Pediatric craniospinal irradiation – The implementation and use of normal tissue complication probability in comparing photon versus proton planning

Purpose: The preferred radiotherapy treatment for medulloblastoma is craniospinal irradiation (CSI). With the aim of developing the potential to reduce normal tissue dose and associated post-treatment complications with photon and proton radiotherapy techniques for CSI. This report aims to carefully...
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Gespeichert in:

Autor*in:	S Balasubramanian [verfasserIn] M K Shobana [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	craniospinal irradiation normal tissue complication probability radiobiological model radiotherapy tumor control probability

Übergeordnetes Werk:	In: Journal of Medical Physics - Wolters Kluwer Medknow Publications, 2006, 46(2021), 4, Seite 244-252
Übergeordnetes Werk:	volume:46 ; year:2021 ; number:4 ; pages:244-252

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.4103/jmp.jmp_75_21

Katalog-ID:	DOAJ078701635

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allfields	10.4103/jmp.jmp_75_21 doi (DE-627)DOAJ078701635 (DE-599)DOAJ553ef9784f314fa7883c48662a67b3ed DE-627 ger DE-627 rakwb eng R895-920 S Balasubramanian verfasserin aut Pediatric craniospinal irradiation – The implementation and use of normal tissue complication probability in comparing photon versus proton planning 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The preferred radiotherapy treatment for medulloblastoma is craniospinal irradiation (CSI). With the aim of developing the potential to reduce normal tissue dose and associated post-treatment complications with photon and proton radiotherapy techniques for CSI. This report aims to carefully compare and rank treatment planning and dosimetric outcomes for pediatric medulloblastoma patients using normal tissue complication probability (NTCP) formalism between photon (three-dimensional conformal radiotherapy, intensity-modulated radiotherapy [IMRT], volumetric-modulated arc therapy [VMAT], and HT) and proton CSI. Methods and Materials: The treatment data of eight pediatric patients who typically received CSI treatment were used in this study. The patients were 7 years of age on average, with ages ranging from 3 to 11 years. A prescription dose of 3600 cGy was delivered in 20 fractions by the established planning methods. The Niemierko's and Lyman–Kutcher–Burman models were followed to carefully estimate NTCP and compare different treatment plans. Results: The NTCP of VMAT plans in upper and middle thoracic volumes was relatively high compared to helical tomotherapy (HT) and pencil beam scanning (PBS) (all P < 0.05). PBS rather than IMRT and VMAT in the middle thoracic region (P < 0.06) could significantly reduce the NTCP of the heart. PBS significantly reduced NTCP of the lungs and liver (all P < 0.05). Conclusion: The NTCP and tumor control probability (TCP) model-based plan ranking along with dosimetric indices will help the clinical practitioner or medical physicists to choose the best treatment plan for each patient based on their anatomical or clinical challenges. craniospinal irradiation normal tissue complication probability radiobiological model radiotherapy tumor control probability Medical physics. Medical radiology. Nuclear medicine M K Shobana verfasserin aut In Journal of Medical Physics Wolters Kluwer Medknow Publications, 2006 46(2021), 4, Seite 244-252 (DE-627)512663793 (DE-600)2236898-X 19983913 nnns volume:46 year:2021 number:4 pages:244-252 https://doi.org/10.4103/jmp.jmp_75_21 kostenfrei https://doaj.org/article/553ef9784f314fa7883c48662a67b3ed kostenfrei http://www.jmp.org.in/article.asp?issn=0971-6203;year=2021;volume=46;issue=4;spage=244;epage=252;aulast=Balasubramanian kostenfrei https://doaj.org/toc/0971-6203 Journal toc kostenfrei https://doaj.org/toc/1998-3913 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2021 4 244-252
spelling	10.4103/jmp.jmp_75_21 doi (DE-627)DOAJ078701635 (DE-599)DOAJ553ef9784f314fa7883c48662a67b3ed DE-627 ger DE-627 rakwb eng R895-920 S Balasubramanian verfasserin aut Pediatric craniospinal irradiation – The implementation and use of normal tissue complication probability in comparing photon versus proton planning 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The preferred radiotherapy treatment for medulloblastoma is craniospinal irradiation (CSI). With the aim of developing the potential to reduce normal tissue dose and associated post-treatment complications with photon and proton radiotherapy techniques for CSI. This report aims to carefully compare and rank treatment planning and dosimetric outcomes for pediatric medulloblastoma patients using normal tissue complication probability (NTCP) formalism between photon (three-dimensional conformal radiotherapy, intensity-modulated radiotherapy [IMRT], volumetric-modulated arc therapy [VMAT], and HT) and proton CSI. Methods and Materials: The treatment data of eight pediatric patients who typically received CSI treatment were used in this study. The patients were 7 years