Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression

Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is triggered by immune imbalance and oxidative stress. Echinochrome A (Ech A), a natural pigment isolated from sea urchins, exerts antioxidant and...
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Autor*in:	Hyeong Rok Yun [verfasserIn] Sang Woo Ahn [verfasserIn] Bomin Seol [verfasserIn] Elena A. Vasileva [verfasserIn] Natalia P. Mishchenko [verfasserIn] Sergey A. Fedoreyev [verfasserIn] Valentin A. Stonik [verfasserIn] Jin Han [verfasserIn] Kyung Soo Ko [verfasserIn] Byoung Doo Rhee [verfasserIn] Jung Eun Seol [verfasserIn] Hyoung Kyu Kim [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2021

Schlagwörter:	atopic dermatitis echinochrome A NC/Nga mice proinflammation mast cell infiltration

Übergeordnetes Werk:	In: Marine Drugs - MDPI AG, 2005, 19(2021), 11, p 622
Übergeordnetes Werk:	volume:19 ; year:2021 ; number:11, p 622

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/md19110622

Katalog-ID:	DOAJ079243045

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520			\|a Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is triggered by immune imbalance and oxidative stress. Echinochrome A (Ech A), a natural pigment isolated from sea urchins, exerts antioxidant and beneficial effects in various inflammatory disease models. In the present study, we tested whether Ech A treatment alleviated AD-like skin lesions. We examined the anti-inflammatory effect of Ech A on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesions in an NC/Nga mouse model. AD-like skin symptoms were induced by treatment with 1% DNCB for 1 week and 0.4% DNCB for 5 weeks in NC/Nga mice. The results showed that Ech A alleviated AD clinical symptoms, such as edema, erythema, and dryness. Treatment with Ech A induced the recovery of epidermis skin lesions as observed histologically. Tewameter<sup<®</sup< and Corneometer<sup<®</sup< measurements indicated that Ech A treatment reduced transepidermal water loss and improved stratum corneum hydration, respectively. Ech A treatment also inhibited inflammatory-response-induced mast cell infiltration in AD-like skin lesions and suppressed the expression of proinflammatory cytokines, such as interferon-γ, interleukin-4, and interleukin-13. Collectively, these results suggest that Ech A may be beneficial for treating AD owing to its anti-inflammatory effects.
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author_variant	h r y hry s w a swa b s bs e a v eav n p m npm s a f saf v a s vas j h jh k s k ksk b d r bdr j e s jes h k k hkk
matchkey_str	article:16603397:2021----::ciohoetetetleitstpcemttsiekneininnai
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allfields	10.3390/md19110622 doi (DE-627)DOAJ079243045 (DE-599)DOAJc5388cc04a764d41beaf9a11cf44525a DE-627 ger DE-627 rakwb eng QH301-705.5 Hyeong Rok Yun verfasserin aut Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is triggered by immune imbalance and oxidative stress. Echinochrome A (Ech A), a natural pigment isolated from sea urchins, exerts antioxidant and beneficial effects in various inflammatory disease models. In the present study, we tested whether Ech A treatment alleviated AD-like skin lesions. We examined the anti-inflammatory effect of Ech A on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesions in an NC/Nga mouse model. AD-like skin symptoms were induced by treatment with 1% DNCB for 1 week and 0.4% DNCB for 5 weeks in NC/Nga mice. The results showed that Ech A alleviated AD clinical symptoms, such as edema, erythema, and dryness. Treatment with Ech A induced the recovery of epidermis skin lesions as observed histologically. Tewameter<sup<®</sup< and Corneometer<sup<®</sup< measurements indicated that Ech A treatment reduced transepidermal water loss and improved stratum corneum hydration, respectively. Ech A treatment also inhibited inflammatory-response-induced mast cell infiltration in AD-like skin lesions and suppressed the expression of proinflammatory cytokines, such as interferon-γ, interleukin-4, and interleukin-13. Collectively, these results suggest that Ech A may be beneficial for treating AD owing to its anti-inflammatory effects. atopic dermatitis echinochrome A NC/Nga mice proinflammation mast cell infiltration Biology (General) Sang Woo Ahn verfasserin aut Bomin Seol verfasserin aut Elena A. Vasileva verfasserin aut Natalia P. Mishchenko verfasserin aut Sergey A. Fedoreyev verfasserin aut Valentin A. Stonik verfasserin aut Jin Han verfasserin aut Kyung Soo Ko verfasserin aut Byoung Doo Rhee verfasserin aut Jung Eun Seol verfasserin aut Hyoung Kyu Kim verfasserin aut In Marine Drugs MDPI AG, 2005 19(2021), 11, p 622 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:19 year:2021 number:11, p 622 https://doi.org/10.3390/md19110622 kostenfrei https://doaj.org/article/c5388cc04a764d41beaf9a11cf44525a kostenfrei https://www.mdpi.com/1660-3397/19/11/622 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 11, p 622
