Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis

Abstract Background Immune-related enterocolitis (irEC) is the most common serious complication from checkpoint inhibitors (CPIs). The current front-line treatment for irEC, high-dose corticosteroids (CS), have significant side effects and prolonged therapy may reduce CPI-anti-tumor activity. Early...
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Autor*in:	Daniel H Johnson [verfasserIn] Chrystia M Zobniw [verfasserIn] Van A Trinh [verfasserIn] Junsheng Ma [verfasserIn] Roland L Bassett [verfasserIn] Noha Abdel-Wahab [verfasserIn] Jaime Anderson [verfasserIn] Jennifer E Davis [verfasserIn] Jocelyn Joseph [verfasserIn] Marc Uemura [verfasserIn] Ali Noman [verfasserIn] Hamzah Abu-Sbeih [verfasserIn] Cassian Yee [verfasserIn] Rodabe Amaria [verfasserIn] Sapna Patel [verfasserIn] Hussein Tawbi [verfasserIn] Isabella C Glitza [verfasserIn] Michael A Davies [verfasserIn] Michael K Wong [verfasserIn] Scott Woodman [verfasserIn] Wen-Jen Hwu [verfasserIn] Patrick Hwu [verfasserIn] Yinghong Wang [verfasserIn] Adi Diab [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Infliximab Immune-related enterocolitis Immune checkpoint inhibitors

Übergeordnetes Werk:	In: Journal for ImmunoTherapy of Cancer - BMJ Publishing Group, 2013, 6(2018), 1, Seite 8
Übergeordnetes Werk:	volume:6 ; year:2018 ; number:1 ; pages:8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s40425-018-0412-0

Katalog-ID:	DOAJ078063280

Internformat


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520			\|a Abstract Background Immune-related enterocolitis (irEC) is the most common serious complication from checkpoint inhibitors (CPIs). The current front-line treatment for irEC, high-dose corticosteroids (CS), have significant side effects and prolonged therapy may reduce CPI-anti-tumor activity. Early addition of TNF-α inhibitors such as infliximab (IFX) may expedite symptom resolution and shorten CS duration. Thus, we conducted the first retrospective study, to our knowledge, evaluating symptom resolution in patients with irEC treated with and without IFX. Methods Data were collected from the medical records of patients diagnosed with irEC. The primary endpoint was time to symptom resolution for irEC for cases managed with IFX plus CS (IFX group) versus CS alone (CS group). Duration of CS, overall survival (OS), and time to treatment failure (TTF) were secondary endpoints. Results Among 75 patients with irEC, 52% received CS alone, and 48% received IFX. Despite higher grade colitis in the IFX group (grade 3/4: 86% vs. 34%; p < 0.001), median times to diarrhea resolution (3 vs. 9 days; p < 0.001) and to steroid titration (4 vs. 13 days; p < 0.001) were shorter in the IFX group than in the CS group without a negative impact on TTF or OS. Total steroid duration (median 35 vs. 51 days; p = 0.150) was numerically lower in the IFX group. Conclusions Despite higher incidence of grade 3/4 colitis, IFX added to CS for the treatment of patients with irEC was associated with a significantly shorter time to symptom resolution. The data suggest that early introduction of IFX should be considered for patients with irEC until definitive prospective clinical trials are conducted.
