Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM

ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine producti...
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Autor*in:	Hongming Miao [verfasserIn] Juanjuan Ou [verfasserIn] Yuan Peng [verfasserIn] Xuan Zhang [verfasserIn] Yujuan Chen [verfasserIn] Lijun Hao [verfasserIn] Ganfeng Xie [verfasserIn] Zhe Wang [verfasserIn] Xueli Pang [verfasserIn] Zhihua Ruan [verfasserIn] Jianjun Li [verfasserIn] Liqing Yu [verfasserIn] Bingzhong Xue [verfasserIn] Hang Shi [verfasserIn] Chunmeng Shi [verfasserIn] Houjie Liang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 7(2016), 1, Seite 12
Übergeordnetes Werk:	volume:7 ; year:2016 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/ncomms11716

Katalog-ID:	DOAJ077386094

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spelling	10.1038/ncomms11716 doi (DE-627)DOAJ077386094 (DE-599)DOAJea637eebb1c5495fbd40d2648ecc7300 DE-627 ger DE-627 rakwb eng Hongming Miao verfasserin aut Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine production. Science Q Juanjuan Ou verfasserin aut Yuan Peng verfasserin aut Xuan Zhang verfasserin aut Yujuan Chen verfasserin aut Lijun Hao verfasserin aut Ganfeng Xie verfasserin aut Zhe Wang verfasserin aut Xueli Pang verfasserin aut Zhihua Ruan verfasserin aut Jianjun Li verfasserin aut Liqing Yu verfasserin aut Bingzhong Xue verfasserin aut Hang Shi verfasserin aut Chunmeng Shi verfasserin aut Houjie Liang verfasserin aut In Nature Communications Nature Portfolio, 2016 7(2016), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:7 year:2016 number:1 pages:12 https://doi.org/10.1038/ncomms11716 kostenfrei https://doaj.org/article/ea637eebb1c5495fbd40d2648ecc7300 kostenfrei https://doi.org/10.1038/ncomms11716 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 1 12
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allfieldsGer	10.1038/ncomms11716 doi (DE-627)DOAJ077386094 (DE-599)DOAJea637eebb1c5495fbd40d2648ecc7300 DE-627 ger DE-627 rakwb eng Hongming Miao verfasserin aut Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine production. Science Q Juanjuan Ou verfasserin aut Yuan Peng verfasserin aut Xuan Zhang verfasserin aut Yujuan Chen verfasserin aut Lijun Hao verfasserin aut Ganfeng Xie verfasserin aut Zhe Wang verfasserin aut Xueli Pang verfasserin aut Zhihua Ruan verfasserin aut Jianjun Li verfasserin aut Liqing Yu verfasserin aut Bingzhong Xue verfasserin aut Hang Shi verfasserin aut Chunmeng Shi verfasserin aut Houjie Liang verfasserin aut In Nature Communications Nature Portfolio, 2016 7(2016), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:7 year:2016 number:1 pages:12 https://doi.org/10.1038/ncomms11716 kostenfrei https://doaj.org/article/ea637eebb1c5495fbd40d2648ecc7300 kostenfrei https://doi.org/10.1038/ncomms11716 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 1 12
allfieldsSound	10.1038/ncomms11716 doi (DE-627)DOAJ077386094 (DE-599)DOAJea637eebb1c5495fbd40d2648ecc7300 DE-627 ger DE-627 rakwb eng Hongming Miao verfasserin aut Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine production. Science Q Juanjuan Ou verfasserin aut Yuan Peng verfasserin aut Xuan Zhang verfasserin aut Yujuan Chen verfasserin aut Lijun Hao verfasserin aut Ganfeng Xie verfasserin aut Zhe Wang verfasserin aut Xueli Pang verfasserin aut Zhihua Ruan verfasserin aut Jianjun Li verfasserin aut Liqing Yu verfasserin aut Bingzhong Xue verfasserin aut Hang Shi verfasserin aut Chunmeng Shi verfasserin aut Houjie Liang verfasserin aut In Nature Communications Nature Portfolio, 2016 7(2016), 1, Seite 12 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:7 year:2016 number:1 pages:12 https://doi.org/10.1038/ncomms11716 kostenfrei https://doaj.org/article/ea637eebb1c5495fbd40d2648ecc7300 kostenfrei https://doi.org/10.1038/ncomms11716 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2016 1 12
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author	Hongming Miao
spellingShingle	Hongming Miao misc Science misc Q Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
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topic_title	Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
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title	Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
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title_full	Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
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author_browse	Hongming Miao Juanjuan Ou Yuan Peng Xuan Zhang Yujuan Chen Lijun Hao Ganfeng Xie Zhe Wang Xueli Pang Zhihua Ruan Jianjun Li Liqing Yu Bingzhong Xue Hang Shi Chunmeng Shi Houjie Liang
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title_sort	macrophage abhd5 promotes colorectal cancer growth by suppressing spermidine production by srm
title_auth	Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
abstract	ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine production.
abstractGer	ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine production.
abstract_unstemmed	ABHD5 is a co-activator of lipolysis. Here the authors show that in tumour-associated macrophages ABHD5 inhibits ROS-dependent induction of C/EBPɛ, which transcriptionally activates spermidine synthase, and that blocking ABHD5 delays colorectal cancer growth in mice by inhibiting spermidine production.
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title_short	Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
url	https://doi.org/10.1038/ncomms11716 https://doaj.org/article/ea637eebb1c5495fbd40d2648ecc7300 https://doaj.org/toc/2041-1723
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up_date	2024-07-04T01:01:18.394Z
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