Dysembryoplastic neuroepithelial tumour: insight into the pathology and pathogenesis

Dysembryoplastic neuroepithelial tumour (DNT) is categorized as a benign glioneuronal neoplasm affecting children and young adults with chronic epileptic seizures. It is characterized by predominant intracortical localization and nodular architecture. Dysembryoplastic neuroepithelial tumour usually...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Iwona Sontowska [verfasserIn] Ewa Matyja [verfasserIn] Jacek Malejczyk [verfasserIn] Wieslawa Grajkowska [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Schlagwörter:	dysembryoplastic neuroepithelial tumour histopathological variants BRAF mTOR DNT – pathology and pathogenesis

Übergeordnetes Werk:	In: Folia Neuropathologica - Termedia Publishing House, 2016, 55(2017), 1, Seite 13
Übergeordnetes Werk:	volume:55 ; year:2017 ; number:1 ; pages:13

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.5114/fn.2017.66708

Katalog-ID:	DOAJ078197260

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520			\|a Dysembryoplastic neuroepithelial tumour (DNT) is categorized as a benign glioneuronal neoplasm affecting children and young adults with chronic epileptic seizures. It is characterized by predominant intracortical localization and nodular architecture. Dysembryoplastic neuroepithelial tumour usually demonstrates a distinctive morphological pattern with a specific glioneuronal element but occasionally, its morphological picture is heterogeneous and unspecific. Thus, considering the morphology of DNT, three different histopathological subtypes are distinguished: simple, complex, and non-specific and diffuse. The DNT lesions are often related with focal cortical dysplasia (FCD) type IIIb, which is postulated to play a role in epileptogenicity. Moreover, the accompanying inflammation process might be implicated in DNT-related epileptogenesis. Dysembryoplastic neuroepithelial tumour is generally characterized by favourable prognosis and good results of surgical treatment. The pathogenesis and molecular mechanisms involved in DNT development remain uncertain. The main molecular findings are connected with BRAF alterations and activation of RAS/ERK, PI3K/AKT and mTOR signalling pathways. The present review summarizes the clinical, histopathological and molecular findings of DNT. The classification controversy, morphological heterogeneity and diagnostic problems are also discussed.
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allfieldsGer	10.5114/fn.2017.66708 doi (DE-627)DOAJ078197260 (DE-599)DOAJ1a6896e27cbf4123ae74b232b971b499 DE-627 ger DE-627 rakwb eng Iwona Sontowska verfasserin aut Dysembryoplastic neuroepithelial tumour: insight into the pathology and pathogenesis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dysembryoplastic neuroepithelial tumour (DNT) is categorized as a benign glioneuronal neoplasm affecting children and young adults with chronic epileptic seizures. It is characterized by predominant intracortical localization and nodular architecture. Dysembryoplastic neuroepithelial tumour usually demonstrates a distinctive morphological pattern with a specific glioneuronal element but occasionally, its morphological picture is heterogeneous and unspecific. Thus, considering the morphology of DNT, three different histopathological subtypes are distinguished: simple, complex, and non-specific and diffuse. The DNT lesions are often related with focal cortical dysplasia (FCD) type IIIb, which is postulated to play a role in epileptogenicity. Moreover, the accompanying inflammation process might be implicated in DNT-related epileptogenesis. Dysembryoplastic neuroepithelial tumour is generally characterized by favourable prognosis and good results of surgical treatment. The pathogenesis and molecular mechanisms involved in DNT development remain uncertain. The main molecular findings are connected with BRAF alterations and activation of RAS/ERK, PI3K/AKT and mTOR signalling pathways. The present review summarizes the clinical, histopathological and molecular findings of DNT. The classification controversy, morphological heterogeneity and diagnostic problems are also discussed. <i<DNT dysembryoplastic neuroepithelial tumour histopathological variants BRAF mTOR DNT – pathology and pathogenesis</i< Medicine R Ewa Matyja verfasserin aut Jacek Malejczyk verfasserin aut Wieslawa Grajkowska verfasserin aut In Folia Neuropathologica Termedia Publishing House, 2016 55(2017), 1, Seite 13 (DE-627)511229119 (DE-600)2233184-0 1509572X nnns volume:55 year:2017 number:1 pages:13 https://doi.org/10.5114/fn.2017.66708 kostenfrei https://doaj.org/article/1a6896e27cbf4123ae74b232b971b499 kostenfrei https://www.termedia.pl/Dysembryoplastic-neuroepithelial-tumour-insight-into-the-pathology-and-pathogenesis,20,29682,1,1.html kostenfrei https://doaj.org/toc/1641-4640 Journal toc kostenfrei https://doaj.org/toc/1509-572X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2017 1 13
