Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis

Abstract Background Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients...
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Autor*in:	Anji Xiong [verfasserIn] Qingting Liu [verfasserIn] Jiaxun Zhong [verfasserIn] Yuzi Cao [verfasserIn] Qilang Xiang [verfasserIn] Ziyi Hu [verfasserIn] Shifeng Zhou [verfasserIn] Zhuoyao Song [verfasserIn] Huini Chen [verfasserIn] Yan Zhang [verfasserIn] Hongxu Cui [verfasserIn] Shiquan Shuai [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Systemic sclerosis Pulmonary hypertension Early diagnosis Mortality Meta-analysis

Übergeordnetes Werk:	In: Advances in Rheumatology - BMC, 2019, 62(2022), 1, Seite 10
Übergeordnetes Werk:	volume:62 ; year:2022 ; number:1 ; pages:10

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s42358-022-00239-2

Katalog-ID:	DOAJ078054605

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520			\|a Abstract Background Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH. Methods We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis. Results The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]). Conclusions This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc.
650		4	\|a Systemic sclerosis
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allfields	10.1186/s42358-022-00239-2 doi (DE-627)DOAJ078054605 (DE-599)DOAJ118f2c2b64f04128947b097ec979d3c1 DE-627 ger DE-627 rakwb eng RC925-935 RC581-607 Anji Xiong verfasserin aut Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH. Methods We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis. Results The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]). Conclusions This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc. Systemic sclerosis Pulmonary hypertension Early diagnosis Mortality Meta-analysis Diseases of the musculoskeletal system Immunologic diseases. Allergy Qingting Liu verfasserin aut Jiaxun Zhong verfasserin aut Yuzi Cao verfasserin aut Qilang Xiang verfasserin aut Ziyi Hu verfasserin aut Shifeng Zhou verfasserin aut Zhuoyao Song verfasserin aut Huini Chen verfasserin aut Yan Zhang verfasserin aut Hongxu Cui verfasserin aut Shiquan Shuai verfasserin aut In Advances in Rheumatology BMC, 2019 62(2022), 1, Seite 10 (DE-627)1028897588 25233106 nnns volume:62 year:2022 number:1 pages:10 https://doi.org/10.1186/s42358-022-00239-2 kostenfrei https://doaj.org/article/118f2c2b64f04128947b097ec979d3c1 kostenfrei https://doi.org/10.1186/s42358-022-00239-2 kostenfrei https://doaj.org/toc/2523-3106 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2022 1 10
spelling	10.1186/s42358-022-00239-2 doi (DE-627)DOAJ078054605 (DE-599)DOAJ118f2c2b64f04128947b097ec979d3c1 DE-627 ger DE-627 rakwb eng RC925-935 RC581-607 Anji Xiong verfasserin aut Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH. Methods We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis. Results The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]). Conclusions This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc. Systemic sclerosis Pulmonary hypertension Early diagnosis Mortality Meta-analysis Diseases of the musculoskeletal system Immunologic diseases. Allergy Qingting Liu verfasserin aut Jiaxun Zhong verfasserin aut Yuzi Cao verfasserin aut Qilang Xiang verfasserin aut Ziyi Hu verfasserin aut Shifeng Zhou verfasserin aut Zhuoyao Song verfasserin aut Huini Chen verfasserin aut Yan Zhang verfasserin aut Hongxu Cui verfasserin aut Shiquan Shuai verfasserin aut In Advances in Rheumatology BMC, 2019 62(2022), 1, Seite 10 (DE-627)1028897588 25233106 nnns volume:62 year:2022 number:1 pages:10 https://doi.org/10.1186/s42358-022-00239-2 kostenfrei https://doaj.org/article/118f2c2b64f04128947b097ec979d3c1 kostenfrei https://doi.org/10.1186/s42358-022-00239-2 kostenfrei https://doaj.org/toc/2523-3106 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2022 1 10
