A novel nanomicelle composed from PEGylated TB di-peptide could be successfully used as a BCG booster

Objective(s): Tuberculosis affects one-third of the world’s population and leads to a high rate of morbidity and mortality. Bacillus Chalmette–Guerin (BCG) as the only approved vaccine for the Mycobacterium tuberculosis (Mtb) does not show enough protection in the vaccinated population. Materials an...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Zohreh Firouzi [verfasserIn] Mahmoud Jaafari [verfasserIn] Mojtaba Sankian [verfasserIn] Sirwan Zare [verfasserIn] Mohsen Tafaghodi [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	nanovaccine nasal and parenteral immunization recombinant fusion peptide self-assembled nanomicelles tuberculosis

Übergeordnetes Werk:	In: Iranian Journal of Basic Medical Sciences - Mashhad University of Medical Sciences, 2009, 25(2022), 2, Seite 223-231
Übergeordnetes Werk:	volume:25 ; year:2022 ; number:2 ; pages:223-231

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.22038/ijbms.2022.61373.13583

Katalog-ID:	DOAJ078561647

Internformat


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spelling	10.22038/ijbms.2022.61373.13583 doi (DE-627)DOAJ078561647 (DE-599)DOAJ04fb710c61d0416388bf9c86bc5ba67c DE-627 ger DE-627 rakwb eng Zohreh Firouzi verfasserin aut A novel nanomicelle composed from PEGylated TB di-peptide could be successfully used as a BCG booster 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective(s): Tuberculosis affects one-third of the world’s population and leads to a high rate of morbidity and mortality. Bacillus Chalmette–Guerin (BCG) as the only approved vaccine for the Mycobacterium tuberculosis (Mtb) does not show enough protection in the vaccinated population. Materials and Methods: The main aim of this study was to prepare a self-assembled nanomicelle composed from a di-block polymer in which, a di-fusion peptide was the hydrophobic block and polyethylene glycol (PEG) was the hydrophilic block. The micelles were characterized in vitro and in vivo as an antigen delivery system/adjuvant both with and without a prime BCG. Results: The micellar nanovaccine was able to elicit good dendritic cell maturation. Nanomicelles could efficiently induce systemic cytokines as well as nasal secretory predominant antibody titers (sIgA). The expression pattern of cytokines indicated the superiority of cellular immunity. Nasal administration of two doses of nanomicelles after a prime subcutaneous administration of BCG induced the highest mucosal and systemic immune responses. Conclusion: Based on our results PEG-HspX/EsxS self-assembled nanomicelle is highly immunogenic and can be considered a potential vaccine candidate against Mtb to boost BCG efficiency. nanovaccine nasal and parenteral immunization recombinant fusion peptide self-assembled nanomicelles tuberculosis Medicine R Mahmoud Jaafari verfasserin aut Mojtaba Sankian verfasserin aut Sirwan Zare verfasserin aut Mohsen Tafaghodi verfasserin aut In Iranian Journal of Basic Medical Sciences Mashhad University of Medical Sciences, 2009 25(2022), 2, Seite 223-231 (DE-627)602537185 (DE-600)2500485-2 20083874 nnns volume:25 year:2022 number:2 pages:223-231 https://doi.org/10.22038/ijbms.2022.61373.13583 kostenfrei https://doaj.org/article/04fb710c61d0416388bf9c86bc5ba67c kostenfrei https://ijbms.mums.ac.ir/article_19657_9829f91e429d0067e00b7b08914cd87b.pdf kostenfrei https://doaj.org/toc/2008-3866 Journal toc kostenfrei https://doaj.org/toc/2008-3874 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2022 2 223-231
allfields_unstemmed	10.22038/ijbms.2022.61373.13583 doi (DE-627)DOAJ078561647 (DE-599)DOAJ04fb710c61d0416388bf9c86bc5ba67c DE-627 ger DE-627 rakwb eng Zohreh Firouzi verfasserin aut A novel nanomicelle composed from PEGylated TB di-peptide could be successfully used as a BCG booster 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective(s): Tuberculosis affects one-third of the world’s population and leads to a high rate of morbidity and mortality. Bacillus Chalmette–Guerin (BCG) as the only approved vaccine for the Mycobacterium tuberculosis (Mtb) does not show enough protection in the vaccinated population. Materials and Methods: The main aim of this study was to prepare a self-assembled nanomicelle composed from a di-block polymer in which, a di-fusion peptide was the hydrophobic block and