L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study

Studies of functional neurosurgery and electroencephalography in Parkinson’s disease have demonstrated abnormally synchronous activity between basal ganglia and motor cortex. Functional neuroimaging studies investigated brain dysfunction during motor task or resting state and primarily have shown al...
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Autor*in:	Stefania Evangelisti [verfasserIn] Francesca Pittau [verfasserIn] Claudia Testa [verfasserIn] Giovanni Rizzo [verfasserIn] Laura Ludovica Gramegna [verfasserIn] Lorenzo Ferri [verfasserIn] Ana Coito [verfasserIn] Pietro Cortelli [verfasserIn] Giovanna Calandra-Buonaura [verfasserIn] Fabio Bisquoli [verfasserIn] Claudio Bianchini [verfasserIn] David Neil Manners [verfasserIn] Lia Talozzi [verfasserIn] Caterina Tonon [verfasserIn] Raffaele Lodi [verfasserIn] Paolo Tinuper [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	Parkinson’s disease EEG-fMRI functional connectivity L-dopa pilot study

Übergeordnetes Werk:	In: Frontiers in Neuroscience - Frontiers Media S.A., 2008, 13(2019)
Übergeordnetes Werk:	volume:13 ; year:2019

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fnins.2019.00611

Katalog-ID:	DOAJ078412757

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spelling	10.3389/fnins.2019.00611 doi (DE-627)DOAJ078412757 (DE-599)DOAJ9b5fbe46d32049ae8d5259d341682e91 DE-627 ger DE-627 rakwb eng RC321-571 Stefania Evangelisti verfasserin aut L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Studies of functional neurosurgery and electroencephalography in Parkinson’s disease have demonstrated abnormally synchronous activity between basal ganglia and motor cortex. Functional neuroimaging studies investigated brain dysfunction during motor task or resting state and primarily have shown altered patterns of activation and connectivity for motor areas. L-dopa administration relatively normalized these functional alterations. The aim of this pilot study was to examine the effects of L-dopa administration on functional connectivity in early-stage PD, as revealed by simultaneous recording of functional magnetic resonance imaging (fMRI) and electroencephalographic (EEG) data. Six patients with diagnosis of probable PD underwent EEG-fMRI acquisitions (1.5 T MR scanner and 64-channel cap) before and immediately after the intake of L-dopa. Regions of interest in the primary motor and sensorimotor regions were used for resting state fMRI analysis. From the EEG data, weighted partial directed coherence was computed in the inverse space after the removal of gradient and cardioballistic artifacts. fMRI results showed that the intake of L-dopa increased functional connectivity within the sensorimotor network, and between motor areas and both attention and default mode networks. EEG connectivity among regions of the motor network did not change significantly, while regions of the default mode network showed a strong tendency to increase their outflow toward the rest of the brain. This pilot study provided a first insight into the potentiality of simultaneous EEG-fMRI acquisitions in PD patients, showing for both techniques the analogous direction of increased connectivity after L-dopa intake, mainly involving motor, dorsal attention and default mode networks. Parkinson’s disease EEG-fMRI functional connectivity L-dopa pilot study Neurosciences. Biological psychiatry. Neuropsychiatry Francesca Pittau verfasserin aut Claudia Testa verfasserin aut Giovanni Rizzo verfasserin aut Giovanni Rizzo verfasserin aut Laura Ludovica Gramegna verfasserin aut Laura Ludovica Gramegna verfasserin aut Lorenzo Ferri verfasserin aut Ana Coito verfasserin aut Pietro Cortelli verfasserin aut Pietro Cortelli verfasserin aut Giovanna Calandra-Buonaura verfasserin aut Giovanna Calandra-Buonaura verfasserin aut Fabio Bisquoli verfasserin aut Fabio Bisquoli verfasserin aut Claudio Bianchini verfasserin aut David Neil Manners verfasserin aut Lia Talozzi verfasserin aut Caterina Tonon verfasserin aut Caterina Tonon verfasserin aut Raffaele Lodi verfasserin aut Raffaele Lodi verfasserin aut Paolo Tinuper verfasserin aut Paolo Tinuper verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 13(2019) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:13 year:2019 https://doi.org/10.3389/fnins.2019.00611 kostenfrei https://doaj.org/article/9b5fbe46d32049ae8d5259d341682e91 kostenfrei https://www.frontiersin.org/article/10.3389/fnins.2019.00611/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2019
