Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation

Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O<sub<2</sub<) homeostasis, adjusting convective O<sub<2</sub< delivery and utilization (i.e., metabolism). Human populations have been exposed to high-altitude hypoxia for thousands of yea...
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Autor*in:	Katie A. O’Brien [verfasserIn] Andrew J. Murray [verfasserIn] Tatum S. Simonson [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	hypobaric hypoxia adaptation Notch signaling hypoxia-inducible factor

Übergeordnetes Werk:	In: Life - MDPI AG, 2012, 12(2022), 3, p 437
Übergeordnetes Werk:	volume:12 ; year:2022 ; number:3, p 437

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/life12030437

Katalog-ID:	DOAJ079246907

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spelling	10.3390/life12030437 doi (DE-627)DOAJ079246907 (DE-599)DOAJa79f616d26214601b6b24978ece3804a DE-627 ger DE-627 rakwb eng Katie A. O’Brien verfasserin aut Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O<sub<2</sub<) homeostasis, adjusting convective O<sub<2</sub< delivery and utilization (i.e., metabolism). Human populations have been exposed to high-altitude hypoxia for thousands of years and, in doing so, have undergone natural selection of multiple gene regions supporting adaptive traits. Some of the strongest selection signals identified in highland populations emanate from hypoxia-inducible factor (HIF) pathway genes. The HIF pathway is a master regulator of the cellular hypoxic response, but it is not the only regulatory pathway under positive selection. For instance, regions linked to the highly conserved Notch signaling pathway are also top targets, and this pathway is likely to play essential roles that confer hypoxia tolerance. Here, we explored the importance of the Notch pathway in mediating the cellular hypoxic response. We assessed transcriptional regulation of the Notch pathway, including close cross-talk with HIF signaling, and its involvement in the mediation of angiogenesis, cellular metabolism, inflammation, and oxidative stress, relating these functions to generational hypoxia adaptation. hypobaric hypoxia adaptation Notch signaling hypoxia-inducible factor Science Q Andrew J. Murray verfasserin aut Tatum S. Simonson verfasserin aut In Life MDPI AG, 2012 12(2022), 3, p 437 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:12 year:2022 number:3, p 437 https://doi.org/10.3390/life12030437 kostenfrei https://doaj.org/article/a79f616d26214601b6b24978ece3804a kostenfrei https://www.mdpi.com/2075-1729/12/3/437 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 3, p 437
allfields_unstemmed	10.3390/life12030437 doi (DE-627)DOAJ079246907 (DE-599)DOAJa79f616d26214601b6b24978ece3804a DE-627 ger DE-627 rakwb eng Katie A. O’Brien verfasserin aut Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O<sub<2</sub<) homeostasis, adjusting convective O<sub<2</sub< delivery and utilization (i.e., metabolism). Human populations have been exposed to high-altitude hypoxia for thousands of years and, in doing so, have undergone natural selection of multiple gene regions supporting adaptive traits. Some of the strongest selection signals identified in highland populations emanate from hypoxia-inducible factor (HIF) pathway genes. The HIF pathway is a master regulator of the cellular hypoxic response, but it is not the only regulatory pathway under positive selection. For instance, regions linked to the highly conserved Notch signaling pathway are also top targets, and this pathway is likely to play essential roles that confer hypoxia tolerance. Here, we explored the importance of the Notch pathway in mediating the cellular hypoxic response. We assessed transcriptional regulation of the Notch pathway, including close cross-talk with HIF signaling, and its involvement in the mediation of angiogenesis, cellular metabolism, inflammation, and oxidative stress, relating these functions to generational hypoxia adaptation. hypobaric hypoxia adaptation Notch signaling hypoxia-inducible factor Science Q Andrew J. Murray verfasserin aut Tatum S. Simonson verfasserin aut In Life MDPI AG, 2012 12(2022), 3, p 437 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:12 year:2022 number:3, p 437 https://doi.org/10.3390/life12030437 kostenfrei https://doaj.org/article/a79f616d26214601b6b24978ece3804a kostenfrei https://www.mdpi.com/2075-1729/12/3/437 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 3, p 437
allfieldsGer	10.3390/life12030437 doi (DE-627)DOAJ079246907 (DE-599)DOAJa79f616d26214601b6b24978ece3804a DE-627 ger DE-627 rakwb eng Katie A. O’Brien verfasserin aut Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O<sub<2</sub<) homeostasis, adjusting convective O<sub<2</sub< delivery and utilization (i.e., metabolism). Human populations have been exposed to high-altitude hypoxia for thousands of years and, in doing so, have undergone natural selection of multiple gene regions supporting adaptive traits. Some of the strongest selection signals identified in highland populations emanate from hypoxia-inducible factor (HIF) pathway genes. The HIF pathway is a master regulator of the cellular hypoxic response, but it is not the only regulatory pathway under positive selection. For instance, regions linked to the highly conserved Notch signaling pathway are also top targets, and this pathway is likely to play essential roles that confer hypoxia tolerance. Here, we explored the importance of the Notch pathway in mediating the cellular hypoxic response. We assessed transcriptional regulation of the Notch pathway, including close cross-talk with HIF signaling, and its involvement in the mediation of angiogenesis, cellular metabolism, inflammation, and oxidative stress, relating these functions to generational hypoxia adaptation. hypobaric hypoxia adaptation Notch signaling hypoxia-inducible factor Science Q Andrew J. Murray verfasserin aut Tatum S. Simonson verfasserin aut In Life MDPI AG, 2012 12(2022), 3, p 437 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:12 year:2022 number:3, p 437 https://doi.org/10.3390/life12030437 kostenfrei https://doaj.org/article/a79f616d26214601b6b24978ece3804a kostenfrei https://www.mdpi.com/2075-1729/12/3/437 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 3, p 437
