Nanomedicine for Immunotherapy Targeting Hematological Malignancies: Current Approaches and Perspective

Conventional chemotherapy has partial therapeutic effects against hematological malignancies and is correlated with serious side effects and great risk of relapse. Recently, immunotherapeutic drugs have provided encouraging results in the treatment of hematological malignancies. Several immunotherap...
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Gespeichert in:

Autor*in:	Alessandro Allegra [verfasserIn] Mario Di Gioacchino [verfasserIn] Alessandro Tonacci [verfasserIn] Claudia Petrarca [verfasserIn] Sebastiano Gangemi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	nanomedicine nanoparticles hematological malignancies immunotherapy immune system tumor microenvironment

Übergeordnetes Werk:	In: Nanomaterials - MDPI AG, 2012, 11(2021), 11, p 2792
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:11, p 2792

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nano11112792

Katalog-ID:	DOAJ077675835

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language	English
source	In Nanomaterials 11(2021), 11, p 2792 volume:11 year:2021 number:11, p 2792
sourceStr	In Nanomaterials 11(2021), 11, p 2792 volume:11 year:2021 number:11, p 2792
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	nanomedicine nanoparticles hematological malignancies immunotherapy immune system tumor microenvironment Chemistry
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container_title	Nanomaterials
authorswithroles_txt_mv	Alessandro Allegra @@aut@@ Mario Di Gioacchino @@aut@@ Alessandro Tonacci @@aut@@ Claudia Petrarca @@aut@@ Sebastiano Gangemi @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
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callnumber-first	Q - Science
author	Alessandro Allegra
spellingShingle	Alessandro Allegra misc QD1-999 misc nanomedicine misc nanoparticles misc hematological malignancies misc immunotherapy misc immune system misc tumor microenvironment misc Chemistry Nanomedicine for Immunotherapy Targeting Hematological Malignancies: Current Approaches and Perspective
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topic	misc QD1-999 misc nanomedicine misc nanoparticles misc hematological malignancies misc immunotherapy misc immune system misc tumor microenvironment misc Chemistry
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title	Nanomedicine for Immunotherapy Targeting Hematological Malignancies: Current Approaches and Perspective
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title_auth	Nanomedicine for Immunotherapy Targeting Hematological Malignancies: Current Approaches and Perspective
abstract	Conventional chemotherapy has partial therapeutic effects against hematological malignancies and is correlated with serious side effects and great risk of relapse. Recently, immunotherapeutic drugs have provided encouraging results in the treatment of hematological malignancies. Several immunotherapeutic antibodies and cell therapeutics are in dynamic development such as immune checkpoint blockades and CAR-T treatment. However, numerous problems restrain the therapeutic effectiveness of tumor immunotherapy as an insufficient anti-tumor immune response, the interference of an immune-suppressive bone marrow, or tumoral milieu with the discharge of immunosuppressive components, access of myeloid-derived suppressor cells, monocyte intrusion, macrophage modifications, all factors facilitating the tumor to escape the anti-cancer immune response, finally reducing the efficiency of the immunotherapy. Nanotechnology can be employed to overcome each of these aspects, therefore having the possibility to successfully produce anti-cancer immune responses. Here, we review recent findings on the use of biomaterial-based nanoparticles in hematological malignancies immunotherapy. In the future, a deeper understanding of tumor immunology and of the implications of nanomedicine will allow nanoparticles to revolutionize tumor immunotherapy, and nanomedicine approaches will reveal their great potential for clinical translation.
abstractGer	Conventional chemotherapy has partial therapeutic effects against hematological malignancies and is correlated with serious side effects and great risk of relapse. Recently, immunotherapeutic drugs have provided encouraging results in the treatment of hematological malignancies. Several immunotherapeutic antibodies and cell therapeutics are in dynamic development such as immune checkpoint blockades and CAR-T treatment. However, numerous problems restrain the therapeutic effectiveness of tumor immunotherapy as an insufficient anti-tumor immune response, the interference of an immune-suppressive bone marrow, or tumoral milieu with the discharge of immunosuppressive components, access of myeloid-derived suppressor cells, monocyte intrusion, macrophage modifications, all factors facilitating the tumor to escape the anti-cancer immune response, finally reducing the efficiency of the immunotherapy. Nanotechnology can be employed to overcome each of these aspects, therefore having the possibility to successfully produce anti-cancer immune responses. Here, we review recent findings on the use of biomaterial-based nanoparticles in hematological malignancies immunotherapy. In the future, a deeper understanding of tumor immunology and of the implications of nanomedicine will allow nanoparticles to revolutionize tumor immunotherapy, and nanomedicine approaches will reveal their great potential for clinical translation.
abstract_unstemmed	Conventional chemotherapy has partial therapeutic effects against hematological malignancies and is correlated with serious side effects and great risk of relapse. Recently, immunotherapeutic drugs have provided encouraging results in the treatment of hematological malignancies. Several immunotherapeutic antibodies and cell therapeutics are in dynamic development such as immune checkpoint blockades and CAR-T treatment. However, numerous problems restrain the therapeutic effectiveness of tumor immunotherapy as an insufficient anti-tumor immune response, the interference of an immune-suppressive bone marrow, or tumoral milieu with the discharge of immunosuppressive components, access of myeloid-derived suppressor cells, monocyte intrusion, macrophage modifications, all factors facilitating the tumor to escape the anti-cancer immune response, finally reducing the efficiency of the immunotherapy. Nanotechnology can be employed to overcome each of these aspects, therefore having the possibility to successfully produce anti-cancer immune responses. Here, we review recent findings on the use of biomaterial-based nanoparticles in hematological malignancies immunotherapy. In the future, a deeper understanding of tumor immunology and of the implications of nanomedicine will allow nanoparticles to revolutionize tumor immunotherapy, and nanomedicine approaches will reveal their great potential for clinical translation.
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title_short	Nanomedicine for Immunotherapy Targeting Hematological Malignancies: Current Approaches and Perspective
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