allfields_unstemmed	10.3389/fnins.2019.00611 doi (DE-627)DOAJ078412757 (DE-599)DOAJ9b5fbe46d32049ae8d5259d341682e91 DE-627 ger DE-627 rakwb eng RC321-571 Stefania Evangelisti verfasserin aut L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Studies of functional neurosurgery and electroencephalography in Parkinson’s disease have demonstrated abnormally synchronous activity between basal ganglia and motor cortex. Functional neuroimaging studies investigated brain dysfunction during motor task or resting state and primarily have shown altered patterns of activation and connectivity for motor areas. L-dopa administration relatively normalized these functional alterations. The aim of this pilot study was to examine the effects of L-dopa administration on functional connectivity in early-stage PD, as revealed by simultaneous recording of functional magnetic resonance imaging (fMRI) and electroencephalographic (EEG) data. Six patients with diagnosis of probable PD underwent EEG-fMRI acquisitions (1.5 T MR scanner and 64-channel cap) before and immediately after the intake of L-dopa. Regions of interest in the primary motor and sensorimotor regions were used for resting state fMRI analysis. From the EEG data, weighted partial directed coherence was computed in the inverse space after the removal of gradient and cardioballistic artifacts. fMRI results showed that the intake of L-dopa increased functional connectivity within the sensorimotor network, and between motor areas and both attention and default mode networks. EEG connectivity among regions of the motor network did not change significantly, while regions of the default mode network showed a strong tendency to increase their outflow toward the rest of the brain. This pilot study provided a first insight into the potentiality of simultaneous EEG-fMRI acquisitions in PD patients, showing for both techniques the analogous direction of increased connectivity after L-dopa intake, mainly involving motor, dorsal attention and default mode networks. Parkinson’s disease EEG-fMRI functional connectivity L-dopa pilot study Neurosciences. Biological psychiatry. Neuropsychiatry Francesca Pittau verfasserin aut Claudia Testa verfasserin aut Giovanni Rizzo verfasserin aut Giovanni Rizzo verfasserin aut Laura Ludovica Gramegna verfasserin aut Laura Ludovica Gramegna verfasserin aut Lorenzo Ferri verfasserin aut Ana Coito verfasserin aut Pietro Cortelli verfasserin aut Pietro Cortelli verfasserin aut Giovanna Calandra-Buonaura verfasserin aut Giovanna Calandra-Buonaura verfasserin aut Fabio Bisquoli verfasserin aut Fabio Bisquoli verfasserin aut Claudio Bianchini verfasserin aut David Neil Manners verfasserin aut Lia Talozzi verfasserin aut Caterina Tonon verfasserin aut Caterina Tonon verfasserin aut Raffaele Lodi verfasserin aut Raffaele Lodi verfasserin aut Paolo Tinuper verfasserin aut Paolo Tinuper verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 13(2019) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:13 year:2019 https://doi.org/10.3389/fnins.2019.00611 kostenfrei https://doaj.org/article/9b5fbe46d32049ae8d5259d341682e91 kostenfrei https://www.frontiersin.org/article/10.3389/fnins.2019.00611/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2019
allfieldsGer	10.3389/fnins.2019.00611 doi (DE-627)DOAJ078412757 (DE-599)DOAJ9b5fbe46d32049ae8d5259d341682e91 DE-627 ger DE-627 rakwb eng RC321-571 Stefania Evangelisti verfasserin aut L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Studies of functional neurosurgery and electroencephalography in Parkinson’s disease have demonstrated abnormally synchronous activity between basal ganglia and motor cortex. Functional neuroimaging studies investigated brain dysfunction during motor task or resting state and primarily have shown altered patterns of activation and connectivity for motor areas. L-dopa administration relatively normalized these functional alterations. The aim of this pilot study was to examine the effects of L-dopa administration on functional connectivity in early-stage PD, as revealed by simultaneous recording of functional magnetic resonance imaging (fMRI) and electroencephalographic (EEG) data. Six patients with diagnosis of probable PD underwent EEG-fMRI acquisitions (1.5 T MR scanner and 64-channel cap) before and immediately after the intake of L-dopa. Regions of interest in the primary motor and sensorimotor regions were used for resting state fMRI analysis. From the EEG data, weighted partial directed coherence was computed in the inverse space after the removal of gradient and cardioballistic artifacts. fMRI results showed that the intake of L-dopa increased functional connectivity within the sensorimotor network, and between motor areas and both attention and default mode networks. EEG connectivity among regions of the motor network did not change significantly, while