Sequential Drug Delivery in Targeted Cancer Therapy

Cancer is a major public health problem and one of the leading causes of death. However, traditional cancer therapy may damage normal cells and cause side effects. Many targeted drug delivery platforms have been developed to overcome the limitations of the free form of therapeutics and biological ba...
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Autor*in:	Han Yu [verfasserIn] Na Ning [verfasserIn] Xi Meng [verfasserIn] Chuda Chittasupho [verfasserIn] Lingling Jiang [verfasserIn] Yunqi Zhao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	sequential targeted drug delivery nucleus targeting mitochondria targeting cancer treatment

Übergeordnetes Werk:	In: Pharmaceutics - MDPI AG, 2010, 14(2022), 3, p 573
Übergeordnetes Werk:	volume:14 ; year:2022 ; number:3, p 573

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/pharmaceutics14030573

Katalog-ID:	DOAJ079246745

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language	English
source	In Pharmaceutics 14(2022), 3, p 573 volume:14 year:2022 number:3, p 573
sourceStr	In Pharmaceutics 14(2022), 3, p 573 volume:14 year:2022 number:3, p 573
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institution	findex.gbv.de
topic_facet	sequential targeted drug delivery nucleus targeting mitochondria targeting cancer treatment Pharmacy and materia medica
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authorswithroles_txt_mv	Han Yu @@aut@@ Na Ning @@aut@@ Xi Meng @@aut@@ Chuda Chittasupho @@aut@@ Lingling Jiang @@aut@@ Yunqi Zhao @@aut@@
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topic	misc RS1-441 misc sequential targeted misc drug delivery misc nucleus targeting misc mitochondria targeting misc cancer treatment misc Pharmacy and materia medica
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title	Sequential Drug Delivery in Targeted Cancer Therapy
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title_auth	Sequential Drug Delivery in Targeted Cancer Therapy
abstract	Cancer is a major public health problem and one of the leading causes of death. However, traditional cancer therapy may damage normal cells and cause side effects. Many targeted drug delivery platforms have been developed to overcome the limitations of the free form of therapeutics and biological barriers. The commonly used cancer cell surface targets are CD44, matrix metalloproteinase-2, folate receptors, etc. Once the drug enters the cell, active delivery of the drug molecule to its final destination is still preferred. The subcellular targeting strategies include using glucocorticoid receptors for nuclear targeting, negative mitochondrial membrane potential and N-acetylgalactosaminyltransferase for Golgi apparatus targeting, etc. Therefore, the most effective way to deliver therapeutic agents is through a sequential drug delivery system that simultaneously achieves cellular- and subcellular-level targeting. The dual-targeting delivery holds great promise for improving therapeutic effects and overcoming drug resistance. This review classifies sequential drug delivery systems based on final targeted organelles. We summarize different targeting strategies and mechanisms and gave examples of each case.
abstractGer	Cancer is a major public health problem and one of the leading causes of death. However, traditional cancer therapy may damage normal cells and cause side effects. Many targeted drug delivery platforms have been developed to overcome the limitations of the free form of therapeutics and biological barriers. The commonly used cancer cell surface targets are CD44, matrix metalloproteinase-2, folate receptors, etc. Once the drug enters the cell, active delivery of the drug molecule to its final destination is still preferred. The subcellular targeting strategies include using glucocorticoid receptors for nuclear targeting, negative mitochondrial membrane potential and N-acetylgalactosaminyltransferase for Golgi apparatus targeting, etc. Therefore, the most effective way to deliver therapeutic agents is through a sequential drug delivery system that simultaneously achieves cellular- and subcellular-level targeting. The dual-targeting delivery holds great promise for improving therapeutic effects and overcoming drug resistance. This review classifies sequential drug delivery systems based on final targeted organelles. We summarize different targeting strategies and mechanisms and gave examples of each case.
abstract_unstemmed	Cancer is a major public health problem and one of the leading causes of death. However, traditional cancer therapy may damage normal cells and cause side effects. Many targeted drug delivery platforms have been developed to overcome the limitations of the free form of therapeutics and biological barriers. The commonly used cancer cell surface targets are CD44, matrix metalloproteinase-2, folate receptors, etc. Once the drug enters the cell, active delivery of the drug molecule to its final destination is still preferred. The subcellular targeting strategies include using glucocorticoid receptors for nuclear targeting, negative mitochondrial membrane potential and N-acetylgalactosaminyltransferase for Golgi apparatus targeting, etc. Therefore, the most effective way to deliver therapeutic agents is through a sequential drug delivery system that simultaneously achieves cellular- and subcellular-level targeting. The dual-targeting delivery holds great promise for improving therapeutic effects and overcoming drug resistance. This review classifies sequential drug delivery systems based on final targeted organelles. We summarize different targeting strategies and mechanisms and gave examples of each case.
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