allfieldsSound	10.5114/fn.2017.66708 doi (DE-627)DOAJ078197260 (DE-599)DOAJ1a6896e27cbf4123ae74b232b971b499 DE-627 ger DE-627 rakwb eng Iwona Sontowska verfasserin aut Dysembryoplastic neuroepithelial tumour: insight into the pathology and pathogenesis 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Dysembryoplastic neuroepithelial tumour (DNT) is categorized as a benign glioneuronal neoplasm affecting children and young adults with chronic epileptic seizures. It is characterized by predominant intracortical localization and nodular architecture. Dysembryoplastic neuroepithelial tumour usually demonstrates a distinctive morphological pattern with a specific glioneuronal element but occasionally, its morphological picture is heterogeneous and unspecific. Thus, considering the morphology of DNT, three different histopathological subtypes are distinguished: simple, complex, and non-specific and diffuse. The DNT lesions are often related with focal cortical dysplasia (FCD) type IIIb, which is postulated to play a role in epileptogenicity. Moreover, the accompanying inflammation process might be implicated in DNT-related epileptogenesis. Dysembryoplastic neuroepithelial tumour is generally characterized by favourable prognosis and good results of surgical treatment. The pathogenesis and molecular mechanisms involved in DNT development remain uncertain. The main molecular findings are connected with BRAF alterations and activation of RAS/ERK, PI3K/AKT and mTOR signalling pathways. The present review summarizes the clinical, histopathological and molecular findings of DNT. The classification controversy, morphological heterogeneity and diagnostic problems are also discussed. <i<DNT dysembryoplastic neuroepithelial tumour histopathological variants BRAF mTOR DNT – pathology and pathogenesis</i< Medicine R Ewa Matyja verfasserin aut Jacek Malejczyk verfasserin aut Wieslawa Grajkowska verfasserin aut In Folia Neuropathologica Termedia Publishing House, 2016 55(2017), 1, Seite 13 (DE-627)511229119 (DE-600)2233184-0 1509572X nnns volume:55 year:2017 number:1 pages:13 https://doi.org/10.5114/fn.2017.66708 kostenfrei https://doaj.org/article/1a6896e27cbf4123ae74b232b971b499 kostenfrei https://www.termedia.pl/Dysembryoplastic-neuroepithelial-tumour-insight-into-the-pathology-and-pathogenesis,20,29682,1,1.html kostenfrei https://doaj.org/toc/1641-4640 Journal toc kostenfrei https://doaj.org/toc/1509-572X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 55 2017 1 13
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author	Iwona Sontowska
spellingShingle	Iwona Sontowska misc <i<DNT misc dysembryoplastic neuroepithelial tumour misc histopathological variants misc BRAF misc mTOR misc DNT – pathology and pathogenesis</i< misc Medicine misc R Dysembryoplastic neuroepithelial tumour: insight into the pathology and pathogenesis
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title	Dysembryoplastic neuroepithelial tumour: insight into the pathology and pathogenesis
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title_full	Dysembryoplastic neuroepithelial tumour: insight into the pathology and pathogenesis
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title_sort	dysembryoplastic neuroepithelial tumour: insight into the pathology and pathogenesis
title_auth	Dysembryoplastic neuroepithelial tumour: insight into the pathology and pathogenesis