allfieldsSound	10.3390/life12030437 doi (DE-627)DOAJ079246907 (DE-599)DOAJa79f616d26214601b6b24978ece3804a DE-627 ger DE-627 rakwb eng Katie A. O’Brien verfasserin aut Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O<sub<2</sub<) homeostasis, adjusting convective O<sub<2</sub< delivery and utilization (i.e., metabolism). Human populations have been exposed to high-altitude hypoxia for thousands of years and, in doing so, have undergone natural selection of multiple gene regions supporting adaptive traits. Some of the strongest selection signals identified in highland populations emanate from hypoxia-inducible factor (HIF) pathway genes. The HIF pathway is a master regulator of the cellular hypoxic response, but it is not the only regulatory pathway under positive selection. For instance, regions linked to the highly conserved Notch signaling pathway are also top targets, and this pathway is likely to play essential roles that confer hypoxia tolerance. Here, we explored the importance of the Notch pathway in mediating the cellular hypoxic response. We assessed transcriptional regulation of the Notch pathway, including close cross-talk with HIF signaling, and its involvement in the mediation of angiogenesis, cellular metabolism, inflammation, and oxidative stress, relating these functions to generational hypoxia adaptation. hypobaric hypoxia adaptation Notch signaling hypoxia-inducible factor Science Q Andrew J. Murray verfasserin aut Tatum S. Simonson verfasserin aut In Life MDPI AG, 2012 12(2022), 3, p 437 (DE-627)718627156 (DE-600)2662250-6 20751729 nnns volume:12 year:2022 number:3, p 437 https://doi.org/10.3390/life12030437 kostenfrei https://doaj.org/article/a79f616d26214601b6b24978ece3804a kostenfrei https://www.mdpi.com/2075-1729/12/3/437 kostenfrei https://doaj.org/toc/2075-1729 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2022 3, p 437
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source	In Life 12(2022), 3, p 437 volume:12 year:2022 number:3, p 437
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authorswithroles_txt_mv	Katie A. O’Brien @@aut@@ Andrew J. Murray @@aut@@ Tatum S. Simonson @@aut@@
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author	Katie A. O’Brien
spellingShingle	Katie A. O’Brien misc hypobaric hypoxia misc adaptation misc Notch signaling misc hypoxia-inducible factor misc Science misc Q Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation
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topic_title	Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation hypobaric hypoxia adaptation Notch signaling hypoxia-inducible factor
topic	misc hypobaric hypoxia misc adaptation misc Notch signaling misc hypoxia-inducible factor misc Science misc Q
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title	Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation
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title_sort	notch signaling and cross-talk in hypoxia: a candidate pathway for high-altitude adaptation
title_auth	Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation
abstract	Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O<sub<2</sub<) homeostasis, adjusting convective O<sub<2</sub< delivery and utilization (i.e., metabolism). Human populations have been exposed to high-altitude hypoxia for thousands of years and, in doing so, have undergone natural selection of multiple gene regions supporting adaptive traits. Some of the strongest selection signals identified in highland populations emanate from hypoxia-inducible factor (HIF) pathway genes. The HIF pathway is a master regulator of the cellular hypoxic response, but it is not the only regulatory pathway under positive selection. For instance, regions linked to the highly conserved Notch signaling pathway are also top targets, and this pathway is likely to play essential roles that confer hypoxia tolerance. Here, we explored the importance of the Notch pathway in mediating the cellular hypoxic response. We assessed transcriptional regulation of the Notch pathway, including close cross-talk with HIF signaling, and its involvement in the mediation of angiogenesis, cellular metabolism, inflammation, and oxidative stress, relating these functions to generational hypoxia adaptation.
abstractGer	Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O<sub<2</sub<) homeostasis, adjusting convective O<sub<2</sub< delivery and utilization (i.e., metabolism). Human populations have been exposed to high-altitude hypoxia for thousands of years and, in doing so, have undergone natural selection of multiple gene regions supporting adaptive traits. Some of the strongest selection signals identified in highland populations emanate from hypoxia-inducible factor (HIF) pathway genes. The HIF pathway is a master regulator of the cellular hypoxic response, but it is not the only regulatory pathway under positive selection. For instance, regions linked to the highly conserved Notch signaling pathway are also top targets, and this pathway is likely to play essential roles that confer hypoxia tolerance. Here, we explored the importance of the Notch pathway in mediating the cellular hypoxic response. We assessed transcriptional regulation of the Notch pathway, including close cross-talk with HIF signaling, and its involvement in the mediation of angiogenesis, cellular metabolism, inflammation, and oxidative stress, relating these functions to generational hypoxia adaptation.
abstract_unstemmed	Hypoxia triggers complex inter- and intracellular signals that regulate tissue oxygen (O<sub<2</sub<) homeostasis, adjusting convective O<sub<2</sub< delivery and utilization (i.e., metabolism). Human populations have been exposed to high-altitude hypoxia for thousands of years and, in doing so, have undergone natural selection of multiple gene regions supporting adaptive traits. Some of the strongest selection signals identified in highland populations emanate from hypoxia-inducible factor (HIF) pathway genes. The HIF pathway is a master regulator of the cellular hypoxic response, but it is not the only regulatory pathway under positive selection. For instance, regions linked to the highly conserved Notch signaling pathway are also top targets, and this pathway is likely to play essential roles that confer hypoxia tolerance. Here, we explored the importance of the Notch pathway in mediating the cellular hypoxic response. We assessed transcriptional regulation of the Notch pathway, including close cross-talk with HIF signaling, and its involvement in the mediation of angiogenesis, cellular metabolism, inflammation, and oxidative stress, relating these functions to generational hypoxia adaptation.
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title_short	Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation
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