Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study

Summary: Background: Introduction of the Omicron variant caused a steep rise in SARS-CoV-2 infections despite high vaccination coverage in the Danish population. We used blood donor serosurveillance to estimate the percentage of recently infected residents in the similarly aged background populatio...
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Autor*in:	Christian Erikstrup [verfasserIn] Anna Damkjær Laksafoss [verfasserIn] Josephine Gladov [verfasserIn] Kathrine Agergård Kaspersen [verfasserIn] Susan Mikkelsen [verfasserIn] Lotte Hindhede [verfasserIn] Jens Kjærgaard Boldsen [verfasserIn] Signe Winther Jørgensen [verfasserIn] Steen Ethelberg [verfasserIn] Dorte Kinggaard Holm [verfasserIn] Mie Topholm Bruun [verfasserIn] Janna Nissen [verfasserIn] Michael Schwinn [verfasserIn] Thorsten Brodersen [verfasserIn] Christina Mikkelsen [verfasserIn] Susanne Gjørup Sækmose [verfasserIn] Erik Sørensen [verfasserIn] Lene Holm Harritshøj [verfasserIn] Bitten Aagaard [verfasserIn] Khoa Manh Dinh [verfasserIn] Michael P. Busch [verfasserIn] Charlotte Sværke Jørgensen [verfasserIn] Tyra Grove Krause [verfasserIn] Henrik Ullum [verfasserIn] Sisse Rye Ostrowski [verfasserIn] Laura Espenhain [verfasserIn] Ole Birger Vesterager Pedersen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	SARS-CoV-2 Seroprevalence Infection fatality rate

Übergeordnetes Werk:	In: The Lancet Regional Health. Europe - Elsevier, 2021, 21(2022), Seite 100479-
Übergeordnetes Werk:	volume:21 ; year:2022 ; pages:100479-

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.lanepe.2022.100479

Katalog-ID:	DOAJ079006469

Internformat


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245	1	0	\|a Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study
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520			\|a Summary: Background: Introduction of the Omicron variant caused a steep rise in SARS-CoV-2 infections despite high vaccination coverage in the Danish population. We used blood donor serosurveillance to estimate the percentage of recently infected residents in the similarly aged background population with no known comorbidity. Methods: To detect SARS-CoV-2 antibodies induced due to recent infection, and not vaccination, we assessed anti-nucleocapsid (anti-N) immunoglobulin G (IgG) in blood donor samples. Individual level data on SARS-CoV-2 RT-PCR results and vaccination status were available. Anti-N IgG was measured fortnightly from January 18 to April 3, 2022. Samples from November 2021 were analysed to assess seroprevalence before introduction of the Omicron variant in Denmark. Findings: A total of 43 088 donations from 35 309 Danish blood donors aged 17–72 years were screened. In November 2021, 1·2% (103/8 701) of donors had detectable anti-N IgG antibodies. Adjusting for test sensitivity (estimates ranging from 74%–81%) and November seroprevalence, we estimate that 66% (95% confidence intervals (CI): 63%–70%) of the healthy, similarly aged Danish population had been infected between November 1, 2021, and March 15, 2022. One third of infections were not captured by SARS-CoV-2 RT-PCR testing. The infection fatality rate (IFR) was 6·2 (CI: 5·1–7·5) per 100 000 infections. Interpretation: Screening for anti-N IgG and linkage to national registers allowed us to detect recent infections and accurately assess assay sensitivity in vaccinated or previously infected individuals during the Omicron outbreak. The IFR was lower than during previous waves. Funding: The Danish Ministry of Health.
