Transcription Factor-Based Biosensor for Dynamic Control in Yeast for Natural Product Synthesis

The synthesis of natural products in yeast has gained remarkable achievements with intensive metabolic engineering efforts. In particular, transcription factor (TF)-based biosensors for dynamic control of gene circuits could facilitate strain evaluation, high-throughput screening (HTS), and adaptive...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Yiming Zhang [verfasserIn] Shuobo Shi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	yeast biosensor natural products fatty acids shikimate pathway MEP/MVA pathway

Übergeordnetes Werk:	In: Frontiers in Bioengineering and Biotechnology - Frontiers Media S.A., 2014, 9(2021)
Übergeordnetes Werk:	volume:9 ; year:2021

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fbioe.2021.635265

Katalog-ID:	DOAJ078443571

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allfields	10.3389/fbioe.2021.635265 doi (DE-627)DOAJ078443571 (DE-599)DOAJa558e41752a54fe888b848274bed2507 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Yiming Zhang verfasserin aut Transcription Factor-Based Biosensor for Dynamic Control in Yeast for Natural Product Synthesis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The synthesis of natural products in yeast has gained remarkable achievements with intensive metabolic engineering efforts. In particular, transcription factor (TF)-based biosensors for dynamic control of gene circuits could facilitate strain evaluation, high-throughput screening (HTS), and adaptive laboratory evolution (ALE) for natural product synthesis. In this review, we summarized recent developments of several TF-based biosensors for core intermediates in natural product synthesis through three important pathways, i.e., fatty acid synthesis pathway, shikimate pathway, and methylerythritol-4-phosphate (MEP)/mevalonate (MVA) pathway. Moreover, we have shown how these biosensors are implemented in synthetic circuits for dynamic control of natural product synthesis and also discussed the design/evaluation principles for improved biosensor performance. yeast biosensor natural products fatty acids shikimate pathway MEP/MVA pathway Biotechnology Shuobo Shi verfasserin aut In Frontiers in Bioengineering and Biotechnology Frontiers Media S.A., 2014 9(2021) (DE-627)74950403X (DE-600)2719493-0 22964185 nnns volume:9 year:2021 https://doi.org/10.3389/fbioe.2021.635265 kostenfrei https://doaj.org/article/a558e41752a54fe888b848274bed2507 kostenfrei https://www.frontiersin.org/articles/10.3389/fbioe.2021.635265/full kostenfrei https://doaj.org/toc/2296-4185 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021
spelling	10.3389/fbioe.2021.635265 doi (DE-627)DOAJ078443571 (DE-599)DOAJa558e41752a54fe888b848274bed2507 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Yiming Zhang verfasserin aut Transcription Factor-Based Biosensor for Dynamic Control in Yeast for Natural Product Synthesis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The synthesis of natural products in yeast has gained remarkable achievements with intensive metabolic engineering efforts. In particular, transcription factor (TF)-based biosensors for dynamic control of gene circuits could facilitate strain evaluation, high-throughput screening (HTS), and adaptive laboratory evolution (ALE) for natural product synthesis. In this review, we summarized recent developments of several TF-based biosensors for core intermediates in natural product synthesis through three important pathways, i.e., fatty acid synthesis pathway, shikimate pathway, and methylerythritol-4-phosphate (MEP)/mevalonate (MVA) pathway. Moreover, we have shown how these biosensors are implemented in synthetic circuits for dynamic control of natural product synthesis and also discussed the design/evaluation principles for improved biosensor performance. yeast biosensor natural products fatty acids shikimate pathway MEP/MVA pathway Biotechnology Shuobo Shi verfasserin aut In Frontiers in Bioengineering and Biotechnology Frontiers Media S.A., 2014 9(2021) (DE-627)74950403X (DE-600)2719493-0 22964185 nnns volume:9 year:2021 https://doi.org/10.3389/fbioe.2021.635265 kostenfrei https://doaj.org/article/a558e41752a54fe888b848274bed2507 kostenfrei https://www.frontiersin.org/articles/10.3389/fbioe.2021.635265/full kostenfrei https://doaj.org/toc/2296-4185 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021
allfields_unstemmed	10.3389/fbioe.2021.635265 doi (DE-627)DOAJ078443571 (DE-599)DOAJa558e41752a54fe888b848274bed2507 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Yiming Zhang verfasserin aut Transcription Factor-Based Biosensor for Dynamic Control in Yeast for Natural Product Synthesis 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The synthesis of natural products in yeast has gained remarkable achievements with intensive metabolic engineering efforts. In particular, transcription factor (TF)-based biosensors for dynamic control of gene circuits could facilitate strain evaluation, high-throughput screening (HTS), and adaptive laboratory evolution (ALE) for natural product synthesis. In this review, we summarized recent developments of several TF-based biosensors for core intermediates in natural product synthesis through three important pathways, i.e., fatty acid synthesis pathway, shikimate pathway, and methylerythritol-4-phosphate (MEP)/mevalonate (MVA) pathway. Moreover, we have shown how these biosensors are implemented in synthetic circuits for dynamic control of natural product synthesis and also discussed the design/evaluation principles for improved biosensor performance. yeast biosensor natural products fatty acids shikimate pathway MEP/MVA pathway Biotechnology Shuobo Shi verfasserin aut In Frontiers in Bioengineering and Biotechnology Frontiers Media S.A., 2014 9(2021) (DE-627)74950403X (DE-600)2719493-0 22964185 nnns volume:9 year:2021 https://doi.org/10.3389/fbioe.2021.635265 kostenfrei https://doaj.org/article/a558e41752a54fe888b848274bed2507 kostenfrei https://www.frontiersin.org/articles/10.3389/fbioe.2021.635265/full kostenfrei https://doaj.org/toc/2296-4185 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2021
