Neurofilaments as Emerging Biomarkers of Neuroaxonal Damage to Differentiate Behavioral Frontotemporal Dementia from Primary Psychiatric Disorders: A Systematic Review

The behavioral variant of frontotemporal dementia (bvFTD) is a clinical syndrome resulting from various causes of neuronal demises associated with frontotemporal lobar degeneration. Symptoms include behavioral and personality changes, social cognitive impairment, and executive function deficits. The...
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Gespeichert in:

Autor*in:	Vincent Davy [verfasserIn] Julien Dumurgier [verfasserIn] Aurore Fayosse [verfasserIn] Claire Paquet [verfasserIn] Emmanuel Cognat [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	neurofilaments blood biomarkers behavioral frontotemporal dementia neuropsychiatry diagnosis single molecular array

Übergeordnetes Werk:	In: Diagnostics - MDPI AG, 2012, 11(2021), 5, p 754
Übergeordnetes Werk:	volume:11 ; year:2021 ; number:5, p 754

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/diagnostics11050754

Katalog-ID:	DOAJ078781477

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allfields	10.3390/diagnostics11050754 doi (DE-627)DOAJ078781477 (DE-599)DOAJ747a79796b64474bb81d0b9d44f39db3 DE-627 ger DE-627 rakwb eng R5-920 Vincent Davy verfasserin aut Neurofilaments as Emerging Biomarkers of Neuroaxonal Damage to Differentiate Behavioral Frontotemporal Dementia from Primary Psychiatric Disorders: A Systematic Review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The behavioral variant of frontotemporal dementia (bvFTD) is a clinical syndrome resulting from various causes of neuronal demises associated with frontotemporal lobar degeneration. Symptoms include behavioral and personality changes, social cognitive impairment, and executive function deficits. There is a significant clinical overlap between this syndrome and various primary psychiatric disorders (PPD). Structural and functional neuroimaging are considered helpful to support the diagnosis of bvFTD, but their sensitivity and specificity remain imperfect. There is growing evidence concerning the potential of neurofilaments as biomarkers reflecting axonal and neuronal lesions. Ultrasensitive analytic platforms have recently enabled neurofilament light chains’ (NfL) detection not only from cerebrospinal fluid but also from peripheral blood samples in FTD patients. In this short review, we present recent advances and perspectives for the use of NfL assessments as biomarkers of neuroaxonal damage to differentiate bvFTD from primary psychiatric disorders. neurofilaments blood biomarkers behavioral frontotemporal dementia neuropsychiatry diagnosis single molecular array Medicine (General) Julien Dumurgier verfasserin aut Aurore Fayosse verfasserin aut Claire Paquet verfasserin aut Emmanuel Cognat verfasserin aut In Diagnostics MDPI AG, 2012 11(2021), 5, p 754 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:11 year:2021 number:5, p 754 https://doi.org/10.3390/diagnostics11050754 kostenfrei https://doaj.org/article/747a79796b64474bb81d0b9d44f39db3 kostenfrei https://www.mdpi.com/2075-4418/11/5/754 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 5, p 754
spelling	10.3390/diagnostics11050754 doi (DE-627)DOAJ078781477 (DE-599)DOAJ747a79796b64474bb81d0b9d44f39db3 DE-627 ger DE-627 rakwb eng R5-920 Vincent Davy verfasserin aut Neurofilaments as Emerging Biomarkers of Neuroaxonal Damage to Differentiate Behavioral Frontotemporal Dementia from Primary Psychiatric Disorders: A Systematic Review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The behavioral variant of frontotemporal dementia (bvFTD) is a clinical syndrome resulting from various causes of neuronal demises associated with frontotemporal lobar degeneration. Symptoms include behavioral and personality changes, social cognitive impairment, and executive function deficits. There is a significant clinical overlap between this syndrome and various primary psychiatric disorders (PPD). Structural and functional neuroimaging are considered helpful to support the diagnosis of bvFTD, but their sensitivity and specificity remain imperfect. There is growing evidence concerning the potential of neurofilaments as biomarkers reflecting axonal and neuronal lesions. Ultrasensitive analytic platforms have recently enabled neurofilament light chains’ (NfL) detection not only from cerebrospinal fluid but also from peripheral blood