Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34

Nanocarriers are delivery platforms of drugs, peptides, nucleic acids and other therapeutic molecules that are indicated for severe human diseases. Gliomas are the most frequent type of brain tumor, with glioblastoma being the most common and malignant type. The current state of glioma treatment req...
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Autor*in:	Nikolaos Naziris [verfasserIn] Natassa Pippa [verfasserIn] Evangelia Sereti [verfasserIn] Varvara Chrysostomou [verfasserIn] Marta Kędzierska [verfasserIn] Jakub Kajdanek [verfasserIn] Maksim Ionov [verfasserIn] Katarzyna Miłowska [verfasserIn] Łucja Balcerzak [verfasserIn] Stefano Garofalo [verfasserIn] Cristina Limatola [verfasserIn] Stergios Pispas [verfasserIn] Konstantinos Dimas [verfasserIn] Maria Bryszewska [verfasserIn] Costas Demetzos [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	chimeric liposomes functional pH-responsive TRAM-34 drug delivery glioblastoma

Übergeordnetes Werk:	In: International Journal of Molecular Sciences - MDPI AG, 2003, 22(2021), 12, p 6271
Übergeordnetes Werk:	volume:22 ; year:2021 ; number:12, p 6271

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.3390/ijms22126271

Katalog-ID:	DOAJ078646448

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allfields	10.3390/ijms22126271 doi (DE-627)DOAJ078646448 (DE-599)DOAJ2e6443f15ecc4c3292e6a1a163e2647c DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Nikolaos Naziris verfasserin aut Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nanocarriers are delivery platforms of drugs, peptides, nucleic acids and other therapeutic molecules that are indicated for severe human diseases. Gliomas are the most frequent type of brain tumor, with glioblastoma being the most common and malignant type. The current state of glioma treatment requires innovative approaches that will lead to efficient and safe therapies. Advanced nanosystems and stimuli-responsive materials are available and well-studied technologies that may contribute to this effort. The present study deals with the development of functional chimeric nanocarriers composed of a phospholipid and a diblock copolymer, for the incorporation, delivery and pH-responsive release of the antiglioma agent TRAM-34 inside glioblastoma cells. Nanocarrier analysis included light scattering, protein incubation and electron microscopy, and fluorescence anisotropy and thermal analysis techniques were also applied. Biological assays were carried out in order to evaluate the nanocarrier nanotoxicity in vitro and in vivo, as well as to evaluate antiglioma activity. The nanosystems were able to successfully manifest functional properties under pH conditions, and their biocompatibility and cellular internalization were also evident. The chimeric nanoplatforms presented herein have shown promise for biomedical applications so far and should be further studied in terms of their ability to deliver TRAM-34 and other therapeutic molecules to glioblastoma cells. chimeric liposomes functional pH-responsive TRAM-34 drug delivery glioblastoma Biology (General) Chemistry Natassa Pippa verfasserin aut Evangelia Sereti verfasserin aut Varvara Chrysostomou verfasserin aut Marta Kędzierska verfasserin aut Jakub Kajdanek verfasserin aut Maksim Ionov verfasserin aut Katarzyna Miłowska verfasserin aut Łucja Balcerzak verfasserin aut Stefano Garofalo verfasserin aut Cristina Limatola verfasserin aut Stergios Pispas verfasserin aut Konstantinos Dimas verfasserin aut Maria Bryszewska verfasserin aut Costas Demetzos verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 12, p 6271 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:12, p 6271 https://doi.org/10.3390/ijms22126271 kostenfrei https://doaj.org/article/2e6443f15ecc4c3292e6a1a163e2647c kostenfrei https://www.mdpi.com/1422-0067/22/12/6271 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 12, p 6271
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allfields_unstemmed	10.3390/ijms22126271 doi (DE-627)DOAJ078646448 (DE-599)DOAJ2e6443f15ecc4c3292e6a1a163e2647c DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Nikolaos Naziris verfasserin aut Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nanocarriers are delivery platforms of drugs, peptides, nucleic acids and other therapeutic molecules that are indicated for severe human diseases. Gliomas are the most frequent type of brain tumor, with glioblastoma being the most common and malignant type. The current state of glioma treatment requires innovative approaches that will lead to efficient and safe therapies. Advanced nanosystems and stimuli-responsive materials are available and well-studied technologies that may contribute to this effort. The present study deals with the development of functional chimeric nanocarriers composed of a phospholipid and a diblock copolymer, for the incorporation, delivery and pH-responsive release of the antiglioma agent TRAM-34 inside glioblastoma cells. Nanocarrier analysis included light scattering, protein incubation and electron