regions of the default mode network showed a strong tendency to increase their outflow toward the rest of the brain. This pilot study provided a first insight into the potentiality of simultaneous EEG-fMRI acquisitions in PD patients, showing for both techniques the analogous direction of increased connectivity after L-dopa intake, mainly involving motor, dorsal attention and default mode networks. Parkinson’s disease EEG-fMRI functional connectivity L-dopa pilot study Neurosciences. Biological psychiatry. Neuropsychiatry Francesca Pittau verfasserin aut Claudia Testa verfasserin aut Giovanni Rizzo verfasserin aut Giovanni Rizzo verfasserin aut Laura Ludovica Gramegna verfasserin aut Laura Ludovica Gramegna verfasserin aut Lorenzo Ferri verfasserin aut Ana Coito verfasserin aut Pietro Cortelli verfasserin aut Pietro Cortelli verfasserin aut Giovanna Calandra-Buonaura verfasserin aut Giovanna Calandra-Buonaura verfasserin aut Fabio Bisquoli verfasserin aut Fabio Bisquoli verfasserin aut Claudio Bianchini verfasserin aut David Neil Manners verfasserin aut Lia Talozzi verfasserin aut Caterina Tonon verfasserin aut Caterina Tonon verfasserin aut Raffaele Lodi verfasserin aut Raffaele Lodi verfasserin aut Paolo Tinuper verfasserin aut Paolo Tinuper verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 13(2019) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:13 year:2019 https://doi.org/10.3389/fnins.2019.00611 kostenfrei https://doaj.org/article/9b5fbe46d32049ae8d5259d341682e91 kostenfrei https://www.frontiersin.org/article/10.3389/fnins.2019.00611/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2019
allfieldsSound	10.3389/fnins.2019.00611 doi (DE-627)DOAJ078412757 (DE-599)DOAJ9b5fbe46d32049ae8d5259d341682e91 DE-627 ger DE-627 rakwb eng RC321-571 Stefania Evangelisti verfasserin aut L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Studies of functional neurosurgery and electroencephalography in Parkinson’s disease have demonstrated abnormally synchronous activity between basal ganglia and motor cortex. Functional neuroimaging studies investigated brain dysfunction during motor task or resting state and primarily have shown altered patterns of activation and connectivity for motor areas. L-dopa administration relatively normalized these functional alterations. The aim of this pilot study was to examine the effects of L-dopa administration on functional connectivity in early-stage PD, as revealed by simultaneous recording of functional magnetic resonance imaging (fMRI) and electroencephalographic (EEG) data. Six patients with diagnosis of probable PD underwent EEG-fMRI acquisitions (1.5 T MR scanner and 64-channel cap) before and immediately after the intake of L-dopa. Regions of interest in the primary motor and sensorimotor regions were used for resting state fMRI analysis. From the EEG data, weighted partial directed coherence was computed in the inverse space after the removal of gradient and cardioballistic artifacts. fMRI results showed that the intake of L-dopa increased functional connectivity within the sensorimotor network, and between motor areas and both attention and default mode networks. EEG connectivity among regions of the motor network did not change significantly, while regions of the default mode network showed a strong tendency to increase their outflow toward the rest of the brain. This pilot study provided a first insight into the potentiality of simultaneous EEG-fMRI acquisitions in PD patients, showing for both techniques the analogous direction of increased connectivity after L-dopa intake, mainly involving motor, dorsal attention and default mode networks. Parkinson’s disease EEG-fMRI functional connectivity L-dopa pilot study Neurosciences. Biological psychiatry. Neuropsychiatry Francesca Pittau verfasserin aut Claudia Testa verfasserin aut Giovanni Rizzo verfasserin aut Giovanni Rizzo verfasserin aut Laura Ludovica Gramegna verfasserin aut Laura Ludovica Gramegna verfasserin aut Lorenzo Ferri verfasserin aut Ana Coito verfasserin aut Pietro Cortelli verfasserin aut Pietro Cortelli verfasserin aut Giovanna Calandra-Buonaura verfasserin aut Giovanna Calandra-Buonaura verfasserin aut Fabio Bisquoli verfasserin aut Fabio Bisquoli verfasserin aut Claudio Bianchini verfasserin aut David Neil Manners verfasserin aut Lia Talozzi verfasserin aut Caterina Tonon verfasserin aut Caterina Tonon verfasserin aut Raffaele Lodi verfasserin aut Raffaele Lodi verfasserin aut Paolo Tinuper verfasserin aut Paolo Tinuper verfasserin aut In Frontiers in Neuroscience Frontiers Media S.A., 2008 13(2019) (DE-627)55908109X (DE-600)2411902-7 1662453X nnns volume:13 year:2019 https://doi.org/10.3389/fnins.2019.00611 kostenfrei https://doaj.org/article/9b5fbe46d32049ae8d5259d341682e91 kostenfrei https://www.frontiersin.org/article/10.3389/fnins.2019.00611/full kostenfrei https://doaj.org/toc/1662-453X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2019
