Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study

We aimed to quantify Soft Mist Inhalers (SMI) delivery to spontaneous breathing model and compare with different adapters via endotracheal tube during mechanical ventilation or by manual resuscitation. A tiotropium SMI was used with a commercial in-line adapter and a T-adapter placed between the Y-a...
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Autor*in:	Tien-Pei Fang [verfasserIn] Yu-Ju Chen [verfasserIn] Tsung-Ming Yang [verfasserIn] Szu-Hu Wang [verfasserIn] Ming-Szu Hung [verfasserIn] Shu-Hua Chiu [verfasserIn] Hsin-Hsien Li [verfasserIn] James B. Fink [verfasserIn] Hui-Ling Lin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	soft mist inhaler mechanical ventilation adapter inhaled dose in vitro

Übergeordnetes Werk:	In: Pharmaceutics - MDPI AG, 2010, 12(2020), 3, p 291
Übergeordnetes Werk:	volume:12 ; year:2020 ; number:3, p 291

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/pharmaceutics12030291

Katalog-ID:	DOAJ079033148

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allfields	10.3390/pharmaceutics12030291 doi (DE-627)DOAJ079033148 (DE-599)DOAJ45ef1889f0ad4d14a77e8adbe5014ad9 DE-627 ger DE-627 rakwb eng RS1-441 Tien-Pei Fang verfasserin aut Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We aimed to quantify Soft Mist Inhalers (SMI) delivery to spontaneous breathing model and compare with different adapters via endotracheal tube during mechanical ventilation or by manual resuscitation. A tiotropium SMI was used with a commercial in-line adapter and a T-adapter placed between the Y-adapter and the inspiratory limb of the ventilator circuit during mechanical ventilation. The SMI was actuated at the beginning of inspiration and expiration. In separate experiments, a manual resuscitator with T-adapter was attached to endotracheal tube, collecting filter, and a passive test lung. Drug was eluted from collecting filters with salt-based solvent and analyzed using high-performance liquid chromatography. Results showed the percent of SMI label dose inhaled was 3-fold higher with the commercial in-line adapter with actuation during expiration than when synchronized with inspiration. SMI with T-adapter delivery via ventilator was similar to inhalation (1.20%) or exhalation (1.02%), and both had lower delivery dose than with manual resuscitator (2.80%; <i<p</i< = 0.01). The inhaled dose via endotracheal tube was much lower than inhaled dose with spontaneous breathing (22.08%). In conclusion, the inhaled dose with the commercial adapter was higher with SMI actuated during expiration, but still far less than reported spontaneous inhaled dose. soft mist inhaler mechanical ventilation adapter inhaled dose in vitro Pharmacy and materia medica Yu-Ju Chen verfasserin aut Tsung-Ming Yang verfasserin aut Szu-Hu Wang verfasserin aut Ming-Szu Hung verfasserin aut Shu-Hua Chiu verfasserin aut Hsin-Hsien Li verfasserin aut James B. Fink verfasserin aut Hui-Ling Lin verfasserin aut In Pharmaceutics MDPI AG, 2010 12(2020), 3, p 291 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:12 year:2020 number:3, p 291 https://doi.org/10.3390/pharmaceutics12030291 kostenfrei https://doaj.org/article/45ef1889f0ad4d14a77e8adbe5014ad9 kostenfrei https://www.mdpi.com/1999-4923/12/3/291 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 3, p 291
spelling	10.3390/pharmaceutics12030291 doi (DE-627)DOAJ079033148 (DE-599)DOAJ45ef1889f0ad4d14a77e8adbe5014ad9 DE-627 ger DE-627 rakwb eng RS1-441 Tien-Pei Fang verfasserin aut Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We aimed to quantify Soft Mist Inhalers (SMI) delivery to spontaneous breathing model and compare with different adapters via endotracheal tube during mechanical ventilation or by manual resuscitation. A tiotropium SMI was used with a commercial in-line adapter and a T-adapter placed between the Y-adapter and the inspiratory limb of the ventilator circuit during