The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome

Background: A proportion of twin-twin transfusion syndrome (TTTS) patients may have elevated liver enzymes (ELEzs) before fetoscopic laser therapy, but the incidence of ELEzs before laser therapy and the association with the perinatal outcomes after laser therapy remain unclear. Methods: From Octobe...
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Autor*in:	Yao-Lung Chang [verfasserIn] An-Shine Chao [verfasserIn] Shuenn-Dyh Chang [verfasserIn] Tzu-Hao Wang [verfasserIn] Po-Jen Cheng [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Übergeordnetes Werk:	In: Biomedical Journal - Elsevier, 2013, 42(2019), 6, Seite 417-421
Übergeordnetes Werk:	volume:42 ; year:2019 ; number:6 ; pages:417-421

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1016/j.bj.2019.05.006

Katalog-ID:	DOAJ079231403

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520			\|a Background: A proportion of twin-twin transfusion syndrome (TTTS) patients may have elevated liver enzymes (ELEzs) before fetoscopic laser therapy, but the incidence of ELEzs before laser therapy and the association with the perinatal outcomes after laser therapy remain unclear. Methods: From October 2008 to April 2015, 93 patients with TTTS who received fetoscopic laser therapy at our hospital were included in this study, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured within 24 h before therapy. If ELEzs (AST < 34 U/L or ALT < 36 U/L) were observed before therapy, the AST and ALT levels were evaluated within 24 h after therapy. The pre-operative characteristics and post-therapy outcomes were compared between patients with and without ELEzs. Results: Among 93 TTTS patients before laser operation, 18 patients (were found with ELEzs (19.4%) before laser therapy. In 17 (94.4%) of the 18 cases, their liver enzymes values dropped after laser surgery. Maternal body mass index, age, gestational age of laser therapy, hemoglobin level before laser therapy and survival rates after laser therapy were not significantly different between TTTS with and without ELEzs. The maternal hemoglobin dropped significantly from 10.8 [1.6] g/dL before surgery to 9.6 [1.5] g/dL after laser therapy in TTTS with ELEzs (p < 0.001). Conclusion: An elevated liver enzyme was not associated with poor perinatal outcomes in patients with TTTS after laser therapy. The authors suspected that the reduced liver enzymes values after laser therapy could partly arise from the hemo-dilution effect. Keywords: Twin-twin transfusion syndrome (TTTS), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Liver enzyme, Fetoscopic laser therapy, Neonatal outcomes
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allfields	10.1016/j.bj.2019.05.006 doi (DE-627)DOAJ079231403 (DE-599)DOAJed4dc170eefa4fd99e445ed4c3ffbff7 DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Yao-Lung Chang verfasserin aut The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: A proportion of twin-twin transfusion syndrome (TTTS) patients may have elevated liver enzymes (ELEzs) before fetoscopic laser therapy, but the incidence of ELEzs before laser therapy and the association with the perinatal outcomes after laser therapy remain unclear. Methods: From October 2008 to April 2015, 93 patients with TTTS who received fetoscopic laser therapy at our hospital were included in this study, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured within 24 h before therapy. If ELEzs (AST < 34 U/L or ALT < 36 U/L) were observed before therapy, the AST and ALT levels were evaluated within 24 h after therapy. The pre-operative characteristics and post-therapy outcomes were compared between patients with and without ELEzs. Results: Among 93 TTTS patients before laser operation, 18 patients (were found with ELEzs (19.4%) before laser therapy. In 17 (94.4%) of the 18 cases, their liver enzymes values dropped after laser surgery. Maternal body mass index, age, gestational age of laser therapy, hemoglobin level before laser therapy and survival rates after laser therapy were not significantly different between TTTS with and without ELEzs. The maternal hemoglobin dropped significantly from 10.8 [1.6] g/dL before surgery to 9.6 [1.5] g/dL