Melody Processing Characterizes Functional Neuroanatomy in the Aging Brain

The functional neuroanatomical mechanisms underpinning cognition in the normal older brain remain poorly defined, but have important implications for understanding the neurobiology of aging and the impact of neurodegenerative diseases. Auditory processing is an attractive model system for addressing...
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Autor*in:	Jennifer L. Agustus [verfasserIn] Hannah L. Golden [verfasserIn] Martina F. Callaghan [verfasserIn] Rebecca L. Bond [verfasserIn] Elia Benhamou [verfasserIn] Julia C. Hailstone [verfasserIn] Nikolaus Weiskopf [verfasserIn] Jason D. Warren [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	aging complex sound fMRI music semantic temporal

Übergeordnetes Werk:	In: Frontiers in Neuroscience - Frontiers Media S.A., 2008, 12(2018)
Übergeordnetes Werk:	volume:12 ; year:2018

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnins.2018.00815

Katalog-ID:	DOAJ078000742

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spelling	10.3389/fnins.2018.00815 doi (DE-627)DOAJ078000742 (DE-599)DOAJ67bb511993cc4808a5801740dd4cad85 DE-627 ger DE-627 rakwb eng RC321-571 Jennifer L. Agustus verfasserin aut Melody Processing Characterizes Functional Neuroanatomy in the Aging Brain 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The functional neuroanatomical mechanisms underpinning cognition in the normal older brain remain poorly defined, but have important implications for understanding the neurobiology of aging and the impact of neurodegenerative diseases. Auditory processing is an attractive model system for addressing these issues. Here, we used fMRI of melody processing to investigate auditory pattern processing in normal older individuals. We manipulated the temporal (rhythmic) structure and familiarity of melodies in a passive listening, ‘sparse’ fMRI protocol. A distributed cortico-subcortical network was activated by auditory stimulation compared with silence; and within this network, we identified separable signatures of anisochrony processing in bilateral posterior superior temporal lobes; melodic familiarity in bilateral anterior temporal and inferior frontal cortices; and melodic novelty in bilateral temporal and left parietal cortices. Left planum temporale emerged as a ‘hub’ region functionally partitioned for processing different melody dimensions. Activation of Heschl’s gyrus by auditory stimulation correlated with the integrity of underlying cortical tissue architecture, measured using multi-parameter mapping. Our findings delineate neural substrates for analyzing perceptual and semantic properties of melodies in normal aging. Melody (auditory pattern) processing may be a useful candidate paradigm for assessing cerebral networks in the older brain and potentially, in neurodegenerative diseases of later life. aging complex sound fMRI music semantic temporal Neurosciences. Biological psychiatry. Neuropsychiatry Hannah L. Golden verfasserin aut Martina F. Callaghan verfasserin aut Rebecca L. Bond verfasserin aut Elia Benhamou verfasserin aut Julia C. Hailstone verfasserin aut Nikolaus Weiskopf verfasserin aut Jason D. Warren verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 12(2018) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:12 year:2018 https://doi.org/10.3389/fnins.2018.00815 kostenfrei https://doaj.org/article/67bb511993cc4808a5801740dd4cad85 kostenfrei https://www.frontiersin.org/article/10.3389/fnins.2018.00815/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018
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allfieldsGer	10.3389/fnins.2018.00815 doi (DE-627)DOAJ078000742 (DE-599)DOAJ67bb511993cc4808a5801740dd4cad85 DE-627 ger DE-627 rakwb eng RC321-571 Jennifer L. Agustus verfasserin aut Melody Processing Characterizes Functional Neuroanatomy in the Aging Brain 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The functional neuroanatomical mechanisms underpinning cognition in the normal older brain remain poorly defined, but have important implications for understanding the neurobiology of aging and the impact of neurodegenerative diseases. Auditory processing is an attractive model system for addressing these issues. Here, we used fMRI of melody processing to investigate auditory pattern processing in normal older individuals. We manipulated the temporal (rhythmic) structure and familiarity of melodies in a passive listening, ‘sparse’ fMRI protocol. A distributed cortico-subcortical network was activated by auditory stimulation compared with silence; and within this network, we identified separable signatures of anisochrony processing in bilateral posterior superior temporal lobes; melodic familiarity in bilateral anterior temporal and inferior frontal cortices; and melodic novelty in bilateral temporal and left parietal cortices. Left planum temporale emerged as a ‘hub’ region functionally partitioned for processing different melody dimensions. Activation of Heschl’s gyrus by auditory stimulation correlated with the integrity of underlying