A novel approach for locating mice brain regions of Cryptococcus neoformans CNS invasion
Aim of this study was to locate the brain regions where Cryptococcus interact with brain cells and invade into brain. After 7 days of intratracheal inocula-tion of GFP-tagged Cryptococcus neoformans strains H99, serial cryosections (10 μm) from 3 C57 BL/6 J mice brains were imaged with immunofluores...
Ausführliche Beschreibung
Autor*in: |
Chunting He [verfasserIn] Qingfen Chen [verfasserIn] Longkun Zhu [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
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2016 |
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Übergeordnetes Werk: |
In: Bangladesh Journal of Pharmacology - Bangladesh Pharmacological Society, 2016, 11(2016), Special, Seite S136-S143 |
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Übergeordnetes Werk: |
volume:11 ; year:2016 ; number:Special ; pages:S136-S143 |
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DOAJ077879392 |
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(DE-627)DOAJ077879392 (DE-599)DOAJ1a41e057f9a740ba8169daa0741a14b6 DE-627 ger DE-627 rakwb eng RM1-950 Chunting He verfasserin aut A novel approach for locating mice brain regions of Cryptococcus neoformans CNS invasion 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim of this study was to locate the brain regions where Cryptococcus interact with brain cells and invade into brain. After 7 days of intratracheal inocula-tion of GFP-tagged Cryptococcus neoformans strains H99, serial cryosections (10 μm) from 3 C57 BL/6 J mice brains were imaged with immunofluorescence microscopy. GFP-tagged H99 were found in some brain regions such as primary motor cortex-secondary motor cortex, caudate putamen, stratum lucidum of hippocampus, field CA1 of hippocampus, dorsal lateral geniculate nucleus, lateral posterior thalamic nucleus, laterorostral part, lateral posterior thalamic nucleus, mediorostral part, retrosplenial agranular cortex, lateral area of secondary visual cortex, and lacunosum molecular layer of the hippocampus. The results will be very useful for further exploring the mechanism of C. neoformans infection of brain. Brain; Cryptococcus neoformans Therapeutics. Pharmacology Qingfen Chen verfasserin aut Longkun Zhu verfasserin aut In Bangladesh Journal of Pharmacology Bangladesh Pharmacological Society, 2016 11(2016), Special, Seite S136-S143 (DE-627)55869540X (DE-600)2410466-8 19910088 nnns volume:11 year:2016 number:Special pages:S136-S143 https://doaj.org/article/1a41e057f9a740ba8169daa0741a14b6 kostenfrei http://www.banglajol.info/bd/index.php/BJP/article/view/26845 kostenfrei https://doaj.org/toc/1991-007X Journal toc kostenfrei https://doaj.org/toc/1991-0088 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 Special S136-S143 |
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(DE-627)DOAJ077879392 (DE-599)DOAJ1a41e057f9a740ba8169daa0741a14b6 DE-627 ger DE-627 rakwb eng RM1-950 Chunting He verfasserin aut A novel approach for locating mice brain regions of Cryptococcus neoformans CNS invasion 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim of this study was to locate the brain regions where Cryptococcus interact with brain cells and invade into brain. After 7 days of intratracheal inocula-tion of GFP-tagged Cryptococcus neoformans strains H99, serial cryosections (10 μm) from 3 C57 BL/6 J mice brains were imaged with immunofluorescence microscopy. GFP-tagged H99 were found in some brain regions such as primary motor cortex-secondary motor cortex, caudate putamen, stratum lucidum of hippocampus, field CA1 of hippocampus, dorsal lateral geniculate nucleus, lateral posterior thalamic nucleus, laterorostral part, lateral posterior thalamic nucleus, mediorostral part, retrosplenial agranular cortex, lateral area of secondary visual cortex, and lacunosum molecular layer of the hippocampus. The results will be very useful for further exploring the mechanism of C. neoformans infection of brain. Brain; Cryptococcus neoformans Therapeutics. Pharmacology Qingfen Chen verfasserin aut Longkun Zhu verfasserin aut In Bangladesh Journal of Pharmacology Bangladesh Pharmacological Society, 2016 11(2016), Special, Seite S136-S143 (DE-627)55869540X (DE-600)2410466-8 19910088 nnns volume:11 year:2016 number:Special pages:S136-S143 https://doaj.org/article/1a41e057f9a740ba8169daa0741a14b6 kostenfrei http://www.banglajol.info/bd/index.php/BJP/article/view/26845 kostenfrei https://doaj.org/toc/1991-007X Journal toc kostenfrei https://doaj.org/toc/1991-0088 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 Special S136-S143 |