language	English
source	In Frontiers in Neuroscience 13(2019) volume:13 year:2019
sourceStr	In Frontiers in Neuroscience 13(2019) volume:13 year:2019
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Parkinson’s disease EEG-fMRI functional connectivity L-dopa pilot study Neurosciences. Biological psychiatry. Neuropsychiatry
isfreeaccess_bool	true
container_title	Frontiers in Neuroscience
authorswithroles_txt_mv	Stefania Evangelisti @@aut@@ Francesca Pittau @@aut@@ Claudia Testa @@aut@@ Giovanni Rizzo @@aut@@ Laura Ludovica Gramegna @@aut@@ Lorenzo Ferri @@aut@@ Ana Coito @@aut@@ Pietro Cortelli @@aut@@ Giovanna Calandra-Buonaura @@aut@@ Fabio Bisquoli @@aut@@ Claudio Bianchini @@aut@@ David Neil Manners @@aut@@ Lia Talozzi @@aut@@ Caterina Tonon @@aut@@ Raffaele Lodi @@aut@@ Paolo Tinuper @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	55908109X
id	DOAJ078412757
language_de	englisch
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callnumber-first	R - Medicine
author	Stefania Evangelisti
spellingShingle	Stefania Evangelisti misc RC321-571 misc Parkinson’s disease misc EEG-fMRI misc functional connectivity misc L-dopa misc pilot study misc Neurosciences. Biological psychiatry. Neuropsychiatry L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study
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topic_title	RC321-571 L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study Parkinson’s disease EEG-fMRI functional connectivity L-dopa pilot study
topic	misc RC321-571 misc Parkinson’s disease misc EEG-fMRI misc functional connectivity misc L-dopa misc pilot study misc Neurosciences. Biological psychiatry. Neuropsychiatry
topic_unstemmed	misc RC321-571 misc Parkinson’s disease misc EEG-fMRI misc functional connectivity misc L-dopa misc pilot study misc Neurosciences. Biological psychiatry. Neuropsychiatry
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title	L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study
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title_full	L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study
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author_browse	Stefania Evangelisti Francesca Pittau Claudia Testa Giovanni Rizzo Laura Ludovica Gramegna Lorenzo Ferri Ana Coito Pietro Cortelli Giovanna Calandra-Buonaura Fabio Bisquoli Claudio Bianchini David Neil Manners Lia Talozzi Caterina Tonon Raffaele Lodi Paolo Tinuper
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title_sort	l-dopa modulation of brain connectivity in parkinson’s disease patients: a pilot eeg-fmri study
callnumber	RC321-571
title_auth	L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study
abstract	Studies of functional neurosurgery and electroencephalography in Parkinson’s disease have demonstrated abnormally synchronous activity between basal ganglia and motor cortex. Functional neuroimaging studies investigated brain dysfunction during motor task or resting state and primarily have shown altered patterns of activation and connectivity for motor areas. L-dopa administration relatively normalized these functional alterations. The aim of this pilot study was to examine the effects of L-dopa administration on functional connectivity in early-stage PD, as revealed by simultaneous recording of functional magnetic resonance imaging (fMRI) and electroencephalographic (EEG) data. Six patients with diagnosis of probable PD underwent EEG-fMRI acquisitions (1.5 T MR scanner and 64-channel cap) before and immediately after the intake of L-dopa. Regions of interest in the primary motor and sensorimotor regions were used for resting state fMRI analysis. From the EEG data, weighted partial directed coherence was computed in the inverse space after the removal of gradient and cardioballistic artifacts. fMRI results showed that the intake of L-dopa increased functional connectivity within the sensorimotor network, and between motor areas and both attention and default mode networks. EEG connectivity among regions of the motor network did not change significantly, while regions of the default mode network showed a strong tendency to increase their outflow toward the rest of the brain. This pilot study provided a first insight into the potentiality of simultaneous EEG-fMRI acquisitions in PD patients, showing for both techniques the analogous direction of increased connectivity after L-dopa intake, mainly involving motor, dorsal attention and default mode networks.