samples in FTD patients. In this short review, we present recent advances and perspectives for the use of NfL assessments as biomarkers of neuroaxonal damage to differentiate bvFTD from primary psychiatric disorders. neurofilaments blood biomarkers behavioral frontotemporal dementia neuropsychiatry diagnosis single molecular array Medicine (General) Julien Dumurgier verfasserin aut Aurore Fayosse verfasserin aut Claire Paquet verfasserin aut Emmanuel Cognat verfasserin aut In Diagnostics MDPI AG, 2012 11(2021), 5, p 754 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:11 year:2021 number:5, p 754 https://doi.org/10.3390/diagnostics11050754 kostenfrei https://doaj.org/article/747a79796b64474bb81d0b9d44f39db3 kostenfrei https://www.mdpi.com/2075-4418/11/5/754 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 5, p 754
allfields_unstemmed	10.3390/diagnostics11050754 doi (DE-627)DOAJ078781477 (DE-599)DOAJ747a79796b64474bb81d0b9d44f39db3 DE-627 ger DE-627 rakwb eng R5-920 Vincent Davy verfasserin aut Neurofilaments as Emerging Biomarkers of Neuroaxonal Damage to Differentiate Behavioral Frontotemporal Dementia from Primary Psychiatric Disorders: A Systematic Review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The behavioral variant of frontotemporal dementia (bvFTD) is a clinical syndrome resulting from various causes of neuronal demises associated with frontotemporal lobar degeneration. Symptoms include behavioral and personality changes, social cognitive impairment, and executive function deficits. There is a significant clinical overlap between this syndrome and various primary psychiatric disorders (PPD). Structural and functional neuroimaging are considered helpful to support the diagnosis of bvFTD, but their sensitivity and specificity remain imperfect. There is growing evidence concerning the potential of neurofilaments as biomarkers reflecting axonal and neuronal lesions. Ultrasensitive analytic platforms have recently enabled neurofilament light chains’ (NfL) detection not only from cerebrospinal fluid but also from peripheral blood samples in FTD patients. In this short review, we present recent advances and perspectives for the use of NfL assessments as biomarkers of neuroaxonal damage to differentiate bvFTD from primary psychiatric disorders. neurofilaments blood biomarkers behavioral frontotemporal dementia neuropsychiatry diagnosis single molecular array Medicine (General) Julien Dumurgier verfasserin aut Aurore Fayosse verfasserin aut Claire Paquet verfasserin aut Emmanuel Cognat verfasserin aut In Diagnostics MDPI AG, 2012 11(2021), 5, p 754 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:11 year:2021 number:5, p 754 https://doi.org/10.3390/diagnostics11050754 kostenfrei https://doaj.org/article/747a79796b64474bb81d0b9d44f39db3 kostenfrei https://www.mdpi.com/2075-4418/11/5/754 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 5, p 754
allfieldsGer	10.3390/diagnostics11050754 doi (DE-627)DOAJ078781477 (DE-599)DOAJ747a79796b64474bb81d0b9d44f39db3 DE-627 ger DE-627 rakwb eng R5-920 Vincent Davy verfasserin aut Neurofilaments as Emerging Biomarkers of Neuroaxonal Damage to Differentiate Behavioral Frontotemporal Dementia from Primary Psychiatric Disorders: A Systematic Review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The behavioral variant of frontotemporal dementia (bvFTD) is a clinical syndrome resulting from various causes of neuronal demises associated with frontotemporal lobar degeneration. Symptoms include behavioral and personality changes, social cognitive impairment, and executive function deficits. There is a significant clinical overlap between this syndrome and various primary psychiatric disorders (PPD). Structural and functional neuroimaging are considered helpful to support the diagnosis of bvFTD, but their sensitivity and specificity remain imperfect. There is growing evidence concerning the potential of neurofilaments as biomarkers reflecting axonal and neuronal lesions. Ultrasensitive analytic platforms have recently enabled neurofilament light chains’ (NfL) detection not only from cerebrospinal fluid but also from peripheral blood samples in FTD patients. In this short review, we present recent advances and perspectives for the use of NfL assessments as biomarkers of neuroaxonal damage to differentiate bvFTD from primary psychiatric disorders. neurofilaments blood biomarkers behavioral frontotemporal dementia neuropsychiatry diagnosis single molecular array Medicine (General) Julien Dumurgier verfasserin aut Aurore Fayosse verfasserin aut Claire Paquet verfasserin aut Emmanuel Cognat verfasserin aut In Diagnostics MDPI AG, 2012 11(2021), 5, p 754 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:11 year:2021 number:5, p 754 https://doi.org/10.3390/diagnostics11050754 kostenfrei https://doaj.org/article/747a79796b64474bb81d0b9d44f39db3 kostenfrei https://www.mdpi.com/2075-4418/11/5/754 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 5, p 754