after laser therapy in TTTS with ELEzs (p < 0.001). Conclusion: An elevated liver enzyme was not associated with poor perinatal outcomes in patients with TTTS after laser therapy. The authors suspected that the reduced liver enzymes values after laser therapy could partly arise from the hemo-dilution effect. Keywords: Twin-twin transfusion syndrome (TTTS), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Liver enzyme, Fetoscopic laser therapy, Neonatal outcomes Medicine (General) Biology (General) An-Shine Chao verfasserin aut Shuenn-Dyh Chang verfasserin aut Tzu-Hao Wang verfasserin aut Po-Jen Cheng verfasserin aut In Biomedical Journal Elsevier, 2013 42(2019), 6, Seite 417-421 (DE-627)734738153 (DE-600)2698541-X 23202890 nnns volume:42 year:2019 number:6 pages:417-421 https://doi.org/10.1016/j.bj.2019.05.006 kostenfrei https://doaj.org/article/ed4dc170eefa4fd99e445ed4c3ffbff7 kostenfrei http://www.sciencedirect.com/science/article/pii/S2319417018302579 kostenfrei https://doaj.org/toc/2319-4170 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2019 6 417-421
spelling	10.1016/j.bj.2019.05.006 doi (DE-627)DOAJ079231403 (DE-599)DOAJed4dc170eefa4fd99e445ed4c3ffbff7 DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Yao-Lung Chang verfasserin aut The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: A proportion of twin-twin transfusion syndrome (TTTS) patients may have elevated liver enzymes (ELEzs) before fetoscopic laser therapy, but the incidence of ELEzs before laser therapy and the association with the perinatal outcomes after laser therapy remain unclear. Methods: From October 2008 to April 2015, 93 patients with TTTS who received fetoscopic laser therapy at our hospital were included in this study, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured within 24 h before therapy. If ELEzs (AST < 34 U/L or ALT < 36 U/L) were observed before therapy, the AST and ALT levels were evaluated within 24 h after therapy. The pre-operative characteristics and post-therapy outcomes were compared between patients with and without ELEzs. Results: Among 93 TTTS patients before laser operation, 18 patients (were found with ELEzs (19.4%) before laser therapy. In 17 (94.4%) of the 18 cases, their liver enzymes values dropped after laser surgery. Maternal body mass index, age, gestational age of laser therapy, hemoglobin level before laser therapy and survival rates after laser therapy were not significantly different between TTTS with and without ELEzs. The maternal hemoglobin dropped significantly from 10.8 [1.6] g/dL before surgery to 9.6 [1.5] g/dL after laser therapy in TTTS with ELEzs (p < 0.001). Conclusion: An elevated liver enzyme was not associated with poor perinatal outcomes in patients with TTTS after laser therapy. The authors suspected that the reduced liver enzymes values after laser therapy could partly arise from the hemo-dilution effect. Keywords: Twin-twin transfusion syndrome (TTTS), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Liver enzyme, Fetoscopic laser therapy, Neonatal outcomes Medicine (General) Biology (General) An-Shine Chao verfasserin aut Shuenn-Dyh Chang verfasserin aut Tzu-Hao Wang verfasserin aut Po-Jen Cheng verfasserin aut In Biomedical Journal Elsevier, 2013 42(2019), 6, Seite 417-421 (DE-627)734738153 (DE-600)2698541-X 23202890 nnns volume:42 year:2019 number:6 pages:417-421 https://doi.org/10.1016/j.bj.2019.05.006 kostenfrei https://doaj.org/article/ed4dc170eefa4fd99e445ed4c3ffbff7 kostenfrei http://www.sciencedirect.com/science/article/pii/S2319417018302579 kostenfrei https://doaj.org/toc/2319-4170 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2019 6 417-421