allfields_unstemmed	10.1186/s42358-022-00239-2 doi (DE-627)DOAJ078054605 (DE-599)DOAJ118f2c2b64f04128947b097ec979d3c1 DE-627 ger DE-627 rakwb eng RC925-935 RC581-607 Anji Xiong verfasserin aut Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH. Methods We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis. Results The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]). Conclusions This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc. Systemic sclerosis Pulmonary hypertension Early diagnosis Mortality Meta-analysis Diseases of the musculoskeletal system Immunologic diseases. Allergy Qingting Liu verfasserin aut Jiaxun Zhong verfasserin aut Yuzi Cao verfasserin aut Qilang Xiang verfasserin aut Ziyi Hu verfasserin aut Shifeng Zhou verfasserin aut Zhuoyao Song verfasserin aut Huini Chen verfasserin aut Yan Zhang verfasserin aut Hongxu Cui verfasserin aut Shiquan Shuai verfasserin aut In Advances in Rheumatology BMC, 2019 62(2022), 1, Seite 10 (DE-627)1028897588 25233106 nnns volume:62 year:2022 number:1 pages:10 https://doi.org/10.1186/s42358-022-00239-2 kostenfrei https://doaj.org/article/118f2c2b64f04128947b097ec979d3c1 kostenfrei https://doi.org/10.1186/s42358-022-00239-2 kostenfrei https://doaj.org/toc/2523-3106 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2022 1 10
allfieldsGer	10.1186/s42358-022-00239-2 doi (DE-627)DOAJ078054605 (DE-599)DOAJ118f2c2b64f04128947b097ec979d3c1 DE-627 ger DE-627 rakwb eng RC925-935 RC581-607 Anji Xiong verfasserin aut Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH. Methods We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis. Results The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]). Conclusions This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc. Systemic sclerosis Pulmonary hypertension Early diagnosis Mortality Meta-analysis Diseases of the musculoskeletal system Immunologic diseases. Allergy Qingting Liu verfasserin aut Jiaxun Zhong verfasserin aut Yuzi Cao verfasserin aut Qilang Xiang verfasserin aut Ziyi Hu verfasserin aut Shifeng Zhou verfasserin aut Zhuoyao Song verfasserin aut Huini Chen verfasserin aut Yan Zhang verfasserin aut Hongxu Cui verfasserin aut Shiquan Shuai verfasserin aut In Advances in Rheumatology BMC, 2019 62(2022), 1, Seite 10 (DE-627)1028897588 25233106 nnns volume:62 year:2022 number:1 pages:10 https://doi.org/10.1186/s42358-022-00239-2 kostenfrei https://doaj.org/article/118f2c2b64f04128947b097ec979d3c1 kostenfrei https://doi.org/10.1186/s42358-022-00239-2 kostenfrei https://doaj.org/toc/2523-3106 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2022 1 10
allfieldsSound	10.1186/s42358-022-00239-2 doi (DE-627)DOAJ078054605 (DE-599)DOAJ118f2c2b64f04128947b097ec979d3c1 DE-627 ger DE-627 rakwb eng RC925-935 RC581-607 Anji Xiong verfasserin aut Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH. Methods We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis. Results The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]). Conclusions This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc. Systemic sclerosis Pulmonary hypertension Early diagnosis Mortality Meta-analysis Diseases of the musculoskeletal system Immunologic diseases. Allergy Qingting Liu verfasserin aut Jiaxun Zhong verfasserin aut Yuzi Cao verfasserin aut Qilang Xiang verfasserin aut Ziyi Hu verfasserin aut Shifeng Zhou verfasserin aut Zhuoyao Song verfasserin aut Huini Chen verfasserin aut Yan Zhang verfasserin aut Hongxu Cui verfasserin aut Shiquan Shuai verfasserin aut In Advances in Rheumatology BMC, 2019 62(2022), 1, Seite 10 (DE-627)1028897588 25233106 nnns volume:62 year:2022 number:1 pages:10 https://doi.org/10.1186/s42358-022-00239-2 kostenfrei https://doaj.org/article/118f2c2b64f04128947b097ec979d3c1 kostenfrei https://doi.org/10.1186/s42358-022-00239-2 kostenfrei https://doaj.org/toc/2523-3106 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 62 2022 1 10
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We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH. Methods We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis. Results The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]). 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callnumber-first	R - Medicine
author	Anji Xiong
spellingShingle	Anji Xiong misc RC925-935 misc RC581-607 misc Systemic sclerosis misc Pulmonary hypertension misc Early diagnosis misc Mortality misc Meta-analysis misc Diseases of the musculoskeletal system misc Immunologic diseases. Allergy Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis
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topic_title	RC925-935 RC581-607 Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis Systemic sclerosis Pulmonary hypertension Early diagnosis Mortality Meta-analysis
topic	misc RC925-935 misc RC581-607 misc Systemic sclerosis misc Pulmonary hypertension misc Early diagnosis misc Mortality misc Meta-analysis misc Diseases of the musculoskeletal system misc Immunologic diseases. Allergy