650		4	\|a Infliximab
650		4	\|a Immune-related enterocolitis
650		4	\|a Immune checkpoint inhibitors
653		0	\|a Neoplasms. Tumors. Oncology. Including cancer and carcinogens
700	0		\|a Chrystia M Zobniw \|e verfasserin \|4 aut
700	0		\|a Van A Trinh \|e verfasserin \|4 aut
700	0		\|a Junsheng Ma \|e verfasserin \|4 aut
700	0		\|a Roland L Bassett \|e verfasserin \|4 aut
700	0		\|a Noha Abdel-Wahab \|e verfasserin \|4 aut
700	0		\|a Jaime Anderson \|e verfasserin \|4 aut
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700	0		\|a Rodabe Amaria \|e verfasserin \|4 aut
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700	0		\|a Michael K Wong \|e verfasserin \|4 aut
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700	0		\|a Adi Diab \|e verfasserin \|4 aut
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allfields	10.1186/s40425-018-0412-0 doi (DE-627)DOAJ078063280 (DE-599)DOAJ1943075ceb3442f28ca3f0d6fae4550c DE-627 ger DE-627 rakwb eng RC254-282 Daniel H Johnson verfasserin aut Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Immune-related enterocolitis (irEC) is the most common serious complication from checkpoint inhibitors (CPIs). The current front-line treatment for irEC, high-dose corticosteroids (CS), have significant side effects and prolonged therapy may reduce CPI-anti-tumor activity. Early addition of TNF-α inhibitors such as infliximab (IFX) may expedite symptom resolution and shorten CS duration. Thus, we conducted the first retrospective study, to our knowledge, evaluating symptom resolution in patients with irEC treated with and without IFX. Methods Data were collected from the medical records of patients diagnosed with irEC. The primary endpoint was time to symptom resolution for irEC for cases managed with IFX plus CS (IFX group) versus CS alone (CS group). Duration of CS, overall survival (OS), and time to treatment failure (TTF) were secondary endpoints. Results Among 75 patients with irEC, 52% received CS alone, and 48% received IFX. Despite higher grade colitis in the IFX group (grade 3/4: 86% vs. 34%; p < 0.001), median times to diarrhea resolution (3 vs. 9 days; p < 0.001) and to steroid titration (4 vs. 13 days; p < 0.001) were shorter in the IFX group than in the CS group without a negative impact on TTF or OS. Total steroid duration (median 35 vs. 51 days; p = 0.150) was numerically lower in the IFX group. Conclusions Despite higher incidence of grade 3/4 colitis, IFX added to CS for the treatment of patients with irEC was associated with a significantly shorter time to symptom resolution. The data suggest that early introduction of IFX should be considered for patients with irEC until definitive prospective clinical trials are conducted. Infliximab Immune-related enterocolitis Immune checkpoint inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chrystia M Zobniw verfasserin aut Van A Trinh verfasserin aut Junsheng Ma verfasserin aut Roland L Bassett verfasserin aut Noha Abdel-Wahab verfasserin aut Jaime Anderson verfasserin aut Jennifer E Davis verfasserin aut Jocelyn Joseph verfasserin aut Marc Uemura verfasserin aut Ali Noman verfasserin aut Hamzah Abu-Sbeih verfasserin aut Cassian Yee verfasserin aut Rodabe Amaria verfasserin aut Sapna Patel verfasserin aut Hussein Tawbi verfasserin aut Isabella C Glitza verfasserin aut Michael A Davies verfasserin aut Michael K Wong verfasserin aut Scott Woodman verfasserin aut Wen-Jen Hwu verfasserin aut Patrick Hwu verfasserin aut Yinghong Wang verfasserin aut Adi Diab verfasserin aut In Journal for ImmunoTherapy of Cancer BMJ Publishing Group, 2013 6(2018), 1, Seite 8 (DE-627)750086335 (DE-600)2719863-7 20511426 nnns volume:6 year:2018 number:1 pages:8 https://doi.org/10.1186/s40425-018-0412-0 kostenfrei https://doaj.org/article/1943075ceb3442f28ca3f0d6fae4550c kostenfrei http://link.springer.com/article/10.1186/s40425-018-0412-0 kostenfrei https://doaj.org/toc/2051-1426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2018 1 8
