Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine.

There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen. However, antibodies induced by such GP vaccines are typically autologous and limited to the other members of t...
Ausführliche Beschreibung

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Autor*in:	Md Niaz Rahim [verfasserIn] Edmund G Wee [verfasserIn] Shihua He [verfasserIn] Jonathan Audet [verfasserIn] Kevin Tierney [verfasserIn] Nathifa Moyo [verfasserIn] Zara Hannoun [verfasserIn] Alison Crook [verfasserIn] Andrea Baines [verfasserIn] Bette Korber [verfasserIn] Xiangguo Qiu [verfasserIn] Tomáš Hanke [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	In: PLoS Pathogens - Public Library of Science (PLoS), 2005, 15(2019), 2, p e1007564
Übergeordnetes Werk:	volume:15 ; year:2019 ; number:2, p e1007564

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1371/journal.ppat.1007564

Katalog-ID:	DOAJ077754719

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Indexfelder

author_variant	m n r mnr e g w egw s h sh j a ja k t kt n m nm z h zh a c ac a b ab b k bk x q xq t h th
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publishDate	2019
allfields	10.1371/journal.ppat.1007564 doi (DE-627)DOAJ077754719 (DE-599)DOAJ6780608bfe9c444b93a3927756e9cc79 DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Md Niaz Rahim verfasserin aut Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine. 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen. However, antibodies induced by such GP vaccines are typically autologous and limited to the other members of the same species. In contrast, T-cell vaccines offer a possibility to design a single pan-filovirus vaccine protecting against all known and even likely existing, but as yet unencountered members of the family. Here, we used a cross-filovirus immunogen based on conserved regions of the filovirus nucleoprotein, matrix and polymerase to construct simian adenovirus- and poxvirus MVA-vectored vaccines, and in a proof-of-concept study demonstrated a protection of the BALB/c and C57BL/6J mice against high, lethal challenges with Ebola and Marburg viruses, two distant members of the family, by vaccine-elicited T cells in the absence of GP antibodies. Immunologic diseases. Allergy Biology (General) Edmund G Wee verfasserin aut Shihua He verfasserin aut Jonathan Audet verfasserin aut Kevin Tierney verfasserin aut Nathifa Moyo verfasserin aut Zara Hannoun verfasserin aut Alison Crook verfasserin aut Andrea Baines verfasserin aut Bette Korber verfasserin aut Xiangguo Qiu verfasserin aut Tomáš Hanke verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 15(2019), 2, p e1007564 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:15 year:2019 number:2, p e1007564 https://doi.org/10.1371/journal.ppat.1007564 kostenfrei https://doaj.org/article/6780608bfe9c444b93a3927756e9cc79 kostenfrei https://doi.org/10.1371/journal.ppat.1007564 kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2019 2, p e1007564
spelling	10.1371/journal.ppat.1007564 doi (DE-627)DOAJ077754719 (DE-599)DOAJ6780608bfe9c444b93a3927756e9cc79 DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Md Niaz Rahim verfasserin aut Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine. 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen. However, antibodies induced by such GP vaccines are typically autologous and limited to the other members of the same species. In contrast, T-cell vaccines offer a possibility to design a single pan-filovirus vaccine protecting against all known and even likely existing, but as yet unencountered members of the family. Here, we used a cross-filovirus immunogen based on conserved regions of the filovirus nucleoprotein, matrix and polymerase to construct simian adenovirus- and poxvirus MVA-vectored vaccines, and in a proof-of-concept study demonstrated a protection of the BALB/c and C57BL/6J mice against high, lethal challenges with Ebola and Marburg viruses, two distant members of the family, by vaccine-elicited T cells in the absence of GP antibodies. Immunologic diseases. Allergy Biology (General) Edmund G Wee verfasserin aut Shihua He verfasserin aut Jonathan Audet verfasserin aut Kevin Tierney verfasserin aut Nathifa Moyo verfasserin aut Zara Hannoun verfasserin aut Alison Crook verfasserin aut Andrea Baines verfasserin aut Bette Korber verfasserin aut Xiangguo Qiu verfasserin aut Tomáš Hanke verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 15(2019), 2, p e1007564 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:15 year:2019 number:2, p e1007564 https://doi.org/10.1371/journal.ppat.1007564 kostenfrei https://doaj.org/article/6780608bfe9c444b93a3927756e9cc79 kostenfrei https://doi.org/10.1371/journal.ppat.1007564 kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2019 2, p e1007564