spelling	10.3390/md19110622 doi (DE-627)DOAJ079243045 (DE-599)DOAJc5388cc04a764d41beaf9a11cf44525a DE-627 ger DE-627 rakwb eng QH301-705.5 Hyeong Rok Yun verfasserin aut Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is triggered by immune imbalance and oxidative stress. Echinochrome A (Ech A), a natural pigment isolated from sea urchins, exerts antioxidant and beneficial effects in various inflammatory disease models. In the present study, we tested whether Ech A treatment alleviated AD-like skin lesions. We examined the anti-inflammatory effect of Ech A on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesions in an NC/Nga mouse model. AD-like skin symptoms were induced by treatment with 1% DNCB for 1 week and 0.4% DNCB for 5 weeks in NC/Nga mice. The results showed that Ech A alleviated AD clinical symptoms, such as edema, erythema, and dryness. Treatment with Ech A induced the recovery of epidermis skin lesions as observed histologically. Tewameter<sup<®</sup< and Corneometer<sup<®</sup< measurements indicated that Ech A treatment reduced transepidermal water loss and improved stratum corneum hydration, respectively. Ech A treatment also inhibited inflammatory-response-induced mast cell infiltration in AD-like skin lesions and suppressed the expression of proinflammatory cytokines, such as interferon-γ, interleukin-4, and interleukin-13. Collectively, these results suggest that Ech A may be beneficial for treating AD owing to its anti-inflammatory effects. atopic dermatitis echinochrome A NC/Nga mice proinflammation mast cell infiltration Biology (General) Sang Woo Ahn verfasserin aut Bomin Seol verfasserin aut Elena A. Vasileva verfasserin aut Natalia P. Mishchenko verfasserin aut Sergey A. Fedoreyev verfasserin aut Valentin A. Stonik verfasserin aut Jin Han verfasserin aut Kyung Soo Ko verfasserin aut Byoung Doo Rhee verfasserin aut Jung Eun Seol verfasserin aut Hyoung Kyu Kim verfasserin aut In Marine Drugs MDPI AG, 2005 19(2021), 11, p 622 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:19 year:2021 number:11, p 622 https://doi.org/10.3390/md19110622 kostenfrei https://doaj.org/article/c5388cc04a764d41beaf9a11cf44525a kostenfrei https://www.mdpi.com/1660-3397/19/11/622 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 11, p 622
allfields_unstemmed	10.3390/md19110622 doi (DE-627)DOAJ079243045 (DE-599)DOAJc5388cc04a764d41beaf9a11cf44525a DE-627 ger DE-627 rakwb eng QH301-705.5 Hyeong Rok Yun verfasserin aut Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is triggered by immune imbalance and oxidative stress. Echinochrome A (Ech A), a natural pigment isolated from sea urchins, exerts antioxidant and beneficial effects in various inflammatory disease models. In the present study, we tested whether Ech A treatment alleviated AD-like skin lesions. We examined the anti-inflammatory effect of Ech A on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesions in an NC/Nga mouse model. AD-like skin symptoms were induced by treatment with 1% DNCB for 1 week and 0.4% DNCB for 5 weeks in NC/Nga mice. The results showed that Ech A alleviated AD clinical symptoms, such as edema, erythema, and dryness. Treatment with Ech A induced the recovery of epidermis skin lesions as observed histologically. Tewameter<sup<®</sup< and Corneometer<sup<®</sup< measurements indicated that Ech A treatment reduced transepidermal water loss and improved stratum corneum hydration, respectively. Ech A treatment also inhibited inflammatory-response-induced mast cell infiltration in AD-like skin lesions and suppressed the expression of proinflammatory cytokines, such as interferon-γ, interleukin-4, and interleukin-13. Collectively, these results suggest that Ech A may be beneficial for treating AD owing to its anti-inflammatory effects. atopic dermatitis echinochrome A NC/Nga mice proinflammation mast cell infiltration Biology (General) Sang Woo Ahn verfasserin aut Bomin Seol verfasserin aut Elena A. Vasileva verfasserin aut Natalia P. Mishchenko verfasserin aut Sergey A. Fedoreyev verfasserin aut Valentin A. Stonik verfasserin aut Jin Han verfasserin aut Kyung Soo Ko verfasserin aut Byoung Doo Rhee verfasserin aut Jung Eun Seol verfasserin aut Hyoung Kyu Kim verfasserin aut In Marine Drugs MDPI AG, 2005 19(2021), 11, p 622 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:19 year:2021 number:11, p 622 https://doi.org/10.3390/md19110622 kostenfrei https://doaj.org/article/c5388cc04a764d41beaf9a11cf44525a kostenfrei https://www.mdpi.com/1660-3397/19/11/622 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 11, p 622
