Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles

The biochemical and functional differences between oxidative and glycolytic muscles could affect human muscle health and animal meat quality. However, present understanding of the epigenetic regulation with respect to lncRNAs and circRNAs is rudimentary. Here, porcine oxidative and glycolytic skelet...
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Autor*in:	Linyuan Shen [verfasserIn] Mailin Gan [verfasserIn] Qianzi Tang [verfasserIn] Guoqing Tang [verfasserIn] Yanzhi Jiang [verfasserIn] Mingzhou Li [verfasserIn] Lei Chen [verfasserIn] Lin Bai [verfasserIn] Surong Shuai [verfasserIn] Jinyong Wang [verfasserIn] Xuewei Li [verfasserIn] Kun Liao [verfasserIn] Shunhua Zhang [verfasserIn] Li Zhu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	long non-coding RNAs oxidative muscle glycolytic muscles pig

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 20(2019), 12, p 2855
Übergeordnetes Werk:	volume:20 ; year:2019 ; number:12, p 2855

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/ijms20122855

Katalog-ID:	DOAJ077421213

Internformat


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Indexfelder

author_variant	l s ls m g mg q t qt g t gt y j yj m l ml l c lc l b lb s s ss j w jw x l xl k l kl s z sz l z lz
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allfields	10.3390/ijms20122855 doi (DE-627)DOAJ077421213 (DE-599)DOAJa9d753fb11364394b90b2d23cf0c3174 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Linyuan Shen verfasserin aut Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The biochemical and functional differences between oxidative and glycolytic muscles could affect human muscle health and animal meat quality. However, present understanding of the epigenetic regulation with respect to lncRNAs and circRNAs is rudimentary. Here, porcine oxidative and glycolytic skeletal muscles, which were at the growth curve inflection point, were sampled to survey variant global expression of lncRNAs and circRNAs using RNA-seq. A total of 4046 lncRNAs were identified, including 911 differentially expressed lncRNAs (<i<p</i< < 0.05). The <i<cis</i<-regulatory analysis identified target genes that were enriched for specific GO terms and pathways (<i<p</i< < 0.05), including the oxidation-reduction process, glycolytic process, and fatty acid metabolic. All these were closely related to different phenotypes between oxidative and glycolytic muscles. Additionally, 810 circRNAs were identified, of which 137 were differentially expressed (<i<p</i< < 0.05). Interestingly, some circRNA-miRNA-mRNA networks were found, which were closely linked to muscle fiber-type switching and mitochondria biogenesis in muscles. Furthermore, 44.69%, 39.19%, and 54.01% of differentially expressed mRNAs, lncRNAs, and circRNAs respectively were significantly enriched in pig quantitative trait loci (QTL) regions for growth and meat quality traits. This study reveals a mass of candidate lncRNAs and circRNAs involved in muscle physiological functions, which may improve understanding of muscle metabolism and development from an epigenetic perspective. long non-coding RNAs oxidative muscle glycolytic muscles pig Biology (General) Chemistry Mailin Gan verfasserin aut Qianzi Tang verfasserin aut Guoqing Tang verfasserin aut Yanzhi Jiang verfasserin aut Mingzhou Li verfasserin aut Lei Chen verfasserin aut Lin Bai verfasserin aut Surong Shuai verfasserin aut Jinyong Wang verfasserin aut Xuewei Li verfasserin aut Kun Liao verfasserin aut Shunhua Zhang verfasserin aut Li Zhu verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 12, p 2855 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:12, p 2855 https://doi.org/10.3390/ijms20122855 kostenfrei https://doaj.org/article/a9d753fb11364394b90b2d23cf0c3174 kostenfrei https://www.mdpi.com/1422-0067/20/12/2855 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 12, p 2855