polyethylene glycol (PEG) was the hydrophilic block. The micelles were characterized in vitro and in vivo as an antigen delivery system/adjuvant both with and without a prime BCG. Results: The micellar nanovaccine was able to elicit good dendritic cell maturation. Nanomicelles could efficiently induce systemic cytokines as well as nasal secretory predominant antibody titers (sIgA). The expression pattern of cytokines indicated the superiority of cellular immunity. Nasal administration of two doses of nanomicelles after a prime subcutaneous administration of BCG induced the highest mucosal and systemic immune responses. Conclusion: Based on our results PEG-HspX/EsxS self-assembled nanomicelle is highly immunogenic and can be considered a potential vaccine candidate against Mtb to boost BCG efficiency. nanovaccine nasal and parenteral immunization recombinant fusion peptide self-assembled nanomicelles tuberculosis Medicine R Mahmoud Jaafari verfasserin aut Mojtaba Sankian verfasserin aut Sirwan Zare verfasserin aut Mohsen Tafaghodi verfasserin aut In Iranian Journal of Basic Medical Sciences Mashhad University of Medical Sciences, 2009 25(2022), 2, Seite 223-231 (DE-627)602537185 (DE-600)2500485-2 20083874 nnns volume:25 year:2022 number:2 pages:223-231 https://doi.org/10.22038/ijbms.2022.61373.13583 kostenfrei https://doaj.org/article/04fb710c61d0416388bf9c86bc5ba67c kostenfrei https://ijbms.mums.ac.ir/article_19657_9829f91e429d0067e00b7b08914cd87b.pdf kostenfrei https://doaj.org/toc/2008-3866 Journal toc kostenfrei https://doaj.org/toc/2008-3874 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2022 2 223-231
allfieldsGer	10.22038/ijbms.2022.61373.13583 doi (DE-627)DOAJ078561647 (DE-599)DOAJ04fb710c61d0416388bf9c86bc5ba67c DE-627 ger DE-627 rakwb eng Zohreh Firouzi verfasserin aut A novel nanomicelle composed from PEGylated TB di-peptide could be successfully used as a BCG booster 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective(s): Tuberculosis affects one-third of the world’s population and leads to a high rate of morbidity and mortality. Bacillus Chalmette–Guerin (BCG) as the only approved vaccine for the Mycobacterium tuberculosis (Mtb) does not show enough protection in the vaccinated population. Materials and Methods: The main aim of this study was to prepare a self-assembled nanomicelle composed from a di-block polymer in which, a di-fusion peptide was the hydrophobic block and polyethylene glycol (PEG) was the hydrophilic block. The micelles were characterized in vitro and in vivo as an antigen delivery system/adjuvant both with and without a prime BCG. Results: The micellar nanovaccine was able to elicit good dendritic cell maturation. Nanomicelles could efficiently induce systemic cytokines as well as nasal secretory predominant antibody titers (sIgA). The expression pattern of cytokines indicated the superiority of cellular immunity. Nasal administration of two doses of nanomicelles after a prime subcutaneous administration of BCG induced the highest mucosal and systemic immune responses. Conclusion: Based on our results PEG-HspX/EsxS self-assembled nanomicelle is highly immunogenic and can be considered a potential vaccine candidate against Mtb to boost BCG efficiency. nanovaccine nasal and parenteral immunization recombinant fusion peptide self-assembled nanomicelles tuberculosis Medicine R Mahmoud Jaafari verfasserin aut Mojtaba Sankian verfasserin aut Sirwan Zare verfasserin aut Mohsen Tafaghodi verfasserin aut In Iranian Journal of Basic Medical Sciences Mashhad University of Medical Sciences, 2009 25(2022), 2, Seite 223-231 (DE-627)602537185 (DE-600)2500485-2 20083874 nnns volume:25 year:2022 number:2 pages:223-231 https://doi.org/10.22038/ijbms.2022.61373.13583 kostenfrei https://doaj.org/article/04fb710c61d0416388bf9c86bc5ba67c kostenfrei https://ijbms.mums.ac.ir/article_19657_9829f91e429d0067e00b7b08914cd87b.pdf kostenfrei https://doaj.org/toc/2008-3866 Journal toc kostenfrei https://doaj.org/toc/2008-3874 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2022 2 223-231