allfields_unstemmed	10.1016/j.bj.2019.05.006 doi (DE-627)DOAJ079231403 (DE-599)DOAJed4dc170eefa4fd99e445ed4c3ffbff7 DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Yao-Lung Chang verfasserin aut The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: A proportion of twin-twin transfusion syndrome (TTTS) patients may have elevated liver enzymes (ELEzs) before fetoscopic laser therapy, but the incidence of ELEzs before laser therapy and the association with the perinatal outcomes after laser therapy remain unclear. Methods: From October 2008 to April 2015, 93 patients with TTTS who received fetoscopic laser therapy at our hospital were included in this study, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured within 24 h before therapy. If ELEzs (AST < 34 U/L or ALT < 36 U/L) were observed before therapy, the AST and ALT levels were evaluated within 24 h after therapy. The pre-operative characteristics and post-therapy outcomes were compared between patients with and without ELEzs. Results: Among 93 TTTS patients before laser operation, 18 patients (were found with ELEzs (19.4%) before laser therapy. In 17 (94.4%) of the 18 cases, their liver enzymes values dropped after laser surgery. Maternal body mass index, age, gestational age of laser therapy, hemoglobin level before laser therapy and survival rates after laser therapy were not significantly different between TTTS with and without ELEzs. The maternal hemoglobin dropped significantly from 10.8 [1.6] g/dL before surgery to 9.6 [1.5] g/dL after laser therapy in TTTS with ELEzs (p < 0.001). Conclusion: An elevated liver enzyme was not associated with poor perinatal outcomes in patients with TTTS after laser therapy. The authors suspected that the reduced liver enzymes values after laser therapy could partly arise from the hemo-dilution effect. Keywords: Twin-twin transfusion syndrome (TTTS), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Liver enzyme, Fetoscopic laser therapy, Neonatal outcomes Medicine (General) Biology (General) An-Shine Chao verfasserin aut Shuenn-Dyh Chang verfasserin aut Tzu-Hao Wang verfasserin aut Po-Jen Cheng verfasserin aut In Biomedical Journal Elsevier, 2013 42(2019), 6, Seite 417-421 (DE-627)734738153 (DE-600)2698541-X 23202890 nnns volume:42 year:2019 number:6 pages:417-421 https://doi.org/10.1016/j.bj.2019.05.006 kostenfrei https://doaj.org/article/ed4dc170eefa4fd99e445ed4c3ffbff7 kostenfrei http://www.sciencedirect.com/science/article/pii/S2319417018302579 kostenfrei https://doaj.org/toc/2319-4170 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2019 6 417-421
allfieldsGer	10.1016/j.bj.2019.05.006 doi (DE-627)DOAJ079231403 (DE-599)DOAJed4dc170eefa4fd99e445ed4c3ffbff7 DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Yao-Lung Chang verfasserin aut The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: A proportion of twin-twin transfusion syndrome (TTTS) patients may have elevated liver enzymes (ELEzs) before fetoscopic laser therapy, but the incidence of ELEzs before laser therapy and the association with the perinatal outcomes after laser therapy remain unclear. Methods: From October 2008 to April 2015, 93 patients with TTTS who received fetoscopic laser therapy at our hospital were included in this study, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured within 24 h before therapy. If ELEzs (AST < 34 U/L or ALT < 36 U/L) were observed before therapy, the AST and ALT levels were evaluated within 24 h after therapy. The pre-operative characteristics and post-therapy outcomes were compared between patients with and without ELEzs. Results: Among 93 TTTS patients before laser operation, 18 patients (were found with ELEzs (19.4%) before laser therapy. In 17 (94.4%) of the 18 cases, their liver enzymes values dropped after laser surgery. Maternal body mass index, age, gestational age of laser therapy, hemoglobin level before laser therapy and survival rates after laser therapy were not significantly different between TTTS with and without ELEzs. The maternal hemoglobin dropped significantly from 10.8 [1.6] g/dL before surgery to 9.6 [1.5] g/dL after laser therapy in TTTS with ELEzs (p < 0.001). Conclusion: An elevated liver enzyme was not associated with poor perinatal outcomes in patients with TTTS after laser therapy. The authors suspected that the reduced liver enzymes values after laser therapy could partly arise from the hemo-dilution effect. Keywords: Twin-twin transfusion syndrome (TTTS), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Liver enzyme, Fetoscopic laser therapy, Neonatal outcomes Medicine (General) Biology (General) An-Shine Chao verfasserin aut Shuenn-Dyh Chang verfasserin aut Tzu-Hao Wang verfasserin aut Po-Jen Cheng verfasserin aut In Biomedical Journal Elsevier, 2013 42(2019), 6, Seite 417-421 (DE-627)734738153 (DE-600)2698541-X 23202890 nnns volume:42 year:2019 number:6 pages:417-421 https://doi.org/10.1016/j.bj.2019.05.006 kostenfrei https://doaj.org/article/ed4dc170eefa4fd99e445ed4c3ffbff7 kostenfrei http://www.sciencedirect.com/science/article/pii/S2319417018302579 kostenfrei https://doaj.org/toc/2319-4170 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2019 6 417-421