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700	0		\|a Anna Damkjær Laksafoss \|e verfasserin \|4 aut
700	0		\|a Josephine Gladov \|e verfasserin \|4 aut
700	0		\|a Kathrine Agergård Kaspersen \|e verfasserin \|4 aut
700	0		\|a Susan Mikkelsen \|e verfasserin \|4 aut
700	0		\|a Lotte Hindhede \|e verfasserin \|4 aut
700	0		\|a Jens Kjærgaard Boldsen \|e verfasserin \|4 aut
700	0		\|a Signe Winther Jørgensen \|e verfasserin \|4 aut
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700	0		\|a Mie Topholm Bruun \|e verfasserin \|4 aut
700	0		\|a Janna Nissen \|e verfasserin \|4 aut
700	0		\|a Michael Schwinn \|e verfasserin \|4 aut
700	0		\|a Thorsten Brodersen \|e verfasserin \|4 aut
700	0		\|a Christina Mikkelsen \|e verfasserin \|4 aut
700	0		\|a Susanne Gjørup Sækmose \|e verfasserin \|4 aut
700	0		\|a Erik Sørensen \|e verfasserin \|4 aut
700	0		\|a Lene Holm Harritshøj \|e verfasserin \|4 aut
700	0		\|a Bitten Aagaard \|e verfasserin \|4 aut
700	0		\|a Khoa Manh Dinh \|e verfasserin \|4 aut
700	0		\|a Michael P. Busch \|e verfasserin \|4 aut
700	0		\|a Charlotte Sværke Jørgensen \|e verfasserin \|4 aut
700	0		\|a Tyra Grove Krause \|e verfasserin \|4 aut
700	0		\|a Henrik Ullum \|e verfasserin \|4 aut
700	0		\|a Sisse Rye Ostrowski \|e verfasserin \|4 aut
700	0		\|a Laura Espenhain \|e verfasserin \|4 aut
700	0		\|a Ole Birger Vesterager Pedersen \|e verfasserin \|4 aut
773	0	8	\|i In \|t The Lancet Regional Health. Europe \|d Elsevier, 2021 \|g 21(2022), Seite 100479- \|w (DE-627)1750524406 \|x 26667762 \|7 nnns
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856	4	0	\|u https://doaj.org/article/191aeb94d35846b3b9091b85386f5cfd \|z kostenfrei
856	4	0	\|u http://www.sciencedirect.com/science/article/pii/S2666776222001752 \|z kostenfrei
856	4	2	\|u https://doaj.org/toc/2666-7762 \|y Journal toc \|z kostenfrei
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912			\|a GBV_ILN_23
912			\|a GBV_ILN_24
912			\|a GBV_ILN_31
912			\|a GBV_ILN_39
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_73
912			\|a GBV_ILN_74
912			\|a GBV_ILN_95
912			\|a GBV_ILN_105
912			\|a GBV_ILN_110
912			\|a GBV_ILN_151
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_206
912			\|a GBV_ILN_213
912			\|a GBV_ILN_230
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_602
912			\|a GBV_ILN_2001
912			\|a GBV_ILN_2003
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2006
912			\|a GBV_ILN_2007
912			\|a GBV_ILN_2008
912			\|a GBV_ILN_2009
912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
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912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2129
912			\|a GBV_ILN_2143
912			\|a GBV_ILN_2153
912			\|a GBV_ILN_2190
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912			\|a GBV_ILN_2470
912			\|a GBV_ILN_2507
912			\|a GBV_ILN_4012
912			\|a GBV_ILN_4035
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912			\|a GBV_ILN_4125
912			\|a GBV_ILN_4126
912			\|a GBV_ILN_4249
912			\|a GBV_ILN_4251
912			\|a GBV_ILN_4305
912			\|a GBV_ILN_4306
912			\|a GBV_ILN_4307
912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4322
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4325
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4338
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author_variant	c e ce a d l adl j g jg k a k kak s m sm l h lh j k b jkb s w j swj s e se d k h dkh m t b mtb j n jn m s ms t b tb c m cm s g s sgs e s es l h h lhh b a ba k m d kmd m p b mpb c s j csj t g k tgk h u hu s r o sro l e le o b v p obvp
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hierarchy_sort_str	2022
callnumber-subject-code	RA
publishDate	2022
allfields	10.1016/j.lanepe.2022.100479 doi (DE-627)DOAJ079006469 (DE-599)DOAJ191aeb94d35846b3b9091b85386f5cfd DE-627 ger DE-627 rakwb eng RA1-1270 Christian Erikstrup verfasserin aut Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Introduction of the Omicron variant caused a steep rise in SARS-CoV-2 infections despite high vaccination coverage in the Danish population. We used blood donor serosurveillance to estimate the percentage of recently infected residents in the similarly aged background population with no known comorbidity. Methods: To detect SARS-CoV-2 antibodies induced due to recent infection, and not vaccination, we assessed anti-nucleocapsid (anti-N) immunoglobulin G (IgG) in blood