allfieldsSound	10.22038/ijbms.2022.61373.13583 doi (DE-627)DOAJ078561647 (DE-599)DOAJ04fb710c61d0416388bf9c86bc5ba67c DE-627 ger DE-627 rakwb eng Zohreh Firouzi verfasserin aut A novel nanomicelle composed from PEGylated TB di-peptide could be successfully used as a BCG booster 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective(s): Tuberculosis affects one-third of the world’s population and leads to a high rate of morbidity and mortality. Bacillus Chalmette–Guerin (BCG) as the only approved vaccine for the Mycobacterium tuberculosis (Mtb) does not show enough protection in the vaccinated population. Materials and Methods: The main aim of this study was to prepare a self-assembled nanomicelle composed from a di-block polymer in which, a di-fusion peptide was the hydrophobic block and polyethylene glycol (PEG) was the hydrophilic block. The micelles were characterized in vitro and in vivo as an antigen delivery system/adjuvant both with and without a prime BCG. Results: The micellar nanovaccine was able to elicit good dendritic cell maturation. Nanomicelles could efficiently induce systemic cytokines as well as nasal secretory predominant antibody titers (sIgA). The expression pattern of cytokines indicated the superiority of cellular immunity. Nasal administration of two doses of nanomicelles after a prime subcutaneous administration of BCG induced the highest mucosal and systemic immune responses. Conclusion: Based on our results PEG-HspX/EsxS self-assembled nanomicelle is highly immunogenic and can be considered a potential vaccine candidate against Mtb to boost BCG efficiency. nanovaccine nasal and parenteral immunization recombinant fusion peptide self-assembled nanomicelles tuberculosis Medicine R Mahmoud Jaafari verfasserin aut Mojtaba Sankian verfasserin aut Sirwan Zare verfasserin aut Mohsen Tafaghodi verfasserin aut In Iranian Journal of Basic Medical Sciences Mashhad University of Medical Sciences, 2009 25(2022), 2, Seite 223-231 (DE-627)602537185 (DE-600)2500485-2 20083874 nnns volume:25 year:2022 number:2 pages:223-231 https://doi.org/10.22038/ijbms.2022.61373.13583 kostenfrei https://doaj.org/article/04fb710c61d0416388bf9c86bc5ba67c kostenfrei https://ijbms.mums.ac.ir/article_19657_9829f91e429d0067e00b7b08914cd87b.pdf kostenfrei https://doaj.org/toc/2008-3866 Journal toc kostenfrei https://doaj.org/toc/2008-3874 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 25 2022 2 223-231
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author	Zohreh Firouzi
spellingShingle	Zohreh Firouzi misc nanovaccine misc nasal and parenteral immunization misc recombinant fusion peptide misc self-assembled nanomicelles misc tuberculosis misc Medicine misc R A novel nanomicelle composed from PEGylated TB di-peptide could be successfully used as a BCG booster
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topic_title	A novel nanomicelle composed from PEGylated TB di-peptide could be successfully used as a BCG booster nanovaccine nasal and parenteral immunization recombinant fusion peptide self-assembled nanomicelles tuberculosis
topic	misc nanovaccine misc nasal and parenteral immunization misc recombinant fusion peptide misc self-assembled nanomicelles misc tuberculosis misc Medicine misc R
topic_unstemmed	misc nanovaccine misc nasal and parenteral immunization misc recombinant fusion peptide misc self-assembled nanomicelles misc tuberculosis misc Medicine misc R
topic_browse	misc nanovaccine misc nasal and parenteral immunization misc recombinant fusion peptide misc self-assembled nanomicelles misc tuberculosis misc Medicine misc R
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title	A novel nanomicelle composed from PEGylated TB di-peptide could be successfully used as a BCG booster
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title_full	A novel nanomicelle composed from PEGylated TB di-peptide could be successfully used as a BCG booster
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author_browse	Zohreh Firouzi Mahmoud Jaafari Mojtaba Sankian Sirwan Zare Mohsen Tafaghodi
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title_sort	novel nanomicelle composed from pegylated tb di-peptide could be successfully used as a bcg booster
title_auth	A novel nanomicelle composed from PEGylated TB di-peptide could be successfully used as a BCG booster