microscopy, and fluorescence anisotropy and thermal analysis techniques were also applied. Biological assays were carried out in order to evaluate the nanocarrier nanotoxicity in vitro and in vivo, as well as to evaluate antiglioma activity. The nanosystems were able to successfully manifest functional properties under pH conditions, and their biocompatibility and cellular internalization were also evident. The chimeric nanoplatforms presented herein have shown promise for biomedical applications so far and should be further studied in terms of their ability to deliver TRAM-34 and other therapeutic molecules to glioblastoma cells. chimeric liposomes functional pH-responsive TRAM-34 drug delivery glioblastoma Biology (General) Chemistry Natassa Pippa verfasserin aut Evangelia Sereti verfasserin aut Varvara Chrysostomou verfasserin aut Marta Kędzierska verfasserin aut Jakub Kajdanek verfasserin aut Maksim Ionov verfasserin aut Katarzyna Miłowska verfasserin aut Łucja Balcerzak verfasserin aut Stefano Garofalo verfasserin aut Cristina Limatola verfasserin aut Stergios Pispas verfasserin aut Konstantinos Dimas verfasserin aut Maria Bryszewska verfasserin aut Costas Demetzos verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 12, p 6271 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:12, p 6271 https://doi.org/10.3390/ijms22126271 kostenfrei https://doaj.org/article/2e6443f15ecc4c3292e6a1a163e2647c kostenfrei https://www.mdpi.com/1422-0067/22/12/6271 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 12, p 6271
allfieldsGer	10.3390/ijms22126271 doi (DE-627)DOAJ078646448 (DE-599)DOAJ2e6443f15ecc4c3292e6a1a163e2647c DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Nikolaos Naziris verfasserin aut Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nanocarriers are delivery platforms of drugs, peptides, nucleic acids and other therapeutic molecules that are indicated for severe human diseases. Gliomas are the most frequent type of brain tumor, with glioblastoma being the most common and malignant type. The current state of glioma treatment requires innovative approaches that will lead to efficient and safe therapies. Advanced nanosystems and stimuli-responsive materials are available and well-studied technologies that may contribute to this effort. The present study deals with the development of functional chimeric nanocarriers composed of a phospholipid and a diblock copolymer, for the incorporation, delivery and pH-responsive release of the antiglioma agent TRAM-34 inside glioblastoma cells. Nanocarrier analysis included light scattering, protein incubation and electron microscopy, and fluorescence anisotropy and thermal analysis techniques were also applied. Biological assays were carried out in order to evaluate the nanocarrier nanotoxicity in vitro and in vivo, as well as to evaluate antiglioma activity. The nanosystems were able to successfully manifest functional properties under pH conditions, and their biocompatibility and cellular internalization were also evident. The chimeric nanoplatforms presented herein have shown promise for biomedical applications so far and should be further studied in terms of their ability to deliver TRAM-34 and other therapeutic molecules to glioblastoma cells. chimeric liposomes functional pH-responsive TRAM-34 drug delivery glioblastoma Biology (General) Chemistry Natassa Pippa verfasserin aut Evangelia Sereti verfasserin aut Varvara Chrysostomou verfasserin aut Marta Kędzierska verfasserin aut Jakub Kajdanek verfasserin aut Maksim Ionov verfasserin aut Katarzyna Miłowska verfasserin aut Łucja Balcerzak verfasserin aut Stefano Garofalo verfasserin aut Cristina Limatola verfasserin aut Stergios Pispas verfasserin aut Konstantinos Dimas verfasserin aut Maria Bryszewska verfasserin aut Costas Demetzos verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 12, p 6271 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:12, p 6271 https://doi.org/10.3390/ijms22126271 kostenfrei https://doaj.org/article/2e6443f15ecc4c3292e6a1a163e2647c kostenfrei https://www.mdpi.com/1422-0067/22/12/6271 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 12, p 6271
allfieldsSound	10.3390/ijms22126271 doi (DE-627)DOAJ078646448 (DE-599)DOAJ2e6443f15ecc4c3292e6a1a163e2647c DE-627 ger DE-627 rakwb eng QH301-705.5 QD1-999 Nikolaos Naziris verfasserin aut Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Nanocarriers are delivery platforms of drugs, peptides, nucleic acids and other therapeutic molecules that are indicated for severe human diseases. Gliomas are the most frequent type of brain tumor, with glioblastoma being the most common and malignant type. The current state of glioma treatment requires innovative approaches that will lead to efficient and safe therapies. Advanced nanosystems and stimuli-responsive materials are available and well-studied technologies that may contribute to this effort. The present study deals with the development of functional chimeric nanocarriers composed of a phospholipid and a diblock copolymer, for the incorporation, delivery and pH-responsive