topic_unstemmed	misc RC925-935 misc RC581-607 misc Systemic sclerosis misc Pulmonary hypertension misc Early diagnosis misc Mortality misc Meta-analysis misc Diseases of the musculoskeletal system misc Immunologic diseases. Allergy
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title	Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis
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title_full	Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis
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author_browse	Anji Xiong Qingting Liu Jiaxun Zhong Yuzi Cao Qilang Xiang Ziyi Hu Shifeng Zhou Zhuoyao Song Huini Chen Yan Zhang Hongxu Cui Shiquan Shuai
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title_sort	increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis
callnumber	RC925-935
title_auth	Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis
abstract	Abstract Background Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH. Methods We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis. Results The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]). Conclusions This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc.
abstractGer	Abstract Background Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH. Methods We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis. Results The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]). Conclusions This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc.
abstract_unstemmed	Abstract Background Pulmonary hypertension (PH) is a frequent complication of systemic sclerosis (SSc) and is currently one of the primary causes of death in patients with this disease. We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH. Methods We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis. Results The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]). Conclusions This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc.
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title_short	Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis
url	https://doi.org/10.1186/s42358-022-00239-2 https://doaj.org/article/118f2c2b64f04128947b097ec979d3c1 https://doaj.org/toc/2523-3106
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author2	Qingting Liu Jiaxun Zhong Yuzi Cao Qilang Xiang Ziyi Hu Shifeng Zhou Zhuoyao Song Huini Chen Yan Zhang Hongxu Cui Shiquan Shuai
author2Str	Qingting Liu Jiaxun Zhong Yuzi Cao Qilang Xiang Ziyi Hu Shifeng Zhou Zhuoyao Song Huini Chen Yan Zhang Hongxu Cui Shiquan Shuai
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up_date	2024-07-03T15:41:09.695Z
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We conducted a systematic review and meta-analysis to assess the association between PH and mortality in patients with SSc to verify trends in mortality in patients with SSc-associated PH. Methods We searched the PubMed and Embase databases for published studies on SSc-associated PH from inception to May 2021. All cohort studies in which mortality and/or survival for SSc-associated PH were reported were included in the analysis. The outcome parameters were pooled and analyzed using a random-effects model via generic inverse-variance weighting in conventional and cumulative meta-analysis. Results The literature search identified 1161 citations, and the full texts of 54 studies were examined. Sixteen articles, with a total of 7857 patients with SSc and 1140 patients with SSc-associated PH, were included in the meta-analysis. Patients with SSc-associated PH had a higher pooled risk of mortality than patients with SSc without PH (risk ratio = 3.12; 95% confidence interval: [2.44, 3.98]). Conclusions This meta-analysis revealed a higher mortality in patients with SSc-associated PH. PH was a significant predictor of death in patients with SSc. Thus, early diagnosis and treatment of PH are important in patients with SSc.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Systemic sclerosis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pulmonary hypertension</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Early diagnosis</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Mortality</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Meta-analysis</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the musculoskeletal system</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Immunologic diseases. 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Increased risk of mortality in systemic sclerosis-associated pulmonary hypertension: a systemic review and meta-analysis

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