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topic_facet	yeast biosensor natural products fatty acids shikimate pathway MEP/MVA pathway Biotechnology
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callnumber-first	T - Technology
author	Yiming Zhang
spellingShingle	Yiming Zhang misc TP248.13-248.65 misc yeast misc biosensor misc natural products misc fatty acids misc shikimate pathway misc MEP/MVA pathway misc Biotechnology Transcription Factor-Based Biosensor for Dynamic Control in Yeast for Natural Product Synthesis
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topic_title	TP248.13-248.65 Transcription Factor-Based Biosensor for Dynamic Control in Yeast for Natural Product Synthesis yeast biosensor natural products fatty acids shikimate pathway MEP/MVA pathway
topic	misc TP248.13-248.65 misc yeast misc biosensor misc natural products misc fatty acids misc shikimate pathway misc MEP/MVA pathway misc Biotechnology
topic_unstemmed	misc TP248.13-248.65 misc yeast misc biosensor misc natural products misc fatty acids misc shikimate pathway misc MEP/MVA pathway misc Biotechnology
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title	Transcription Factor-Based Biosensor for Dynamic Control in Yeast for Natural Product Synthesis
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title_full	Transcription Factor-Based Biosensor for Dynamic Control in Yeast for Natural Product Synthesis
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title_sort	transcription factor-based biosensor for dynamic control in yeast for natural product synthesis
callnumber	TP248.13-248.65
title_auth	Transcription Factor-Based Biosensor for Dynamic Control in Yeast for Natural Product Synthesis
abstract	The synthesis of natural products in yeast has gained remarkable achievements with intensive metabolic engineering efforts. In particular, transcription factor (TF)-based biosensors for dynamic control of gene circuits could facilitate strain evaluation, high-throughput screening (HTS), and adaptive laboratory evolution (ALE) for natural product synthesis. In this review, we summarized recent developments of several TF-based biosensors for core intermediates in natural product synthesis through three important pathways, i.e., fatty acid synthesis pathway, shikimate pathway, and methylerythritol-4-phosphate (MEP)/mevalonate (MVA) pathway. Moreover, we have shown how these biosensors are implemented in synthetic circuits for dynamic control of natural product synthesis and also discussed the design/evaluation principles for improved biosensor performance.
abstractGer	The synthesis of natural products in yeast has gained remarkable achievements with intensive metabolic engineering efforts. In particular, transcription factor (TF)-based biosensors for dynamic control of gene circuits could facilitate strain evaluation, high-throughput screening (HTS), and adaptive laboratory evolution (ALE) for natural product synthesis. In this review, we summarized recent developments of several TF-based biosensors for core intermediates in natural product synthesis through three important pathways, i.e., fatty acid synthesis pathway, shikimate pathway, and methylerythritol-4-phosphate (MEP)/mevalonate (MVA) pathway. Moreover, we have shown how these biosensors are implemented in synthetic circuits for dynamic control of natural product synthesis and also discussed the design/evaluation principles for improved biosensor performance.
abstract_unstemmed	The synthesis of natural products in yeast has gained remarkable achievements with intensive metabolic engineering efforts. In particular, transcription factor (TF)-based biosensors for dynamic control of gene circuits could facilitate strain evaluation, high-throughput screening (HTS), and adaptive laboratory evolution (ALE) for natural product synthesis. In this review, we summarized recent developments of several TF-based biosensors for core intermediates in natural product synthesis through three important pathways, i.e., fatty acid synthesis pathway, shikimate pathway, and methylerythritol-4-phosphate (MEP)/mevalonate (MVA) pathway. Moreover, we have shown how these biosensors are implemented in synthetic circuits for dynamic control of natural product synthesis and also discussed the design/evaluation principles for improved biosensor performance.
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title_short	Transcription Factor-Based Biosensor for Dynamic Control in Yeast for Natural Product Synthesis
url	https://doi.org/10.3389/fbioe.2021.635265 https://doaj.org/article/a558e41752a54fe888b848274bed2507 https://www.frontiersin.org/articles/10.3389/fbioe.2021.635265/full https://doaj.org/toc/2296-4185
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up_date	2024-07-03T18:00:32.751Z
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