Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release

Sortilin is an endocytosis receptor with a luminal β-propeller domain. Here the authors present the structures of the β-propeller domain at neutral and acidic pH, which reveal that sortilin dimerises and undergoes conformational changes at low pH and further propose a model for low pH-induced ligand...
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Autor*in:	Nadia Leloup [verfasserIn] Philip Lössl [verfasserIn] Dimphna H. Meijer [verfasserIn] Martha Brennich [verfasserIn] Albert J. R. Heck [verfasserIn] Dominique M. E. Thies-Weesie [verfasserIn] Bert J. C. Janssen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 8(2017), 1, Seite 16
Übergeordnetes Werk:	volume:8 ; year:2017 ; number:1 ; pages:16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-017-01485-5

Katalog-ID:	DOAJ07766860X

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spelling	10.1038/s41467-017-01485-5 doi (DE-627)DOAJ07766860X (DE-599)DOAJ6012de2c7ca2445a89156e52dab21cee DE-627 ger DE-627 rakwb eng Nadia Leloup verfasserin aut Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Sortilin is an endocytosis receptor with a luminal β-propeller domain. Here the authors present the structures of the β-propeller domain at neutral and acidic pH, which reveal that sortilin dimerises and undergoes conformational changes at low pH and further propose a model for low pH-induced ligand release by endocytosis receptors. Science Q Philip Lössl verfasserin aut Dimphna H. Meijer verfasserin aut Martha Brennich verfasserin aut Albert J. R. Heck verfasserin aut Dominique M. E. Thies-Weesie verfasserin aut Bert J. C. Janssen verfasserin aut In Nature Communications Nature Portfolio, 2016 8(2017), 1, Seite 16 (DE-627)626457688 (DE-600)2553671-0 20411723 nnns volume:8 year:2017 number:1 pages:16 https://doi.org/10.1038/s41467-017-01485-5 kostenfrei https://doaj.org/article/6012de2c7ca2445a89156e52dab21cee kostenfrei https://doi.org/10.1038/s41467-017-01485-5 kostenfrei https://doaj.org/toc/2041-1723 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_211 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2110 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2017 1 16
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author	Nadia Leloup
spellingShingle	Nadia Leloup misc Science misc Q Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release
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topic_title	Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release
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title	Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release
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title_full	Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release
author_sort	Nadia Leloup
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author_browse	Nadia Leloup Philip Lössl Dimphna H. Meijer Martha Brennich Albert J. R. Heck Dominique M. E. Thies-Weesie Bert J. C. Janssen
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title_sort	low ph-induced conformational change and dimerization of sortilin triggers endocytosed ligand release
title_auth	Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release
abstract	Sortilin is an endocytosis receptor with a luminal β-propeller domain. Here the authors present the structures of the β-propeller domain at neutral and acidic pH, which reveal that sortilin dimerises and undergoes conformational changes at low pH and further propose a model for low pH-induced ligand release by endocytosis receptors.
abstractGer	Sortilin is an endocytosis receptor with a luminal β-propeller domain. Here the authors present the structures of the β-propeller domain at neutral and acidic pH, which reveal that sortilin dimerises and undergoes conformational changes at low pH and further propose a model for low pH-induced ligand release by endocytosis receptors.
abstract_unstemmed	Sortilin is an endocytosis receptor with a luminal β-propeller domain. Here the authors present the structures of the β-propeller domain at neutral and acidic pH, which reveal that sortilin dimerises and undergoes conformational changes at low pH and further propose a model for low pH-induced ligand release by endocytosis receptors.
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container_issue	1
title_short	Low pH-induced conformational change and dimerization of sortilin triggers endocytosed ligand release
url	https://doi.org/10.1038/s41467-017-01485-5 https://doaj.org/article/6012de2c7ca2445a89156e52dab21cee https://doaj.org/toc/2041-1723
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author2	Philip Lössl Dimphna H. Meijer Martha Brennich Albert J. R. Heck Dominique M. E. Thies-Weesie Bert J. C. Janssen
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up_date	2024-07-03T13:24:05.171Z
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