Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer

Recently, circular RNAs (circRNAs) have become an intense focus of research and large numbers of circRNAs have been identified, awaiting functional elucidation. Thus, the present study aims to examine the regulation of circRNAs and its molecular mechanism in lung cancer growth. Here, we show that ci...
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Autor*in:	Xin Hu [verfasserIn] Ping Wang [verfasserIn] Chen Qu [verfasserIn] Haibo Zhang [verfasserIn] Liang Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	circ_0000677 mir-106b-5p ccnd1 proliferation non-small cell lung cancer

Übergeordnetes Werk:	In: Bioengineered - Taylor & Francis Group, 2019, 12(2021), 1, Seite 6229-6239
Übergeordnetes Werk:	volume:12 ; year:2021 ; number:1 ; pages:6229-6239

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc Journal toc

DOI / URN:	10.1080/21655979.2021.1965697

Katalog-ID:	DOAJ078707692

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allfields	10.1080/21655979.2021.1965697 doi (DE-627)DOAJ078707692 (DE-599)DOAJ6f68c2cb8bde4a629f30b55bcaf843b6 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Xin Hu verfasserin aut Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Recently, circular RNAs (circRNAs) have become an intense focus of research and large numbers of circRNAs have been identified, awaiting functional elucidation. Thus, the present study aims to examine the regulation of circRNAs and its molecular mechanism in lung cancer growth. Here, we show that circular RNA circ_0000677 was overexpressed and correlated with poor prognosis in non‐small cell lung cancer (NSCLC) patients. Functionally, circ_0000677 knockdown markedly inhibited proliferation of NSCLC cells by observing of immunofluorescence staining of Ki67, clone formation assay, and xenograft experiments. In mechanism, circ_0000677 acted as a sponge of microRNA-106b and further regulated CCDND1 gene expression in NSCLC cells by dual luciferase activity assay and their expression examination. Taken together, these findings suggest a role for circ_0000677/miR-106b/CCND1 regulation axis in promoting NSCLC growth and progression. circ_0000677 mir-106b-5p ccnd1 proliferation non-small cell lung cancer Biotechnology Ping Wang verfasserin aut Chen Qu verfasserin aut Haibo Zhang verfasserin aut Liang Li verfasserin aut In Bioengineered Taylor & Francis Group, 2019 12(2021), 1, Seite 6229-6239 (DE-627)770398189 (DE-600)2737830-5 21655987 nnns volume:12 year:2021 number:1 pages:6229-6239 https://doi.org/10.1080/21655979.2021.1965697 kostenfrei https://doaj.org/article/6f68c2cb8bde4a629f30b55bcaf843b6 kostenfrei http://dx.doi.org/10.1080/21655979.2021.1965697 kostenfrei https://doaj.org/toc/2165-5979 Journal toc kostenfrei https://doaj.org/toc/2165-5987 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 6229-6239
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allfieldsSound	10.1080/21655979.2021.1965697 doi (DE-627)DOAJ078707692 (DE-599)DOAJ6f68c2cb8bde4a629f30b55bcaf843b6 DE-627 ger DE-627 rakwb eng TP248.13-248.65 Xin Hu verfasserin aut Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Recently, circular RNAs (circRNAs) have become an intense focus of research and large numbers of circRNAs have been identified, awaiting functional elucidation. Thus, the present study aims to examine the regulation of circRNAs and its molecular mechanism in lung cancer growth. Here, we show that circular RNA circ_0000677 was overexpressed and correlated with poor prognosis in non‐small cell lung cancer (NSCLC) patients. Functionally, circ_0000677 knockdown markedly inhibited proliferation of NSCLC cells by observing of immunofluorescence staining of Ki67, clone formation assay, and xenograft experiments. In mechanism, circ_0000677 acted as a sponge of microRNA-106b and further regulated CCDND1 gene expression in NSCLC cells by dual luciferase activity assay and their expression examination. Taken together, these findings suggest a role for circ_0000677/miR-106b/CCND1 regulation axis in promoting NSCLC growth and progression. circ_0000677 mir-106b-5p ccnd1 proliferation non-small cell lung cancer Biotechnology Ping Wang verfasserin aut Chen Qu verfasserin aut Haibo Zhang verfasserin aut Liang Li verfasserin aut In Bioengineered Taylor & Francis Group, 2019 12(2021), 1, Seite 6229-6239 (DE-627)770398189 (DE-600)2737830-5 21655987 nnns volume:12 year:2021 number:1 pages:6229-6239 https://doi.org/10.1080/21655979.2021.1965697 kostenfrei https://doaj.org/article/6f68c2cb8bde4a629f30b55bcaf843b6 kostenfrei http://dx.doi.org/10.1080/21655979.2021.1965697 kostenfrei https://doaj.org/toc/2165-5979 Journal toc kostenfrei https://doaj.org/toc/2165-5987 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2021 1 6229-6239
language	English
source	In Bioengineered 12(2021), 1, Seite 6229-6239 volume:12 year:2021 number:1 pages:6229-6239