allfieldsSound	10.3390/diagnostics11050754 doi (DE-627)DOAJ078781477 (DE-599)DOAJ747a79796b64474bb81d0b9d44f39db3 DE-627 ger DE-627 rakwb eng R5-920 Vincent Davy verfasserin aut Neurofilaments as Emerging Biomarkers of Neuroaxonal Damage to Differentiate Behavioral Frontotemporal Dementia from Primary Psychiatric Disorders: A Systematic Review 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The behavioral variant of frontotemporal dementia (bvFTD) is a clinical syndrome resulting from various causes of neuronal demises associated with frontotemporal lobar degeneration. Symptoms include behavioral and personality changes, social cognitive impairment, and executive function deficits. There is a significant clinical overlap between this syndrome and various primary psychiatric disorders (PPD). Structural and functional neuroimaging are considered helpful to support the diagnosis of bvFTD, but their sensitivity and specificity remain imperfect. There is growing evidence concerning the potential of neurofilaments as biomarkers reflecting axonal and neuronal lesions. Ultrasensitive analytic platforms have recently enabled neurofilament light chains’ (NfL) detection not only from cerebrospinal fluid but also from peripheral blood samples in FTD patients. In this short review, we present recent advances and perspectives for the use of NfL assessments as biomarkers of neuroaxonal damage to differentiate bvFTD from primary psychiatric disorders. neurofilaments blood biomarkers behavioral frontotemporal dementia neuropsychiatry diagnosis single molecular array Medicine (General) Julien Dumurgier verfasserin aut Aurore Fayosse verfasserin aut Claire Paquet verfasserin aut Emmanuel Cognat verfasserin aut In Diagnostics MDPI AG, 2012 11(2021), 5, p 754 (DE-627)718627814 (DE-600)2662336-5 20754418 nnns volume:11 year:2021 number:5, p 754 https://doi.org/10.3390/diagnostics11050754 kostenfrei https://doaj.org/article/747a79796b64474bb81d0b9d44f39db3 kostenfrei https://www.mdpi.com/2075-4418/11/5/754 kostenfrei https://doaj.org/toc/2075-4418 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2021 5, p 754
language	English
source	In Diagnostics 11(2021), 5, p 754 volume:11 year:2021 number:5, p 754
sourceStr	In Diagnostics 11(2021), 5, p 754 volume:11 year:2021 number:5, p 754
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topic_facet	neurofilaments blood biomarkers behavioral frontotemporal dementia neuropsychiatry diagnosis single molecular array Medicine (General)
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container_title	Diagnostics
authorswithroles_txt_mv	Vincent Davy @@aut@@ Julien Dumurgier @@aut@@ Aurore Fayosse @@aut@@ Claire Paquet @@aut@@ Emmanuel Cognat @@aut@@
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callnumber-first	R - Medicine
author	Vincent Davy
spellingShingle	Vincent Davy misc R5-920 misc neurofilaments misc blood biomarkers misc behavioral frontotemporal dementia misc neuropsychiatry misc diagnosis misc single molecular array misc Medicine (General) Neurofilaments as Emerging Biomarkers of Neuroaxonal Damage to Differentiate Behavioral Frontotemporal Dementia from Primary Psychiatric Disorders: A Systematic Review
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topic_title	R5-920 Neurofilaments as Emerging Biomarkers of Neuroaxonal Damage to Differentiate Behavioral Frontotemporal Dementia from Primary Psychiatric Disorders: A Systematic Review neurofilaments blood biomarkers behavioral frontotemporal dementia neuropsychiatry diagnosis single molecular array
topic	misc R5-920 misc neurofilaments misc blood biomarkers misc behavioral frontotemporal dementia misc neuropsychiatry misc diagnosis misc single molecular array misc Medicine (General)
topic_unstemmed	misc R5-920 misc neurofilaments misc blood biomarkers misc behavioral frontotemporal dementia misc neuropsychiatry misc diagnosis misc single molecular array misc Medicine (General)
