K-Carrageenan Stimulates Pre-Osteoblast Proliferation and Osteogenic Differentiation: A Potential Factor for the Promotion of Bone Regeneration?
Current cell-based bone tissue regeneration strategies cannot cover large bone defects. K-carrageenan is a highly hydrophilic and biocompatible seaweed-derived sulfated polysaccharide, that has been proposed as a promising candidate for tissue engineering applications. Whether κ-carrageenan can be u...
Ausführliche Beschreibung
Autor*in: |
Wei Cao [verfasserIn] Jianfeng Jin [verfasserIn] Gang Wu [verfasserIn] Nathalie Bravenboer [verfasserIn] Marco N. Helder [verfasserIn] Janak L. Pathak [verfasserIn] Behrouz Zandieh-Doulabi [verfasserIn] Jolanda M. A. Hogervorst [verfasserIn] Shingo Matsukawa [verfasserIn] Lester C. Geonzon [verfasserIn] Rommel G. Bacabac [verfasserIn] Engelbert A. J. M. Schulten [verfasserIn] Jenneke Klein-Nulend [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2021 |
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In: Molecules - MDPI AG, 2003, 26(2021), 20, p 6131 |
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Übergeordnetes Werk: |
volume:26 ; year:2021 ; number:20, p 6131 |
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DOI / URN: |
10.3390/molecules26206131 |
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Katalog-ID: |
DOAJ077582179 |
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10.3390/molecules26206131 doi (DE-627)DOAJ077582179 (DE-599)DOAJ3830504806be4c38a23e399032fbf077 DE-627 ger DE-627 rakwb eng QD241-441 Wei Cao verfasserin aut K-Carrageenan Stimulates Pre-Osteoblast Proliferation and Osteogenic Differentiation: A Potential Factor for the Promotion of Bone Regeneration? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Current cell-based bone tissue regeneration strategies cannot cover large bone defects. K-carrageenan is a highly hydrophilic and biocompatible seaweed-derived sulfated polysaccharide, that has been proposed as a promising candidate for tissue engineering applications. Whether κ-carrageenan can be used to enhance bone regeneration is still unclear. In this study, we aimed to investigate whether κ-carrageenan has osteogenic potential by testing its effect on pre-osteoblast proliferation and osteogenic differentiation in vitro. Treatment with κ-carrageenan (0.5 and 2 mg/mL) increased both MC3T3-E1 pre-osteoblast adhesion and spreading at 1 h. K-carrageenan (0.125–2 mg/mL) dose-dependently increased pre-osteoblast proliferation and metabolic activity, with a maximum effect at 2 mg/mL at day three. K-carrageenan (0.5 and 2 mg/mL) increased osteogenic differentiation, as shown by enhanced alkaline phosphatase activity (1.8-fold increase at 2 mg/mL) at day four, and matrix mineralization (6.2-fold increase at 2 mg/mL) at day 21. K-carrageenan enhanced osteogenic gene expression (<i<Opn</i<, <i<Dmp1</i<, and <i<Mepe</i<) at day 14 and 21. In conclusion, κ-carrageenan promoted MC3T3-E1 pre-osteoblast adhesion and spreading, metabolic activity, proliferation, and osteogenic differentiation, suggesting that κ-carrageenan is a potential osteogenic inductive factor for clinical application to enhance bone regeneration. cell-based bone tissue engineering bone defect bone regeneration κ-carrageenan MC3T3-E1 pre-osteoblast cell proliferation Organic chemistry Jianfeng Jin verfasserin aut Gang Wu verfasserin aut Nathalie Bravenboer verfasserin aut Marco N. Helder verfasserin aut Janak L. Pathak verfasserin aut Behrouz Zandieh-Doulabi verfasserin aut Jolanda M. A. Hogervorst verfasserin aut Shingo Matsukawa verfasserin aut Lester C. Geonzon verfasserin aut Rommel G. Bacabac verfasserin aut Engelbert A. J. M. Schulten verfasserin aut Jenneke Klein-Nulend verfasserin aut In Molecules MDPI AG, 2003 26(2021), 20, p 6131 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:20, p 6131 https://doi.org/10.3390/molecules26206131 kostenfrei https://doaj.org/article/3830504806be4c38a23e399032fbf077 kostenfrei https://www.mdpi.com/1420-3049/26/20/6131 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 20, p 6131 |