of age on average, with ages ranging from 3 to 11 years. A prescription dose of 3600 cGy was delivered in 20 fractions by the established planning methods. The Niemierko's and Lyman–Kutcher–Burman models were followed to carefully estimate NTCP and compare different treatment plans. Results: The NTCP of VMAT plans in upper and middle thoracic volumes was relatively high compared to helical tomotherapy (HT) and pencil beam scanning (PBS) (all P < 0.05). PBS rather than IMRT and VMAT in the middle thoracic region (P < 0.06) could significantly reduce the NTCP of the heart. PBS significantly reduced NTCP of the lungs and liver (all P < 0.05). Conclusion: The NTCP and tumor control probability (TCP) model-based plan ranking along with dosimetric indices will help the clinical practitioner or medical physicists to choose the best treatment plan for each patient based on their anatomical or clinical challenges. craniospinal irradiation normal tissue complication probability radiobiological model radiotherapy tumor control probability Medical physics. Medical radiology. Nuclear medicine M K Shobana verfasserin aut In Journal of Medical Physics Wolters Kluwer Medknow Publications, 2006 46(2021), 4, Seite 244-252 (DE-627)512663793 (DE-600)2236898-X 19983913 nnns volume:46 year:2021 number:4 pages:244-252 https://doi.org/10.4103/jmp.jmp_75_21 kostenfrei https://doaj.org/article/553ef9784f314fa7883c48662a67b3ed kostenfrei http://www.jmp.org.in/article.asp?issn=0971-6203;year=2021;volume=46;issue=4;spage=244;epage=252;aulast=Balasubramanian kostenfrei https://doaj.org/toc/0971-6203 Journal toc kostenfrei https://doaj.org/toc/1998-3913 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2021 4 244-252
allfields_unstemmed	10.4103/jmp.jmp_75_21 doi (DE-627)DOAJ078701635 (DE-599)DOAJ553ef9784f314fa7883c48662a67b3ed DE-627 ger DE-627 rakwb eng R895-920 S Balasubramanian verfasserin aut Pediatric craniospinal irradiation – The implementation and use of normal tissue complication probability in comparing photon versus proton planning 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The preferred radiotherapy treatment for medulloblastoma is craniospinal irradiation (CSI). With the aim of developing the potential to reduce normal tissue dose and associated post-treatment complications with photon and proton radiotherapy techniques for CSI. This report aims to carefully compare and rank treatment planning and dosimetric outcomes for pediatric medulloblastoma patients using normal tissue complication probability (NTCP) formalism between photon (three-dimensional conformal radiotherapy, intensity-modulated radiotherapy [IMRT], volumetric-modulated arc therapy [VMAT], and HT) and proton CSI. Methods and Materials: The treatment data of eight pediatric patients who typically received CSI treatment were used in this study. The patients were 7 years of age on average, with ages ranging from 3 to 11 years. A prescription dose of 3600 cGy was delivered in 20 fractions by the established planning methods. The Niemierko's and Lyman–Kutcher–Burman models were followed to carefully estimate NTCP and compare different treatment plans. Results: The NTCP of VMAT plans in upper and middle thoracic volumes was relatively high compared to helical tomotherapy (HT) and pencil beam scanning (PBS) (all P < 0.05). PBS rather than IMRT and VMAT in the middle thoracic region (P < 0.06) could significantly reduce the NTCP of the heart. PBS significantly reduced NTCP of the lungs and liver (all P < 0.05). Conclusion: The NTCP and tumor control probability (TCP) model-based plan ranking along with dosimetric indices will help the clinical practitioner or medical physicists to choose the best treatment plan for each patient based on their anatomical or clinical challenges. craniospinal irradiation normal tissue complication probability radiobiological model radiotherapy tumor control probability Medical physics. Medical radiology. Nuclear medicine M K Shobana verfasserin aut In Journal of Medical Physics Wolters Kluwer Medknow Publications, 2006 46(2021), 4, Seite 244-252 (DE-627)512663793 (DE-600)2236898-X 19983913 nnns volume:46 year:2021 number:4 pages:244-252 https://doi.org/10.4103/jmp.jmp_75_21 kostenfrei https://doaj.org/article/553ef9784f314fa7883c48662a67b3ed kostenfrei http://www.jmp.org.in/article.asp?issn=0971-6203;year=2021;volume=46;issue=4;spage=244;epage=252;aulast=Balasubramanian kostenfrei https://doaj.org/toc/0971-6203 Journal toc kostenfrei https://doaj.org/toc/1998-3913 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2021 4 244-252