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title	Neurofilaments as Emerging Biomarkers of Neuroaxonal Damage to Differentiate Behavioral Frontotemporal Dementia from Primary Psychiatric Disorders: A Systematic Review
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title_sort	neurofilaments as emerging biomarkers of neuroaxonal damage to differentiate behavioral frontotemporal dementia from primary psychiatric disorders: a systematic review
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title_auth	Neurofilaments as Emerging Biomarkers of Neuroaxonal Damage to Differentiate Behavioral Frontotemporal Dementia from Primary Psychiatric Disorders: A Systematic Review
abstract	The behavioral variant of frontotemporal dementia (bvFTD) is a clinical syndrome resulting from various causes of neuronal demises associated with frontotemporal lobar degeneration. Symptoms include behavioral and personality changes, social cognitive impairment, and executive function deficits. There is a significant clinical overlap between this syndrome and various primary psychiatric disorders (PPD). Structural and functional neuroimaging are considered helpful to support the diagnosis of bvFTD, but their sensitivity and specificity remain imperfect. There is growing evidence concerning the potential of neurofilaments as biomarkers reflecting axonal and neuronal lesions. Ultrasensitive analytic platforms have recently enabled neurofilament light chains’ (NfL) detection not only from cerebrospinal fluid but also from peripheral blood samples in FTD patients. In this short review, we present recent advances and perspectives for the use of NfL assessments as biomarkers of neuroaxonal damage to differentiate bvFTD from primary psychiatric disorders.
abstractGer	The behavioral variant of frontotemporal dementia (bvFTD) is a clinical syndrome resulting from various causes of neuronal demises associated with frontotemporal lobar degeneration. Symptoms include behavioral and personality changes, social cognitive impairment, and executive function deficits. There is a significant clinical overlap between this syndrome and various primary psychiatric disorders (PPD). Structural and functional neuroimaging are considered helpful to support the diagnosis of bvFTD, but their sensitivity and specificity remain imperfect. There is growing evidence concerning the potential of neurofilaments as biomarkers reflecting axonal and neuronal lesions. Ultrasensitive analytic platforms have recently enabled neurofilament light chains’ (NfL) detection not only from cerebrospinal fluid but also from peripheral blood samples in FTD patients. In this short review, we present recent advances and perspectives for the use of NfL assessments as biomarkers of neuroaxonal damage to differentiate bvFTD from primary psychiatric disorders.
abstract_unstemmed	The behavioral variant of frontotemporal dementia (bvFTD) is a clinical syndrome resulting from various causes of neuronal demises associated with frontotemporal lobar degeneration. Symptoms include behavioral and personality changes, social cognitive impairment, and executive function deficits. There is a significant clinical overlap between this syndrome and various primary psychiatric disorders (PPD). Structural and functional neuroimaging are considered helpful to support the diagnosis of bvFTD, but their sensitivity and specificity remain imperfect. There is growing evidence concerning the potential of neurofilaments as biomarkers reflecting axonal and neuronal lesions. Ultrasensitive analytic platforms have recently enabled neurofilament light chains’ (NfL) detection not only from cerebrospinal fluid but also from peripheral blood samples in FTD patients. In this short review, we present recent advances and perspectives for the use of NfL assessments as biomarkers of neuroaxonal damage to differentiate bvFTD from primary psychiatric disorders.
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title_short	Neurofilaments as Emerging Biomarkers of Neuroaxonal Damage to Differentiate Behavioral Frontotemporal Dementia from Primary Psychiatric Disorders: A Systematic Review
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Neurofilaments as Emerging Biomarkers of Neuroaxonal Damage to Differentiate Behavioral Frontotemporal Dementia from Primary Psychiatric Disorders: A Systematic Review

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