spelling	10.1186/s40425-018-0412-0 doi (DE-627)DOAJ078063280 (DE-599)DOAJ1943075ceb3442f28ca3f0d6fae4550c DE-627 ger DE-627 rakwb eng RC254-282 Daniel H Johnson verfasserin aut Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Immune-related enterocolitis (irEC) is the most common serious complication from checkpoint inhibitors (CPIs). The current front-line treatment for irEC, high-dose corticosteroids (CS), have significant side effects and prolonged therapy may reduce CPI-anti-tumor activity. Early addition of TNF-α inhibitors such as infliximab (IFX) may expedite symptom resolution and shorten CS duration. Thus, we conducted the first retrospective study, to our knowledge, evaluating symptom resolution in patients with irEC treated with and without IFX. Methods Data were collected from the medical records of patients diagnosed with irEC. The primary endpoint was time to symptom resolution for irEC for cases managed with IFX plus CS (IFX group) versus CS alone (CS group). Duration of CS, overall survival (OS), and time to treatment failure (TTF) were secondary endpoints. Results Among 75 patients with irEC, 52% received CS alone, and 48% received IFX. Despite higher grade colitis in the IFX group (grade 3/4: 86% vs. 34%; p < 0.001), median times to diarrhea resolution (3 vs. 9 days; p < 0.001) and to steroid titration (4 vs. 13 days; p < 0.001) were shorter in the IFX group than in the CS group without a negative impact on TTF or OS. Total steroid duration (median 35 vs. 51 days; p = 0.150) was numerically lower in the IFX group. Conclusions Despite higher incidence of grade 3/4 colitis, IFX added to CS for the treatment of patients with irEC was associated with a significantly shorter time to symptom resolution. The data suggest that early introduction of IFX should be considered for patients with irEC until definitive prospective clinical trials are conducted. Infliximab Immune-related enterocolitis Immune checkpoint inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chrystia M Zobniw verfasserin aut Van A Trinh verfasserin aut Junsheng Ma verfasserin aut Roland L Bassett verfasserin aut Noha Abdel-Wahab verfasserin aut Jaime Anderson verfasserin aut Jennifer E Davis verfasserin aut Jocelyn Joseph verfasserin aut Marc Uemura verfasserin aut Ali Noman verfasserin aut Hamzah Abu-Sbeih verfasserin aut Cassian Yee verfasserin aut Rodabe Amaria verfasserin aut Sapna Patel verfasserin aut Hussein Tawbi verfasserin aut Isabella C Glitza verfasserin aut Michael A Davies verfasserin aut Michael K Wong verfasserin aut Scott Woodman verfasserin aut Wen-Jen Hwu verfasserin aut Patrick Hwu verfasserin aut Yinghong Wang verfasserin aut Adi Diab verfasserin aut In Journal for ImmunoTherapy of Cancer BMJ Publishing Group, 2013 6(2018), 1, Seite 8 (DE-627)750086335 (DE-600)2719863-7 20511426 nnns volume:6 year:2018 number:1 pages:8 https://doi.org/10.1186/s40425-018-0412-0 kostenfrei https://doaj.org/article/1943075ceb3442f28ca3f0d6fae4550c kostenfrei http://link.springer.com/article/10.1186/s40425-018-0412-0 kostenfrei https://doaj.org/toc/2051-1426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2018 1 8