allfieldsGer	10.4103/jmp.jmp_75_21 doi (DE-627)DOAJ078701635 (DE-599)DOAJ553ef9784f314fa7883c48662a67b3ed DE-627 ger DE-627 rakwb eng R895-920 S Balasubramanian verfasserin aut Pediatric craniospinal irradiation – The implementation and use of normal tissue complication probability in comparing photon versus proton planning 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The preferred radiotherapy treatment for medulloblastoma is craniospinal irradiation (CSI). With the aim of developing the potential to reduce normal tissue dose and associated post-treatment complications with photon and proton radiotherapy techniques for CSI. This report aims to carefully compare and rank treatment planning and dosimetric outcomes for pediatric medulloblastoma patients using normal tissue complication probability (NTCP) formalism between photon (three-dimensional conformal radiotherapy, intensity-modulated radiotherapy [IMRT], volumetric-modulated arc therapy [VMAT], and HT) and proton CSI. Methods and Materials: The treatment data of eight pediatric patients who typically received CSI treatment were used in this study. The patients were 7 years of age on average, with ages ranging from 3 to 11 years. A prescription dose of 3600 cGy was delivered in 20 fractions by the established planning methods. The Niemierko's and Lyman–Kutcher–Burman models were followed to carefully estimate NTCP and compare different treatment plans. Results: The NTCP of VMAT plans in upper and middle thoracic volumes was relatively high compared to helical tomotherapy (HT) and pencil beam scanning (PBS) (all P < 0.05). PBS rather than IMRT and VMAT in the middle thoracic region (P < 0.06) could significantly reduce the NTCP of the heart. PBS significantly reduced NTCP of the lungs and liver (all P < 0.05). Conclusion: The NTCP and tumor control probability (TCP) model-based plan ranking along with dosimetric indices will help the clinical practitioner or medical physicists to choose the best treatment plan for each patient based on their anatomical or clinical challenges. craniospinal irradiation normal tissue complication probability radiobiological model radiotherapy tumor control probability Medical physics. Medical radiology. Nuclear medicine M K Shobana verfasserin aut In Journal of Medical Physics Wolters Kluwer Medknow Publications, 2006 46(2021), 4, Seite 244-252 (DE-627)512663793 (DE-600)2236898-X 19983913 nnns volume:46 year:2021 number:4 pages:244-252 https://doi.org/10.4103/jmp.jmp_75_21 kostenfrei https://doaj.org/article/553ef9784f314fa7883c48662a67b3ed kostenfrei http://www.jmp.org.in/article.asp?issn=0971-6203;year=2021;volume=46;issue=4;spage=244;epage=252;aulast=Balasubramanian kostenfrei https://doaj.org/toc/0971-6203 Journal toc kostenfrei https://doaj.org/toc/1998-3913 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2021 4 244-252
allfieldsSound	10.4103/jmp.jmp_75_21 doi (DE-627)DOAJ078701635 (DE-599)DOAJ553ef9784f314fa7883c48662a67b3ed DE-627 ger DE-627 rakwb eng R895-920 S Balasubramanian verfasserin aut Pediatric craniospinal irradiation – The implementation and use of normal tissue complication probability in comparing photon versus proton planning 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: The preferred radiotherapy treatment for medulloblastoma is craniospinal irradiation (CSI). With the aim of developing the potential to reduce normal tissue dose and associated post-treatment complications with photon and proton radiotherapy techniques for CSI. This report aims to carefully compare and rank treatment planning and dosimetric outcomes for pediatric medulloblastoma patients using normal tissue complication probability (NTCP) formalism between photon (three-dimensional conformal radiotherapy, intensity-modulated radiotherapy [IMRT], volumetric-modulated arc therapy [VMAT], and HT) and proton CSI. Methods and Materials: The treatment data of eight pediatric patients who typically received CSI treatment were used in this study. The patients were 7 years of age on average, with ages ranging from 3 to 11 years. A prescription dose of 3600 cGy was delivered in 20 fractions by the established planning methods. The Niemierko's and Lyman–Kutcher–Burman models were followed to carefully estimate NTCP and compare different treatment plans. Results: The NTCP of VMAT plans in upper and middle thoracic volumes was relatively high compared to helical tomotherapy (HT) and pencil beam scanning (PBS) (all P < 0.05). PBS rather than IMRT and VMAT in the middle thoracic region (P < 0.06) could significantly reduce the NTCP of the heart. PBS significantly reduced NTCP of the lungs and liver (all P < 0.05). Conclusion: The NTCP and tumor control probability (TCP) model-based plan ranking along with dosimetric indices will help the clinical practitioner or medical physicists to choose the best treatment plan for each patient based on their anatomical or clinical challenges. craniospinal irradiation normal tissue complication probability radiobiological model radiotherapy tumor control probability Medical physics. Medical radiology. Nuclear medicine M K Shobana verfasserin aut In Journal of Medical Physics Wolters Kluwer Medknow Publications, 2006 46(2021), 4, Seite 244-252 (DE-627)512663793 (DE-600)2236898-X 19983913 nnns volume:46 year:2021 number:4 pages:244-252 https://doi.org/10.4103/jmp.jmp_75_21 kostenfrei https://doaj.org/article/553ef9784f314fa7883c48662a67b3ed kostenfrei http://www.jmp.org.in/article.asp?issn=0971-6203;year=2021;volume=46;issue=4;spage=244;epage=252;aulast=Balasubramanian kostenfrei https://doaj.org/toc/0971-6203 Journal toc kostenfrei https://doaj.org/toc/1998-3913 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_138 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 46 2021 4 244-252