release of the antiglioma agent TRAM-34 inside glioblastoma cells. Nanocarrier analysis included light scattering, protein incubation and electron microscopy, and fluorescence anisotropy and thermal analysis techniques were also applied. Biological assays were carried out in order to evaluate the nanocarrier nanotoxicity in vitro and in vivo, as well as to evaluate antiglioma activity. The nanosystems were able to successfully manifest functional properties under pH conditions, and their biocompatibility and cellular internalization were also evident. The chimeric nanoplatforms presented herein have shown promise for biomedical applications so far and should be further studied in terms of their ability to deliver TRAM-34 and other therapeutic molecules to glioblastoma cells. chimeric liposomes functional pH-responsive TRAM-34 drug delivery glioblastoma Biology (General) Chemistry Natassa Pippa verfasserin aut Evangelia Sereti verfasserin aut Varvara Chrysostomou verfasserin aut Marta Kędzierska verfasserin aut Jakub Kajdanek verfasserin aut Maksim Ionov verfasserin aut Katarzyna Miłowska verfasserin aut Łucja Balcerzak verfasserin aut Stefano Garofalo verfasserin aut Cristina Limatola verfasserin aut Stergios Pispas verfasserin aut Konstantinos Dimas verfasserin aut Maria Bryszewska verfasserin aut Costas Demetzos verfasserin aut In International Journal of Molecular Sciences MDPI AG, 2003 22(2021), 12, p 6271 (DE-627)316340715 (DE-600)2019364-6 14220067 nnns volume:22 year:2021 number:12, p 6271 https://doi.org/10.3390/ijms22126271 kostenfrei https://doaj.org/article/2e6443f15ecc4c3292e6a1a163e2647c kostenfrei https://www.mdpi.com/1422-0067/22/12/6271 kostenfrei https://doaj.org/toc/1661-6596 Journal toc kostenfrei https://doaj.org/toc/1422-0067 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2021 12, p 6271
language	English
source	In International Journal of Molecular Sciences 22(2021), 12, p 6271 volume:22 year:2021 number:12, p 6271
sourceStr	In International Journal of Molecular Sciences 22(2021), 12, p 6271 volume:22 year:2021 number:12, p 6271
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	chimeric liposomes functional pH-responsive TRAM-34 drug delivery glioblastoma Biology (General) Chemistry
isfreeaccess_bool	true
container_title	International Journal of Molecular Sciences
authorswithroles_txt_mv	Nikolaos Naziris @@aut@@ Natassa Pippa @@aut@@ Evangelia Sereti @@aut@@ Varvara Chrysostomou @@aut@@ Marta Kędzierska @@aut@@ Jakub Kajdanek @@aut@@ Maksim Ionov @@aut@@ Katarzyna Miłowska @@aut@@ Łucja Balcerzak @@aut@@ Stefano Garofalo @@aut@@ Cristina Limatola @@aut@@ Stergios Pispas @@aut@@ Konstantinos Dimas @@aut@@ Maria Bryszewska @@aut@@ Costas Demetzos @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	316340715
id	DOAJ078646448
language_de	englisch
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callnumber-first	Q - Science
author	Nikolaos Naziris
spellingShingle	Nikolaos Naziris misc QH301-705.5 misc QD1-999 misc chimeric liposomes misc functional misc pH-responsive misc TRAM-34 misc drug delivery misc glioblastoma misc Biology (General) misc Chemistry Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34
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topic_title	QH301-705.5 QD1-999 Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34 chimeric liposomes functional pH-responsive TRAM-34 drug delivery glioblastoma
topic	misc QH301-705.5 misc QD1-999 misc chimeric liposomes misc functional misc pH-responsive misc TRAM-34 misc drug delivery misc glioblastoma misc Biology (General) misc Chemistry
topic_unstemmed	misc QH301-705.5 misc QD1-999 misc chimeric liposomes misc functional misc pH-responsive misc TRAM-34 misc drug delivery misc glioblastoma misc Biology (General) misc Chemistry
topic_browse	misc QH301-705.5 misc QD1-999 misc chimeric liposomes misc functional misc pH-responsive misc TRAM-34 misc drug delivery misc glioblastoma misc Biology (General) misc Chemistry
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title	Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34
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title_full	Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34
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author_browse	Nikolaos Naziris Natassa Pippa Evangelia Sereti Varvara Chrysostomou Marta Kędzierska Jakub Kajdanek Maksim Ionov Katarzyna Miłowska Łucja Balcerzak Stefano Garofalo Cristina Limatola Stergios Pispas Konstantinos Dimas Maria Bryszewska Costas Demetzos
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doi_str_mv	10.3390/ijms22126271
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title_sort	chimeric stimuli-responsive liposomes as nanocarriers for the delivery of the anti-glioma agent tram-34
callnumber	QH301-705.5
title_auth	Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34