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authorswithroles_txt_mv	Xin Hu @@aut@@ Ping Wang @@aut@@ Chen Qu @@aut@@ Haibo Zhang @@aut@@ Liang Li @@aut@@
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callnumber-first	T - Technology
author	Xin Hu
spellingShingle	Xin Hu misc TP248.13-248.65 misc circ_0000677 misc mir-106b-5p misc ccnd1 misc proliferation misc non-small cell lung cancer misc Biotechnology Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer
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topic_title	TP248.13-248.65 Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer circ_0000677 mir-106b-5p ccnd1 proliferation non-small cell lung cancer
topic	misc TP248.13-248.65 misc circ_0000677 misc mir-106b-5p misc ccnd1 misc proliferation misc non-small cell lung cancer misc Biotechnology
topic_unstemmed	misc TP248.13-248.65 misc circ_0000677 misc mir-106b-5p misc ccnd1 misc proliferation misc non-small cell lung cancer misc Biotechnology
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title	Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer
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title_full	Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer
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title_sort	circular rna circ_0000677 promotes cell proliferation by regulating microrna-106b-5p/ccnd1 in non-small cell lung cancer
callnumber	TP248.13-248.65
title_auth	Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer
abstract	Recently, circular RNAs (circRNAs) have become an intense focus of research and large numbers of circRNAs have been identified, awaiting functional elucidation. Thus, the present study aims to examine the regulation of circRNAs and its molecular mechanism in lung cancer growth. Here, we show that circular RNA circ_0000677 was overexpressed and correlated with poor prognosis in non‐small cell lung cancer (NSCLC) patients. Functionally, circ_0000677 knockdown markedly inhibited proliferation of NSCLC cells by observing of immunofluorescence staining of Ki67, clone formation assay, and xenograft experiments. In mechanism, circ_0000677 acted as a sponge of microRNA-106b and further regulated CCDND1 gene expression in NSCLC cells by dual luciferase activity assay and their expression examination. Taken together, these findings suggest a role for circ_0000677/miR-106b/CCND1 regulation axis in promoting NSCLC growth and progression.
abstractGer	Recently, circular RNAs (circRNAs) have become an intense focus of research and large numbers of circRNAs have been identified, awaiting functional elucidation. Thus, the present study aims to examine the regulation of circRNAs and its molecular mechanism in lung cancer growth. Here, we show that circular RNA circ_0000677 was overexpressed and correlated with poor prognosis in non‐small cell lung cancer (NSCLC) patients. Functionally, circ_0000677 knockdown markedly inhibited proliferation of NSCLC cells by observing of immunofluorescence staining of Ki67, clone formation assay, and xenograft experiments. In mechanism, circ_0000677 acted as a sponge of microRNA-106b and further regulated CCDND1 gene expression in NSCLC cells by dual luciferase activity assay and their expression examination. Taken together, these findings suggest a role for circ_0000677/miR-106b/CCND1 regulation axis in promoting NSCLC growth and progression.
abstract_unstemmed	Recently, circular RNAs (circRNAs) have become an intense focus of research and large numbers of circRNAs have been identified, awaiting functional elucidation. Thus, the present study aims to examine the regulation of circRNAs and its molecular mechanism in lung cancer growth. Here, we show that circular RNA circ_0000677 was overexpressed and correlated with poor prognosis in non‐small cell lung cancer (NSCLC) patients. Functionally, circ_0000677 knockdown markedly inhibited proliferation of NSCLC cells by observing of immunofluorescence staining of Ki67, clone formation assay, and xenograft experiments. In mechanism, circ_0000677 acted as a sponge of microRNA-106b and further regulated CCDND1 gene expression in NSCLC cells by dual luciferase activity assay and their expression examination. Taken together, these findings suggest a role for circ_0000677/miR-106b/CCND1 regulation axis in promoting NSCLC growth and progression.
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title_short	Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer
url	https://doi.org/10.1080/21655979.2021.1965697 https://doaj.org/article/6f68c2cb8bde4a629f30b55bcaf843b6 http://dx.doi.org/10.1080/21655979.2021.1965697 https://doaj.org/toc/2165-5979 https://doaj.org/toc/2165-5987
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Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer

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