abstract	Objective(s): Tuberculosis affects one-third of the world’s population and leads to a high rate of morbidity and mortality. Bacillus Chalmette–Guerin (BCG) as the only approved vaccine for the Mycobacterium tuberculosis (Mtb) does not show enough protection in the vaccinated population. Materials and Methods: The main aim of this study was to prepare a self-assembled nanomicelle composed from a di-block polymer in which, a di-fusion peptide was the hydrophobic block and polyethylene glycol (PEG) was the hydrophilic block. The micelles were characterized in vitro and in vivo as an antigen delivery system/adjuvant both with and without a prime BCG. Results: The micellar nanovaccine was able to elicit good dendritic cell maturation. Nanomicelles could efficiently induce systemic cytokines as well as nasal secretory predominant antibody titers (sIgA). The expression pattern of cytokines indicated the superiority of cellular immunity. Nasal administration of two doses of nanomicelles after a prime subcutaneous administration of BCG induced the highest mucosal and systemic immune responses. Conclusion: Based on our results PEG-HspX/EsxS self-assembled nanomicelle is highly immunogenic and can be considered a potential vaccine candidate against Mtb to boost BCG efficiency.
abstractGer	Objective(s): Tuberculosis affects one-third of the world’s population and leads to a high rate of morbidity and mortality. Bacillus Chalmette–Guerin (BCG) as the only approved vaccine for the Mycobacterium tuberculosis (Mtb) does not show enough protection in the vaccinated population. Materials and Methods: The main aim of this study was to prepare a self-assembled nanomicelle composed from a di-block polymer in which, a di-fusion peptide was the hydrophobic block and polyethylene glycol (PEG) was the hydrophilic block. The micelles were characterized in vitro and in vivo as an antigen delivery system/adjuvant both with and without a prime BCG. Results: The micellar nanovaccine was able to elicit good dendritic cell maturation. Nanomicelles could efficiently induce systemic cytokines as well as nasal secretory predominant antibody titers (sIgA). The expression pattern of cytokines indicated the superiority of cellular immunity. Nasal administration of two doses of nanomicelles after a prime subcutaneous administration of BCG induced the highest mucosal and systemic immune responses. Conclusion: Based on our results PEG-HspX/EsxS self-assembled nanomicelle is highly immunogenic and can be considered a potential vaccine candidate against Mtb to boost BCG efficiency.
abstract_unstemmed	Objective(s): Tuberculosis affects one-third of the world’s population and leads to a high rate of morbidity and mortality. Bacillus Chalmette–Guerin (BCG) as the only approved vaccine for the Mycobacterium tuberculosis (Mtb) does not show enough protection in the vaccinated population. Materials and Methods: The main aim of this study was to prepare a self-assembled nanomicelle composed from a di-block polymer in which, a di-fusion peptide was the hydrophobic block and polyethylene glycol (PEG) was the hydrophilic block. The micelles were characterized in vitro and in vivo as an antigen delivery system/adjuvant both with and without a prime BCG. Results: The micellar nanovaccine was able to elicit good dendritic cell maturation. Nanomicelles could efficiently induce systemic cytokines as well as nasal secretory predominant antibody titers (sIgA). The expression pattern of cytokines indicated the superiority of cellular immunity. Nasal administration of two doses of nanomicelles after a prime subcutaneous administration of BCG induced the highest mucosal and systemic immune responses. Conclusion: Based on our results PEG-HspX/EsxS self-assembled nanomicelle is highly immunogenic and can be considered a potential vaccine candidate against Mtb to boost BCG efficiency.
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title_short	A novel nanomicelle composed from PEGylated TB di-peptide could be successfully used as a BCG booster
url	https://doi.org/10.22038/ijbms.2022.61373.13583 https://doaj.org/article/04fb710c61d0416388bf9c86bc5ba67c https://ijbms.mums.ac.ir/article_19657_9829f91e429d0067e00b7b08914cd87b.pdf https://doaj.org/toc/2008-3866 https://doaj.org/toc/2008-3874
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author2	Mahmoud Jaafari Mojtaba Sankian Sirwan Zare Mohsen Tafaghodi
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doi_str	10.22038/ijbms.2022.61373.13583
up_date	2024-07-03T18:43:49.036Z
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A novel nanomicelle composed from PEGylated TB di-peptide could be successfully used as a BCG booster

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