Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients

7α-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish that this compound is an intermediate in huma...
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Gespeichert in:

Autor*in:	Russell F. Hanson [verfasserIn] Peter D. Klein [verfasserIn] Gale C. Williams [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	1973

Schlagwörter:	cholic acid chenodeoxycholic acid

Übergeordnetes Werk:	In: Journal of Lipid Research - Elsevier, 2021, 14(1973), 1, Seite 50-53
Übergeordnetes Werk:	volume:14 ; year:1973 ; number:1 ; pages:50-53

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/S0022-2275(20)39328-7

Katalog-ID:	DOAJ078341507

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allfields	10.1016/S0022-2275(20)39328-7 doi (DE-627)DOAJ078341507 (DE-599)DOAJ10e837bad99f4356bd79aad80133a254 DE-627 ger DE-627 rakwb eng QD415-436 Russell F. Hanson verfasserin aut Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients 1973 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier 7α-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish that this compound is an intermediate in human bile acid synthesis, its metabolism was studied in subjects with complete bile fistulas. After administration of 3H-labeled 7α-hydroxy-4-cholesten-3-one by single intravenous injection, approximately 85% of the administered isotope was recovered in the bile during the first 12 hr. More than 96% of the radioactivity recovered in the bile was identified as either chenodeoxycholic acid or cholic acid, with only a trace amount of the radioactivity present as neutral sterols. This study gives support to the hypothesis that 7α-hydroxy-4-cholesten-3-one is a natural intermediate in human bile acid synthesis. cholic acid chenodeoxycholic acid Biochemistry Peter D. Klein verfasserin aut Gale C. Williams verfasserin aut In Journal of Lipid Research Elsevier, 2021 14(1973), 1, Seite 50-53 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:14 year:1973 number:1 pages:50-53 https://doi.org/10.1016/S0022-2275(20)39328-7 kostenfrei https://doaj.org/article/10e837bad99f4356bd79aad80133a254 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520393287 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 1973 1 50-53
spelling	10.1016/S0022-2275(20)39328-7 doi (DE-627)DOAJ078341507 (DE-599)DOAJ10e837bad99f4356bd79aad80133a254 DE-627 ger DE-627 rakwb eng QD415-436 Russell F. Hanson verfasserin aut Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients 1973 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier 7α-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish that this compound is an intermediate in human bile acid synthesis, its metabolism was studied in subjects with complete bile fistulas. After administration of 3H-labeled 7α-hydroxy-4-cholesten-3-one by single intravenous injection, approximately 85% of the administered isotope was recovered in the bile during the first 12 hr. More than 96% of the radioactivity recovered in the bile was identified as either chenodeoxycholic acid or cholic acid, with only a trace amount of the radioactivity present as neutral sterols. This study gives support to the hypothesis that 7α-hydroxy-4-cholesten-3-one is a natural intermediate in human bile acid synthesis. cholic acid chenodeoxycholic acid Biochemistry Peter D. Klein verfasserin aut Gale C. Williams verfasserin aut In Journal of Lipid Research Elsevier, 2021 14(1973), 1, Seite 50-53 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:14 year:1973 number:1 pages:50-53 https://doi.org/10.1016/S0022-2275(20)39328-7 kostenfrei https://doaj.org/article/10e837bad99f4356bd79aad80133a254 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520393287 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 1973 1 50-53
allfields_unstemmed	10.1016/S0022-2275(20)39328-7 doi (DE-627)DOAJ078341507 (DE-599)DOAJ10e837bad99f4356bd79aad80133a254 DE-627 ger DE-627 rakwb eng QD415-436 Russell F. Hanson verfasserin aut Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients 1973 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier 7α-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish that this compound is an intermediate in human bile acid synthesis, its metabolism was studied in subjects with complete bile fistulas. After administration of 3H-labeled 7α-hydroxy-4-cholesten-3-one by single intravenous injection, approximately 85% of the administered isotope was recovered in the bile during the first 12 hr. More than 96% of the radioactivity recovered in the bile was identified as either chenodeoxycholic acid or cholic acid, with only a trace amount of the radioactivity present as neutral sterols. This study gives support to the hypothesis that 7α-hydroxy-4-cholesten-3-one is a natural intermediate in human bile acid synthesis. cholic acid chenodeoxycholic acid Biochemistry Peter D. Klein verfasserin aut Gale C. Williams verfasserin aut In Journal of Lipid Research Elsevier, 2021 14(1973), 1, Seite 50-53 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:14 year:1973 number:1 pages:50-53 https://doi.org/10.1016/S0022-2275(20)39328-7 kostenfrei https://doaj.org/article/10e837bad99f4356bd79aad80133a254 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520393287 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 1973 1 50-53
allfieldsGer	10.1016/S0022-2275(20)39328-7 doi (DE-627)DOAJ078341507 (DE-599)DOAJ10e837bad99f4356bd79aad80133a254 DE-627 ger DE-627 rakwb eng QD415-436 Russell F. Hanson verfasserin aut Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients 1973 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier 7α-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish that this compound is an intermediate in human bile acid synthesis, its metabolism was studied in subjects with complete bile fistulas. After administration of 3H-labeled 7α-hydroxy-4-cholesten-3-one by single intravenous injection, approximately 85% of the administered isotope was recovered in the bile during the first 12 hr. More than 96% of the radioactivity recovered in the bile was identified as either chenodeoxycholic acid or cholic acid, with only a trace amount of the radioactivity present as neutral sterols. This study gives support to the hypothesis that 7α-hydroxy-4-cholesten-3-one is a natural intermediate in human bile acid synthesis. cholic acid chenodeoxycholic acid Biochemistry Peter D. Klein verfasserin aut Gale C. Williams verfasserin aut In Journal of Lipid Research Elsevier, 2021 14(1973), 1, Seite 50-53 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:14 year:1973 number:1 pages:50-53 https://doi.org/10.1016/S0022-2275(20)39328-7 kostenfrei https://doaj.org/article/10e837bad99f4356bd79aad80133a254 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520393287 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 1973 1 50-53