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(DE-627)DOAJ077879392 (DE-599)DOAJ1a41e057f9a740ba8169daa0741a14b6 DE-627 ger DE-627 rakwb eng RM1-950 Chunting He verfasserin aut A novel approach for locating mice brain regions of Cryptococcus neoformans CNS invasion 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim of this study was to locate the brain regions where Cryptococcus interact with brain cells and invade into brain. After 7 days of intratracheal inocula-tion of GFP-tagged Cryptococcus neoformans strains H99, serial cryosections (10 μm) from 3 C57 BL/6 J mice brains were imaged with immunofluorescence microscopy. GFP-tagged H99 were found in some brain regions such as primary motor cortex-secondary motor cortex, caudate putamen, stratum lucidum of hippocampus, field CA1 of hippocampus, dorsal lateral geniculate nucleus, lateral posterior thalamic nucleus, laterorostral part, lateral posterior thalamic nucleus, mediorostral part, retrosplenial agranular cortex, lateral area of secondary visual cortex, and lacunosum molecular layer of the hippocampus. The results will be very useful for further exploring the mechanism of C. neoformans infection of brain. Brain; Cryptococcus neoformans Therapeutics. Pharmacology Qingfen Chen verfasserin aut Longkun Zhu verfasserin aut In Bangladesh Journal of Pharmacology Bangladesh Pharmacological Society, 2016 11(2016), Special, Seite S136-S143 (DE-627)55869540X (DE-600)2410466-8 19910088 nnns volume:11 year:2016 number:Special pages:S136-S143 https://doaj.org/article/1a41e057f9a740ba8169daa0741a14b6 kostenfrei http://www.banglajol.info/bd/index.php/BJP/article/view/26845 kostenfrei https://doaj.org/toc/1991-007X Journal toc kostenfrei https://doaj.org/toc/1991-0088 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 Special S136-S143 |
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(DE-627)DOAJ077879392 (DE-599)DOAJ1a41e057f9a740ba8169daa0741a14b6 DE-627 ger DE-627 rakwb eng RM1-950 Chunting He verfasserin aut A novel approach for locating mice brain regions of Cryptococcus neoformans CNS invasion 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim of this study was to locate the brain regions where Cryptococcus interact with brain cells and invade into brain. After 7 days of intratracheal inocula-tion of GFP-tagged Cryptococcus neoformans strains H99, serial cryosections (10 μm) from 3 C57 BL/6 J mice brains were imaged with immunofluorescence microscopy. GFP-tagged H99 were found in some brain regions such as primary motor cortex-secondary motor cortex, caudate putamen, stratum lucidum of hippocampus, field CA1 of hippocampus, dorsal lateral geniculate nucleus, lateral posterior thalamic nucleus, laterorostral part, lateral posterior thalamic nucleus, mediorostral part, retrosplenial agranular cortex, lateral area of secondary visual cortex, and lacunosum molecular layer of the hippocampus. The results will be very useful for further exploring the mechanism of C. neoformans infection of brain. Brain; Cryptococcus neoformans Therapeutics. Pharmacology Qingfen Chen verfasserin aut Longkun Zhu verfasserin aut In Bangladesh Journal of Pharmacology Bangladesh Pharmacological Society, 2016 11(2016), Special, Seite S136-S143 (DE-627)55869540X (DE-600)2410466-8 19910088 nnns volume:11 year:2016 number:Special pages:S136-S143 https://doaj.org/article/1a41e057f9a740ba8169daa0741a14b6 kostenfrei http://www.banglajol.info/bd/index.php/BJP/article/view/26845 kostenfrei https://doaj.org/toc/1991-007X Journal toc kostenfrei https://doaj.org/toc/1991-0088 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 Special S136-S143 |