allfields_unstemmed	10.1186/s40425-018-0412-0 doi (DE-627)DOAJ078063280 (DE-599)DOAJ1943075ceb3442f28ca3f0d6fae4550c DE-627 ger DE-627 rakwb eng RC254-282 Daniel H Johnson verfasserin aut Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Immune-related enterocolitis (irEC) is the most common serious complication from checkpoint inhibitors (CPIs). The current front-line treatment for irEC, high-dose corticosteroids (CS), have significant side effects and prolonged therapy may reduce CPI-anti-tumor activity. Early addition of TNF-α inhibitors such as infliximab (IFX) may expedite symptom resolution and shorten CS duration. Thus, we conducted the first retrospective study, to our knowledge, evaluating symptom resolution in patients with irEC treated with and without IFX. Methods Data were collected from the medical records of patients diagnosed with irEC. The primary endpoint was time to symptom resolution for irEC for cases managed with IFX plus CS (IFX group) versus CS alone (CS group). Duration of CS, overall survival (OS), and time to treatment failure (TTF) were secondary endpoints. Results Among 75 patients with irEC, 52% received CS alone, and 48% received IFX. Despite higher grade colitis in the IFX group (grade 3/4: 86% vs. 34%; p < 0.001), median times to diarrhea resolution (3 vs. 9 days; p < 0.001) and to steroid titration (4 vs. 13 days; p < 0.001) were shorter in the IFX group than in the CS group without a negative impact on TTF or OS. Total steroid duration (median 35 vs. 51 days; p = 0.150) was numerically lower in the IFX group. Conclusions Despite higher incidence of grade 3/4 colitis, IFX added to CS for the treatment of patients with irEC was associated with a significantly shorter time to symptom resolution. The data suggest that early introduction of IFX should be considered for patients with irEC until definitive prospective clinical trials are conducted. Infliximab Immune-related enterocolitis Immune checkpoint inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chrystia M Zobniw verfasserin aut Van A Trinh verfasserin aut Junsheng Ma verfasserin aut Roland L Bassett verfasserin aut Noha Abdel-Wahab verfasserin aut Jaime Anderson verfasserin aut Jennifer E Davis verfasserin aut Jocelyn Joseph verfasserin aut Marc Uemura verfasserin aut Ali Noman verfasserin aut Hamzah Abu-Sbeih verfasserin aut Cassian Yee verfasserin aut Rodabe Amaria verfasserin aut Sapna Patel verfasserin aut Hussein Tawbi verfasserin aut Isabella C Glitza verfasserin aut Michael A Davies verfasserin aut Michael K Wong verfasserin aut Scott Woodman verfasserin aut Wen-Jen Hwu verfasserin aut Patrick Hwu verfasserin aut Yinghong Wang verfasserin aut Adi Diab verfasserin aut In Journal for ImmunoTherapy of Cancer BMJ Publishing Group, 2013 6(2018), 1, Seite 8 (DE-627)750086335 (DE-600)2719863-7 20511426 nnns volume:6 year:2018 number:1 pages:8 https://doi.org/10.1186/s40425-018-0412-0 kostenfrei https://doaj.org/article/1943075ceb3442f28ca3f0d6fae4550c kostenfrei http://link.springer.com/article/10.1186/s40425-018-0412-0 kostenfrei https://doaj.org/toc/2051-1426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2018 1 8
allfieldsGer	10.1186/s40425-018-0412-0 doi (DE-627)DOAJ078063280 (DE-599)DOAJ1943075ceb3442f28ca3f0d6fae4550c DE-627 ger DE-627 rakwb eng RC254-282 Daniel H Johnson verfasserin aut Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Immune-related enterocolitis (irEC) is the most common serious complication from checkpoint inhibitors (CPIs). The current front-line treatment for irEC, high-dose corticosteroids (CS), have significant side effects and prolonged therapy may reduce CPI-anti-tumor activity. Early addition of TNF-α inhibitors such as infliximab (IFX) may expedite symptom resolution and shorten CS duration. Thus, we conducted the first retrospective study, to our knowledge, evaluating symptom resolution in patients with irEC treated with and without IFX. Methods Data were collected from the medical records of patients diagnosed with irEC. The primary endpoint was time to symptom resolution for irEC for cases managed with IFX plus CS (IFX group) versus CS alone (CS group). Duration of CS, overall survival (OS), and time to treatment