donor samples. Individual level data on SARS-CoV-2 RT-PCR results and vaccination status were available. Anti-N IgG was measured fortnightly from January 18 to April 3, 2022. Samples from November 2021 were analysed to assess seroprevalence before introduction of the Omicron variant in Denmark. Findings: A total of 43 088 donations from 35 309 Danish blood donors aged 17–72 years were screened. In November 2021, 1·2% (103/8 701) of donors had detectable anti-N IgG antibodies. Adjusting for test sensitivity (estimates ranging from 74%–81%) and November seroprevalence, we estimate that 66% (95% confidence intervals (CI): 63%–70%) of the healthy, similarly aged Danish population had been infected between November 1, 2021, and March 15, 2022. One third of infections were not captured by SARS-CoV-2 RT-PCR testing. The infection fatality rate (IFR) was 6·2 (CI: 5·1–7·5) per 100 000 infections. Interpretation: Screening for anti-N IgG and linkage to national registers allowed us to detect recent infections and accurately assess assay sensitivity in vaccinated or previously infected individuals during the Omicron outbreak. The IFR was lower than during previous waves. Funding: The Danish Ministry of Health. SARS-CoV-2 Seroprevalence Infection fatality rate Public aspects of medicine Anna Damkjær Laksafoss verfasserin aut Josephine Gladov verfasserin aut Kathrine Agergård Kaspersen verfasserin aut Susan Mikkelsen verfasserin aut Lotte Hindhede verfasserin aut Jens Kjærgaard Boldsen verfasserin aut Signe Winther Jørgensen verfasserin aut Steen Ethelberg verfasserin aut Dorte Kinggaard Holm verfasserin aut Mie Topholm Bruun verfasserin aut Janna Nissen verfasserin aut Michael Schwinn verfasserin aut Thorsten Brodersen verfasserin aut Christina Mikkelsen verfasserin aut Susanne Gjørup Sækmose verfasserin aut Erik Sørensen verfasserin aut Lene Holm Harritshøj verfasserin aut Bitten Aagaard verfasserin aut Khoa Manh Dinh verfasserin aut Michael P. Busch verfasserin aut Charlotte Sværke Jørgensen verfasserin aut Tyra Grove Krause verfasserin aut Henrik Ullum verfasserin aut Sisse Rye Ostrowski verfasserin aut Laura Espenhain verfasserin aut Ole Birger Vesterager Pedersen verfasserin aut In The Lancet Regional Health. Europe Elsevier, 2021 21(2022), Seite 100479- (DE-627)1750524406 26667762 nnns volume:21 year:2022 pages:100479- https://doi.org/10.1016/j.lanepe.2022.100479 kostenfrei https://doaj.org/article/191aeb94d35846b3b9091b85386f5cfd kostenfrei http://www.sciencedirect.com/science/article/pii/S2666776222001752 kostenfrei https://doaj.org/toc/2666-7762 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2022 100479-
spelling	10.1016/j.lanepe.2022.100479 doi (DE-627)DOAJ079006469 (DE-599)DOAJ191aeb94d35846b3b9091b85386f5cfd DE-627 ger DE-627 rakwb eng RA1-1270 Christian Erikstrup verfasserin aut Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Introduction of the Omicron variant caused a steep rise in SARS-CoV-2 infections despite high vaccination coverage in the Danish population. We used blood donor serosurveillance to estimate the percentage of recently infected residents in the similarly aged background population with no known comorbidity. Methods: To detect SARS-CoV-2 antibodies induced due to recent infection, and not vaccination, we assessed anti-nucleocapsid (anti-N) immunoglobulin G (IgG) in blood donor samples. Individual level data on SARS-CoV-2 RT-PCR results and vaccination status were available. Anti-N IgG was measured fortnightly from January 18 to April 3, 2022. Samples from November 2021 were analysed to assess seroprevalence before introduction of the Omicron variant in Denmark. Findings: A total of 43 088 donations from 35 309 Danish blood donors aged 17–72 years were screened. In November 2021, 1·2% (103/8 701) of donors had detectable anti-N IgG antibodies. Adjusting for test sensitivity (estimates ranging from 74%–81%) and November seroprevalence, we estimate that 66% (95% confidence intervals (CI): 63%–70%) of the healthy, similarly aged Danish population had been infected between November 1, 2021, and March 15, 2022. One third of infections were not captured by SARS-CoV-2 RT-PCR testing. The infection fatality rate (IFR) was 6·2 (CI: 5·1–7·5) per 100 000 infections. Interpretation: Screening for anti-N IgG and linkage to national registers allowed us to detect recent infections and accurately assess