spelling	10.3390/ijms20122855 doi (DE-627)DOAJ077421213 (DE-599)DOAJa9d753fb11364394b90b2d23cf0c3174 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Linyuan Shen verfasserin aut Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The biochemical and functional differences between oxidative and glycolytic muscles could affect human muscle health and animal meat quality. However, present understanding of the epigenetic regulation with respect to lncRNAs and circRNAs is rudimentary. Here, porcine oxidative and glycolytic skeletal muscles, which were at the growth curve inflection point, were sampled to survey variant global expression of lncRNAs and circRNAs using RNA-seq. A total of 4046 lncRNAs were identified, including 911 differentially expressed lncRNAs (<i<p</i< < 0.05). The <i<cis</i<-regulatory analysis identified target genes that were enriched for specific GO terms and pathways (<i<p</i< < 0.05), including the oxidation-reduction process, glycolytic process, and fatty acid metabolic. All these were closely related to different phenotypes between oxidative and glycolytic muscles. Additionally, 810 circRNAs were identified, of which 137 were differentially expressed (<i<p</i< < 0.05). Interestingly, some circRNA-miRNA-mRNA networks were found, which were closely linked to muscle fiber-type switching and mitochondria biogenesis in muscles. Furthermore, 44.69%, 39.19%, and 54.01% of differentially expressed mRNAs, lncRNAs, and circRNAs respectively were significantly enriched in pig quantitative trait loci (QTL) regions for growth and meat quality traits. This study reveals a mass of candidate lncRNAs and circRNAs involved in muscle physiological functions, which may improve understanding of muscle metabolism and development from an epigenetic perspective. long non-coding RNAs oxidative muscle glycolytic muscles pig Biology (General) Chemistry Mailin Gan verfasserin aut Qianzi Tang verfasserin aut Guoqing Tang verfasserin aut Yanzhi Jiang verfasserin aut Mingzhou Li verfasserin aut Lei Chen verfasserin aut Lin Bai verfasserin aut Surong Shuai verfasserin aut Jinyong Wang verfasserin aut Xuewei Li verfasserin aut Kun Liao verfasserin aut Shunhua Zhang verfasserin aut Li Zhu verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 12, p 2855 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:12, p 2855 https://doi.org/10.3390/ijms20122855 kostenfrei https://doaj.org/article/a9d753fb11364394b90b2d23cf0c3174 kostenfrei https://www.mdpi.com/1422-0067/20/12/2855 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 12, p 2855
allfields_unstemmed	10.3390/ijms20122855 doi (DE-627)DOAJ077421213 (DE-599)DOAJa9d753fb11364394b90b2d23cf0c3174 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Linyuan Shen verfasserin aut Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The biochemical and functional differences between oxidative and glycolytic muscles could affect human muscle health and animal meat quality. However, present understanding of the epigenetic regulation with respect to lncRNAs and circRNAs is rudimentary. Here, porcine oxidative and glycolytic skeletal muscles, which were at the growth curve inflection point, were sampled to survey variant global expression of lncRNAs and circRNAs using RNA-seq. A total of 4046 lncRNAs were identified, including 911 differentially expressed lncRNAs (<i<p</i< < 0.05). The <i<cis</i<-regulatory analysis identified target genes that were enriched for specific GO terms and pathways (<i<p</i< < 0.05), including the oxidation-reduction process, glycolytic process, and fatty acid metabolic. All these were closely related to different phenotypes between oxidative and glycolytic muscles. Additionally, 810 circRNAs were identified, of which 137 were differentially expressed (<i<p</i< < 0.05). Interestingly, some circRNA-miRNA-mRNA networks were found, which were closely linked to muscle fiber-type switching and mitochondria biogenesis in muscles. Furthermore, 44.69%, 39.19%, and 54.01% of differentially expressed mRNAs, lncRNAs, and circRNAs respectively were significantly enriched in pig quantitative trait loci (QTL) regions for growth and meat quality traits. This study reveals a mass of candidate lncRNAs and circRNAs involved in muscle physiological functions, which may improve understanding of muscle metabolism and development from an epigenetic perspective. long non-coding RNAs oxidative muscle glycolytic muscles pig Biology (General) Chemistry Mailin Gan verfasserin aut Qianzi Tang verfasserin aut Guoqing Tang verfasserin aut Yanzhi Jiang verfasserin aut Mingzhou Li verfasserin aut Lei Chen verfasserin aut Lin Bai verfasserin aut Surong Shuai verfasserin aut Jinyong Wang verfasserin aut Xuewei Li verfasserin aut Kun Liao verfasserin aut Shunhua Zhang verfasserin aut Li Zhu verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 12, p 2855 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:12, p 2855 https://doi.org/10.3390/ijms20122855 kostenfrei https://doaj.org/article/a9d753fb11364394b90b2d23cf0c3174 kostenfrei https://www.mdpi.com/1422-0067/20/12/2855 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 12, p 2855
