesco Blasi verfasserin aut In Respiratory Research BMC, 2003 18(2017), 1, Seite 13 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:18 year:2017 number:1 pages:13 https://doi.org/10.1186/s12931-017-0691-x kostenfrei https://doaj.org/article/3173e7f3be7a43019e71e315df706597 kostenfrei http://link.springer.com/article/10.1186/s12931-017-0691-x kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 13
allfieldsGer	10.1186/s12931-017-0691-x doi (DE-627)DOAJ077300750 (DE-599)DOAJ3173e7f3be7a43019e71e315df706597 DE-627 ger DE-627 rakwb eng RC705-779 Andrea Gramegna verfasserin aut Neutrophil elastase in bronchiectasis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systematic search of scientific evidence was performed. Two investigators independently performed the search on PubMed and included studies published up to May 15, 2017 according to predefined criteria. A final pool of 31 studies was included in the systematic review, with a total of 2679 patients. For each paper data of interest were extracted and reported in table. In this review sputum NE has proved useful as an inflammatory marker both in stable state bronchiectasis and during exacerbations and local or systemic antibiotic treatment. NE has also been associated with risk of exacerbation, time to next exacerbation and all-cause mortality. This study reviews also the role of NE as a specific target of treatment in bronchiectasis. Inhibition of NE is at a very early stage and future interventional studies should evaluate safety and efficacy for new molecules and formulations. Bronchiectasis Neutrophil elastase Protease Neutrophil elastase inhibitors Desmosine Diseases of the respiratory system Francesco Amati verfasserin aut Leonardo Terranova verfasserin aut Giovanni Sotgiu verfasserin aut Paolo Tarsia verfasserin aut Daniela Miglietta verfasserin aut Maria Adelaide Calderazzo verfasserin aut Stefano Aliberti verfasserin aut Francesco Blasi verfasserin aut In Respiratory Research BMC, 2003 18(2017), 1, Seite 13 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:18 year:2017 number:1 pages:13 https://doi.org/10.1186/s12931-017-0691-x kostenfrei https://doaj.org/article/3173e7f3be7a43019e71e315df706597 kostenfrei http://link.springer.com/article/10.1186/s12931-017-0691-x kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 13
allfieldsSound	10.1186/s12931-017-0691-x doi (DE-627)DOAJ077300750 (DE-599)DOAJ3173e7f3be7a43019e71e315df706597 DE-627 ger DE-627 rakwb eng RC705-779 Andrea Gramegna verfasserin aut Neutrophil elastase in bronchiectasis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systematic search of scientific evidence was performed. Two investigators independently performed the search on PubMed and included studies published up to May 15, 2017 according to predefined criteria. A final pool of 31 studies was included in the systematic review, with a total of 2679 patients. For each paper data of interest were extracted and reported in table. In this review sputum NE has proved useful as an inflammatory marker both in stable state bronchiectasis and during exacerbations and local or systemic antibiotic treatment. NE has also been associated with risk of exacerbation, time to next exacerbation and all-cause mortality. This study reviews also the role of NE as a specific target of treatment in bronchiectasis. Inhibition of NE is at a very early stage and future interventional studies should evaluate safety and efficacy for new molecules and formulations. Bronchiectasis Neutrophil elastase Protease Neutrophil elastase inhibitors Desmosine Diseases of the respiratory system Francesco Amati verfasserin aut Leonardo Terranova verfasserin aut Giovanni Sotgiu verfasserin aut Paolo Tarsia verfasserin aut Daniela Miglietta verfasserin aut Maria Adelaide Calderazzo verfasserin aut Stefano Aliberti verfasserin aut Francesco Blasi verfasserin aut In Respiratory Research BMC, 2003 18(2017), 1, Seite 13 (DE-627)326646485 (DE-600)2041675-1 1465993X nnns volume:18 year:2017 number:1 pages:13 https://doi.org/10.1186/s12931-017-0691-x kostenfrei https://doaj.org/article/3173e7f3be7a43019e71e315df706597 kostenfrei http://link.springer.com/article/10.1186/s12931-017-0691-x kostenfrei https://doaj.org/toc/1465-993X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 18 2017 1 13
language	English
source	In Respiratory Research 18(2017), 1, Seite 13 volume:18 year:2017 number:1 pages:13
sourceStr	In Respiratory Research 18(2017), 1, Seite 13 volume:18 year:2017 number:1 pages:13
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Bronchiectasis Neutrophil elastase Protease Neutrophil elastase inhibitors Desmosine Diseases of the respiratory system
isfreeaccess_bool	true
container_title	Respiratory Research
authorswithroles_txt_mv	Andrea Gramegna @@aut@@ Francesco Amati @@aut@@ Leonardo Terranova @@aut@@ Giovanni Sotgiu @@aut@@ Paolo Tarsia @@aut@@ Daniela Miglietta @@aut@@ Maria Adelaide Calderazzo @@aut@@ Stefano Aliberti @@aut@@ Francesco Blasi @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