language	English
source	In Journal of Medical Physics 46(2021), 4, Seite 244-252 volume:46 year:2021 number:4 pages:244-252
sourceStr	In Journal of Medical Physics 46(2021), 4, Seite 244-252 volume:46 year:2021 number:4 pages:244-252
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	craniospinal irradiation normal tissue complication probability radiobiological model radiotherapy tumor control probability Medical physics. Medical radiology. Nuclear medicine
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container_title	Journal of Medical Physics
authorswithroles_txt_mv	S Balasubramanian @@aut@@ M K Shobana @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
hierarchy_top_id	512663793
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language_de	englisch
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callnumber-first	R - Medicine
author	S Balasubramanian
spellingShingle	S Balasubramanian misc R895-920 misc craniospinal irradiation misc normal tissue complication probability misc radiobiological model misc radiotherapy misc tumor control probability misc Medical physics. Medical radiology. Nuclear medicine Pediatric craniospinal irradiation – The implementation and use of normal tissue complication probability in comparing photon versus proton planning
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topic_title	R895-920 Pediatric craniospinal irradiation – The implementation and use of normal tissue complication probability in comparing photon versus proton planning craniospinal irradiation normal tissue complication probability radiobiological model radiotherapy tumor control probability
topic	misc R895-920 misc craniospinal irradiation misc normal tissue complication probability misc radiobiological model misc radiotherapy misc tumor control probability misc Medical physics. Medical radiology. Nuclear medicine
topic_unstemmed	misc R895-920 misc craniospinal irradiation misc normal tissue complication probability misc radiobiological model misc radiotherapy misc tumor control probability misc Medical physics. Medical radiology. Nuclear medicine
topic_browse	misc R895-920 misc craniospinal irradiation misc normal tissue complication probability misc radiobiological model misc radiotherapy misc tumor control probability misc Medical physics. Medical radiology. Nuclear medicine
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title	Pediatric craniospinal irradiation – The implementation and use of normal tissue complication probability in comparing photon versus proton planning
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title_full	Pediatric craniospinal irradiation – The implementation and use of normal tissue complication probability in comparing photon versus proton planning
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author_browse	S Balasubramanian M K Shobana
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title_sort	pediatric craniospinal irradiation – the implementation and use of normal tissue complication probability in comparing photon versus proton planning
callnumber	R895-920
title_auth	Pediatric craniospinal irradiation – The implementation and use of normal tissue complication probability in comparing photon versus proton planning
abstract	Purpose: The preferred radiotherapy treatment for medulloblastoma is craniospinal irradiation (CSI). With the aim of developing the potential to reduce normal tissue dose and associated post-treatment complications with photon and proton radiotherapy techniques for CSI. This report aims to carefully compare and rank treatment planning and dosimetric outcomes for pediatric medulloblastoma patients using normal tissue complication probability (NTCP) formalism between photon (three-dimensional conformal radiotherapy, intensity-modulated radiotherapy [IMRT], volumetric-modulated arc therapy [VMAT], and HT) and proton CSI. Methods and Materials: The treatment data of eight pediatric patients who typically received CSI treatment were used in this study. The patients were 7 years of age on average, with ages ranging from 3 to 11 years. A prescription dose of 3600 cGy was delivered in 20 fractions by the established planning methods. The Niemierko's and Lyman–Kutcher–Burman models were followed to carefully estimate NTCP and compare different treatment plans. Results: The NTCP of VMAT plans in upper and middle thoracic volumes was relatively high compared to helical tomotherapy (HT) and pencil beam scanning (PBS) (all P < 0.05). PBS rather than IMRT and VMAT in the middle thoracic region (P < 0.06) could significantly reduce the NTCP of the heart. PBS significantly reduced NTCP of the lungs and liver (all P < 0.05). Conclusion: The NTCP and tumor control probability (TCP) model-based plan ranking along with dosimetric indices will help the clinical practitioner or medical physicists to choose the best treatment plan for each patient based on their anatomical or clinical challenges.