allfieldsGer	10.3390/md19110622 doi (DE-627)DOAJ079243045 (DE-599)DOAJc5388cc04a764d41beaf9a11cf44525a DE-627 ger DE-627 rakwb eng QH301-705.5 Hyeong Rok Yun verfasserin aut Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is triggered by immune imbalance and oxidative stress. Echinochrome A (Ech A), a natural pigment isolated from sea urchins, exerts antioxidant and beneficial effects in various inflammatory disease models. In the present study, we tested whether Ech A treatment alleviated AD-like skin lesions. We examined the anti-inflammatory effect of Ech A on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesions in an NC/Nga mouse model. AD-like skin symptoms were induced by treatment with 1% DNCB for 1 week and 0.4% DNCB for 5 weeks in NC/Nga mice. The results showed that Ech A alleviated AD clinical symptoms, such as edema, erythema, and dryness. Treatment with Ech A induced the recovery of epidermis skin lesions as observed histologically. Tewameter<sup<®</sup< and Corneometer<sup<®</sup< measurements indicated that Ech A treatment reduced transepidermal water loss and improved stratum corneum hydration, respectively. Ech A treatment also inhibited inflammatory-response-induced mast cell infiltration in AD-like skin lesions and suppressed the expression of proinflammatory cytokines, such as interferon-γ, interleukin-4, and interleukin-13. Collectively, these results suggest that Ech A may be beneficial for treating AD owing to its anti-inflammatory effects. atopic dermatitis echinochrome A NC/Nga mice proinflammation mast cell infiltration Biology (General) Sang Woo Ahn verfasserin aut Bomin Seol verfasserin aut Elena A. Vasileva verfasserin aut Natalia P. Mishchenko verfasserin aut Sergey A. Fedoreyev verfasserin aut Valentin A. Stonik verfasserin aut Jin Han verfasserin aut Kyung Soo Ko verfasserin aut Byoung Doo Rhee verfasserin aut Jung Eun Seol verfasserin aut Hyoung Kyu Kim verfasserin aut In Marine Drugs MDPI AG, 2005 19(2021), 11, p 622 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:19 year:2021 number:11, p 622 https://doi.org/10.3390/md19110622 kostenfrei https://doaj.org/article/c5388cc04a764d41beaf9a11cf44525a kostenfrei https://www.mdpi.com/1660-3397/19/11/622 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 11, p 622
allfieldsSound	10.3390/md19110622 doi (DE-627)DOAJ079243045 (DE-599)DOAJc5388cc04a764d41beaf9a11cf44525a DE-627 ger DE-627 rakwb eng QH301-705.5 Hyeong Rok Yun verfasserin aut Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression 2021 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is triggered by immune imbalance and oxidative stress. Echinochrome A (Ech A), a natural pigment isolated from sea urchins, exerts antioxidant and beneficial effects in various inflammatory disease models. In the present study, we tested whether Ech A treatment alleviated AD-like skin lesions. We examined the anti-inflammatory effect of Ech A on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesions in an NC/Nga mouse model. AD-like skin symptoms were induced by treatment with 1% DNCB for 1 week and 0.4% DNCB for 5 weeks in NC/Nga mice. The results showed that Ech A alleviated AD clinical symptoms, such as edema, erythema, and dryness. Treatment with Ech A induced the recovery of epidermis skin lesions as observed histologically. Tewameter<sup<®</sup< and Corneometer<sup<®</sup< measurements indicated that Ech A treatment reduced transepidermal water loss and improved stratum corneum hydration, respectively. Ech A treatment also inhibited inflammatory-response-induced mast cell infiltration in AD-like skin lesions and suppressed the expression of proinflammatory cytokines, such as interferon-γ, interleukin-4, and interleukin-13. Collectively, these results suggest that Ech A may be beneficial for treating AD owing to its anti-inflammatory