assay sensitivity in vaccinated or previously infected individuals during the Omicron outbreak. The IFR was lower than during previous waves. Funding: The Danish Ministry of Health. SARS-CoV-2 Seroprevalence Infection fatality rate Public aspects of medicine Anna Damkjær Laksafoss verfasserin aut Josephine Gladov verfasserin aut Kathrine Agergård Kaspersen verfasserin aut Susan Mikkelsen verfasserin aut Lotte Hindhede verfasserin aut Jens Kjærgaard Boldsen verfasserin aut Signe Winther Jørgensen verfasserin aut Steen Ethelberg verfasserin aut Dorte Kinggaard Holm verfasserin aut Mie Topholm Bruun verfasserin aut Janna Nissen verfasserin aut Michael Schwinn verfasserin aut Thorsten Brodersen verfasserin aut Christina Mikkelsen verfasserin aut Susanne Gjørup Sækmose verfasserin aut Erik Sørensen verfasserin aut Lene Holm Harritshøj verfasserin aut Bitten Aagaard verfasserin aut Khoa Manh Dinh verfasserin aut Michael P. Busch verfasserin aut Charlotte Sværke Jørgensen verfasserin aut Tyra Grove Krause verfasserin aut Henrik Ullum verfasserin aut Sisse Rye Ostrowski verfasserin aut Laura Espenhain verfasserin aut Ole Birger Vesterager Pedersen verfasserin aut In The Lancet Regional Health. Europe Elsevier, 2021 21(2022), Seite 100479- (DE-627)1750524406 26667762 nnns volume:21 year:2022 pages:100479- https://doi.org/10.1016/j.lanepe.2022.100479 kostenfrei https://doaj.org/article/191aeb94d35846b3b9091b85386f5cfd kostenfrei http://www.sciencedirect.com/science/article/pii/S2666776222001752 kostenfrei https://doaj.org/toc/2666-7762 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2022 100479-
allfields_unstemmed	10.1016/j.lanepe.2022.100479 doi (DE-627)DOAJ079006469 (DE-599)DOAJ191aeb94d35846b3b9091b85386f5cfd DE-627 ger DE-627 rakwb eng RA1-1270 Christian Erikstrup verfasserin aut Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Introduction of the Omicron variant caused a steep rise in SARS-CoV-2 infections despite high vaccination coverage in the Danish population. We used blood donor serosurveillance to estimate the percentage of recently infected residents in the similarly aged background population with no known comorbidity. Methods: To detect SARS-CoV-2 antibodies induced due to recent infection, and not vaccination, we assessed anti-nucleocapsid (anti-N) immunoglobulin G (IgG) in blood donor samples. Individual level data on SARS-CoV-2 RT-PCR results and vaccination status were available. Anti-N IgG was measured fortnightly from January 18 to April 3, 2022. Samples from November 2021 were analysed to assess seroprevalence before introduction of the Omicron variant in Denmark. Findings: A total of 43 088 donations from 35 309 Danish blood donors aged 17–72 years were screened. In November 2021, 1·2% (103/8 701) of donors had detectable anti-N IgG antibodies. Adjusting for test sensitivity (estimates ranging from 74%–81%) and November seroprevalence, we estimate that 66% (95% confidence intervals (CI): 63%–70%) of the healthy, similarly aged Danish population had been infected between November 1, 2021, and March 15, 2022. One third of infections were not captured by SARS-CoV-2 RT-PCR testing. The infection fatality rate (IFR) was 6·2 (CI: 5·1–7·5) per 100 000 infections. Interpretation: Screening for anti-N IgG and linkage to national registers allowed us to detect recent infections and accurately assess assay sensitivity in vaccinated or previously infected individuals during the Omicron outbreak. The IFR was lower than during previous waves. Funding: The Danish Ministry of Health. SARS-CoV-2 Seroprevalence Infection fatality rate Public aspects of medicine Anna Damkjær Laksafoss verfasserin aut Josephine Gladov verfasserin aut Kathrine Agergård Kaspersen verfasserin aut Susan Mikkelsen verfasserin aut Lotte Hindhede verfasserin aut Jens Kjærgaard Boldsen verfasserin aut Signe Winther Jørgensen verfasserin aut Steen Ethelberg verfasserin aut Dorte Kinggaard Holm verfasserin aut Mie Topholm Bruun verfasserin aut Janna Nissen verfasserin aut Michael Schwinn verfasserin aut Thorsten Brodersen verfasserin aut Christina Mikkelsen verfasserin aut Susanne Gjørup Sækmose verfasserin aut Erik Sørensen verfasserin aut Lene Holm Harritshøj verfasserin aut Bitten Aagaard verfasserin aut Khoa Manh Dinh verfasserin aut Michael P. Busch verfasserin aut Charlotte Sværke Jørgensen verfasserin aut Tyra Grove Krause verfasserin aut Henrik Ullum verfasserin aut Sisse Rye Ostrowski verfasserin aut Laura Espenhain verfasserin aut Ole Birger Vesterager Pedersen verfasserin aut In The Lancet Regional Health. Europe Elsevier, 2021 21(2022), Seite 100479- (DE-627)1750524406 26667762 nnns volume:21 year:2022 pages:100479- https://doi.org/10.1016/j.lanepe.2022.100479 kostenfrei https://doaj.org/article/191aeb94d35846b3b9091b85386f5cfd kostenfrei http://www.sciencedirect.com/science/article/pii/S2666776222001752 kostenfrei https://doaj.org/toc/2666-7762 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2022 100479-