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10.3390/molecules26206131 doi (DE-627)DOAJ077582179 (DE-599)DOAJ3830504806be4c38a23e399032fbf077 DE-627 ger DE-627 rakwb eng QD241-441 Wei Cao verfasserin aut K-Carrageenan Stimulates Pre-Osteoblast Proliferation and Osteogenic Differentiation: A Potential Factor for the Promotion of Bone Regeneration? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Current cell-based bone tissue regeneration strategies cannot cover large bone defects. K-carrageenan is a highly hydrophilic and biocompatible seaweed-derived sulfated polysaccharide, that has been proposed as a promising candidate for tissue engineering applications. Whether κ-carrageenan can be used to enhance bone regeneration is still unclear. In this study, we aimed to investigate whether κ-carrageenan has osteogenic potential by testing its effect on pre-osteoblast proliferation and osteogenic differentiation in vitro. Treatment with κ-carrageenan (0.5 and 2 mg/mL) increased both MC3T3-E1 pre-osteoblast adhesion and spreading at 1 h. K-carrageenan (0.125–2 mg/mL) dose-dependently increased pre-osteoblast proliferation and metabolic activity, with a maximum effect at 2 mg/mL at day three. K-carrageenan (0.5 and 2 mg/mL) increased osteogenic differentiation, as shown by enhanced alkaline phosphatase activity (1.8-fold increase at 2 mg/mL) at day four, and matrix mineralization (6.2-fold increase at 2 mg/mL) at day 21. K-carrageenan enhanced osteogenic gene expression (<i<Opn</i<, <i<Dmp1</i<, and <i<Mepe</i<) at day 14 and 21. In conclusion, κ-carrageenan promoted MC3T3-E1 pre-osteoblast adhesion and spreading, metabolic activity, proliferation, and osteogenic differentiation, suggesting that κ-carrageenan is a potential osteogenic inductive factor for clinical application to enhance bone regeneration. cell-based bone tissue engineering bone defect bone regeneration κ-carrageenan MC3T3-E1 pre-osteoblast cell proliferation Organic chemistry Jianfeng Jin verfasserin aut Gang Wu verfasserin aut Nathalie Bravenboer verfasserin aut Marco N. Helder verfasserin aut Janak L. Pathak verfasserin aut Behrouz Zandieh-Doulabi verfasserin aut Jolanda M. A. Hogervorst verfasserin aut Shingo Matsukawa verfasserin aut Lester C. Geonzon verfasserin aut Rommel G. Bacabac verfasserin aut Engelbert A. J. M. Schulten verfasserin aut Jenneke Klein-Nulend verfasserin aut In Molecules MDPI AG, 2003 26(2021), 20, p 6131 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:20, p 6131 https://doi.org/10.3390/molecules26206131 kostenfrei https://doaj.org/article/3830504806be4c38a23e399032fbf077 kostenfrei https://www.mdpi.com/1420-3049/26/20/6131 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 20, p 6131 |
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10.3390/molecules26206131 doi (DE-627)DOAJ077582179 (DE-599)DOAJ3830504806be4c38a23e399032fbf077 DE-627 ger DE-627 rakwb eng QD241-441 Wei Cao verfasserin aut K-Carrageenan Stimulates Pre-Osteoblast Proliferation and Osteogenic Differentiation: A Potential Factor for the Promotion of Bone Regeneration? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Current cell-based bone tissue regeneration strategies cannot cover large bone defects. K-carrageenan is a highly hydrophilic and biocompatible seaweed-derived sulfated polysaccharide, that has been proposed as a promising candidate for tissue engineering applications. Whether κ-carrageenan can be used to enhance bone regeneration is still unclear. In this study, we aimed to investigate whether κ-carrageenan has osteogenic potential by testing its effect on pre-osteoblast proliferation and osteogenic differentiation in vitro. Treatment with κ-carrageenan (0.5 and 2 mg/mL) increased both MC3T3-E1 pre-osteoblast adhesion and spreading at 1 h. K-carrageenan (0.125–2 mg/mL) dose-dependently increased pre-osteoblast proliferation and metabolic activity, with a maximum effect at 2 mg/mL at day three. K-carrageenan (0.5 and 2 mg/mL) increased osteogenic differentiation, as shown by enhanced alkaline phosphatase activity (1.8-fold