failure (TTF) were secondary endpoints. Results Among 75 patients with irEC, 52% received CS alone, and 48% received IFX. Despite higher grade colitis in the IFX group (grade 3/4: 86% vs. 34%; p < 0.001), median times to diarrhea resolution (3 vs. 9 days; p < 0.001) and to steroid titration (4 vs. 13 days; p < 0.001) were shorter in the IFX group than in the CS group without a negative impact on TTF or OS. Total steroid duration (median 35 vs. 51 days; p = 0.150) was numerically lower in the IFX group. Conclusions Despite higher incidence of grade 3/4 colitis, IFX added to CS for the treatment of patients with irEC was associated with a significantly shorter time to symptom resolution. The data suggest that early introduction of IFX should be considered for patients with irEC until definitive prospective clinical trials are conducted. Infliximab Immune-related enterocolitis Immune checkpoint inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chrystia M Zobniw verfasserin aut Van A Trinh verfasserin aut Junsheng Ma verfasserin aut Roland L Bassett verfasserin aut Noha Abdel-Wahab verfasserin aut Jaime Anderson verfasserin aut Jennifer E Davis verfasserin aut Jocelyn Joseph verfasserin aut Marc Uemura verfasserin aut Ali Noman verfasserin aut Hamzah Abu-Sbeih verfasserin aut Cassian Yee verfasserin aut Rodabe Amaria verfasserin aut Sapna Patel verfasserin aut Hussein Tawbi verfasserin aut Isabella C Glitza verfasserin aut Michael A Davies verfasserin aut Michael K Wong verfasserin aut Scott Woodman verfasserin aut Wen-Jen Hwu verfasserin aut Patrick Hwu verfasserin aut Yinghong Wang verfasserin aut Adi Diab verfasserin aut In Journal for ImmunoTherapy of Cancer BMJ Publishing Group, 2013 6(2018), 1, Seite 8 (DE-627)750086335 (DE-600)2719863-7 20511426 nnns volume:6 year:2018 number:1 pages:8 https://doi.org/10.1186/s40425-018-0412-0 kostenfrei https://doaj.org/article/1943075ceb3442f28ca3f0d6fae4550c kostenfrei http://link.springer.com/article/10.1186/s40425-018-0412-0 kostenfrei https://doaj.org/toc/2051-1426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2018 1 8
allfieldsSound	10.1186/s40425-018-0412-0 doi (DE-627)DOAJ078063280 (DE-599)DOAJ1943075ceb3442f28ca3f0d6fae4550c DE-627 ger DE-627 rakwb eng RC254-282 Daniel H Johnson verfasserin aut Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis 2018 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Background Immune-related enterocolitis (irEC) is the most common serious complication from checkpoint inhibitors (CPIs). The current front-line treatment for irEC, high-dose corticosteroids (CS), have significant side effects and prolonged therapy may reduce CPI-anti-tumor activity. Early addition of TNF-α inhibitors such as infliximab (IFX) may expedite symptom resolution and shorten CS duration. Thus, we conducted the first retrospective study, to our knowledge, evaluating symptom resolution in patients with irEC treated with and without IFX. Methods Data were collected from the medical records of patients diagnosed with irEC. The primary endpoint was time to symptom resolution for irEC for cases managed with IFX plus CS (IFX group) versus CS alone (CS group). Duration of CS, overall survival (OS), and time to treatment failure (TTF) were secondary endpoints. Results Among 75 patients with irEC, 52% received CS alone, and 48% received IFX. Despite higher grade colitis in the IFX group (grade 3/4: 86% vs. 34%; p < 0.001), median times to diarrhea resolution (3 vs. 9 days; p < 0.001) and to steroid titration (4 vs. 13 days; p < 0.001) were shorter in the IFX group than in the CS group without a negative impact on TTF or OS. Total steroid duration (median 35 vs. 51 days; p = 0.150) was numerically lower in the IFX group. Conclusions Despite higher incidence of grade 