allfieldsSound	10.1016/j.bj.2019.05.006 doi (DE-627)DOAJ079231403 (DE-599)DOAJed4dc170eefa4fd99e445ed4c3ffbff7 DE-627 ger DE-627 rakwb eng R5-920 QH301-705.5 Yao-Lung Chang verfasserin aut The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background: A proportion of twin-twin transfusion syndrome (TTTS) patients may have elevated liver enzymes (ELEzs) before fetoscopic laser therapy, but the incidence of ELEzs before laser therapy and the association with the perinatal outcomes after laser therapy remain unclear. Methods: From October 2008 to April 2015, 93 patients with TTTS who received fetoscopic laser therapy at our hospital were included in this study, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured within 24 h before therapy. If ELEzs (AST < 34 U/L or ALT < 36 U/L) were observed before therapy, the AST and ALT levels were evaluated within 24 h after therapy. The pre-operative characteristics and post-therapy outcomes were compared between patients with and without ELEzs. Results: Among 93 TTTS patients before laser operation, 18 patients (were found with ELEzs (19.4%) before laser therapy. In 17 (94.4%) of the 18 cases, their liver enzymes values dropped after laser surgery. Maternal body mass index, age, gestational age of laser therapy, hemoglobin level before laser therapy and survival rates after laser therapy were not significantly different between TTTS with and without ELEzs. The maternal hemoglobin dropped significantly from 10.8 [1.6] g/dL before surgery to 9.6 [1.5] g/dL after laser therapy in TTTS with ELEzs (p < 0.001). Conclusion: An elevated liver enzyme was not associated with poor perinatal outcomes in patients with TTTS after laser therapy. The authors suspected that the reduced liver enzymes values after laser therapy could partly arise from the hemo-dilution effect. Keywords: Twin-twin transfusion syndrome (TTTS), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Liver enzyme, Fetoscopic laser therapy, Neonatal outcomes Medicine (General) Biology (General) An-Shine Chao verfasserin aut Shuenn-Dyh Chang verfasserin aut Tzu-Hao Wang verfasserin aut Po-Jen Cheng verfasserin aut In Biomedical Journal Elsevier, 2013 42(2019), 6, Seite 417-421 (DE-627)734738153 (DE-600)2698541-X 23202890 nnns volume:42 year:2019 number:6 pages:417-421 https://doi.org/10.1016/j.bj.2019.05.006 kostenfrei https://doaj.org/article/ed4dc170eefa4fd99e445ed4c3ffbff7 kostenfrei http://www.sciencedirect.com/science/article/pii/S2319417018302579 kostenfrei https://doaj.org/toc/2319-4170 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2027 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 42 2019 6 417-421
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Methods: From October 2008 to April 2015, 93 patients with TTTS who received fetoscopic laser therapy at our hospital were included in this study, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured within 24 h before therapy. If ELEzs (AST < 34 U/L or ALT < 36 U/L) were observed before therapy, the AST and ALT levels were evaluated within 24 h after therapy. The pre-operative characteristics and post-therapy outcomes were compared between patients with and without ELEzs. Results: Among 93 TTTS patients before laser operation, 18 patients (were found with ELEzs (19.4%) before laser therapy. In 17 (94.4%) of the 18 cases, their liver enzymes values dropped after laser surgery. Maternal body mass index, age, gestational age of laser therapy, hemoglobin level before laser therapy and survival rates after laser therapy were not significantly different between TTTS with and without ELEzs. The maternal hemoglobin dropped significantly from 10.8 [1.6] g/dL before surgery to 9.6 [1.5] g/dL after laser therapy in TTTS with ELEzs (p < 0.001). Conclusion: An elevated liver enzyme was not associated with poor perinatal outcomes in patients with TTTS after laser therapy. The authors suspected that the reduced liver enzymes values after laser therapy could partly arise from the hemo-dilution effect. 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callnumber-first	R - Medicine