allfieldsGer	10.3390/ijms20122855 doi (DE-627)DOAJ077421213 (DE-599)DOAJa9d753fb11364394b90b2d23cf0c3174 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Linyuan Shen verfasserin aut Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The biochemical and functional differences between oxidative and glycolytic muscles could affect human muscle health and animal meat quality. However, present understanding of the epigenetic regulation with respect to lncRNAs and circRNAs is rudimentary. Here, porcine oxidative and glycolytic skeletal muscles, which were at the growth curve inflection point, were sampled to survey variant global expression of lncRNAs and circRNAs using RNA-seq. A total of 4046 lncRNAs were identified, including 911 differentially expressed lncRNAs (<i<p</i< < 0.05). The <i<cis</i<-regulatory analysis identified target genes that were enriched for specific GO terms and pathways (<i<p</i< < 0.05), including the oxidation-reduction process, glycolytic process, and fatty acid metabolic. All these were closely related to different phenotypes between oxidative and glycolytic muscles. Additionally, 810 circRNAs were identified, of which 137 were differentially expressed (<i<p</i< < 0.05). Interestingly, some circRNA-miRNA-mRNA networks were found, which were closely linked to muscle fiber-type switching and mitochondria biogenesis in muscles. Furthermore, 44.69%, 39.19%, and 54.01% of differentially expressed mRNAs, lncRNAs, and circRNAs respectively were significantly enriched in pig quantitative trait loci (QTL) regions for growth and meat quality traits. This study reveals a mass of candidate lncRNAs and circRNAs involved in muscle physiological functions, which may improve understanding of muscle metabolism and development from an epigenetic perspective. long non-coding RNAs oxidative muscle glycolytic muscles pig Biology (General) Chemistry Mailin Gan verfasserin aut Qianzi Tang verfasserin aut Guoqing Tang verfasserin aut Yanzhi Jiang verfasserin aut Mingzhou Li verfasserin aut Lei Chen verfasserin aut Lin Bai verfasserin aut Surong Shuai verfasserin aut Jinyong Wang verfasserin aut Xuewei Li verfasserin aut Kun Liao verfasserin aut Shunhua Zhang verfasserin aut Li Zhu verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 12, p 2855 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:12, p 2855 https://doi.org/10.3390/ijms20122855 kostenfrei https://doaj.org/article/a9d753fb11364394b90b2d23cf0c3174 kostenfrei https://www.mdpi.com/1422-0067/20/12/2855 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 12, p 2855
allfieldsSound	10.3390/ijms20122855 doi (DE-627)DOAJ077421213 (DE-599)DOAJa9d753fb11364394b90b2d23cf0c3174 DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Linyuan Shen verfasserin aut Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The biochemical and functional differences between oxidative and glycolytic muscles could affect human muscle health and animal meat quality. However, present understanding of the epigenetic regulation with respect to lncRNAs and circRNAs is rudimentary. Here, porcine oxidative and glycolytic skeletal muscles, which were at the growth curve inflection point, were sampled to survey variant global expression of lncRNAs and circRNAs using RNA-seq. A total of 4046 lncRNAs were identified, including 911 differentially expressed lncRNAs (<i<p</i< < 0.05). The <i<cis</i<-regulatory analysis identified target genes that were enriched for specific GO terms and pathways (<i<p</i< < 0.05), including the oxidation-reduction process, glycolytic process, and fatty acid metabolic. All these were closely related to different phenotypes between oxidative and glycolytic muscles. Additionally, 810 circRNAs were identified, of which 137 were differentially expressed (<i<p</i< < 0.05). Interestingly, some circRNA-miRNA-mRNA networks were found, which were closely linked to muscle fiber-type switching and mitochondria biogenesis in muscles. Furthermore, 44.69%, 39.19%, and 54.01% of differentially expressed mRNAs, lncRNAs, and circRNAs respectively were significantly enriched in pig quantitative trait loci (QTL) regions for growth and meat quality traits. This study reveals a mass of candidate lncRNAs and circRNAs involved in muscle physiological functions, which may improve