3/4 colitis, IFX added to CS for the treatment of patients with irEC was associated with a significantly shorter time to symptom resolution. The data suggest that early introduction of IFX should be considered for patients with irEC until definitive prospective clinical trials are conducted. Infliximab Immune-related enterocolitis Immune checkpoint inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens Chrystia M Zobniw verfasserin aut Van A Trinh verfasserin aut Junsheng Ma verfasserin aut Roland L Bassett verfasserin aut Noha Abdel-Wahab verfasserin aut Jaime Anderson verfasserin aut Jennifer E Davis verfasserin aut Jocelyn Joseph verfasserin aut Marc Uemura verfasserin aut Ali Noman verfasserin aut Hamzah Abu-Sbeih verfasserin aut Cassian Yee verfasserin aut Rodabe Amaria verfasserin aut Sapna Patel verfasserin aut Hussein Tawbi verfasserin aut Isabella C Glitza verfasserin aut Michael A Davies verfasserin aut Michael K Wong verfasserin aut Scott Woodman verfasserin aut Wen-Jen Hwu verfasserin aut Patrick Hwu verfasserin aut Yinghong Wang verfasserin aut Adi Diab verfasserin aut In Journal for ImmunoTherapy of Cancer BMJ Publishing Group, 2013 6(2018), 1, Seite 8 (DE-627)750086335 (DE-600)2719863-7 20511426 nnns volume:6 year:2018 number:1 pages:8 https://doi.org/10.1186/s40425-018-0412-0 kostenfrei https://doaj.org/article/1943075ceb3442f28ca3f0d6fae4550c kostenfrei http://link.springer.com/article/10.1186/s40425-018-0412-0 kostenfrei https://doaj.org/toc/2051-1426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2018 1 8
language	English
source	In Journal for ImmunoTherapy of Cancer 6(2018), 1, Seite 8 volume:6 year:2018 number:1 pages:8
sourceStr	In Journal for ImmunoTherapy of Cancer 6(2018), 1, Seite 8 volume:6 year:2018 number:1 pages:8
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Infliximab Immune-related enterocolitis Immune checkpoint inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens
isfreeaccess_bool	true
container_title	Journal for ImmunoTherapy of Cancer
authorswithroles_txt_mv	Daniel H Johnson @@aut@@ Chrystia M Zobniw @@aut@@ Van A Trinh @@aut@@ Junsheng Ma @@aut@@ Roland L Bassett @@aut@@ Noha Abdel-Wahab @@aut@@ Jaime Anderson @@aut@@ Jennifer E Davis @@aut@@ Jocelyn Joseph @@aut@@ Marc Uemura @@aut@@ Ali Noman @@aut@@ Hamzah Abu-Sbeih @@aut@@ Cassian Yee @@aut@@ Rodabe Amaria @@aut@@ Sapna Patel @@aut@@ Hussein Tawbi @@aut@@ Isabella C Glitza @@aut@@ Michael A Davies @@aut@@ Michael K Wong @@aut@@ Scott Woodman @@aut@@ Wen-Jen Hwu @@aut@@ Patrick Hwu @@aut@@ Yinghong Wang @@aut@@ Adi Diab @@aut@@
publishDateDaySort_date	2018-01-01T00:00:00Z
hierarchy_top_id	750086335
id	DOAJ078063280
language_de	englisch
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The current front-line treatment for irEC, high-dose corticosteroids (CS), have significant side effects and prolonged therapy may reduce CPI-anti-tumor activity. Early addition of TNF-α inhibitors such as infliximab (IFX) may expedite symptom resolution and shorten CS duration. Thus, we conducted the first retrospective study, to our knowledge, evaluating symptom resolution in patients with irEC treated with and without IFX. Methods Data were collected from the medical records of patients diagnosed with irEC. The primary endpoint was time to symptom resolution for irEC for cases managed with IFX plus CS (IFX group) versus CS alone (CS group). Duration of CS, overall survival (OS), and time to treatment failure (TTF) were secondary endpoints. Results Among 75 patients with irEC, 52% received CS alone, and 48% received IFX. Despite higher grade colitis in the IFX group (grade 3/4: 86% vs. 34%; p < 0.001), median times to diarrhea resolution (3 vs. 9 days; p < 0.001) and to steroid titration (4 vs. 13 days; p < 0.001) were shorter in the IFX group than in the CS group without a negative impact on TTF or OS. Total steroid duration (median 35 vs. 51 days; p = 0.150) was numerically lower in the IFX group. Conclusions Despite higher incidence of grade 3/4 colitis, IFX added to CS for the treatment of patients with irEC was associated with a significantly shorter time to symptom resolution. 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callnumber-first	R - Medicine
