Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells

Porcine circovirus type 2 (PCV2) can cause severe disease in infected pigs, resulting in massive economic loss for the swine industry. Transcriptomic and proteomic approaches have been widely employed to identify the underlying molecular mechanisms of the PCV2 infection. Numerous differentially expr...
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Autor*in:	Jin He [verfasserIn] Chaoliang Leng [verfasserIn] Jiazhen Pan [verfasserIn] Aoqi Li [verfasserIn] Hua Zhang [verfasserIn] Feng Cong [verfasserIn] Huanan Wang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	PCV2 lncRNA pig RNA-seq

Übergeordnetes Werk:	In: Pathogens - MDPI AG, 2012, 9(2020), 6, p 479
Übergeordnetes Werk:	volume:9 ; year:2020 ; number:6, p 479

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/pathogens9060479

Katalog-ID:	DOAJ079061613

Internformat


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520			\|a Porcine circovirus type 2 (PCV2) can cause severe disease in infected pigs, resulting in massive economic loss for the swine industry. Transcriptomic and proteomic approaches have been widely employed to identify the underlying molecular mechanisms of the PCV2 infection. Numerous differentially expressed mRNAs, miRNAs, and proteins, together with their associated signaling pathways, have been identified during PCV2 infection, paving the way for analysis of their biological functions. Long noncoding RNAs (lncRNAs) are important regulators of multiple biological processes. However, little is known regarding their role in the PCV2 infection. Hence, in our study, RNA-seq was performed by infecting PK-15 cells with PCV2. Analysis of the differentially expressed genes (DEGs) suggested that the cytoskeleton, apoptosis, cell division, and protein phosphorylation were significantly disturbed. Then, using stringent parameters, six lncRNAs were identified. Additionally, potential targets of the lncRNAs were predicted using both cis- and trans-prediction methods. Interestingly, we found that the <i<HOXB</i< (Homeobox <i<B</i<) gene cluster was probably the target of the lncRNA <i<LOC106505099</i<. Enrichment analysis of the target genes showed that numerous developmental processes were altered during PCV2 infection. Therefore, our study revealed that lncRNAs might affect porcine embryonic development through the regulation of the <i<HOXB</i< genes.
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allfields	10.3390/pathogens9060479 doi (DE-627)DOAJ079061613 (DE-599)DOAJ67b99c6b506c43639fcf9ca7afb4ecfb DE-627 ger DE-627 rakwb eng Jin He verfasserin aut Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Porcine circovirus type 2 (PCV2) can cause severe disease in infected pigs, resulting in massive economic loss for the swine industry. Transcriptomic and proteomic approaches have been widely employed to identify the underlying molecular mechanisms of the PCV2 infection. Numerous differentially expressed mRNAs, miRNAs, and proteins, together with their associated signaling pathways, have been identified during PCV2 infection, paving the way for analysis of their biological functions. Long noncoding RNAs (lncRNAs) are important regulators of multiple biological processes. However, little is known regarding their role in the PCV2 infection. Hence, in our study, RNA-seq was performed by infecting PK-15 cells with PCV2. Analysis of the differentially expressed genes (DEGs) suggested that the cytoskeleton, apoptosis, cell division, and protein phosphorylation were significantly disturbed. Then, using stringent parameters, six lncRNAs were identified. Additionally, potential targets of the lncRNAs were predicted using both cis- and trans-prediction methods. Interestingly, we found that the <i<HOXB</i< (Homeobox <i<B</i<) gene cluster was probably the target of the lncRNA <i<LOC106505099</i<. Enrichment analysis of the target genes showed that numerous developmental processes were altered during PCV2 infection. Therefore, our study revealed that lncRNAs might affect porcine embryonic development through the regulation of the <i<HOXB</i< genes. PCV2 lncRNA pig RNA-seq Medicine R Chaoliang Leng verfasserin aut Jiazhen Pan verfasserin aut Aoqi Li verfasserin aut Hua Zhang verfasserin aut Feng Cong verfasserin aut Huanan Wang verfasserin aut In Pathogens MDPI AG, 2012 9(2020), 6, p 479 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:9 year:2020 number:6, p 479 https://doi.org/10.3390/pathogens9060479 kostenfrei https://doaj.org/article/67b99c6b506c43639fcf9ca7afb4ecfb kostenfrei https://www.mdpi.com/2076-0817/9/6/479 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 6, p 479