allfieldsSound	10.1016/S0022-2275(20)39328-7 doi (DE-627)DOAJ078341507 (DE-599)DOAJ10e837bad99f4356bd79aad80133a254 DE-627 ger DE-627 rakwb eng QD415-436 Russell F. Hanson verfasserin aut Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients 1973 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier 7α-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish that this compound is an intermediate in human bile acid synthesis, its metabolism was studied in subjects with complete bile fistulas. After administration of 3H-labeled 7α-hydroxy-4-cholesten-3-one by single intravenous injection, approximately 85% of the administered isotope was recovered in the bile during the first 12 hr. More than 96% of the radioactivity recovered in the bile was identified as either chenodeoxycholic acid or cholic acid, with only a trace amount of the radioactivity present as neutral sterols. This study gives support to the hypothesis that 7α-hydroxy-4-cholesten-3-one is a natural intermediate in human bile acid synthesis. cholic acid chenodeoxycholic acid Biochemistry Peter D. Klein verfasserin aut Gale C. Williams verfasserin aut In Journal of Lipid Research Elsevier, 2021 14(1973), 1, Seite 50-53 (DE-627)26601593X (DE-600)1466675-3 15397262 nnns volume:14 year:1973 number:1 pages:50-53 https://doi.org/10.1016/S0022-2275(20)39328-7 kostenfrei https://doaj.org/article/10e837bad99f4356bd79aad80133a254 kostenfrei http://www.sciencedirect.com/science/article/pii/S0022227520393287 kostenfrei https://doaj.org/toc/0022-2275 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_252 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2006 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 1973 1 50-53
language	English
source	In Journal of Lipid Research 14(1973), 1, Seite 50-53 volume:14 year:1973 number:1 pages:50-53
sourceStr	In Journal of Lipid Research 14(1973), 1, Seite 50-53 volume:14 year:1973 number:1 pages:50-53
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	cholic acid chenodeoxycholic acid Biochemistry
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container_title	Journal of Lipid Research
authorswithroles_txt_mv	Russell F. Hanson @@aut@@ Peter D. Klein @@aut@@ Gale C. Williams @@aut@@
publishDateDaySort_date	1973-01-01T00:00:00Z
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author	Russell F. Hanson
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topic_title	QD415-436 Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients cholic acid chenodeoxycholic acid
topic	misc QD415-436 misc cholic acid misc chenodeoxycholic acid misc Biochemistry
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title	Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients
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title_sort	bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients
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title_auth	Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients
abstract	7α-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish that this compound is an intermediate in human bile acid synthesis, its metabolism was studied in subjects with complete bile fistulas. After administration of 3H-labeled 7α-hydroxy-4-cholesten-3-one by single intravenous injection, approximately 85% of the administered isotope was recovered in the bile during the first 12 hr. More than 96% of the radioactivity recovered in the bile was identified as either chenodeoxycholic acid or cholic acid, with only a trace amount of the radioactivity present as neutral sterols. This study gives support to the hypothesis that 7α-hydroxy-4-cholesten-3-one is a natural intermediate in human bile acid synthesis.
abstractGer	7α-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish that this compound is an intermediate in human bile acid synthesis, its metabolism was studied in subjects with complete bile fistulas. After administration of 3H-labeled 7α-hydroxy-4-cholesten-3-one by single intravenous injection, approximately 85% of the administered isotope was recovered in the bile during the first 12 hr. More than 96% of the radioactivity recovered in the bile was identified as either chenodeoxycholic acid or cholic acid, with only a trace amount of the radioactivity present as neutral sterols. This study gives support to the hypothesis that 7α-hydroxy-4-cholesten-3-one is a natural intermediate in human bile acid synthesis.
abstract_unstemmed	7α-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish that this compound is an intermediate in human bile acid synthesis, its metabolism was studied in subjects with complete bile fistulas. After administration of 3H-labeled 7α-hydroxy-4-cholesten-3-one by single intravenous injection, approximately 85% of the administered isotope was recovered in the bile during the first 12 hr. More than 96% of the radioactivity recovered in the bile was identified as either chenodeoxycholic acid or cholic acid, with only a trace amount of the radioactivity present as neutral sterols. This study gives support to the hypothesis that 7α-hydroxy-4-cholesten-3-one is a natural intermediate in human bile acid synthesis.
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title_short	Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients
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Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients

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