author	Daniel H Johnson
spellingShingle	Daniel H Johnson misc RC254-282 misc Infliximab misc Immune-related enterocolitis misc Immune checkpoint inhibitors misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis
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topic_title	RC254-282 Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis Infliximab Immune-related enterocolitis Immune checkpoint inhibitors
topic	misc RC254-282 misc Infliximab misc Immune-related enterocolitis misc Immune checkpoint inhibitors misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc Infliximab misc Immune-related enterocolitis misc Immune checkpoint inhibitors misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_browse	misc RC254-282 misc Infliximab misc Immune-related enterocolitis misc Immune checkpoint inhibitors misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis
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title_full	Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis
author_sort	Daniel H Johnson
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author_browse	Daniel H Johnson Chrystia M Zobniw Van A Trinh Junsheng Ma Roland L Bassett Noha Abdel-Wahab Jaime Anderson Jennifer E Davis Jocelyn Joseph Marc Uemura Ali Noman Hamzah Abu-Sbeih Cassian Yee Rodabe Amaria Sapna Patel Hussein Tawbi Isabella C Glitza Michael A Davies Michael K Wong Scott Woodman Wen-Jen Hwu Patrick Hwu Yinghong Wang Adi Diab
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title_sort	infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis
callnumber	RC254-282
title_auth	Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis
abstract	Abstract Background Immune-related enterocolitis (irEC) is the most common serious complication from checkpoint inhibitors (CPIs). The current front-line treatment for irEC, high-dose corticosteroids (CS), have significant side effects and prolonged therapy may reduce CPI-anti-tumor activity. Early addition of TNF-α inhibitors such as infliximab (IFX) may expedite symptom resolution and shorten CS duration. Thus, we conducted the first retrospective study, to our knowledge, evaluating symptom resolution in patients with irEC treated with and without IFX. Methods Data were collected from the medical records of patients diagnosed with irEC. The primary endpoint was time to symptom resolution for irEC for cases managed with IFX plus CS (IFX group) versus CS alone (CS group). Duration of CS, overall survival (OS), and time to treatment failure (TTF) were secondary endpoints. Results Among 75 patients with irEC, 52% received CS alone, and 48% received IFX. Despite higher grade colitis in the IFX group (grade 3/4: 86% vs. 34%; p < 0.001), median times to diarrhea resolution (3 vs. 9 days; p < 0.001) and to steroid titration (4 vs. 13 days; p < 0.001) were shorter in the IFX group than in the CS group without a negative impact on TTF or OS. Total steroid duration (median 35 vs. 51 days; p = 0.150) was numerically lower in the IFX group. Conclusions Despite higher incidence of grade 3/4 colitis, IFX added to CS for the treatment of patients with irEC was associated with a significantly shorter time to symptom resolution. The data suggest that early introduction of IFX should be considered for patients with irEC until definitive prospective clinical trials are conducted.