allfields_unstemmed	10.1371/journal.ppat.1007564 doi (DE-627)DOAJ077754719 (DE-599)DOAJ6780608bfe9c444b93a3927756e9cc79 DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Md Niaz Rahim verfasserin aut Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine. 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen. However, antibodies induced by such GP vaccines are typically autologous and limited to the other members of the same species. In contrast, T-cell vaccines offer a possibility to design a single pan-filovirus vaccine protecting against all known and even likely existing, but as yet unencountered members of the family. Here, we used a cross-filovirus immunogen based on conserved regions of the filovirus nucleoprotein, matrix and polymerase to construct simian adenovirus- and poxvirus MVA-vectored vaccines, and in a proof-of-concept study demonstrated a protection of the BALB/c and C57BL/6J mice against high, lethal challenges with Ebola and Marburg viruses, two distant members of the family, by vaccine-elicited T cells in the absence of GP antibodies. Immunologic diseases. Allergy Biology (General) Edmund G Wee verfasserin aut Shihua He verfasserin aut Jonathan Audet verfasserin aut Kevin Tierney verfasserin aut Nathifa Moyo verfasserin aut Zara Hannoun verfasserin aut Alison Crook verfasserin aut Andrea Baines verfasserin aut Bette Korber verfasserin aut Xiangguo Qiu verfasserin aut Tomáš Hanke verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 15(2019), 2, p e1007564 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:15 year:2019 number:2, p e1007564 https://doi.org/10.1371/journal.ppat.1007564 kostenfrei https://doaj.org/article/6780608bfe9c444b93a3927756e9cc79 kostenfrei https://doi.org/10.1371/journal.ppat.1007564 kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2019 2, p e1007564
allfieldsGer	10.1371/journal.ppat.1007564 doi (DE-627)DOAJ077754719 (DE-599)DOAJ6780608bfe9c444b93a3927756e9cc79 DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Md Niaz Rahim verfasserin aut Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine. 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen. However, antibodies induced by such GP vaccines are typically autologous and limited to the other members of the same species. In contrast, T-cell vaccines offer a possibility to design a single pan-filovirus vaccine protecting against all known and even likely existing, but as yet unencountered members of the family. Here, we used a cross-filovirus immunogen based on conserved regions of the filovirus nucleoprotein, matrix and polymerase to construct simian adenovirus- and poxvirus MVA-vectored vaccines, and in a proof-of-concept study demonstrated a protection of the BALB/c and C57BL/6J mice against high, lethal challenges with Ebola and Marburg viruses, two distant members of the family, by vaccine-elicited T cells in the absence of GP antibodies. Immunologic diseases. Allergy Biology (General) Edmund G Wee verfasserin aut Shihua He verfasserin aut Jonathan Audet verfasserin aut Kevin Tierney verfasserin aut Nathifa Moyo verfasserin aut Zara Hannoun verfasserin aut Alison Crook verfasserin aut Andrea Baines verfasserin aut Bette Korber verfasserin aut Xiangguo Qiu verfasserin aut Tomáš Hanke verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 15(2019), 2, p e1007564 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:15 year:2019 number:2, p e1007564 https://doi.org/10.1371/journal.ppat.1007564 kostenfrei https://doaj.org/article/6780608bfe9c444b93a3927756e9cc79 kostenfrei https://doi.org/10.1371/journal.ppat.1007564 kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2019 2, p e1007564
allfieldsSound	10.1371/journal.ppat.1007564 doi (DE-627)DOAJ077754719 (DE-599)DOAJ6780608bfe9c444b93a3927756e9cc79 DE-627 ger DE-627 rakwb eng RC581-607 QH301-705.5 Md Niaz Rahim verfasserin aut Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine. 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen. However, antibodies induced by such GP vaccines are typically autologous and limited to the other members of the same species. In contrast, T-cell vaccines offer a possibility to design a single pan-filovirus vaccine protecting against all known and even likely existing, but as yet unencountered members of the family. Here, we used a cross-filovirus immunogen based on conserved regions of the filovirus nucleoprotein, matrix and polymerase to construct simian adenovirus- and poxvirus MVA-vectored vaccines, and in a proof-of-concept study demonstrated a protection of the BALB/c and C57BL/6J mice against high, lethal challenges with Ebola and Marburg viruses, two distant members of the family, by vaccine-elicited T cells in the absence of GP antibodies. Immunologic diseases. Allergy Biology (General) Edmund G Wee verfasserin aut Shihua He verfasserin aut Jonathan Audet verfasserin aut Kevin Tierney verfasserin aut Nathifa Moyo verfasserin aut Zara Hannoun verfasserin aut Alison Crook verfasserin aut Andrea Baines verfasserin aut Bette Korber verfasserin aut Xiangguo Qiu verfasserin aut Tomáš Hanke verfasserin aut In PLoS Pathogens Public Library of Science (PLoS), 2005 15(2019), 2, p e1007564 (DE-627)501074422 (DE-600)2205412-1 15537374 nnns volume:15 year:2019 number:2, p e1007564 https://doi.org/10.1371/journal.ppat.1007564 kostenfrei https://doaj.org/article/6780608bfe9c444b93a3927756e9cc79 kostenfrei https://doi.org/10.1371/journal.ppat.1007564 kostenfrei https://doaj.org/toc/1553-7366 Journal toc kostenfrei https://doaj.org/toc/1553-7374 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2019 2, p e1007564
language	English
source	In PLoS Pathogens 15(2019), 2, p e1007564 volume:15 year:2019 number:2, p e1007564