abstract	Nanocarriers are delivery platforms of drugs, peptides, nucleic acids and other therapeutic molecules that are indicated for severe human diseases. Gliomas are the most frequent type of brain tumor, with glioblastoma being the most common and malignant type. The current state of glioma treatment requires innovative approaches that will lead to efficient and safe therapies. Advanced nanosystems and stimuli-responsive materials are available and well-studied technologies that may contribute to this effort. The present study deals with the development of functional chimeric nanocarriers composed of a phospholipid and a diblock copolymer, for the incorporation, delivery and pH-responsive release of the antiglioma agent TRAM-34 inside glioblastoma cells. Nanocarrier analysis included light scattering, protein incubation and electron microscopy, and fluorescence anisotropy and thermal analysis techniques were also applied. Biological assays were carried out in order to evaluate the nanocarrier nanotoxicity in vitro and in vivo, as well as to evaluate antiglioma activity. The nanosystems were able to successfully manifest functional properties under pH conditions, and their biocompatibility and cellular internalization were also evident. The chimeric nanoplatforms presented herein have shown promise for biomedical applications so far and should be further studied in terms of their ability to deliver TRAM-34 and other therapeutic molecules to glioblastoma cells.
abstractGer	Nanocarriers are delivery platforms of drugs, peptides, nucleic acids and other therapeutic molecules that are indicated for severe human diseases. Gliomas are the most frequent type of brain tumor, with glioblastoma being the most common and malignant type. The current state of glioma treatment requires innovative approaches that will lead to efficient and safe therapies. Advanced nanosystems and stimuli-responsive materials are available and well-studied technologies that may contribute to this effort. The present study deals with the development of functional chimeric nanocarriers composed of a phospholipid and a diblock copolymer, for the incorporation, delivery and pH-responsive release of the antiglioma agent TRAM-34 inside glioblastoma cells. Nanocarrier analysis included light scattering, protein incubation and electron microscopy, and fluorescence anisotropy and thermal analysis techniques were also applied. Biological assays were carried out in order to evaluate the nanocarrier nanotoxicity in vitro and in vivo, as well as to evaluate antiglioma activity. The nanosystems were able to successfully manifest functional properties under pH conditions, and their biocompatibility and cellular internalization were also evident. The chimeric nanoplatforms presented herein have shown promise for biomedical applications so far and should be further studied in terms of their ability to deliver TRAM-34 and other therapeutic molecules to glioblastoma cells.
abstract_unstemmed	Nanocarriers are delivery platforms of drugs, peptides, nucleic acids and other therapeutic molecules that are indicated for severe human diseases. Gliomas are the most frequent type of brain tumor, with glioblastoma being the most common and malignant type. The current state of glioma treatment requires innovative approaches that will lead to efficient and safe therapies. Advanced nanosystems and stimuli-responsive materials are available and well-studied technologies that may contribute to this effort. The present study deals with the development of functional chimeric nanocarriers composed of a phospholipid and a diblock copolymer, for the incorporation, delivery and pH-responsive release of the antiglioma agent TRAM-34 inside glioblastoma cells. Nanocarrier analysis included light scattering, protein incubation and electron microscopy, and fluorescence anisotropy and thermal analysis techniques were also applied. Biological assays were carried out in order to evaluate the nanocarrier nanotoxicity in vitro and in vivo, as well as to evaluate antiglioma activity. The nanosystems were able to successfully manifest functional properties under pH conditions, and their biocompatibility and cellular internalization were also evident. The chimeric nanoplatforms presented herein have shown promise for biomedical applications so far and should be further studied in terms of their ability to deliver TRAM-34 and other therapeutic molecules to glioblastoma cells.
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container_issue	12, p 6271
title_short	Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34
url	https://doi.org/10.3390/ijms22126271 https://doaj.org/article/2e6443f15ecc4c3292e6a1a163e2647c https://www.mdpi.com/1422-0067/22/12/6271 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067
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author2Str	Natassa Pippa Evangelia Sereti Varvara Chrysostomou Marta Kędzierska Jakub Kajdanek Maksim Ionov Katarzyna Miłowska Łucja Balcerzak Stefano Garofalo Cristina Limatola Stergios Pispas Konstantinos Dimas Maria Bryszewska Costas Demetzos
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Chimeric Stimuli-Responsive Liposomes as Nanocarriers for the Delivery of the Anti-Glioma Agent TRAM-34

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