allfieldsGer	10.1016/j.lanepe.2022.100479 doi (DE-627)DOAJ079006469 (DE-599)DOAJ191aeb94d35846b3b9091b85386f5cfd DE-627 ger DE-627 rakwb eng RA1-1270 Christian Erikstrup verfasserin aut Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Introduction of the Omicron variant caused a steep rise in SARS-CoV-2 infections despite high vaccination coverage in the Danish population. We used blood donor serosurveillance to estimate the percentage of recently infected residents in the similarly aged background population with no known comorbidity. Methods: To detect SARS-CoV-2 antibodies induced due to recent infection, and not vaccination, we assessed anti-nucleocapsid (anti-N) immunoglobulin G (IgG) in blood donor samples. Individual level data on SARS-CoV-2 RT-PCR results and vaccination status were available. Anti-N IgG was measured fortnightly from January 18 to April 3, 2022. Samples from November 2021 were analysed to assess seroprevalence before introduction of the Omicron variant in Denmark. Findings: A total of 43 088 donations from 35 309 Danish blood donors aged 17–72 years were screened. In November 2021, 1·2% (103/8 701) of donors had detectable anti-N IgG antibodies. Adjusting for test sensitivity (estimates ranging from 74%–81%) and November seroprevalence, we estimate that 66% (95% confidence intervals (CI): 63%–70%) of the healthy, similarly aged Danish population had been infected between November 1, 2021, and March 15, 2022. One third of infections were not captured by SARS-CoV-2 RT-PCR testing. The infection fatality rate (IFR) was 6·2 (CI: 5·1–7·5) per 100 000 infections. Interpretation: Screening for anti-N IgG and linkage to national registers allowed us to detect recent infections and accurately assess assay sensitivity in vaccinated or previously infected individuals during the Omicron outbreak. The IFR was lower than during previous waves. Funding: The Danish Ministry of Health. SARS-CoV-2 Seroprevalence Infection fatality rate Public aspects of medicine Anna Damkjær Laksafoss verfasserin aut Josephine Gladov verfasserin aut Kathrine Agergård Kaspersen verfasserin aut Susan Mikkelsen verfasserin aut Lotte Hindhede verfasserin aut Jens Kjærgaard Boldsen verfasserin aut Signe Winther Jørgensen verfasserin aut Steen Ethelberg verfasserin aut Dorte Kinggaard Holm verfasserin aut Mie Topholm Bruun verfasserin aut Janna Nissen verfasserin aut Michael Schwinn verfasserin aut Thorsten Brodersen verfasserin aut Christina Mikkelsen verfasserin aut Susanne Gjørup Sækmose verfasserin aut Erik Sørensen verfasserin aut Lene Holm Harritshøj verfasserin aut Bitten Aagaard verfasserin aut Khoa Manh Dinh verfasserin aut Michael P. Busch verfasserin aut Charlotte Sværke Jørgensen verfasserin aut Tyra Grove Krause verfasserin aut Henrik Ullum verfasserin aut Sisse Rye Ostrowski verfasserin aut Laura Espenhain verfasserin aut Ole Birger Vesterager Pedersen verfasserin aut In The Lancet Regional Health. Europe Elsevier, 2021 21(2022), Seite 100479- (DE-627)1750524406 26667762 nnns volume:21 year:2022 pages:100479- https://doi.org/10.1016/j.lanepe.2022.100479 kostenfrei https://doaj.org/article/191aeb94d35846b3b9091b85386f5cfd kostenfrei http://www.sciencedirect.com/science/article/pii/S2666776222001752 kostenfrei https://doaj.org/toc/2666-7762 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2022 100479-