understanding of muscle metabolism and development from an epigenetic perspective. long non-coding RNAs oxidative muscle glycolytic muscles pig Biology (General) Chemistry Mailin Gan verfasserin aut Qianzi Tang verfasserin aut Guoqing Tang verfasserin aut Yanzhi Jiang verfasserin aut Mingzhou Li verfasserin aut Lei Chen verfasserin aut Lin Bai verfasserin aut Surong Shuai verfasserin aut Jinyong Wang verfasserin aut Xuewei Li verfasserin aut Kun Liao verfasserin aut Shunhua Zhang verfasserin aut Li Zhu verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 20(2019), 12, p 2855 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:20 year:2019 number:12, p 2855 https://doi.org/10.3390/ijms20122855 kostenfrei https://doaj.org/article/a9d753fb11364394b90b2d23cf0c3174 kostenfrei https://www.mdpi.com/1422-0067/20/12/2855 kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2019 12, p 2855
language	English
source	In International Journal of Molecular Sciences 20(2019), 12, p 2855 volume:20 year:2019 number:12, p 2855
sourceStr	In International Journal of Molecular Sciences 20(2019), 12, p 2855 volume:20 year:2019 number:12, p 2855
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	long non-coding RNAs oxidative muscle glycolytic muscles pig Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Linyuan Shen @@aut@@ Mailin Gan @@aut@@ Qianzi Tang @@aut@@ Guoqing Tang @@aut@@ Yanzhi Jiang @@aut@@ Mingzhou Li @@aut@@ Lei Chen @@aut@@ Lin Bai @@aut@@ Surong Shuai @@aut@@ Jinyong Wang @@aut@@ Xuewei Li @@aut@@ Kun Liao @@aut@@ Shunhua Zhang @@aut@@ Li Zhu @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ077421213
language_de	englisch
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callnumber-first	Q - Science
author	Linyuan Shen
spellingShingle	Linyuan Shen misc QH301-705.5 misc QD1-999 misc long non-coding RNAs misc oxidative muscle misc glycolytic muscles misc pig misc Biology (General) misc Chemistry Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles
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topic_title	QH301-705.5 QD1-999 Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles long non-coding RNAs oxidative muscle glycolytic muscles pig
topic	misc QH301-705.5 misc QD1-999 misc long non-coding RNAs misc oxidative muscle misc glycolytic muscles misc pig misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc long non-coding RNAs misc oxidative muscle misc glycolytic muscles misc pig misc Biology (General) misc Chemistry
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title	Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles
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title_full	Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles
author_sort	Linyuan Shen
journal	International Journal of Molecular Sciences
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author_browse	Linyuan Shen Mailin Gan Qianzi Tang Guoqing Tang Yanzhi Jiang Mingzhou Li Lei Chen Lin Bai Surong Shuai Jinyong Wang Xuewei Li Kun Liao Shunhua Zhang Li Zhu
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author-letter	Linyuan Shen
doi_str_mv	10.3390/ijms20122855
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title_sort	comprehensive analysis of lncrnas and circrnas reveals the metabolic specialization in oxidative and glycolytic skeletal muscles
callnumber	QH301-705.5
title_auth	Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles
abstract	The biochemical and functional differences between oxidative and glycolytic muscles could affect human muscle health and animal meat quality. However, present understanding of the epigenetic regulation with respect to lncRNAs and circRNAs is rudimentary. Here, porcine oxidative and glycolytic skeletal muscles, which were at the growth curve inflection point, were sampled to survey variant global expression of lncRNAs and circRNAs using RNA-seq. A total of 4046 lncRNAs were identified, including 911 differentially expressed lncRNAs (<i<p</i< < 0.05). The <i<cis</i<-regulatory analysis identified target genes that were enriched for specific GO terms and pathways (<i<p</i< < 0.05), including the oxidation-reduction process, glycolytic process, and fatty acid metabolic. All these were closely related to different phenotypes between oxidative and glycolytic muscles. Additionally, 810 circRNAs were identified, of which 137 were differentially expressed (<i<p</i< < 0.05). Interestingly, some circRNA-miRNA-mRNA networks were found, which were closely linked to muscle fiber-type switching and mitochondria biogenesis in muscles. Furthermore, 44.69%, 39.19%, and 54.01% of differentially expressed mRNAs, lncRNAs, and circRNAs respectively were significantly enriched in pig quantitative trait loci (QTL) regions for growth and meat quality traits. This study reveals a mass of candidate lncRNAs and circRNAs involved in muscle physiological functions, which may improve understanding of muscle metabolism and development from an epigenetic perspective.