author	Yao-Lung Chang
spellingShingle	Yao-Lung Chang misc R5-920 misc QH301-705.5 misc Medicine (General) misc Biology (General) The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome
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topic_title	R5-920 QH301-705.5 The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome
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title	The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome
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title_full	The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome
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author_browse	Yao-Lung Chang An-Shine Chao Shuenn-Dyh Chang Tzu-Hao Wang Po-Jen Cheng
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title_sort	outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome
callnumber	R5-920
title_auth	The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome
abstract	Background: A proportion of twin-twin transfusion syndrome (TTTS) patients may have elevated liver enzymes (ELEzs) before fetoscopic laser therapy, but the incidence of ELEzs before laser therapy and the association with the perinatal outcomes after laser therapy remain unclear. Methods: From October 2008 to April 2015, 93 patients with TTTS who received fetoscopic laser therapy at our hospital were included in this study, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured within 24 h before therapy. If ELEzs (AST < 34 U/L or ALT < 36 U/L) were observed before therapy, the AST and ALT levels were evaluated within 24 h after therapy. The pre-operative characteristics and post-therapy outcomes were compared between patients with and without ELEzs. Results: Among 93 TTTS patients before laser operation, 18 patients (were found with ELEzs (19.4%) before laser therapy. In 17 (94.4%) of the 18 cases, their liver enzymes values dropped after laser surgery. Maternal body mass index, age, gestational age of laser therapy, hemoglobin level before laser therapy and survival rates after laser therapy were not significantly different between TTTS with and without ELEzs. The maternal hemoglobin dropped significantly from 10.8 [1.6] g/dL before surgery to 9.6 [1.5] g/dL after laser therapy in TTTS with ELEzs (p < 0.001). Conclusion: An elevated liver enzyme was not associated with poor perinatal outcomes in patients with TTTS after laser therapy. The authors suspected that the reduced liver enzymes values after laser therapy could partly arise from the hemo-dilution effect. Keywords: Twin-twin transfusion syndrome (TTTS), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Liver enzyme, Fetoscopic laser therapy, Neonatal outcomes
abstractGer	Background: A proportion of twin-twin transfusion syndrome (TTTS) patients may have elevated liver enzymes (ELEzs) before fetoscopic laser therapy, but the incidence of ELEzs before laser therapy and the association with the perinatal outcomes after laser therapy remain unclear. Methods: From October 2008 to April 2015, 93 patients with TTTS who received fetoscopic laser therapy at our hospital were included in this study, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured within 24 h before therapy. If ELEzs (AST < 34 U/L or ALT < 36 U/L) were observed before therapy, the AST and ALT levels were evaluated within 24 h after therapy. The pre-operative characteristics and post-therapy outcomes were compared between patients with and without ELEzs. Results: Among 93 TTTS patients before laser operation, 18 patients (were found with ELEzs (19.4%) before laser therapy. In 17 (94.4%) of the 18 cases, their liver enzymes values dropped after laser surgery. Maternal body mass index, age, gestational age of laser therapy, hemoglobin level before laser therapy and survival rates after laser therapy were not significantly different between TTTS with and without ELEzs. The maternal hemoglobin dropped significantly from 10.8 [1.6] g/dL before surgery to 9.6 [1.5] g/dL after laser therapy in TTTS with ELEzs (p < 0.001). Conclusion: An elevated liver enzyme was not associated with poor perinatal outcomes in patients with TTTS after laser therapy. The authors suspected that the reduced liver enzymes values after laser therapy could partly arise from the hemo-dilution effect. Keywords: Twin-twin transfusion syndrome (TTTS), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Liver enzyme, Fetoscopic laser therapy, Neonatal outcomes