allfieldsSound	10.1016/j.lanepe.2022.100479 doi (DE-627)DOAJ079006469 (DE-599)DOAJ191aeb94d35846b3b9091b85386f5cfd DE-627 ger DE-627 rakwb eng RA1-1270 Christian Erikstrup verfasserin aut Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Summary: Background: Introduction of the Omicron variant caused a steep rise in SARS-CoV-2 infections despite high vaccination coverage in the Danish population. We used blood donor serosurveillance to estimate the percentage of recently infected residents in the similarly aged background population with no known comorbidity. Methods: To detect SARS-CoV-2 antibodies induced due to recent infection, and not vaccination, we assessed anti-nucleocapsid (anti-N) immunoglobulin G (IgG) in blood donor samples. Individual level data on SARS-CoV-2 RT-PCR results and vaccination status were available. Anti-N IgG was measured fortnightly from January 18 to April 3, 2022. Samples from November 2021 were analysed to assess seroprevalence before introduction of the Omicron variant in Denmark. Findings: A total of 43 088 donations from 35 309 Danish blood donors aged 17–72 years were screened. In November 2021, 1·2% (103/8 701) of donors had detectable anti-N IgG antibodies. Adjusting for test sensitivity (estimates ranging from 74%–81%) and November seroprevalence, we estimate that 66% (95% confidence intervals (CI): 63%–70%) of the healthy, similarly aged Danish population had been infected between November 1, 2021, and March 15, 2022. One third of infections were not captured by SARS-CoV-2 RT-PCR testing. The infection fatality rate (IFR) was 6·2 (CI: 5·1–7·5) per 100 000 infections. Interpretation: Screening for anti-N IgG and linkage to national registers allowed us to detect recent infections and accurately assess assay sensitivity in vaccinated or previously infected individuals during the Omicron outbreak. The IFR was lower than during previous waves. Funding: The Danish Ministry of Health. SARS-CoV-2 Seroprevalence Infection fatality rate Public aspects of medicine Anna Damkjær Laksafoss verfasserin aut Josephine Gladov verfasserin aut Kathrine Agergård Kaspersen verfasserin aut Susan Mikkelsen verfasserin aut Lotte Hindhede verfasserin aut Jens Kjærgaard Boldsen verfasserin aut Signe Winther Jørgensen verfasserin aut Steen Ethelberg verfasserin aut Dorte Kinggaard Holm verfasserin aut Mie Topholm Bruun verfasserin aut Janna Nissen verfasserin aut Michael Schwinn verfasserin aut Thorsten Brodersen verfasserin aut Christina Mikkelsen verfasserin aut Susanne Gjørup Sækmose verfasserin aut Erik Sørensen verfasserin aut Lene Holm Harritshøj verfasserin aut Bitten Aagaard verfasserin aut Khoa Manh Dinh verfasserin aut Michael P. Busch verfasserin aut Charlotte Sværke Jørgensen verfasserin aut Tyra Grove Krause verfasserin aut Henrik Ullum verfasserin aut Sisse Rye Ostrowski verfasserin aut Laura Espenhain verfasserin aut Ole Birger Vesterager Pedersen verfasserin aut In The Lancet Regional Health. Europe Elsevier, 2021 21(2022), Seite 100479- (DE-627)1750524406 26667762 nnns volume:21 year:2022 pages:100479- https://doi.org/10.1016/j.lanepe.2022.100479 kostenfrei https://doaj.org/article/191aeb94d35846b3b9091b85386f5cfd kostenfrei http://www.sciencedirect.com/science/article/pii/S2666776222001752 kostenfrei https://doaj.org/toc/2666-7762 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2110 GBV_ILN_2112 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 21 2022 100479-
language	English
source	In The Lancet Regional Health. Europe 21(2022), Seite 100479- volume:21 year:2022 pages:100479-
sourceStr	In The Lancet Regional Health. Europe 21(2022), Seite 100479- volume:21 year:2022 pages:100479-
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	SARS-CoV-2 Seroprevalence Infection fatality rate Public aspects of medicine
isfreeaccess_bool	true
container_title	The Lancet Regional Health. Europe
authorswithroles_txt_mv	Christian Erikstrup @@aut@@ Anna Damkjær Laksafoss @@aut@@ Josephine Gladov @@aut@@ Kathrine Agergård Kaspersen @@aut@@ Susan Mikkelsen @@aut@@ Lotte Hindhede @@aut@@ Jens Kjærgaard Boldsen @@aut@@ Signe Winther Jørgensen @@aut@@ Steen Ethelberg @@aut@@ Dorte Kinggaard Holm @@aut@@ Mie Topholm Bruun @@aut@@ Janna Nissen @@aut@@ Michael Schwinn @@aut@@ Thorsten Brodersen @@aut@@ Christina Mikkelsen @@aut@@ Susanne Gjørup Sækmose @@aut@@ Erik Sørensen @@aut@@ Lene Holm Harritshøj @@aut@@ Bitten Aagaard @@aut@@ Khoa Manh Dinh @@aut@@ Michael P. Busch @@aut@@ Charlotte Sværke Jørgensen @@aut@@ Tyra Grove Krause @@aut@@ Henrik Ullum @@aut@@ Sisse Rye Ostrowski @@aut@@ Laura Espenhain @@aut@@ Ole Birger Vesterager Pedersen @@aut@@
publishDateDaySort_date	2022-01-01T00:00:00Z
hierarchy_top_id	1750524406
id	DOAJ079006469
language_de	englisch