abstractGer	The biochemical and functional differences between oxidative and glycolytic muscles could affect human muscle health and animal meat quality. However, present understanding of the epigenetic regulation with respect to lncRNAs and circRNAs is rudimentary. Here, porcine oxidative and glycolytic skeletal muscles, which were at the growth curve inflection point, were sampled to survey variant global expression of lncRNAs and circRNAs using RNA-seq. A total of 4046 lncRNAs were identified, including 911 differentially expressed lncRNAs (<i<p</i< < 0.05). The <i<cis</i<-regulatory analysis identified target genes that were enriched for specific GO terms and pathways (<i<p</i< < 0.05), including the oxidation-reduction process, glycolytic process, and fatty acid metabolic. All these were closely related to different phenotypes between oxidative and glycolytic muscles. Additionally, 810 circRNAs were identified, of which 137 were differentially expressed (<i<p</i< < 0.05). Interestingly, some circRNA-miRNA-mRNA networks were found, which were closely linked to muscle fiber-type switching and mitochondria biogenesis in muscles. Furthermore, 44.69%, 39.19%, and 54.01% of differentially expressed mRNAs, lncRNAs, and circRNAs respectively were significantly enriched in pig quantitative trait loci (QTL) regions for growth and meat quality traits. This study reveals a mass of candidate lncRNAs and circRNAs involved in muscle physiological functions, which may improve understanding of muscle metabolism and development from an epigenetic perspective.
abstract_unstemmed	The biochemical and functional differences between oxidative and glycolytic muscles could affect human muscle health and animal meat quality. However, present understanding of the epigenetic regulation with respect to lncRNAs and circRNAs is rudimentary. Here, porcine oxidative and glycolytic skeletal muscles, which were at the growth curve inflection point, were sampled to survey variant global expression of lncRNAs and circRNAs using RNA-seq. A total of 4046 lncRNAs were identified, including 911 differentially expressed lncRNAs (<i<p</i< < 0.05). The <i<cis</i<-regulatory analysis identified target genes that were enriched for specific GO terms and pathways (<i<p</i< < 0.05), including the oxidation-reduction process, glycolytic process, and fatty acid metabolic. All these were closely related to different phenotypes between oxidative and glycolytic muscles. Additionally, 810 circRNAs were identified, of which 137 were differentially expressed (<i<p</i< < 0.05). Interestingly, some circRNA-miRNA-mRNA networks were found, which were closely linked to muscle fiber-type switching and mitochondria biogenesis in muscles. Furthermore, 44.69%, 39.19%, and 54.01% of differentially expressed mRNAs, lncRNAs, and circRNAs respectively were significantly enriched in pig quantitative trait loci (QTL) regions for growth and meat quality traits. This study reveals a mass of candidate lncRNAs and circRNAs involved in muscle physiological functions, which may improve understanding of muscle metabolism and development from an epigenetic perspective.
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container_issue	12, p 2855
title_short	Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles
url	https://doi.org/10.3390/ijms20122855 https://doaj.org/article/a9d753fb11364394b90b2d23cf0c3174 https://www.mdpi.com/1422-0067/20/12/2855 https://doaj.org/toc/1422-0067
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author2	Mailin Gan Qianzi Tang Guoqing Tang Yanzhi Jiang Mingzhou Li Lei Chen Lin Bai Surong Shuai Jinyong Wang Xuewei Li Kun Liao Shunhua Zhang Li Zhu
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Comprehensive Analysis of lncRNAs and circRNAs Reveals the Metabolic Specialization in Oxidative and Glycolytic Skeletal Muscles

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Vorhandene Bände

Nicht das Richtige dabei?