increase at 2 mg/mL) at day four, and matrix mineralization (6.2-fold increase at 2 mg/mL) at day 21. K-carrageenan enhanced osteogenic gene expression (<i<Opn</i<, <i<Dmp1</i<, and <i<Mepe</i<) at day 14 and 21. In conclusion, κ-carrageenan promoted MC3T3-E1 pre-osteoblast adhesion and spreading, metabolic activity, proliferation, and osteogenic differentiation, suggesting that κ-carrageenan is a potential osteogenic inductive factor for clinical application to enhance bone regeneration. cell-based bone tissue engineering bone defect bone regeneration κ-carrageenan MC3T3-E1 pre-osteoblast cell proliferation Organic chemistry Jianfeng Jin verfasserin aut Gang Wu verfasserin aut Nathalie Bravenboer verfasserin aut Marco N. Helder verfasserin aut Janak L. Pathak verfasserin aut Behrouz Zandieh-Doulabi verfasserin aut Jolanda M. A. Hogervorst verfasserin aut Shingo Matsukawa verfasserin aut Lester C. Geonzon verfasserin aut Rommel G. Bacabac verfasserin aut Engelbert A. J. M. Schulten verfasserin aut Jenneke Klein-Nulend verfasserin aut In Molecules MDPI AG, 2003 26(2021), 20, p 6131 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:20, p 6131 https://doi.org/10.3390/molecules26206131 kostenfrei https://doaj.org/article/3830504806be4c38a23e399032fbf077 kostenfrei https://www.mdpi.com/1420-3049/26/20/6131 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 20, p 6131 |
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10.3390/molecules26206131 doi (DE-627)DOAJ077582179 (DE-599)DOAJ3830504806be4c38a23e399032fbf077 DE-627 ger DE-627 rakwb eng QD241-441 Wei Cao verfasserin aut K-Carrageenan Stimulates Pre-Osteoblast Proliferation and Osteogenic Differentiation: A Potential Factor for the Promotion of Bone Regeneration? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Current cell-based bone tissue regeneration strategies cannot cover large bone defects. K-carrageenan is a highly hydrophilic and biocompatible seaweed-derived sulfated polysaccharide, that has been proposed as a promising candidate for tissue engineering applications. Whether κ-carrageenan can be used to enhance bone regeneration is still unclear. In this study, we aimed to investigate whether κ-carrageenan has osteogenic potential by testing its effect on pre-osteoblast proliferation and osteogenic differentiation in vitro. Treatment with κ-carrageenan (0.5 and 2 mg/mL) increased both MC3T3-E1 pre-osteoblast adhesion and spreading at 1 h. K-carrageenan (0.125–2 mg/mL) dose-dependently increased pre-osteoblast proliferation and metabolic activity, with a maximum effect at 2 mg/mL at day three. K-carrageenan (0.5 and 2 mg/mL) increased osteogenic differentiation, as shown by enhanced alkaline phosphatase activity (1.8-fold increase at 2 mg/mL) at day four, and matrix mineralization (6.2-fold increase at 2 mg/mL) at day 21. K-carrageenan enhanced osteogenic gene expression (<i<Opn</i<, <i<Dmp1</i<, and <i<Mepe</i<) at day 14 and 21. In conclusion, κ-carrageenan promoted MC3T3-E1 pre-osteoblast adhesion and spreading, metabolic activity, proliferation, and osteogenic differentiation, suggesting that κ-carrageenan is a potential osteogenic inductive factor for clinical application to enhance bone regeneration. cell-based bone tissue engineering bone defect bone regeneration κ-carrageenan MC3T3-E1 pre-osteoblast cell proliferation Organic chemistry Jianfeng Jin verfasserin aut Gang Wu verfasserin aut Nathalie Bravenboer verfasserin aut Marco N. Helder verfasserin aut Janak L. Pathak verfasserin aut Behrouz Zandieh-Doulabi verfasserin aut Jolanda M. A. Hogervorst verfasserin aut Shingo Matsukawa verfasserin aut Lester C. Geonzon verfasserin aut Rommel G. Bacabac verfasserin aut Engelbert A. J. M. Schulten verfasserin aut Jenneke Klein-Nulend verfasserin aut In Molecules MDPI AG, 2003 26(2021), 20, p 6131 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:20, p 6131 https://doi.org/10.3390/molecules26206131 kostenfrei https://doaj.org/article/3830504806be4c38a23e399032fbf077 kostenfrei https://www.mdpi.com/1420-3049/26/20/6131 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 20, p 6131 |