mechanical ventilation. The SMI was actuated at the beginning of inspiration and expiration. In separate experiments, a manual resuscitator with T-adapter was attached to endotracheal tube, collecting filter, and a passive test lung. Drug was eluted from collecting filters with salt-based solvent and analyzed using high-performance liquid chromatography. Results showed the percent of SMI label dose inhaled was 3-fold higher with the commercial in-line adapter with actuation during expiration than when synchronized with inspiration. SMI with T-adapter delivery via ventilator was similar to inhalation (1.20%) or exhalation (1.02%), and both had lower delivery dose than with manual resuscitator (2.80%; <i<p</i< = 0.01). The inhaled dose via endotracheal tube was much lower than inhaled dose with spontaneous breathing (22.08%). In conclusion, the inhaled dose with the commercial adapter was higher with SMI actuated during expiration, but still far less than reported spontaneous inhaled dose. soft mist inhaler mechanical ventilation adapter inhaled dose in vitro Pharmacy and materia medica Yu-Ju Chen verfasserin aut Tsung-Ming Yang verfasserin aut Szu-Hu Wang verfasserin aut Ming-Szu Hung verfasserin aut Shu-Hua Chiu verfasserin aut Hsin-Hsien Li verfasserin aut James B. Fink verfasserin aut Hui-Ling Lin verfasserin aut In Pharmaceutics MDPI AG, 2010 12(2020), 3, p 291 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:12 year:2020 number:3, p 291 https://doi.org/10.3390/pharmaceutics12030291 kostenfrei https://doaj.org/article/45ef1889f0ad4d14a77e8adbe5014ad9 kostenfrei https://www.mdpi.com/1999-4923/12/3/291 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 3, p 291
allfields_unstemmed	10.3390/pharmaceutics12030291 doi (DE-627)DOAJ079033148 (DE-599)DOAJ45ef1889f0ad4d14a77e8adbe5014ad9 DE-627 ger DE-627 rakwb eng RS1-441 Tien-Pei Fang verfasserin aut Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We aimed to quantify Soft Mist Inhalers (SMI) delivery to spontaneous breathing model and compare with different adapters via endotracheal tube during mechanical ventilation or by manual resuscitation. A tiotropium SMI was used with a commercial in-line adapter and a T-adapter placed between the Y-adapter and the inspiratory limb of the ventilator circuit during mechanical ventilation. The SMI was actuated at the beginning of inspiration and expiration. In separate experiments, a manual resuscitator with T-adapter was attached to endotracheal tube, collecting filter, and a passive test lung. Drug was eluted from collecting filters with salt-based solvent and analyzed using high-performance liquid chromatography. Results showed the percent of SMI label dose inhaled was 3-fold higher with the commercial in-line adapter with actuation during expiration than when synchronized with inspiration. SMI with T-adapter delivery via ventilator was similar to inhalation (1.20%) or exhalation (1.02%), and both had lower delivery dose than with manual resuscitator (2.80%; <i<p</i< = 0.01). The inhaled dose via endotracheal tube was much lower than inhaled dose with spontaneous breathing (22.08%). In conclusion, the inhaled dose with the commercial adapter was higher with SMI actuated during expiration, but still far less than reported spontaneous inhaled dose. soft mist inhaler mechanical ventilation adapter inhaled dose in vitro Pharmacy and materia medica Yu-Ju Chen verfasserin aut Tsung-Ming Yang verfasserin aut Szu-Hu Wang verfasserin aut Ming-Szu Hung verfasserin aut Shu-Hua Chiu verfasserin aut Hsin-Hsien Li verfasserin aut James B. Fink verfasserin aut Hui-Ling Lin verfasserin aut In Pharmaceutics MDPI AG, 2010 12(2020), 3, p 291 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:12 year:2020 number:3, p 291 https://doi.org/10.3390/pharmaceutics12030291 kostenfrei https://doaj.org/article/45ef1889f0ad4d14a77e8adbe5014ad9 kostenfrei https://www.mdpi.com/1999-4923/12/3/291 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 3, p 291