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Adjusting for test sensitivity (estimates ranging from 74%–81%) and November seroprevalence, we estimate that 66% (95% confidence intervals (CI): 63%–70%) of the healthy, similarly aged Danish population had been infected between November 1, 2021, and March 15, 2022. One third of infections were not captured by SARS-CoV-2 RT-PCR testing. The infection fatality rate (IFR) was 6·2 (CI: 5·1–7·5) per 100 000 infections. Interpretation: Screening for anti-N IgG and linkage to national registers allowed us to detect recent infections and accurately assess assay sensitivity in vaccinated or previously infected individuals during the Omicron outbreak. The IFR was lower than during previous waves. 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callnumber-first	R - Medicine
author	Christian Erikstrup
spellingShingle	Christian Erikstrup misc RA1-1270 misc SARS-CoV-2 misc Seroprevalence misc Infection fatality rate misc Public aspects of medicine Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study
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topic_title	RA1-1270 Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study SARS-CoV-2 Seroprevalence Infection fatality rate
topic	misc RA1-1270 misc SARS-CoV-2 misc Seroprevalence misc Infection fatality rate misc Public aspects of medicine
topic_unstemmed	misc RA1-1270 misc SARS-CoV-2 misc Seroprevalence misc Infection fatality rate misc Public aspects of medicine
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title	Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study
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title_full	Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study
author_sort	Christian Erikstrup
journal	The Lancet Regional Health. Europe
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author_browse	Christian Erikstrup Anna Damkjær Laksafoss Josephine Gladov Kathrine Agergård Kaspersen Susan Mikkelsen Lotte Hindhede Jens Kjærgaard Boldsen Signe Winther Jørgensen Steen Ethelberg Dorte Kinggaard Holm Mie Topholm Bruun Janna Nissen Michael Schwinn Thorsten Brodersen Christina Mikkelsen Susanne Gjørup Sækmose Erik Sørensen Lene Holm Harritshøj Bitten Aagaard Khoa Manh Dinh Michael P. Busch Charlotte Sværke Jørgensen Tyra Grove Krause Henrik Ullum Sisse Rye Ostrowski Laura Espenhain Ole Birger Vesterager Pedersen
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author-letter	Christian Erikstrup
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title_sort	seroprevalence and infection fatality rate of the sars-cov-2 omicron variant in denmark: a nationwide serosurveillance study
callnumber	RA1-1270
title_auth	Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study
abstract	Summary: Background: Introduction of the Omicron variant caused a steep rise in SARS-CoV-2 infections despite high vaccination coverage in the Danish population. We used blood donor serosurveillance to estimate the percentage of recently infected residents in the similarly aged background population with no known comorbidity. Methods: To detect SARS-CoV-2 antibodies induced due to recent infection, and not vaccination, we assessed anti-nucleocapsid (anti-N) immunoglobulin G (IgG) in blood donor samples. Individual level data on SARS-CoV-2 RT-PCR results and vaccination status were available. Anti-N IgG was measured fortnightly from January 18 to April 3, 2022. Samples from November 2021 were analysed to assess seroprevalence before introduction of the Omicron variant in Denmark. Findings: A total of 43 088 donations from 35 309 Danish blood donors aged 17–72 years were screened. In November 2021, 1·2% (103/8 701) of donors had detectable anti-N IgG antibodies. Adjusting for test sensitivity (estimates ranging from 74%–81%) and November seroprevalence, we estimate that 66% (95% confidence intervals (CI): 63%–70%) of the healthy, similarly aged Danish population had been infected between November 1, 2021, and March 15, 2022. One third of infections were not captured by SARS-CoV-2 RT-PCR testing. The infection fatality rate (IFR) was 6·2 (CI: 5·1–7·5) per 100 000 infections. Interpretation: Screening for anti-N IgG and linkage to national registers allowed us to detect recent infections and accurately assess assay sensitivity in vaccinated or previously infected individuals during the Omicron outbreak. The IFR was lower than during previous waves. Funding: The Danish Ministry of Health.