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(DE-627)DOAJ077879392 (DE-599)DOAJ1a41e057f9a740ba8169daa0741a14b6 DE-627 ger DE-627 rakwb eng RM1-950 Chunting He verfasserin aut A novel approach for locating mice brain regions of Cryptococcus neoformans CNS invasion 2016 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Aim of this study was to locate the brain regions where Cryptococcus interact with brain cells and invade into brain. After 7 days of intratracheal inocula-tion of GFP-tagged Cryptococcus neoformans strains H99, serial cryosections (10 μm) from 3 C57 BL/6 J mice brains were imaged with immunofluorescence microscopy. GFP-tagged H99 were found in some brain regions such as primary motor cortex-secondary motor cortex, caudate putamen, stratum lucidum of hippocampus, field CA1 of hippocampus, dorsal lateral geniculate nucleus, lateral posterior thalamic nucleus, laterorostral part, lateral posterior thalamic nucleus, mediorostral part, retrosplenial agranular cortex, lateral area of secondary visual cortex, and lacunosum molecular layer of the hippocampus. The results will be very useful for further exploring the mechanism of C. neoformans infection of brain. Brain; Cryptococcus neoformans Therapeutics. Pharmacology Qingfen Chen verfasserin aut Longkun Zhu verfasserin aut In Bangladesh Journal of Pharmacology Bangladesh Pharmacological Society, 2016 11(2016), Special, Seite S136-S143 (DE-627)55869540X (DE-600)2410466-8 19910088 nnns volume:11 year:2016 number:Special pages:S136-S143 https://doaj.org/article/1a41e057f9a740ba8169daa0741a14b6 kostenfrei http://www.banglajol.info/bd/index.php/BJP/article/view/26845 kostenfrei https://doaj.org/toc/1991-007X Journal toc kostenfrei https://doaj.org/toc/1991-0088 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2016 Special S136-S143 |
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A novel approach for locating mice brain regions of Cryptococcus neoformans CNS invasion |
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Aim of this study was to locate the brain regions where Cryptococcus interact with brain cells and invade into brain. After 7 days of intratracheal inocula-tion of GFP-tagged Cryptococcus neoformans strains H99, serial cryosections (10 μm) from 3 C57 BL/6 J mice brains were imaged with immunofluorescence microscopy. GFP-tagged H99 were found in some brain regions such as primary motor cortex-secondary motor cortex, caudate putamen, stratum lucidum of hippocampus, field CA1 of hippocampus, dorsal lateral geniculate nucleus, lateral posterior thalamic nucleus, laterorostral part, lateral posterior thalamic nucleus, mediorostral part, retrosplenial agranular cortex, lateral area of secondary visual cortex, and lacunosum molecular layer of the hippocampus. The results will be very useful for further exploring the mechanism of C. neoformans infection of brain. |
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Aim of this study was to locate the brain regions where Cryptococcus interact with brain cells and invade into brain. After 7 days of intratracheal inocula-tion of GFP-tagged Cryptococcus neoformans strains H99, serial cryosections (10 μm) from 3 C57 BL/6 J mice brains were imaged with immunofluorescence microscopy. GFP-tagged H99 were found in some brain regions such as primary motor cortex-secondary motor cortex, caudate putamen, stratum lucidum of hippocampus, field CA1 of hippocampus, dorsal lateral geniculate nucleus, lateral posterior thalamic nucleus, laterorostral part, lateral posterior thalamic nucleus, mediorostral part, retrosplenial agranular cortex, lateral area of secondary visual cortex, and lacunosum molecular layer of the hippocampus. The results will be very useful for further exploring the mechanism of C. neoformans infection of brain. |
abstract_unstemmed |
Aim of this study was to locate the brain regions where Cryptococcus interact with brain cells and invade into brain. After 7 days of intratracheal inocula-tion of GFP-tagged Cryptococcus neoformans strains H99, serial cryosections (10 μm) from 3 C57 BL/6 J mice brains were imaged with immunofluorescence microscopy. GFP-tagged H99 were found in some brain regions such as primary motor cortex-secondary motor cortex, caudate putamen, stratum lucidum of hippocampus, field CA1 of hippocampus, dorsal lateral geniculate nucleus, lateral posterior thalamic nucleus, laterorostral part, lateral posterior thalamic nucleus, mediorostral part, retrosplenial agranular cortex, lateral area of secondary visual cortex, and lacunosum molecular layer of the hippocampus. The results will be very useful for further exploring the mechanism of C. neoformans infection of brain. |
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|
score |
7.400463 |