abstractGer	Studies of functional neurosurgery and electroencephalography in Parkinson’s disease have demonstrated abnormally synchronous activity between basal ganglia and motor cortex. Functional neuroimaging studies investigated brain dysfunction during motor task or resting state and primarily have shown altered patterns of activation and connectivity for motor areas. L-dopa administration relatively normalized these functional alterations. The aim of this pilot study was to examine the effects of L-dopa administration on functional connectivity in early-stage PD, as revealed by simultaneous recording of functional magnetic resonance imaging (fMRI) and electroencephalographic (EEG) data. Six patients with diagnosis of probable PD underwent EEG-fMRI acquisitions (1.5 T MR scanner and 64-channel cap) before and immediately after the intake of L-dopa. Regions of interest in the primary motor and sensorimotor regions were used for resting state fMRI analysis. From the EEG data, weighted partial directed coherence was computed in the inverse space after the removal of gradient and cardioballistic artifacts. fMRI results showed that the intake of L-dopa increased functional connectivity within the sensorimotor network, and between motor areas and both attention and default mode networks. EEG connectivity among regions of the motor network did not change significantly, while regions of the default mode network showed a strong tendency to increase their outflow toward the rest of the brain. This pilot study provided a first insight into the potentiality of simultaneous EEG-fMRI acquisitions in PD patients, showing for both techniques the analogous direction of increased connectivity after L-dopa intake, mainly involving motor, dorsal attention and default mode networks.
abstract_unstemmed	Studies of functional neurosurgery and electroencephalography in Parkinson’s disease have demonstrated abnormally synchronous activity between basal ganglia and motor cortex. Functional neuroimaging studies investigated brain dysfunction during motor task or resting state and primarily have shown altered patterns of activation and connectivity for motor areas. L-dopa administration relatively normalized these functional alterations. The aim of this pilot study was to examine the effects of L-dopa administration on functional connectivity in early-stage PD, as revealed by simultaneous recording of functional magnetic resonance imaging (fMRI) and electroencephalographic (EEG) data. Six patients with diagnosis of probable PD underwent EEG-fMRI acquisitions (1.5 T MR scanner and 64-channel cap) before and immediately after the intake of L-dopa. Regions of interest in the primary motor and sensorimotor regions were used for resting state fMRI analysis. From the EEG data, weighted partial directed coherence was computed in the inverse space after the removal of gradient and cardioballistic artifacts. fMRI results showed that the intake of L-dopa increased functional connectivity within the sensorimotor network, and between motor areas and both attention and default mode networks. EEG connectivity among regions of the motor network did not change significantly, while regions of the default mode network showed a strong tendency to increase their outflow toward the rest of the brain. This pilot study provided a first insight into the potentiality of simultaneous EEG-fMRI acquisitions in PD patients, showing for both techniques the analogous direction of increased connectivity after L-dopa intake, mainly involving motor, dorsal attention and default mode networks.
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title_short	L-Dopa Modulation of Brain Connectivity in Parkinson’s Disease Patients: A Pilot EEG-fMRI Study
url	https://doi.org/10.3389/fnins.2019.00611 https://doaj.org/article/9b5fbe46d32049ae8d5259d341682e91 https://www.frontiersin.org/article/10.3389/fnins.2019.00611/full https://doaj.org/toc/1662-453X
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author2	Francesca Pittau Claudia Testa Giovanni Rizzo Laura Ludovica Gramegna Lorenzo Ferri Ana Coito Pietro Cortelli Giovanna Calandra-Buonaura Fabio Bisquoli Claudio Bianchini David Neil Manners Lia Talozzi Caterina Tonon Raffaele Lodi Paolo Tinuper
author2Str	Francesca Pittau Claudia Testa Giovanni Rizzo Laura Ludovica Gramegna Lorenzo Ferri Ana Coito Pietro Cortelli Giovanna Calandra-Buonaura Fabio Bisquoli Claudio Bianchini David Neil Manners Lia Talozzi Caterina Tonon Raffaele Lodi Paolo Tinuper
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up_date	2024-07-03T17:49:27.879Z
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