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10.3390/molecules26206131 doi (DE-627)DOAJ077582179 (DE-599)DOAJ3830504806be4c38a23e399032fbf077 DE-627 ger DE-627 rakwb eng QD241-441 Wei Cao verfasserin aut K-Carrageenan Stimulates Pre-Osteoblast Proliferation and Osteogenic Differentiation: A Potential Factor for the Promotion of Bone Regeneration? 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Current cell-based bone tissue regeneration strategies cannot cover large bone defects. K-carrageenan is a highly hydrophilic and biocompatible seaweed-derived sulfated polysaccharide, that has been proposed as a promising candidate for tissue engineering applications. Whether κ-carrageenan can be used to enhance bone regeneration is still unclear. In this study, we aimed to investigate whether κ-carrageenan has osteogenic potential by testing its effect on pre-osteoblast proliferation and osteogenic differentiation in vitro. Treatment with κ-carrageenan (0.5 and 2 mg/mL) increased both MC3T3-E1 pre-osteoblast adhesion and spreading at 1 h. K-carrageenan (0.125–2 mg/mL) dose-dependently increased pre-osteoblast proliferation and metabolic activity, with a maximum effect at 2 mg/mL at day three. K-carrageenan (0.5 and 2 mg/mL) increased osteogenic differentiation, as shown by enhanced alkaline phosphatase activity (1.8-fold increase at 2 mg/mL) at day four, and matrix mineralization (6.2-fold increase at 2 mg/mL) at day 21. K-carrageenan enhanced osteogenic gene expression (<i<Opn</i<, <i<Dmp1</i<, and <i<Mepe</i<) at day 14 and 21. In conclusion, κ-carrageenan promoted MC3T3-E1 pre-osteoblast adhesion and spreading, metabolic activity, proliferation, and osteogenic differentiation, suggesting that κ-carrageenan is a potential osteogenic inductive factor for clinical application to enhance bone regeneration. cell-based bone tissue engineering bone defect bone regeneration κ-carrageenan MC3T3-E1 pre-osteoblast cell proliferation Organic chemistry Jianfeng Jin verfasserin aut Gang Wu verfasserin aut Nathalie Bravenboer verfasserin aut Marco N. Helder verfasserin aut Janak L. Pathak verfasserin aut Behrouz Zandieh-Doulabi verfasserin aut Jolanda M. A. Hogervorst verfasserin aut Shingo Matsukawa verfasserin aut Lester C. Geonzon verfasserin aut Rommel G. Bacabac verfasserin aut Engelbert A. J. M. Schulten verfasserin aut Jenneke Klein-Nulend verfasserin aut In Molecules MDPI AG, 2003 26(2021), 20, p 6131 (DE-627)311313132 (DE-600)2008644-1 14203049 nnns volume:26 year:2021 number:20, p 6131 https://doi.org/10.3390/molecules26206131 kostenfrei https://doaj.org/article/3830504806be4c38a23e399032fbf077 kostenfrei https://www.mdpi.com/1420-3049/26/20/6131 kostenfrei https://doaj.org/toc/1420-3049 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2021 20, p 6131 |
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Wei Cao Jianfeng Jin Gang Wu Nathalie Bravenboer Marco N. Helder Janak L. Pathak Behrouz Zandieh-Doulabi Jolanda M. A. Hogervorst Shingo Matsukawa Lester C. Geonzon Rommel G. Bacabac Engelbert A. J. M. Schulten Jenneke Klein-Nulend |
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k-carrageenan stimulates pre-osteoblast proliferation and osteogenic differentiation: a potential factor for the promotion of bone regeneration? |
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K-Carrageenan Stimulates Pre-Osteoblast Proliferation and Osteogenic Differentiation: A Potential Factor for the Promotion of Bone Regeneration? |