allfieldsGer	10.3390/pharmaceutics12030291 doi (DE-627)DOAJ079033148 (DE-599)DOAJ45ef1889f0ad4d14a77e8adbe5014ad9 DE-627 ger DE-627 rakwb eng RS1-441 Tien-Pei Fang verfasserin aut Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We aimed to quantify Soft Mist Inhalers (SMI) delivery to spontaneous breathing model and compare with different adapters via endotracheal tube during mechanical ventilation or by manual resuscitation. A tiotropium SMI was used with a commercial in-line adapter and a T-adapter placed between the Y-adapter and the inspiratory limb of the ventilator circuit during mechanical ventilation. The SMI was actuated at the beginning of inspiration and expiration. In separate experiments, a manual resuscitator with T-adapter was attached to endotracheal tube, collecting filter, and a passive test lung. Drug was eluted from collecting filters with salt-based solvent and analyzed using high-performance liquid chromatography. Results showed the percent of SMI label dose inhaled was 3-fold higher with the commercial in-line adapter with actuation during expiration than when synchronized with inspiration. SMI with T-adapter delivery via ventilator was similar to inhalation (1.20%) or exhalation (1.02%), and both had lower delivery dose than with manual resuscitator (2.80%; <i<p</i< = 0.01). The inhaled dose via endotracheal tube was much lower than inhaled dose with spontaneous breathing (22.08%). In conclusion, the inhaled dose with the commercial adapter was higher with SMI actuated during expiration, but still far less than reported spontaneous inhaled dose. soft mist inhaler mechanical ventilation adapter inhaled dose in vitro Pharmacy and materia medica Yu-Ju Chen verfasserin aut Tsung-Ming Yang verfasserin aut Szu-Hu Wang verfasserin aut Ming-Szu Hung verfasserin aut Shu-Hua Chiu verfasserin aut Hsin-Hsien Li verfasserin aut James B. Fink verfasserin aut Hui-Ling Lin verfasserin aut In Pharmaceutics MDPI AG, 2010 12(2020), 3, p 291 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:12 year:2020 number:3, p 291 https://doi.org/10.3390/pharmaceutics12030291 kostenfrei https://doaj.org/article/45ef1889f0ad4d14a77e8adbe5014ad9 kostenfrei https://www.mdpi.com/1999-4923/12/3/291 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 3, p 291
allfieldsSound	10.3390/pharmaceutics12030291 doi (DE-627)DOAJ079033148 (DE-599)DOAJ45ef1889f0ad4d14a77e8adbe5014ad9 DE-627 ger DE-627 rakwb eng RS1-441 Tien-Pei Fang verfasserin aut Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier We aimed to quantify Soft Mist Inhalers (SMI) delivery to spontaneous breathing model and compare with different adapters via endotracheal tube during mechanical ventilation or by manual resuscitation. A tiotropium SMI was used with a commercial in-line adapter and a T-adapter placed between the Y-adapter and the inspiratory limb of the ventilator circuit during mechanical ventilation. The SMI was actuated at the beginning of inspiration and expiration. In separate experiments, a manual resuscitator with T-adapter was attached to endotracheal tube, collecting filter, and a passive test lung. Drug was eluted from collecting filters with salt-based solvent and analyzed using high-performance liquid chromatography. Results showed the percent of SMI label dose inhaled was 3-fold higher with the commercial in-line adapter with actuation during expiration than when synchronized with inspiration. SMI with T-adapter delivery via ventilator was similar to inhalation (1.20%) or exhalation (1.02%), and both had lower delivery dose than with manual resuscitator (2.80%; <i<p</i< = 0.01). The inhaled dose via endotracheal tube was much lower than inhaled dose with spontaneous breathing (22.08%). In conclusion, the inhaled dose with the commercial adapter was higher with SMI actuated during expiration, but still far less than reported spontaneous inhaled dose. soft mist inhaler mechanical ventilation