abstract	Dysembryoplastic neuroepithelial tumour (DNT) is categorized as a benign glioneuronal neoplasm affecting children and young adults with chronic epileptic seizures. It is characterized by predominant intracortical localization and nodular architecture. Dysembryoplastic neuroepithelial tumour usually demonstrates a distinctive morphological pattern with a specific glioneuronal element but occasionally, its morphological picture is heterogeneous and unspecific. Thus, considering the morphology of DNT, three different histopathological subtypes are distinguished: simple, complex, and non-specific and diffuse. The DNT lesions are often related with focal cortical dysplasia (FCD) type IIIb, which is postulated to play a role in epileptogenicity. Moreover, the accompanying inflammation process might be implicated in DNT-related epileptogenesis. Dysembryoplastic neuroepithelial tumour is generally characterized by favourable prognosis and good results of surgical treatment. The pathogenesis and molecular mechanisms involved in DNT development remain uncertain. The main molecular findings are connected with BRAF alterations and activation of RAS/ERK, PI3K/AKT and mTOR signalling pathways. The present review summarizes the clinical, histopathological and molecular findings of DNT. The classification controversy, morphological heterogeneity and diagnostic problems are also discussed.
abstractGer	Dysembryoplastic neuroepithelial tumour (DNT) is categorized as a benign glioneuronal neoplasm affecting children and young adults with chronic epileptic seizures. It is characterized by predominant intracortical localization and nodular architecture. Dysembryoplastic neuroepithelial tumour usually demonstrates a distinctive morphological pattern with a specific glioneuronal element but occasionally, its morphological picture is heterogeneous and unspecific. Thus, considering the morphology of DNT, three different histopathological subtypes are distinguished: simple, complex, and non-specific and diffuse. The DNT lesions are often related with focal cortical dysplasia (FCD) type IIIb, which is postulated to play a role in epileptogenicity. Moreover, the accompanying inflammation process might be implicated in DNT-related epileptogenesis. Dysembryoplastic neuroepithelial tumour is generally characterized by favourable prognosis and good results of surgical treatment. The pathogenesis and molecular mechanisms involved in DNT development remain uncertain. The main molecular findings are connected with BRAF alterations and activation of RAS/ERK, PI3K/AKT and mTOR signalling pathways. The present review summarizes the clinical, histopathological and molecular findings of DNT. The classification controversy, morphological heterogeneity and diagnostic problems are also discussed.
abstract_unstemmed	Dysembryoplastic neuroepithelial tumour (DNT) is categorized as a benign glioneuronal neoplasm affecting children and young adults with chronic epileptic seizures. It is characterized by predominant intracortical localization and nodular architecture. Dysembryoplastic neuroepithelial tumour usually demonstrates a distinctive morphological pattern with a specific glioneuronal element but occasionally, its morphological picture is heterogeneous and unspecific. Thus, considering the morphology of DNT, three different histopathological subtypes are distinguished: simple, complex, and non-specific and diffuse. The DNT lesions are often related with focal cortical dysplasia (FCD) type IIIb, which is postulated to play a role in epileptogenicity. Moreover, the accompanying inflammation process might be implicated in DNT-related epileptogenesis. Dysembryoplastic neuroepithelial tumour is generally characterized by favourable prognosis and good results of surgical treatment. The pathogenesis and molecular mechanisms involved in DNT development remain uncertain. The main molecular findings are connected with BRAF alterations and activation of RAS/ERK, PI3K/AKT and mTOR signalling pathways. The present review summarizes the clinical, histopathological and molecular findings of DNT. The classification controversy, morphological heterogeneity and diagnostic problems are also discussed.
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title_short	Dysembryoplastic neuroepithelial tumour: insight into the pathology and pathogenesis
url	https://doi.org/10.5114/fn.2017.66708 https://doaj.org/article/1a6896e27cbf4123ae74b232b971b499 https://www.termedia.pl/Dysembryoplastic-neuroepithelial-tumour-insight-into-the-pathology-and-pathogenesis,20,29682,1,1.html https://doaj.org/toc/1641-4640 https://doaj.org/toc/1509-572X
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