Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma
Tissue context can dictate why a gene can have seemingly opposing functions in different settings. ELF3 is tumor suppressive in many cancers of epithelial origin but in lung cancer, the authors describe an oncogenic role in the adenocarcinoma histology of non-small cell lung cancer.
Autor*in: |
Katey S. S. Enfield [verfasserIn] Erin A. Marshall [verfasserIn] Christine Anderson [verfasserIn] Kevin W. Ng [verfasserIn] Sara Rahmati [verfasserIn] Zhaolin Xu [verfasserIn] Megan Fuller [verfasserIn] Katy Milne [verfasserIn] Daniel Lu [verfasserIn] Rocky Shi [verfasserIn] David A. Rowbotham [verfasserIn] Daiana D. Becker-Santos [verfasserIn] Fraser D. Johnson [verfasserIn] John C. English [verfasserIn] Calum E. MacAulay [verfasserIn] Stephen Lam [verfasserIn] William W. Lockwood [verfasserIn] Raj Chari [verfasserIn] Aly Karsan [verfasserIn] Igor Jurisica [verfasserIn] Wan L. Lam [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2019 |
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Übergeordnetes Werk: |
In: Nature Communications - Nature Portfolio, 2016, 10(2019), 1, Seite 13 |
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Übergeordnetes Werk: |
volume:10 ; year:2019 ; number:1 ; pages:13 |
Links: |
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DOI / URN: |
10.1038/s41467-019-13295-y |
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Katalog-ID: |
DOAJ077409485 |
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Epithelial tumor suppressor ELF3 is a lineage-specific amplified oncogene in lung adenocarcinoma |
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Tissue context can dictate why a gene can have seemingly opposing functions in different settings. ELF3 is tumor suppressive in many cancers of epithelial origin but in lung cancer, the authors describe an oncogenic role in the adenocarcinoma histology of non-small cell lung cancer. |
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Tissue context can dictate why a gene can have seemingly opposing functions in different settings. ELF3 is tumor suppressive in many cancers of epithelial origin but in lung cancer, the authors describe an oncogenic role in the adenocarcinoma histology of non-small cell lung cancer. |
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