spelling	10.3390/pathogens9060479 doi (DE-627)DOAJ079061613 (DE-599)DOAJ67b99c6b506c43639fcf9ca7afb4ecfb DE-627 ger DE-627 rakwb eng Jin He verfasserin aut Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Porcine circovirus type 2 (PCV2) can cause severe disease in infected pigs, resulting in massive economic loss for the swine industry. Transcriptomic and proteomic approaches have been widely employed to identify the underlying molecular mechanisms of the PCV2 infection. Numerous differentially expressed mRNAs, miRNAs, and proteins, together with their associated signaling pathways, have been identified during PCV2 infection, paving the way for analysis of their biological functions. Long noncoding RNAs (lncRNAs) are important regulators of multiple biological processes. However, little is known regarding their role in the PCV2 infection. Hence, in our study, RNA-seq was performed by infecting PK-15 cells with PCV2. Analysis of the differentially expressed genes (DEGs) suggested that the cytoskeleton, apoptosis, cell division, and protein phosphorylation were significantly disturbed. Then, using stringent parameters, six lncRNAs were identified. Additionally, potential targets of the lncRNAs were predicted using both cis- and trans-prediction methods. Interestingly, we found that the <i<HOXB</i< (Homeobox <i<B</i<) gene cluster was probably the target of the lncRNA <i<LOC106505099</i<. Enrichment analysis of the target genes showed that numerous developmental processes were altered during PCV2 infection. Therefore, our study revealed that lncRNAs might affect porcine embryonic development through the regulation of the <i<HOXB</i< genes. PCV2 lncRNA pig RNA-seq Medicine R Chaoliang Leng verfasserin aut Jiazhen Pan verfasserin aut Aoqi Li verfasserin aut Hua Zhang verfasserin aut Feng Cong verfasserin aut Huanan Wang verfasserin aut In Pathogens MDPI AG, 2012 9(2020), 6, p 479 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:9 year:2020 number:6, p 479 https://doi.org/10.3390/pathogens9060479 kostenfrei https://doaj.org/article/67b99c6b506c43639fcf9ca7afb4ecfb kostenfrei https://www.mdpi.com/2076-0817/9/6/479 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 6, p 479
allfields_unstemmed	10.3390/pathogens9060479 doi (DE-627)DOAJ079061613 (DE-599)DOAJ67b99c6b506c43639fcf9ca7afb4ecfb DE-627 ger DE-627 rakwb eng Jin He verfasserin aut Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Porcine circovirus type 2 (PCV2) can cause severe disease in infected pigs, resulting in massive economic loss for the swine industry. Transcriptomic and proteomic approaches have been widely employed to identify the underlying molecular mechanisms of the PCV2 infection. Numerous differentially expressed mRNAs, miRNAs, and proteins, together with their associated signaling pathways, have been identified during PCV2 infection, paving the way for analysis of their biological functions. Long noncoding RNAs (lncRNAs) are important regulators of multiple biological processes. However, little is known regarding their role in the PCV2 infection. Hence, in our study, RNA-seq was performed by infecting PK-15 cells with PCV2. Analysis of the differentially expressed genes (DEGs) suggested that the cytoskeleton, apoptosis, cell division, and protein phosphorylation were significantly disturbed. Then, using stringent parameters, six lncRNAs were identified. Additionally, potential targets of the lncRNAs were predicted using both cis- and trans-prediction methods. Interestingly, we found that the <i<HOXB</i< (Homeobox <i<B</i<) gene cluster was probably the target of the lncRNA <i<LOC106505099</i<. Enrichment analysis of the target genes showed that numerous developmental processes were altered during PCV2 infection. Therefore, our study revealed that lncRNAs might affect porcine embryonic development through the regulation of the <i<HOXB</i< genes. PCV2 lncRNA pig RNA-seq Medicine R Chaoliang Leng verfasserin aut Jiazhen Pan verfasserin aut Aoqi Li verfasserin aut Hua Zhang verfasserin aut Feng Cong verfasserin aut Huanan Wang verfasserin aut In Pathogens MDPI AG, 2012 9(2020), 6, p 479 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:9 year:2020 number:6, p 479 https://doi.org/10.3390/pathogens9060479 kostenfrei https://doaj.org/article/67b99c6b506c43639fcf9ca7afb4ecfb kostenfrei https://www.mdpi.com/2076-0817/9/6/479 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 6, p 479