adapter inhaled dose in vitro Pharmacy and materia medica Yu-Ju Chen verfasserin aut Tsung-Ming Yang verfasserin aut Szu-Hu Wang verfasserin aut Ming-Szu Hung verfasserin aut Shu-Hua Chiu verfasserin aut Hsin-Hsien Li verfasserin aut James B. Fink verfasserin aut Hui-Ling Lin verfasserin aut In Pharmaceutics MDPI AG, 2010 12(2020), 3, p 291 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:12 year:2020 number:3, p 291 https://doi.org/10.3390/pharmaceutics12030291 kostenfrei https://doaj.org/article/45ef1889f0ad4d14a77e8adbe5014ad9 kostenfrei https://www.mdpi.com/1999-4923/12/3/291 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2020 3, p 291
language	English
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authorswithroles_txt_mv	Tien-Pei Fang @@aut@@ Yu-Ju Chen @@aut@@ Tsung-Ming Yang @@aut@@ Szu-Hu Wang @@aut@@ Ming-Szu Hung @@aut@@ Shu-Hua Chiu @@aut@@ Hsin-Hsien Li @@aut@@ James B. Fink @@aut@@ Hui-Ling Lin @@aut@@
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callnumber-first	R - Medicine
author	Tien-Pei Fang
spellingShingle	Tien-Pei Fang misc RS1-441 misc soft mist inhaler misc mechanical ventilation misc adapter misc inhaled dose misc in vitro misc Pharmacy and materia medica Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study
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topic_title	RS1-441 Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study soft mist inhaler mechanical ventilation adapter inhaled dose in vitro
topic	misc RS1-441 misc soft mist inhaler misc mechanical ventilation misc adapter misc inhaled dose misc in vitro misc Pharmacy and materia medica
topic_unstemmed	misc RS1-441 misc soft mist inhaler misc mechanical ventilation misc adapter misc inhaled dose misc in vitro misc Pharmacy and materia medica
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title	Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study
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title_full	Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study
author_sort	Tien-Pei Fang
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author_browse	Tien-Pei Fang Yu-Ju Chen Tsung-Ming Yang Szu-Hu Wang Ming-Szu Hung Shu-Hua Chiu Hsin-Hsien Li James B. Fink Hui-Ling Lin
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doi_str_mv	10.3390/pharmaceutics12030291
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title_sort	optimal connection for tiotropium smi delivery through mechanical ventilation: an in vitro study
callnumber	RS1-441
title_auth	Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study
abstract	We aimed to quantify Soft Mist Inhalers (SMI) delivery to spontaneous breathing model and compare with different adapters via endotracheal tube during mechanical ventilation or by manual resuscitation. A tiotropium SMI was used with a commercial in-line adapter and a T-adapter placed between the Y-adapter and the inspiratory limb of the ventilator circuit during mechanical ventilation. The SMI was actuated at the beginning of inspiration and expiration. In separate experiments, a manual resuscitator with T-adapter was attached to endotracheal tube, collecting filter, and a passive test lung. Drug was eluted from collecting filters with salt-based solvent and analyzed using high-performance liquid chromatography. Results showed the percent of SMI label dose inhaled was 3-fold higher with the commercial in-line adapter with actuation during expiration than when synchronized with inspiration. SMI with T-adapter delivery via ventilator was similar to inhalation (1.20%) or exhalation (1.02%), and both had lower delivery dose than with manual resuscitator (2.80%; <i<p</i< = 0.01). The inhaled dose via endotracheal tube was much lower than inhaled dose with spontaneous breathing (22.08%). In conclusion, the inhaled dose with the commercial adapter was higher with SMI actuated during expiration, but still far less than reported spontaneous inhaled dose.