cortical tissue architecture, measured using multi-parameter mapping. Our findings delineate neural substrates for analyzing perceptual and semantic properties of melodies in normal aging. Melody (auditory pattern) processing may be a useful candidate paradigm for assessing cerebral networks in the older brain and potentially, in neurodegenerative diseases of later life. aging complex sound fMRI music semantic temporal Neurosciences. Biological psychiatry. Neuropsychiatry Hannah L. Golden verfasserin aut Martina F. Callaghan verfasserin aut Rebecca L. Bond verfasserin aut Elia Benhamou verfasserin aut Julia C. Hailstone verfasserin aut Nikolaus Weiskopf verfasserin aut Jason D. Warren verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 12(2018) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:12 year:2018 https://doi.org/10.3389/fnins.2018.00815 kostenfrei https://doaj.org/article/67bb511993cc4808a5801740dd4cad85 kostenfrei https://www.frontiersin.org/article/10.3389/fnins.2018.00815/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018
allfieldsSound	10.3389/fnins.2018.00815 doi (DE-627)DOAJ078000742 (DE-599)DOAJ67bb511993cc4808a5801740dd4cad85 DE-627 ger DE-627 rakwb eng RC321-571 Jennifer L. Agustus verfasserin aut Melody Processing Characterizes Functional Neuroanatomy in the Aging Brain 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The functional neuroanatomical mechanisms underpinning cognition in the normal older brain remain poorly defined, but have important implications for understanding the neurobiology of aging and the impact of neurodegenerative diseases. Auditory processing is an attractive model system for addressing these issues. Here, we used fMRI of melody processing to investigate auditory pattern processing in normal older individuals. We manipulated the temporal (rhythmic) structure and familiarity of melodies in a passive listening, ‘sparse’ fMRI protocol. A distributed cortico-subcortical network was activated by auditory stimulation compared with silence; and within this network, we identified separable signatures of anisochrony processing in bilateral posterior superior temporal lobes; melodic familiarity in bilateral anterior temporal and inferior frontal cortices; and melodic novelty in bilateral temporal and left parietal cortices. Left planum temporale emerged as a ‘hub’ region functionally partitioned for processing different melody dimensions. Activation of Heschl’s gyrus by auditory stimulation correlated with the integrity of underlying cortical tissue architecture, measured using multi-parameter mapping. Our findings delineate neural substrates for analyzing perceptual and semantic properties of melodies in normal aging. Melody (auditory pattern) processing may be a useful candidate paradigm for assessing cerebral networks in the older brain and potentially, in neurodegenerative diseases of later life. aging complex sound fMRI music semantic temporal Neurosciences. Biological psychiatry. Neuropsychiatry Hannah L. Golden verfasserin aut Martina F. Callaghan verfasserin aut Rebecca L. Bond verfasserin aut Elia Benhamou verfasserin aut Julia C. Hailstone verfasserin aut Nikolaus Weiskopf verfasserin aut Jason D. Warren verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 12(2018) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:12 year:2018 https://doi.org/10.3389/fnins.2018.00815 kostenfrei https://doaj.org/article/67bb511993cc4808a5801740dd4cad85 kostenfrei https://www.frontiersin.org/article/10.3389/fnins.2018.00815/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2018
language	English
source	In Frontiers in Neuroscience 12(2018) volume:12 year:2018
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topic_facet	aging complex sound fMRI music semantic temporal Neurosciences. Biological psychiatry. Neuropsychiatry
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container_title	Frontiers in Neuroscience
authorswithroles_txt_mv	Jennifer L. Agustus @@aut@@ Hannah L. Golden @@aut@@ Martina F. Callaghan @@aut@@ Rebecca L. Bond @@aut@@ Elia Benhamou @@aut@@ Julia C. Hailstone @@aut@@ Nikolaus Weiskopf @@aut@@ Jason D. Warren @@aut@@
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callnumber-first	R - Medicine
author	Jennifer L. Agustus
spellingShingle	Jennifer L. Agustus misc RC321-571 misc aging misc complex sound misc fMRI misc music misc semantic misc temporal misc Neurosciences. Biological psychiatry. Neuropsychiatry Melody Processing Characterizes Functional Neuroanatomy in the Aging Brain
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topic	misc RC321-571 misc aging misc complex sound misc fMRI misc music misc semantic misc temporal misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	Melody Processing Characterizes Functional Neuroanatomy in the Aging Brain
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title_full	Melody Processing Characterizes Functional Neuroanatomy in the Aging Brain
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author_browse	Jennifer L. Agustus Hannah L. Golden Martina F. Callaghan Rebecca L. Bond Elia Benhamou Julia C. Hailstone Nikolaus Weiskopf Jason D. Warren