abstractGer	Abstract Background Immune-related enterocolitis (irEC) is the most common serious complication from checkpoint inhibitors (CPIs). The current front-line treatment for irEC, high-dose corticosteroids (CS), have significant side effects and prolonged therapy may reduce CPI-anti-tumor activity. Early addition of TNF-α inhibitors such as infliximab (IFX) may expedite symptom resolution and shorten CS duration. Thus, we conducted the first retrospective study, to our knowledge, evaluating symptom resolution in patients with irEC treated with and without IFX. Methods Data were collected from the medical records of patients diagnosed with irEC. The primary endpoint was time to symptom resolution for irEC for cases managed with IFX plus CS (IFX group) versus CS alone (CS group). Duration of CS, overall survival (OS), and time to treatment failure (TTF) were secondary endpoints. Results Among 75 patients with irEC, 52% received CS alone, and 48% received IFX. Despite higher grade colitis in the IFX group (grade 3/4: 86% vs. 34%; p < 0.001), median times to diarrhea resolution (3 vs. 9 days; p < 0.001) and to steroid titration (4 vs. 13 days; p < 0.001) were shorter in the IFX group than in the CS group without a negative impact on TTF or OS. Total steroid duration (median 35 vs. 51 days; p = 0.150) was numerically lower in the IFX group. Conclusions Despite higher incidence of grade 3/4 colitis, IFX added to CS for the treatment of patients with irEC was associated with a significantly shorter time to symptom resolution. The data suggest that early introduction of IFX should be considered for patients with irEC until definitive prospective clinical trials are conducted.
abstract_unstemmed	Abstract Background Immune-related enterocolitis (irEC) is the most common serious complication from checkpoint inhibitors (CPIs). The current front-line treatment for irEC, high-dose corticosteroids (CS), have significant side effects and prolonged therapy may reduce CPI-anti-tumor activity. Early addition of TNF-α inhibitors such as infliximab (IFX) may expedite symptom resolution and shorten CS duration. Thus, we conducted the first retrospective study, to our knowledge, evaluating symptom resolution in patients with irEC treated with and without IFX. Methods Data were collected from the medical records of patients diagnosed with irEC. The primary endpoint was time to symptom resolution for irEC for cases managed with IFX plus CS (IFX group) versus CS alone (CS group). Duration of CS, overall survival (OS), and time to treatment failure (TTF) were secondary endpoints. Results Among 75 patients with irEC, 52% received CS alone, and 48% received IFX. Despite higher grade colitis in the IFX group (grade 3/4: 86% vs. 34%; p < 0.001), median times to diarrhea resolution (3 vs. 9 days; p < 0.001) and to steroid titration (4 vs. 13 days; p < 0.001) were shorter in the IFX group than in the CS group without a negative impact on TTF or OS. Total steroid duration (median 35 vs. 51 days; p = 0.150) was numerically lower in the IFX group. Conclusions Despite higher incidence of grade 3/4 colitis, IFX added to CS for the treatment of patients with irEC was associated with a significantly shorter time to symptom resolution. The data suggest that early introduction of IFX should be considered for patients with irEC until definitive prospective clinical trials are conducted.
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title_short	Infliximab associated with faster symptom resolution compared with corticosteroids alone for the management of immune-related enterocolitis
url	https://doi.org/10.1186/s40425-018-0412-0 https://doaj.org/article/1943075ceb3442f28ca3f0d6fae4550c http://link.springer.com/article/10.1186/s40425-018-0412-0 https://doaj.org/toc/2051-1426
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author2	Chrystia M Zobniw Van A Trinh Junsheng Ma Roland L Bassett Noha Abdel-Wahab Jaime Anderson Jennifer E Davis Jocelyn Joseph Marc Uemura Ali Noman Hamzah Abu-Sbeih Cassian Yee Rodabe Amaria Sapna Patel Hussein Tawbi Isabella C Glitza Michael A Davies Michael K Wong Scott Woodman Wen-Jen Hwu Patrick Hwu Yinghong Wang Adi Diab
author2Str	Chrystia M Zobniw Van A Trinh Junsheng Ma Roland L Bassett Noha Abdel-Wahab Jaime Anderson Jennifer E Davis Jocelyn Joseph Marc Uemura Ali Noman Hamzah Abu-Sbeih Cassian Yee Rodabe Amaria Sapna Patel Hussein Tawbi Isabella C Glitza Michael A Davies Michael K Wong Scott Woodman Wen-Jen Hwu Patrick Hwu Yinghong Wang Adi Diab
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up_date	2024-07-03T15:44:21.067Z
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