effects. atopic dermatitis echinochrome A NC/Nga mice proinflammation mast cell infiltration Biology (General) Sang Woo Ahn verfasserin aut Bomin Seol verfasserin aut Elena A. Vasileva verfasserin aut Natalia P. Mishchenko verfasserin aut Sergey A. Fedoreyev verfasserin aut Valentin A. Stonik verfasserin aut Jin Han verfasserin aut Kyung Soo Ko verfasserin aut Byoung Doo Rhee verfasserin aut Jung Eun Seol verfasserin aut Hyoung Kyu Kim verfasserin aut In Marine Drugs MDPI AG, 2005 19(2021), 11, p 622 (DE-627)477992420 (DE-600)2175190-0 16603397 nnns volume:19 year:2021 number:11, p 622 https://doi.org/10.3390/md19110622 kostenfrei https://doaj.org/article/c5388cc04a764d41beaf9a11cf44525a kostenfrei https://www.mdpi.com/1660-3397/19/11/622 kostenfrei https://doaj.org/toc/1660-3397 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_381 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2021 11, p 622
language	English
source	In Marine Drugs 19(2021), 11, p 622 volume:19 year:2021 number:11, p 622
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topic_facet	atopic dermatitis echinochrome A NC/Nga mice proinflammation mast cell infiltration Biology (General)
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authorswithroles_txt_mv	Hyeong Rok Yun @@aut@@ Sang Woo Ahn @@aut@@ Bomin Seol @@aut@@ Elena A. Vasileva @@aut@@ Natalia P. Mishchenko @@aut@@ Sergey A. Fedoreyev @@aut@@ Valentin A. Stonik @@aut@@ Jin Han @@aut@@ Kyung Soo Ko @@aut@@ Byoung Doo Rhee @@aut@@ Jung Eun Seol @@aut@@ Hyoung Kyu Kim @@aut@@
publishDateDaySort_date	2021-01-01T00:00:00Z
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topic_title	QH301-705.5 Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression atopic dermatitis echinochrome A NC/Nga mice proinflammation mast cell infiltration
topic	misc QH301-705.5 misc atopic dermatitis misc echinochrome A misc NC/Nga mice misc proinflammation misc mast cell infiltration misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc atopic dermatitis misc echinochrome A misc NC/Nga mice misc proinflammation misc mast cell infiltration misc Biology (General)
topic_browse	misc QH301-705.5 misc atopic dermatitis misc echinochrome A misc NC/Nga mice misc proinflammation misc mast cell infiltration misc Biology (General)
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title	Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression
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title_full	Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression
author_sort	Hyeong Rok Yun
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author_browse	Hyeong Rok Yun Sang Woo Ahn Bomin Seol Elena A. Vasileva Natalia P. Mishchenko Sergey A. Fedoreyev Valentin A. Stonik Jin Han Kyung Soo Ko Byoung Doo Rhee Jung Eun Seol Hyoung Kyu Kim
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author-letter	Hyeong Rok Yun
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title_sort	echinochrome a treatment alleviates atopic dermatitis-like skin lesions in nc/nga mice via il-4 and il-13 suppression
callnumber	QH301-705.5
title_auth	Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression
abstract	Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is triggered by immune imbalance and oxidative stress. Echinochrome A (Ech A), a natural pigment isolated from sea urchins, exerts antioxidant and beneficial effects in various inflammatory disease models. In the present study, we tested whether Ech A treatment alleviated AD-like skin lesions. We examined the anti-inflammatory effect of Ech A on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesions in an NC/Nga mouse model. AD-like skin symptoms were induced by treatment with 1% DNCB for 1 week and 0.4% DNCB for 5 weeks in NC/Nga mice. The results showed that Ech A alleviated AD clinical symptoms, such as edema, erythema, and dryness. Treatment with Ech A induced the recovery of epidermis skin lesions as observed histologically. Tewameter<sup<®</sup< and Corneometer<sup<®</sup< measurements indicated that Ech A treatment reduced transepidermal water loss and improved stratum corneum hydration, respectively. Ech A treatment also inhibited inflammatory-response-induced mast cell infiltration in AD-like skin lesions and suppressed the expression of proinflammatory cytokines, such as interferon-γ, interleukin-4, and interleukin-13. Collectively, these results suggest that Ech A may be beneficial for treating AD owing to its anti-inflammatory effects.