abstractGer	We aimed to quantify Soft Mist Inhalers (SMI) delivery to spontaneous breathing model and compare with different adapters via endotracheal tube during mechanical ventilation or by manual resuscitation. A tiotropium SMI was used with a commercial in-line adapter and a T-adapter placed between the Y-adapter and the inspiratory limb of the ventilator circuit during mechanical ventilation. The SMI was actuated at the beginning of inspiration and expiration. In separate experiments, a manual resuscitator with T-adapter was attached to endotracheal tube, collecting filter, and a passive test lung. Drug was eluted from collecting filters with salt-based solvent and analyzed using high-performance liquid chromatography. Results showed the percent of SMI label dose inhaled was 3-fold higher with the commercial in-line adapter with actuation during expiration than when synchronized with inspiration. SMI with T-adapter delivery via ventilator was similar to inhalation (1.20%) or exhalation (1.02%), and both had lower delivery dose than with manual resuscitator (2.80%; <i<p</i< = 0.01). The inhaled dose via endotracheal tube was much lower than inhaled dose with spontaneous breathing (22.08%). In conclusion, the inhaled dose with the commercial adapter was higher with SMI actuated during expiration, but still far less than reported spontaneous inhaled dose.
abstract_unstemmed	We aimed to quantify Soft Mist Inhalers (SMI) delivery to spontaneous breathing model and compare with different adapters via endotracheal tube during mechanical ventilation or by manual resuscitation. A tiotropium SMI was used with a commercial in-line adapter and a T-adapter placed between the Y-adapter and the inspiratory limb of the ventilator circuit during mechanical ventilation. The SMI was actuated at the beginning of inspiration and expiration. In separate experiments, a manual resuscitator with T-adapter was attached to endotracheal tube, collecting filter, and a passive test lung. Drug was eluted from collecting filters with salt-based solvent and analyzed using high-performance liquid chromatography. Results showed the percent of SMI label dose inhaled was 3-fold higher with the commercial in-line adapter with actuation during expiration than when synchronized with inspiration. SMI with T-adapter delivery via ventilator was similar to inhalation (1.20%) or exhalation (1.02%), and both had lower delivery dose than with manual resuscitator (2.80%; <i<p</i< = 0.01). The inhaled dose via endotracheal tube was much lower than inhaled dose with spontaneous breathing (22.08%). In conclusion, the inhaled dose with the commercial adapter was higher with SMI actuated during expiration, but still far less than reported spontaneous inhaled dose.
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container_issue	3, p 291
title_short	Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study
url	https://doi.org/10.3390/pharmaceutics12030291 https://doaj.org/article/45ef1889f0ad4d14a77e8adbe5014ad9 https://www.mdpi.com/1999-4923/12/3/291 https://doaj.org/toc/1999-4923
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author2	Yu-Ju Chen Tsung-Ming Yang Szu-Hu Wang Ming-Szu Hung Shu-Hua Chiu Hsin-Hsien Li James B. Fink Hui-Ling Lin
author2Str	Yu-Ju Chen Tsung-Ming Yang Szu-Hu Wang Ming-Szu Hung Shu-Hua Chiu Hsin-Hsien Li James B. Fink Hui-Ling Lin
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up_date	2024-07-03T21:19:24.055Z
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A tiotropium SMI was used with a commercial in-line adapter and a T-adapter placed between the Y-adapter and the inspiratory limb of the ventilator circuit during mechanical ventilation. The SMI was actuated at the beginning of inspiration and expiration. In separate experiments, a manual resuscitator with T-adapter was attached to endotracheal tube, collecting filter, and a passive test lung. Drug was eluted from collecting filters with salt-based solvent and analyzed using high-performance liquid chromatography. Results showed the percent of SMI label dose inhaled was 3-fold higher with the commercial in-line adapter with actuation during expiration than when synchronized with inspiration. SMI with T-adapter delivery via ventilator was similar to inhalation (1.20%) or exhalation (1.02%), and both had lower delivery dose than with manual resuscitator (2.80%; <i<p</i< = 0.01). The inhaled dose via endotracheal tube was much lower than inhaled dose with spontaneous breathing (22.08%). 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Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study

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