Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era

Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes. This review aims to provide a complete description of inherited cancer syndromes associated with medulloblastoma. We exa...
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Autor*in:	Roberto Carta [verfasserIn] Giada Del Baldo [verfasserIn] Evelina Miele [verfasserIn] Agnese Po [verfasserIn] Zein Mersini Besharat [verfasserIn] Francesca Nazio [verfasserIn] Giovanna Stefania Colafati [verfasserIn] Eleonora Piccirilli [verfasserIn] Emanuele Agolini [verfasserIn] Martina Rinelli [verfasserIn] Mariachiara Lodi [verfasserIn] Antonella Cacchione [verfasserIn] Andrea Carai [verfasserIn] Luigi Boccuto [verfasserIn] Elisabetta Ferretti [verfasserIn] Franco Locatelli [verfasserIn] Angela Mastronuzzi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	pediatric brain tumors cancer predisposition hereditary neoplastic syndromes cancer syndromes medulloblastoma cancer genes

Übergeordnetes Werk:	In: Frontiers in Oncology - Frontiers Media S.A., 2012, 10(2020)
Übergeordnetes Werk:	volume:10 ; year:2020

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fonc.2020.566822

Katalog-ID:	DOAJ078183707

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language	English
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sourceStr	In Frontiers in Oncology 10(2020) volume:10 year:2020
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topic_facet	pediatric brain tumors cancer predisposition hereditary neoplastic syndromes cancer syndromes medulloblastoma cancer genes Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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container_title	Frontiers in Oncology
authorswithroles_txt_mv	Roberto Carta @@aut@@ Giada Del Baldo @@aut@@ Evelina Miele @@aut@@ Agnese Po @@aut@@ Zein Mersini Besharat @@aut@@ Francesca Nazio @@aut@@ Giovanna Stefania Colafati @@aut@@ Eleonora Piccirilli @@aut@@ Emanuele Agolini @@aut@@ Martina Rinelli @@aut@@ Mariachiara Lodi @@aut@@ Antonella Cacchione @@aut@@ Andrea Carai @@aut@@ Luigi Boccuto @@aut@@ Elisabetta Ferretti @@aut@@ Franco Locatelli @@aut@@ Angela Mastronuzzi @@aut@@
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callnumber-first	R - Medicine
author	Roberto Carta
spellingShingle	Roberto Carta misc RC254-282 misc pediatric brain tumors misc cancer predisposition misc hereditary neoplastic syndromes misc cancer syndromes misc medulloblastoma misc cancer genes misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era
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topic_title	RC254-282 Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era pediatric brain tumors cancer predisposition hereditary neoplastic syndromes cancer syndromes medulloblastoma cancer genes
topic	misc RC254-282 misc pediatric brain tumors misc cancer predisposition misc hereditary neoplastic syndromes misc cancer syndromes misc medulloblastoma misc cancer genes misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
topic_unstemmed	misc RC254-282 misc pediatric brain tumors misc cancer predisposition misc hereditary neoplastic syndromes misc cancer syndromes misc medulloblastoma misc cancer genes misc Neoplasms. Tumors. Oncology. Including cancer and carcinogens
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title	Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era
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title_full	Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era
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author_browse	Roberto Carta Giada Del Baldo Evelina Miele Agnese Po Zein Mersini Besharat Francesca Nazio Giovanna Stefania Colafati Eleonora Piccirilli Emanuele Agolini Martina Rinelli Mariachiara Lodi Antonella Cacchione Andrea Carai Luigi Boccuto Elisabetta Ferretti Franco Locatelli Angela Mastronuzzi
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title_sort	cancer predisposition syndromes and medulloblastoma in the molecular era
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title_auth	Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era
abstract	Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes. This review aims to provide a complete description of inherited cancer syndromes associated with medulloblastoma. We examine their epidemiological, clinical, genetic, and diagnostic features and therapeutic approaches, including their correlation with medulloblastoma. Furthermore, according to the most recent molecular advances, we describe the association between the various molecular subgroups of medulloblastoma and each cancer predisposition syndrome. Knowledge of the aforementioned conditions can guide pediatric oncologists in performing adequate cancer surveillance. This will allow clinicians to promptly diagnose and treat medulloblastoma in syndromic children, forming a team with all specialists necessary for the correct management of the other various manifestations/symptoms related to the inherited cancer syndromes.
abstractGer	Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes. This review aims to provide a complete description of inherited cancer syndromes associated with medulloblastoma. We examine their epidemiological, clinical, genetic, and diagnostic features and therapeutic approaches, including their correlation with medulloblastoma. Furthermore, according to the most recent molecular advances, we describe the association between the various molecular subgroups of medulloblastoma and each cancer predisposition syndrome. Knowledge of the aforementioned conditions can guide pediatric oncologists in performing adequate cancer surveillance. This will allow clinicians to promptly diagnose and treat medulloblastoma in syndromic children, forming a team with all specialists necessary for the correct management of the other various manifestations/symptoms related to the inherited cancer syndromes.
abstract_unstemmed	Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes. This review aims to provide a complete description of inherited cancer syndromes associated with medulloblastoma. We examine their epidemiological, clinical, genetic, and diagnostic features and therapeutic approaches, including their correlation with medulloblastoma. Furthermore, according to the most recent molecular advances, we describe the association between the various molecular subgroups of medulloblastoma and each cancer predisposition syndrome. Knowledge of the aforementioned conditions can guide pediatric oncologists in performing adequate cancer surveillance. This will allow clinicians to promptly diagnose and treat medulloblastoma in syndromic children, forming a team with all specialists necessary for the correct management of the other various manifestations/symptoms related to the inherited cancer syndromes.
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title_short	Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era
url	https://doi.org/10.3389/fonc.2020.566822 https://doaj.org/article/7fb97d77b7d94c22b2abad6f29164764 https://www.frontiersin.org/articles/10.3389/fonc.2020.566822/full https://doaj.org/toc/2234-943X
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author2Str	Giada Del Baldo Evelina Miele Agnese Po Zein Mersini Besharat Francesca Nazio Giovanna Stefania Colafati Eleonora Piccirilli Emanuele Agolini Martina Rinelli Mariachiara Lodi Antonella Cacchione Andrea Carai Luigi Boccuto Elisabetta Ferretti Franco Locatelli Angela Mastronuzzi
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up_date	2024-07-03T16:26:49.716Z
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In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes. This review aims to provide a complete description of inherited cancer syndromes associated with medulloblastoma. We examine their epidemiological, clinical, genetic, and diagnostic features and therapeutic approaches, including their correlation with medulloblastoma. Furthermore, according to the most recent molecular advances, we describe the association between the various molecular subgroups of medulloblastoma and each cancer predisposition syndrome. Knowledge of the aforementioned conditions can guide pediatric oncologists in performing adequate cancer surveillance. 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Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era

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