sourceStr	In PLoS Pathogens 15(2019), 2, p e1007564 volume:15 year:2019 number:2, p e1007564
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Immunologic diseases. Allergy Biology (General)
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container_title	PLoS Pathogens
authorswithroles_txt_mv	Md Niaz Rahim @@aut@@ Edmund G Wee @@aut@@ Shihua He @@aut@@ Jonathan Audet @@aut@@ Kevin Tierney @@aut@@ Nathifa Moyo @@aut@@ Zara Hannoun @@aut@@ Alison Crook @@aut@@ Andrea Baines @@aut@@ Bette Korber @@aut@@ Xiangguo Qiu @@aut@@ Tomáš Hanke @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	501074422
id	DOAJ077754719
language_de	englisch
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callnumber-first	R - Medicine
author	Md Niaz Rahim
spellingShingle	Md Niaz Rahim misc RC581-607 misc QH301-705.5 misc Immunologic diseases. Allergy misc Biology (General) Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine.
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topic_title	RC581-607 QH301-705.5 Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine
topic	misc RC581-607 misc QH301-705.5 misc Immunologic diseases. Allergy misc Biology (General)
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title	Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine.
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title_full	Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine
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author_browse	Md Niaz Rahim Edmund G Wee Shihua He Jonathan Audet Kevin Tierney Nathifa Moyo Zara Hannoun Alison Crook Andrea Baines Bette Korber Xiangguo Qiu Tomáš Hanke
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title_sort	complete protection of the balb/c and c57bl/6j mice against ebola and marburg virus lethal challenges by pan-filovirus t-cell epigraph vaccine
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title_auth	Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine.
abstract	There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen. However, antibodies induced by such GP vaccines are typically autologous and limited to the other members of the same species. In contrast, T-cell vaccines offer a possibility to design a single pan-filovirus vaccine protecting against all known and even likely existing, but as yet unencountered members of the family. Here, we used a cross-filovirus immunogen based on conserved regions of the filovirus nucleoprotein, matrix and polymerase to construct simian adenovirus- and poxvirus MVA-vectored vaccines, and in a proof-of-concept study demonstrated a protection of the BALB/c and C57BL/6J mice against high, lethal challenges with Ebola and Marburg viruses, two distant members of the family, by vaccine-elicited T cells in the absence of GP antibodies.
abstractGer	There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen. However, antibodies induced by such GP vaccines are typically autologous and limited to the other members of the same species. In contrast, T-cell vaccines offer a possibility to design a single pan-filovirus vaccine protecting against all known and even likely existing, but as yet unencountered members of the family. Here, we used a cross-filovirus immunogen based on conserved regions of the filovirus nucleoprotein, matrix and polymerase to construct simian adenovirus- and poxvirus MVA-vectored vaccines, and in a proof-of-concept study demonstrated a protection of the BALB/c and C57BL/6J mice against high, lethal challenges with Ebola and Marburg viruses, two distant members of the family, by vaccine-elicited T cells in the absence of GP antibodies.
abstract_unstemmed	There are a number of vaccine candidates under development against a small number of the most common outbreak filoviruses all employing the virus glycoprotein (GP) as the vaccine immunogen. However, antibodies induced by such GP vaccines are typically autologous and limited to the other members of the same species. In contrast, T-cell vaccines offer a possibility to design a single pan-filovirus vaccine protecting against all known and even likely existing, but as yet unencountered members of the family. Here, we used a cross-filovirus immunogen based on conserved regions of the filovirus nucleoprotein, matrix and polymerase to construct simian adenovirus- and poxvirus MVA-vectored vaccines, and in a proof-of-concept study demonstrated a protection of the BALB/c and C57BL/6J mice against high, lethal challenges with Ebola and Marburg viruses, two distant members of the family, by vaccine-elicited T cells in the absence of GP antibodies.
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title_short	Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine.
url	https://doi.org/10.1371/journal.ppat.1007564 https://doaj.org/article/6780608bfe9c444b93a3927756e9cc79 https://doaj.org/toc/1553-7366 https://doaj.org/toc/1553-7374
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up_date	2024-07-03T13:54:57.227Z
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Complete protection of the BALB/c and C57BL/6J mice against Ebola and Marburg virus lethal challenges by pan-filovirus T-cell epigraph vaccine.

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