abstractGer	Summary: Background: Introduction of the Omicron variant caused a steep rise in SARS-CoV-2 infections despite high vaccination coverage in the Danish population. We used blood donor serosurveillance to estimate the percentage of recently infected residents in the similarly aged background population with no known comorbidity. Methods: To detect SARS-CoV-2 antibodies induced due to recent infection, and not vaccination, we assessed anti-nucleocapsid (anti-N) immunoglobulin G (IgG) in blood donor samples. Individual level data on SARS-CoV-2 RT-PCR results and vaccination status were available. Anti-N IgG was measured fortnightly from January 18 to April 3, 2022. Samples from November 2021 were analysed to assess seroprevalence before introduction of the Omicron variant in Denmark. Findings: A total of 43 088 donations from 35 309 Danish blood donors aged 17–72 years were screened. In November 2021, 1·2% (103/8 701) of donors had detectable anti-N IgG antibodies. Adjusting for test sensitivity (estimates ranging from 74%–81%) and November seroprevalence, we estimate that 66% (95% confidence intervals (CI): 63%–70%) of the healthy, similarly aged Danish population had been infected between November 1, 2021, and March 15, 2022. One third of infections were not captured by SARS-CoV-2 RT-PCR testing. The infection fatality rate (IFR) was 6·2 (CI: 5·1–7·5) per 100 000 infections. Interpretation: Screening for anti-N IgG and linkage to national registers allowed us to detect recent infections and accurately assess assay sensitivity in vaccinated or previously infected individuals during the Omicron outbreak. The IFR was lower than during previous waves. Funding: The Danish Ministry of Health.
abstract_unstemmed	Summary: Background: Introduction of the Omicron variant caused a steep rise in SARS-CoV-2 infections despite high vaccination coverage in the Danish population. We used blood donor serosurveillance to estimate the percentage of recently infected residents in the similarly aged background population with no known comorbidity. Methods: To detect SARS-CoV-2 antibodies induced due to recent infection, and not vaccination, we assessed anti-nucleocapsid (anti-N) immunoglobulin G (IgG) in blood donor samples. Individual level data on SARS-CoV-2 RT-PCR results and vaccination status were available. Anti-N IgG was measured fortnightly from January 18 to April 3, 2022. Samples from November 2021 were analysed to assess seroprevalence before introduction of the Omicron variant in Denmark. Findings: A total of 43 088 donations from 35 309 Danish blood donors aged 17–72 years were screened. In November 2021, 1·2% (103/8 701) of donors had detectable anti-N IgG antibodies. Adjusting for test sensitivity (estimates ranging from 74%–81%) and November seroprevalence, we estimate that 66% (95% confidence intervals (CI): 63%–70%) of the healthy, similarly aged Danish population had been infected between November 1, 2021, and March 15, 2022. One third of infections were not captured by SARS-CoV-2 RT-PCR testing. The infection fatality rate (IFR) was 6·2 (CI: 5·1–7·5) per 100 000 infections. Interpretation: Screening for anti-N IgG and linkage to national registers allowed us to detect recent infections and accurately assess assay sensitivity in vaccinated or previously infected individuals during the Omicron outbreak. The IFR was lower than during previous waves. Funding: The Danish Ministry of Health.
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title_short	Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study
url	https://doi.org/10.1016/j.lanepe.2022.100479 https://doaj.org/article/191aeb94d35846b3b9091b85386f5cfd http://www.sciencedirect.com/science/article/pii/S2666776222001752 https://doaj.org/toc/2666-7762
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author2	Anna Damkjær Laksafoss Josephine Gladov Kathrine Agergård Kaspersen Susan Mikkelsen Lotte Hindhede Jens Kjærgaard Boldsen Signe Winther Jørgensen Steen Ethelberg Dorte Kinggaard Holm Mie Topholm Bruun Janna Nissen Michael Schwinn Thorsten Brodersen Christina Mikkelsen Susanne Gjørup Sækmose Erik Sørensen Lene Holm Harritshøj Bitten Aagaard Khoa Manh Dinh Michael P. Busch Charlotte Sværke Jørgensen Tyra Grove Krause Henrik Ullum Sisse Rye Ostrowski Laura Espenhain Ole Birger Vesterager Pedersen
author2Str	Anna Damkjær Laksafoss Josephine Gladov Kathrine Agergård Kaspersen Susan Mikkelsen Lotte Hindhede Jens Kjærgaard Boldsen Signe Winther Jørgensen Steen Ethelberg Dorte Kinggaard Holm Mie Topholm Bruun Janna Nissen Michael Schwinn Thorsten Brodersen Christina Mikkelsen Susanne Gjørup Sækmose Erik Sørensen Lene Holm Harritshøj Bitten Aagaard Khoa Manh Dinh Michael P. Busch Charlotte Sværke Jørgensen Tyra Grove Krause Henrik Ullum Sisse Rye Ostrowski Laura Espenhain Ole Birger Vesterager Pedersen
ppnlink	1750524406
callnumber-subject	RA - Public Medicine
mediatype_str_mv	c
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hochschulschrift_bool	false
doi_str	10.1016/j.lanepe.2022.100479
callnumber-a	RA1-1270
up_date	2024-07-03T21:09:54.319Z
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Seroprevalence and infection fatality rate of the SARS-CoV-2 Omicron variant in Denmark: A nationwide serosurveillance study

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