ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity

Specialized receptors that recognize molecular patterns such as double stranded RNA duplexes—indicative of viral replication—are potent triggers of the innate immune system. Although their activation is beneficial during viral infection, RNA transcribed from endogenous mobile genetic elements may al...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Mart M. Lamers [verfasserIn] Bernadette G. van den Hoogen [verfasserIn] Bart L. Haagmans [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	ADAR1 cytoplasmic innate immunity PKR MDA5 OAS RIG-I

Übergeordnetes Werk:	In: Frontiers in Immunology - Frontiers Media S.A., 2011, 10(2019)
Übergeordnetes Werk:	volume:10 ; year:2019

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fimmu.2019.01763

Katalog-ID:	DOAJ078055164

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520			\|a Specialized receptors that recognize molecular patterns such as double stranded RNA duplexes—indicative of viral replication—are potent triggers of the innate immune system. Although their activation is beneficial during viral infection, RNA transcribed from endogenous mobile genetic elements may also act as ligands potentially causing autoimmunity. Recent advances indicate that the adenosine deaminase ADAR1 through RNA editing is involved in dampening the canonical antiviral RIG-I-like receptor-, PKR-, and OAS-RNAse L pathways to prevent autoimmunity. However, this inhibitory effect must be overcome during viral infections. In this review we discuss ADAR1's critical role in balancing immune activation and self-tolerance.
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allfieldsGer	10.3389/fimmu.2019.01763 doi (DE-627)DOAJ078055164 (DE-599)DOAJb8864e03f7ca4e8db1ade3371615ff2a DE-627 ger DE-627 rakwb eng RC581-607 Mart M. Lamers verfasserin aut ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Specialized receptors that recognize molecular patterns such as double stranded RNA duplexes—indicative of viral replication—are potent triggers of the innate immune system. Although their activation is beneficial during viral infection, RNA transcribed from endogenous mobile genetic elements may also act as ligands potentially causing autoimmunity. Recent advances indicate that the adenosine deaminase ADAR1 through RNA editing is involved in dampening the canonical antiviral RIG-I-like receptor-, PKR-, and OAS-RNAse L pathways to prevent autoimmunity. However, this inhibitory effect must be overcome during viral infections. In this review we discuss ADAR1's critical role in balancing immune activation and self-tolerance. ADAR1 cytoplasmic innate immunity PKR MDA5 OAS RIG-I Immunologic diseases. Allergy Bernadette G. van den Hoogen verfasserin aut Bart L. Haagmans verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2019) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2019 https://doi.org/10.3389/fimmu.2019.01763 kostenfrei https://doaj.org/article/b8864e03f7ca4e8db1ade3371615ff2a kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.01763/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019
allfieldsSound	10.3389/fimmu.2019.01763 doi (DE-627)DOAJ078055164 (DE-599)DOAJb8864e03f7ca4e8db1ade3371615ff2a DE-627 ger DE-627 rakwb eng RC581-607 Mart M. Lamers verfasserin aut ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Specialized receptors that recognize molecular patterns such as double stranded RNA duplexes—indicative of viral replication—are potent triggers of the innate immune system. Although their activation is beneficial during viral infection, RNA transcribed from endogenous mobile genetic elements may also act as ligands potentially causing autoimmunity. Recent advances indicate that the adenosine deaminase ADAR1 through RNA editing is involved in dampening the canonical antiviral RIG-I-like receptor-, PKR-, and OAS-RNAse L pathways to prevent autoimmunity. However, this inhibitory effect must be overcome during viral infections. In this review we discuss ADAR1's critical role in balancing immune activation and self-tolerance. ADAR1 cytoplasmic innate immunity PKR MDA5 OAS RIG-I Immunologic diseases. Allergy Bernadette G. van den Hoogen verfasserin aut Bart L. Haagmans verfasserin aut In Frontiers in Immunology Frontiers Media S.A., 2011 10(2019) (DE-627)657998354 (DE-600)2606827-8 16643224 nnns volume:10 year:2019 https://doi.org/10.3389/fimmu.2019.01763 kostenfrei https://doaj.org/article/b8864e03f7ca4e8db1ade3371615ff2a kostenfrei https://www.frontiersin.org/article/10.3389/fimmu.2019.01763/full kostenfrei https://doaj.org/toc/1664-3224 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 10 2019
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topic_facet	ADAR1 cytoplasmic innate immunity PKR MDA5 OAS RIG-I Immunologic diseases. Allergy
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container_title	Frontiers in Immunology
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callnumber-first	R - Medicine
author	Mart M. Lamers
spellingShingle	Mart M. Lamers misc RC581-607 misc ADAR1 misc cytoplasmic innate immunity misc PKR misc MDA5 misc OAS misc RIG-I misc Immunologic diseases. Allergy ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity
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topic_title	RC581-607 ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity ADAR1 cytoplasmic innate immunity PKR MDA5 OAS RIG-I
topic	misc RC581-607 misc ADAR1 misc cytoplasmic innate immunity misc PKR misc MDA5 misc OAS misc RIG-I misc Immunologic diseases. Allergy
topic_unstemmed	misc RC581-607 misc ADAR1 misc cytoplasmic innate immunity misc PKR misc MDA5 misc OAS misc RIG-I misc Immunologic diseases. Allergy
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title	ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity
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author_browse	Mart M. Lamers Bernadette G. van den Hoogen Bart L. Haagmans
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title_sort	adar1: “editor-in-chief” of cytoplasmic innate immunity
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title_auth	ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity
abstract	Specialized receptors that recognize molecular patterns such as double stranded RNA duplexes—indicative of viral replication—are potent triggers of the innate immune system. Although their activation is beneficial during viral infection, RNA transcribed from endogenous mobile genetic elements may also act as ligands potentially causing autoimmunity. Recent advances indicate that the adenosine deaminase ADAR1 through RNA editing is involved in dampening the canonical antiviral RIG-I-like receptor-, PKR-, and OAS-RNAse L pathways to prevent autoimmunity. However, this inhibitory effect must be overcome during viral infections. In this review we discuss ADAR1's critical role in balancing immune activation and self-tolerance.
abstractGer	Specialized receptors that recognize molecular patterns such as double stranded RNA duplexes—indicative of viral replication—are potent triggers of the innate immune system. Although their activation is beneficial during viral infection, RNA transcribed from endogenous mobile genetic elements may also act as ligands potentially causing autoimmunity. Recent advances indicate that the adenosine deaminase ADAR1 through RNA editing is involved in dampening the canonical antiviral RIG-I-like receptor-, PKR-, and OAS-RNAse L pathways to prevent autoimmunity. However, this inhibitory effect must be overcome during viral infections. In this review we discuss ADAR1's critical role in balancing immune activation and self-tolerance.
abstract_unstemmed	Specialized receptors that recognize molecular patterns such as double stranded RNA duplexes—indicative of viral replication—are potent triggers of the innate immune system. Although their activation is beneficial during viral infection, RNA transcribed from endogenous mobile genetic elements may also act as ligands potentially causing autoimmunity. Recent advances indicate that the adenosine deaminase ADAR1 through RNA editing is involved in dampening the canonical antiviral RIG-I-like receptor-, PKR-, and OAS-RNAse L pathways to prevent autoimmunity. However, this inhibitory effect must be overcome during viral infections. In this review we discuss ADAR1's critical role in balancing immune activation and self-tolerance.
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title_short	ADAR1: “Editor-in-Chief” of Cytoplasmic Innate Immunity
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up_date	2024-07-03T15:41:22.175Z
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