hierarchy_top_id	326646485
id	DOAJ077300750
language_de	englisch
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callnumber-first	R - Medicine
author	Andrea Gramegna
spellingShingle	Andrea Gramegna misc RC705-779 misc Bronchiectasis misc Neutrophil elastase misc Protease misc Neutrophil elastase inhibitors misc Desmosine misc Diseases of the respiratory system Neutrophil elastase in bronchiectasis
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topic_title	RC705-779 Neutrophil elastase in bronchiectasis Bronchiectasis Neutrophil elastase Protease Neutrophil elastase inhibitors Desmosine
topic	misc RC705-779 misc Bronchiectasis misc Neutrophil elastase misc Protease misc Neutrophil elastase inhibitors misc Desmosine misc Diseases of the respiratory system
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title	Neutrophil elastase in bronchiectasis
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title_full	Neutrophil elastase in bronchiectasis
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title_sort	neutrophil elastase in bronchiectasis
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title_auth	Neutrophil elastase in bronchiectasis
abstract	Abstract The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systematic search of scientific evidence was performed. Two investigators independently performed the search on PubMed and included studies published up to May 15, 2017 according to predefined criteria. A final pool of 31 studies was included in the systematic review, with a total of 2679 patients. For each paper data of interest were extracted and reported in table. In this review sputum NE has proved useful as an inflammatory marker both in stable state bronchiectasis and during exacerbations and local or systemic antibiotic treatment. NE has also been associated with risk of exacerbation, time to next exacerbation and all-cause mortality. This study reviews also the role of NE as a specific target of treatment in bronchiectasis. Inhibition of NE is at a very early stage and future interventional studies should evaluate safety and efficacy for new molecules and formulations.
abstractGer	Abstract The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systematic search of scientific evidence was performed. Two investigators independently performed the search on PubMed and included studies published up to May 15, 2017 according to predefined criteria. A final pool of 31 studies was included in the systematic review, with a total of 2679 patients. For each paper data of interest were extracted and reported in table. In this review sputum NE has proved useful as an inflammatory marker both in stable state bronchiectasis and during exacerbations and local or systemic antibiotic treatment. NE has also been associated with risk of exacerbation, time to next exacerbation and all-cause mortality. This study reviews also the role of NE as a specific target of treatment in bronchiectasis. Inhibition of NE is at a very early stage and future interventional studies should evaluate safety and efficacy for new molecules and formulations.
abstract_unstemmed	Abstract The role of neutrophil elastase (NE) is poorly understood in bronchiectasis because of the lack of preclinical data and so most of the assumptions made about NE inhibitor potential benefit is based on data from CF. In this context, NE seems to be a predictor of long-term clinical outcomes and a possible target of treatment. In order to better evaluate the role of NE in bronchiectasis, a systematic search of scientific evidence was performed. Two investigators independently performed the search on PubMed and included studies published up to May 15, 2017 according to predefined criteria. A final pool of 31 studies was included in the systematic review, with a total of 2679 patients. For each paper data of interest were extracted and reported in table. In this review sputum NE has proved useful as an inflammatory marker both in stable state bronchiectasis and during exacerbations and local or systemic antibiotic treatment. NE has also been associated with risk of exacerbation, time to next exacerbation and all-cause mortality. This study reviews also the role of NE as a specific target of treatment in bronchiectasis. Inhibition of NE is at a very early stage and future interventional studies should evaluate safety and efficacy for new molecules and formulations.
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title_short	Neutrophil elastase in bronchiectasis
url	https://doi.org/10.1186/s12931-017-0691-x https://doaj.org/article/3173e7f3be7a43019e71e315df706597 http://link.springer.com/article/10.1186/s12931-017-0691-x https://doaj.org/toc/1465-993X
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