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title_sort	melody processing characterizes functional neuroanatomy in the aging brain
callnumber	RC321-571
title_auth	Melody Processing Characterizes Functional Neuroanatomy in the Aging Brain
abstract	The functional neuroanatomical mechanisms underpinning cognition in the normal older brain remain poorly defined, but have important implications for understanding the neurobiology of aging and the impact of neurodegenerative diseases. Auditory processing is an attractive model system for addressing these issues. Here, we used fMRI of melody processing to investigate auditory pattern processing in normal older individuals. We manipulated the temporal (rhythmic) structure and familiarity of melodies in a passive listening, ‘sparse’ fMRI protocol. A distributed cortico-subcortical network was activated by auditory stimulation compared with silence; and within this network, we identified separable signatures of anisochrony processing in bilateral posterior superior temporal lobes; melodic familiarity in bilateral anterior temporal and inferior frontal cortices; and melodic novelty in bilateral temporal and left parietal cortices. Left planum temporale emerged as a ‘hub’ region functionally partitioned for processing different melody dimensions. Activation of Heschl’s gyrus by auditory stimulation correlated with the integrity of underlying cortical tissue architecture, measured using multi-parameter mapping. Our findings delineate neural substrates for analyzing perceptual and semantic properties of melodies in normal aging. Melody (auditory pattern) processing may be a useful candidate paradigm for assessing cerebral networks in the older brain and potentially, in neurodegenerative diseases of later life.
abstractGer	The functional neuroanatomical mechanisms underpinning cognition in the normal older brain remain poorly defined, but have important implications for understanding the neurobiology of aging and the impact of neurodegenerative diseases. Auditory processing is an attractive model system for addressing these issues. Here, we used fMRI of melody processing to investigate auditory pattern processing in normal older individuals. We manipulated the temporal (rhythmic) structure and familiarity of melodies in a passive listening, ‘sparse’ fMRI protocol. A distributed cortico-subcortical network was activated by auditory stimulation compared with silence; and within this network, we identified separable signatures of anisochrony processing in bilateral posterior superior temporal lobes; melodic familiarity in bilateral anterior temporal and inferior frontal cortices; and melodic novelty in bilateral temporal and left parietal cortices. Left planum temporale emerged as a ‘hub’ region functionally partitioned for processing different melody dimensions. Activation of Heschl’s gyrus by auditory stimulation correlated with the integrity of underlying cortical tissue architecture, measured using multi-parameter mapping. Our findings delineate neural substrates for analyzing perceptual and semantic properties of melodies in normal aging. Melody (auditory pattern) processing may be a useful candidate paradigm for assessing cerebral networks in the older brain and potentially, in neurodegenerative diseases of later life.
abstract_unstemmed	The functional neuroanatomical mechanisms underpinning cognition in the normal older brain remain poorly defined, but have important implications for understanding the neurobiology of aging and the impact of neurodegenerative diseases. Auditory processing is an attractive model system for addressing these issues. Here, we used fMRI of melody processing to investigate auditory pattern processing in normal older individuals. We manipulated the temporal (rhythmic) structure and familiarity of melodies in a passive listening, ‘sparse’ fMRI protocol. A distributed cortico-subcortical network was activated by auditory stimulation compared with silence; and within this network, we identified separable signatures of anisochrony processing in bilateral posterior superior temporal lobes; melodic familiarity in bilateral anterior temporal and inferior frontal cortices; and melodic novelty in bilateral temporal and left parietal cortices. Left planum temporale emerged as a ‘hub’ region functionally partitioned for processing different melody dimensions. Activation of Heschl’s gyrus by auditory stimulation correlated with the integrity of underlying cortical tissue architecture, measured using multi-parameter mapping. Our findings delineate neural substrates for analyzing perceptual and semantic properties of melodies in normal aging. Melody (auditory pattern) processing may be a useful candidate paradigm for assessing cerebral networks in the older brain and potentially, in neurodegenerative diseases of later life.
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title_short	Melody Processing Characterizes Functional Neuroanatomy in the Aging Brain
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