abstractGer	Purpose: The preferred radiotherapy treatment for medulloblastoma is craniospinal irradiation (CSI). With the aim of developing the potential to reduce normal tissue dose and associated post-treatment complications with photon and proton radiotherapy techniques for CSI. This report aims to carefully compare and rank treatment planning and dosimetric outcomes for pediatric medulloblastoma patients using normal tissue complication probability (NTCP) formalism between photon (three-dimensional conformal radiotherapy, intensity-modulated radiotherapy [IMRT], volumetric-modulated arc therapy [VMAT], and HT) and proton CSI. Methods and Materials: The treatment data of eight pediatric patients who typically received CSI treatment were used in this study. The patients were 7 years of age on average, with ages ranging from 3 to 11 years. A prescription dose of 3600 cGy was delivered in 20 fractions by the established planning methods. The Niemierko's and Lyman–Kutcher–Burman models were followed to carefully estimate NTCP and compare different treatment plans. Results: The NTCP of VMAT plans in upper and middle thoracic volumes was relatively high compared to helical tomotherapy (HT) and pencil beam scanning (PBS) (all P < 0.05). PBS rather than IMRT and VMAT in the middle thoracic region (P < 0.06) could significantly reduce the NTCP of the heart. PBS significantly reduced NTCP of the lungs and liver (all P < 0.05). Conclusion: The NTCP and tumor control probability (TCP) model-based plan ranking along with dosimetric indices will help the clinical practitioner or medical physicists to choose the best treatment plan for each patient based on their anatomical or clinical challenges.
abstract_unstemmed	Purpose: The preferred radiotherapy treatment for medulloblastoma is craniospinal irradiation (CSI). With the aim of developing the potential to reduce normal tissue dose and associated post-treatment complications with photon and proton radiotherapy techniques for CSI. This report aims to carefully compare and rank treatment planning and dosimetric outcomes for pediatric medulloblastoma patients using normal tissue complication probability (NTCP) formalism between photon (three-dimensional conformal radiotherapy, intensity-modulated radiotherapy [IMRT], volumetric-modulated arc therapy [VMAT], and HT) and proton CSI. Methods and Materials: The treatment data of eight pediatric patients who typically received CSI treatment were used in this study. The patients were 7 years of age on average, with ages ranging from 3 to 11 years. A prescription dose of 3600 cGy was delivered in 20 fractions by the established planning methods. The Niemierko's and Lyman–Kutcher–Burman models were followed to carefully estimate NTCP and compare different treatment plans. Results: The NTCP of VMAT plans in upper and middle thoracic volumes was relatively high compared to helical tomotherapy (HT) and pencil beam scanning (PBS) (all P < 0.05). PBS rather than IMRT and VMAT in the middle thoracic region (P < 0.06) could significantly reduce the NTCP of the heart. PBS significantly reduced NTCP of the lungs and liver (all P < 0.05). Conclusion: The NTCP and tumor control probability (TCP) model-based plan ranking along with dosimetric indices will help the clinical practitioner or medical physicists to choose the best treatment plan for each patient based on their anatomical or clinical challenges.
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title_short	Pediatric craniospinal irradiation – The implementation and use of normal tissue complication probability in comparing photon versus proton planning
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