abstract_unstemmed	Background: A proportion of twin-twin transfusion syndrome (TTTS) patients may have elevated liver enzymes (ELEzs) before fetoscopic laser therapy, but the incidence of ELEzs before laser therapy and the association with the perinatal outcomes after laser therapy remain unclear. Methods: From October 2008 to April 2015, 93 patients with TTTS who received fetoscopic laser therapy at our hospital were included in this study, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured within 24 h before therapy. If ELEzs (AST < 34 U/L or ALT < 36 U/L) were observed before therapy, the AST and ALT levels were evaluated within 24 h after therapy. The pre-operative characteristics and post-therapy outcomes were compared between patients with and without ELEzs. Results: Among 93 TTTS patients before laser operation, 18 patients (were found with ELEzs (19.4%) before laser therapy. In 17 (94.4%) of the 18 cases, their liver enzymes values dropped after laser surgery. Maternal body mass index, age, gestational age of laser therapy, hemoglobin level before laser therapy and survival rates after laser therapy were not significantly different between TTTS with and without ELEzs. The maternal hemoglobin dropped significantly from 10.8 [1.6] g/dL before surgery to 9.6 [1.5] g/dL after laser therapy in TTTS with ELEzs (p < 0.001). Conclusion: An elevated liver enzyme was not associated with poor perinatal outcomes in patients with TTTS after laser therapy. The authors suspected that the reduced liver enzymes values after laser therapy could partly arise from the hemo-dilution effect. Keywords: Twin-twin transfusion syndrome (TTTS), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Liver enzyme, Fetoscopic laser therapy, Neonatal outcomes
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title_short	The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome
url	https://doi.org/10.1016/j.bj.2019.05.006 https://doaj.org/article/ed4dc170eefa4fd99e445ed4c3ffbff7 http://www.sciencedirect.com/science/article/pii/S2319417018302579 https://doaj.org/toc/2319-4170
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author2	An-Shine Chao Shuenn-Dyh Chang Tzu-Hao Wang Po-Jen Cheng
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up_date	2024-07-03T22:24:20.174Z
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Methods: From October 2008 to April 2015, 93 patients with TTTS who received fetoscopic laser therapy at our hospital were included in this study, and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured within 24 h before therapy. If ELEzs (AST < 34 U/L or ALT < 36 U/L) were observed before therapy, the AST and ALT levels were evaluated within 24 h after therapy. The pre-operative characteristics and post-therapy outcomes were compared between patients with and without ELEzs. Results: Among 93 TTTS patients before laser operation, 18 patients (were found with ELEzs (19.4%) before laser therapy. In 17 (94.4%) of the 18 cases, their liver enzymes values dropped after laser surgery. Maternal body mass index, age, gestational age of laser therapy, hemoglobin level before laser therapy and survival rates after laser therapy were not significantly different between TTTS with and without ELEzs. The maternal hemoglobin dropped significantly from 10.8 [1.6] g/dL before surgery to 9.6 [1.5] g/dL after laser therapy in TTTS with ELEzs (p < 0.001). Conclusion: An elevated liver enzyme was not associated with poor perinatal outcomes in patients with TTTS after laser therapy. The authors suspected that the reduced liver enzymes values after laser therapy could partly arise from the hemo-dilution effect. 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The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome

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