abstractGer	Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is triggered by immune imbalance and oxidative stress. Echinochrome A (Ech A), a natural pigment isolated from sea urchins, exerts antioxidant and beneficial effects in various inflammatory disease models. In the present study, we tested whether Ech A treatment alleviated AD-like skin lesions. We examined the anti-inflammatory effect of Ech A on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesions in an NC/Nga mouse model. AD-like skin symptoms were induced by treatment with 1% DNCB for 1 week and 0.4% DNCB for 5 weeks in NC/Nga mice. The results showed that Ech A alleviated AD clinical symptoms, such as edema, erythema, and dryness. Treatment with Ech A induced the recovery of epidermis skin lesions as observed histologically. Tewameter<sup<®</sup< and Corneometer<sup<®</sup< measurements indicated that Ech A treatment reduced transepidermal water loss and improved stratum corneum hydration, respectively. Ech A treatment also inhibited inflammatory-response-induced mast cell infiltration in AD-like skin lesions and suppressed the expression of proinflammatory cytokines, such as interferon-γ, interleukin-4, and interleukin-13. Collectively, these results suggest that Ech A may be beneficial for treating AD owing to its anti-inflammatory effects.
abstract_unstemmed	Atopic dermatitis (AD) is a chronic inflammatory skin disease in which skin barrier dysfunction leads to dryness, pruritus, and erythematous lesions. AD is triggered by immune imbalance and oxidative stress. Echinochrome A (Ech A), a natural pigment isolated from sea urchins, exerts antioxidant and beneficial effects in various inflammatory disease models. In the present study, we tested whether Ech A treatment alleviated AD-like skin lesions. We examined the anti-inflammatory effect of Ech A on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesions in an NC/Nga mouse model. AD-like skin symptoms were induced by treatment with 1% DNCB for 1 week and 0.4% DNCB for 5 weeks in NC/Nga mice. The results showed that Ech A alleviated AD clinical symptoms, such as edema, erythema, and dryness. Treatment with Ech A induced the recovery of epidermis skin lesions as observed histologically. Tewameter<sup<®</sup< and Corneometer<sup<®</sup< measurements indicated that Ech A treatment reduced transepidermal water loss and improved stratum corneum hydration, respectively. Ech A treatment also inhibited inflammatory-response-induced mast cell infiltration in AD-like skin lesions and suppressed the expression of proinflammatory cytokines, such as interferon-γ, interleukin-4, and interleukin-13. Collectively, these results suggest that Ech A may be beneficial for treating AD owing to its anti-inflammatory effects.
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title_short	Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression
url	https://doi.org/10.3390/md19110622 https://doaj.org/article/c5388cc04a764d41beaf9a11cf44525a https://www.mdpi.com/1660-3397/19/11/622 https://doaj.org/toc/1660-3397
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author2	Sang Woo Ahn Bomin Seol Elena A. Vasileva Natalia P. Mishchenko Sergey A. Fedoreyev Valentin A. Stonik Jin Han Kyung Soo Ko Byoung Doo Rhee Jung Eun Seol Hyoung Kyu Kim
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up_date	2024-07-03T22:28:06.099Z
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