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Current cell-based bone tissue regeneration strategies cannot cover large bone defects. K-carrageenan is a highly hydrophilic and biocompatible seaweed-derived sulfated polysaccharide, that has been proposed as a promising candidate for tissue engineering applications. Whether κ-carrageenan can be used to enhance bone regeneration is still unclear. In this study, we aimed to investigate whether κ-carrageenan has osteogenic potential by testing its effect on pre-osteoblast proliferation and osteogenic differentiation in vitro. Treatment with κ-carrageenan (0.5 and 2 mg/mL) increased both MC3T3-E1 pre-osteoblast adhesion and spreading at 1 h. K-carrageenan (0.125–2 mg/mL) dose-dependently increased pre-osteoblast proliferation and metabolic activity, with a maximum effect at 2 mg/mL at day three. K-carrageenan (0.5 and 2 mg/mL) increased osteogenic differentiation, as shown by enhanced alkaline phosphatase activity (1.8-fold increase at 2 mg/mL) at day four, and matrix mineralization (6.2-fold increase at 2 mg/mL) at day 21. K-carrageenan enhanced osteogenic gene expression (<i<Opn</i<, <i<Dmp1</i<, and <i<Mepe</i<) at day 14 and 21. In conclusion, κ-carrageenan promoted MC3T3-E1 pre-osteoblast adhesion and spreading, metabolic activity, proliferation, and osteogenic differentiation, suggesting that κ-carrageenan is a potential osteogenic inductive factor for clinical application to enhance bone regeneration. |
abstractGer |
Current cell-based bone tissue regeneration strategies cannot cover large bone defects. K-carrageenan is a highly hydrophilic and biocompatible seaweed-derived sulfated polysaccharide, that has been proposed as a promising candidate for tissue engineering applications. Whether κ-carrageenan can be used to enhance bone regeneration is still unclear. In this study, we aimed to investigate whether κ-carrageenan has osteogenic potential by testing its effect on pre-osteoblast proliferation and osteogenic differentiation in vitro. Treatment with κ-carrageenan (0.5 and 2 mg/mL) increased both MC3T3-E1 pre-osteoblast adhesion and spreading at 1 h. K-carrageenan (0.125–2 mg/mL) dose-dependently increased pre-osteoblast proliferation and metabolic activity, with a maximum effect at 2 mg/mL at day three. K-carrageenan (0.5 and 2 mg/mL) increased osteogenic differentiation, as shown by enhanced alkaline phosphatase activity (1.8-fold increase at 2 mg/mL) at day four, and matrix mineralization (6.2-fold increase at 2 mg/mL) at day 21. K-carrageenan enhanced osteogenic gene expression (<i<Opn</i<, <i<Dmp1</i<, and <i<Mepe</i<) at day 14 and 21. In conclusion, κ-carrageenan promoted MC3T3-E1 pre-osteoblast adhesion and spreading, metabolic activity, proliferation, and osteogenic differentiation, suggesting that κ-carrageenan is a potential osteogenic inductive factor for clinical application to enhance bone regeneration. |
abstract_unstemmed |
Current cell-based bone tissue regeneration strategies cannot cover large bone defects. K-carrageenan is a highly hydrophilic and biocompatible seaweed-derived sulfated polysaccharide, that has been proposed as a promising candidate for tissue engineering applications. Whether κ-carrageenan can be used to enhance bone regeneration is still unclear. In this study, we aimed to investigate whether κ-carrageenan has osteogenic potential by testing its effect on pre-osteoblast proliferation and osteogenic differentiation in vitro. Treatment with κ-carrageenan (0.5 and 2 mg/mL) increased both MC3T3-E1 pre-osteoblast adhesion and spreading at 1 h. K-carrageenan (0.125–2 mg/mL) dose-dependently increased pre-osteoblast proliferation and metabolic activity, with a maximum effect at 2 mg/mL at day three. K-carrageenan (0.5 and 2 mg/mL) increased osteogenic differentiation, as shown by enhanced alkaline phosphatase activity (1.8-fold increase at 2 mg/mL) at day four, and matrix mineralization (6.2-fold increase at 2 mg/mL) at day 21. K-carrageenan enhanced osteogenic gene expression (<i<Opn</i<, <i<Dmp1</i<, and <i<Mepe</i<) at day 14 and 21. In conclusion, κ-carrageenan promoted MC3T3-E1 pre-osteoblast adhesion and spreading, metabolic activity, proliferation, and osteogenic differentiation, suggesting that κ-carrageenan is a potential osteogenic inductive factor for clinical application to enhance bone regeneration. |
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K-Carrageenan Stimulates Pre-Osteoblast Proliferation and Osteogenic Differentiation: A Potential Factor for the Promotion of Bone Regeneration? |
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