allfieldsGer	10.3390/pathogens9060479 doi (DE-627)DOAJ079061613 (DE-599)DOAJ67b99c6b506c43639fcf9ca7afb4ecfb DE-627 ger DE-627 rakwb eng Jin He verfasserin aut Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Porcine circovirus type 2 (PCV2) can cause severe disease in infected pigs, resulting in massive economic loss for the swine industry. Transcriptomic and proteomic approaches have been widely employed to identify the underlying molecular mechanisms of the PCV2 infection. Numerous differentially expressed mRNAs, miRNAs, and proteins, together with their associated signaling pathways, have been identified during PCV2 infection, paving the way for analysis of their biological functions. Long noncoding RNAs (lncRNAs) are important regulators of multiple biological processes. However, little is known regarding their role in the PCV2 infection. Hence, in our study, RNA-seq was performed by infecting PK-15 cells with PCV2. Analysis of the differentially expressed genes (DEGs) suggested that the cytoskeleton, apoptosis, cell division, and protein phosphorylation were significantly disturbed. Then, using stringent parameters, six lncRNAs were identified. Additionally, potential targets of the lncRNAs were predicted using both cis- and trans-prediction methods. Interestingly, we found that the <i<HOXB</i< (Homeobox <i<B</i<) gene cluster was probably the target of the lncRNA <i<LOC106505099</i<. Enrichment analysis of the target genes showed that numerous developmental processes were altered during PCV2 infection. Therefore, our study revealed that lncRNAs might affect porcine embryonic development through the regulation of the <i<HOXB</i< genes. PCV2 lncRNA pig RNA-seq Medicine R Chaoliang Leng verfasserin aut Jiazhen Pan verfasserin aut Aoqi Li verfasserin aut Hua Zhang verfasserin aut Feng Cong verfasserin aut Huanan Wang verfasserin aut In Pathogens MDPI AG, 2012 9(2020), 6, p 479 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:9 year:2020 number:6, p 479 https://doi.org/10.3390/pathogens9060479 kostenfrei https://doaj.org/article/67b99c6b506c43639fcf9ca7afb4ecfb kostenfrei https://www.mdpi.com/2076-0817/9/6/479 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 6, p 479
allfieldsSound	10.3390/pathogens9060479 doi (DE-627)DOAJ079061613 (DE-599)DOAJ67b99c6b506c43639fcf9ca7afb4ecfb DE-627 ger DE-627 rakwb eng Jin He verfasserin aut Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Porcine circovirus type 2 (PCV2) can cause severe disease in infected pigs, resulting in massive economic loss for the swine industry. Transcriptomic and proteomic approaches have been widely employed to identify the underlying molecular mechanisms of the PCV2 infection. Numerous differentially expressed mRNAs, miRNAs, and proteins, together with their associated signaling pathways, have been identified during PCV2 infection, paving the way for analysis of their biological functions. Long noncoding RNAs (lncRNAs) are important regulators of multiple biological processes. However, little is known regarding their role in the PCV2 infection. Hence, in our study, RNA-seq was performed by infecting PK-15 cells with PCV2. Analysis of the differentially expressed genes (DEGs) suggested that the cytoskeleton, apoptosis, cell division, and protein phosphorylation were significantly disturbed. Then, using stringent parameters, six lncRNAs were identified. Additionally, potential targets of the lncRNAs were predicted using both cis- and trans-prediction methods. Interestingly, we found that the <i<HOXB</i< (Homeobox <i<B</i<) gene cluster was probably the target of the lncRNA <i<LOC106505099</i<. Enrichment analysis of the target genes showed that numerous developmental processes were altered during PCV2 infection. Therefore, our study revealed that lncRNAs might affect porcine embryonic development through the regulation of the <i<HOXB</i< genes. PCV2 lncRNA pig RNA-seq Medicine R Chaoliang Leng verfasserin aut Jiazhen Pan verfasserin aut Aoqi Li verfasserin aut Hua Zhang verfasserin aut Feng Cong verfasserin aut Huanan Wang verfasserin aut In Pathogens MDPI AG, 2012 9(2020), 6, p 479 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:9 year:2020 number:6, p 479 https://doi.org/10.3390/pathogens9060479 kostenfrei https://doaj.org/article/67b99c6b506c43639fcf9ca7afb4ecfb kostenfrei https://www.mdpi.com/2076-0817/9/6/479 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2020 6, p 479
language	English
source	In Pathogens 9(2020), 6, p 479 volume:9 year:2020 number:6, p 479
sourceStr	In Pathogens 9(2020), 6, p 479 volume:9 year:2020 number:6, p 479
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	PCV2 lncRNA pig RNA-seq Medicine R
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container_title	Pathogens
authorswithroles_txt_mv	Jin He @@aut@@ Chaoliang Leng @@aut@@ Jiazhen Pan @@aut@@ Aoqi Li @@aut@@ Hua Zhang @@aut@@ Feng Cong @@aut@@ Huanan Wang @@aut@@
publishDateDaySort_date	2020-01-01T00:00:00Z
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author	Jin He
spellingShingle	Jin He misc PCV2 misc lncRNA misc pig misc RNA-seq misc Medicine misc R Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells
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topic_title	Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells PCV2 lncRNA pig RNA-seq
topic	misc PCV2 misc lncRNA misc pig misc RNA-seq misc Medicine misc R
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title	Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells
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title_full	Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells
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author_browse	Jin He Chaoliang Leng Jiazhen Pan Aoqi Li Hua Zhang Feng Cong Huanan Wang
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title_sort	identification of lncrnas involved in pcv2 infection of pk-15 cells
title_auth	Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells
abstract	Porcine circovirus type 2 (PCV2) can cause severe disease in infected pigs, resulting in massive economic loss for the swine industry. Transcriptomic and proteomic approaches have been widely employed to identify the underlying molecular mechanisms of the PCV2 infection. Numerous differentially expressed mRNAs, miRNAs, and proteins, together with their associated signaling pathways, have been identified during PCV2 infection, paving the way for analysis of their biological functions. Long noncoding RNAs (lncRNAs) are important regulators of multiple biological processes. However, little is known regarding their role in the PCV2 infection. Hence, in our study, RNA-seq was performed by infecting PK-15 cells with PCV2. Analysis of the differentially expressed genes (DEGs) suggested that the cytoskeleton, apoptosis, cell division, and protein phosphorylation were significantly disturbed. Then, using stringent parameters, six lncRNAs were identified. Additionally, potential targets of the lncRNAs were predicted using both cis- and trans-prediction methods. Interestingly, we found that the <i<HOXB</i< (Homeobox <i<B</i<) gene cluster was probably the target of the lncRNA <i<LOC106505099</i<. Enrichment analysis of the target genes showed that numerous developmental processes were altered during PCV2 infection. Therefore, our study revealed that lncRNAs might affect porcine embryonic development through the regulation of the <i<HOXB</i< genes.
abstractGer	Porcine circovirus type 2 (PCV2) can cause severe disease in infected pigs, resulting in massive economic loss for the swine industry. Transcriptomic and proteomic approaches have been widely employed to identify the underlying molecular mechanisms of the PCV2 infection. Numerous differentially expressed mRNAs, miRNAs, and proteins, together with their associated signaling pathways, have been identified during PCV2 infection, paving the way for analysis of their biological functions. Long noncoding RNAs (lncRNAs) are important regulators of multiple biological processes. However, little is known regarding their role in the PCV2 infection. Hence, in our study, RNA-seq was performed by infecting PK-15 cells with PCV2. Analysis of the differentially expressed genes (DEGs) suggested that the cytoskeleton, apoptosis, cell division, and protein phosphorylation were significantly disturbed. Then, using stringent parameters, six lncRNAs were identified. Additionally, potential targets of the lncRNAs were predicted using both cis- and trans-prediction methods. Interestingly, we found that the <i<HOXB</i< (Homeobox <i<B</i<) gene cluster was probably the target of the lncRNA <i<LOC106505099</i<. Enrichment analysis of the target genes showed that numerous developmental processes were altered during PCV2 infection. Therefore, our study revealed that lncRNAs might affect porcine embryonic development through the regulation of the <i<HOXB</i< genes.
abstract_unstemmed	Porcine circovirus type 2 (PCV2) can cause severe disease in infected pigs, resulting in massive economic loss for the swine industry. Transcriptomic and proteomic approaches have been widely employed to identify the underlying molecular mechanisms of the PCV2 infection. Numerous differentially expressed mRNAs, miRNAs, and proteins, together with their associated signaling pathways, have been identified during PCV2 infection, paving the way for analysis of their biological functions. Long noncoding RNAs (lncRNAs) are important regulators of multiple biological processes. However, little is known regarding their role in the PCV2 infection. Hence, in our study, RNA-seq was performed by infecting PK-15 cells with PCV2. Analysis of the differentially expressed genes (DEGs) suggested that the cytoskeleton, apoptosis, cell division, and protein phosphorylation were significantly disturbed. Then, using stringent parameters, six lncRNAs were identified. Additionally, potential targets of the lncRNAs were predicted using both cis- and trans-prediction methods. Interestingly, we found that the <i<HOXB</i< (Homeobox <i<B</i<) gene cluster was probably the target of the lncRNA <i<LOC106505099</i<. Enrichment analysis of the target genes showed that numerous developmental processes were altered during PCV2 infection. Therefore, our study revealed that lncRNAs might affect porcine embryonic development through the regulation of the <i<HOXB</i< genes.
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title_short	Identification of lncRNAs Involved in PCV2 Infection of PK-15 Cells
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