New Cytotoxic Cyclic Peptide from the Marine Sponge-Associated Nocardiopsis sp. UR67

A new cyclic hexapeptide, nocardiotide A (1), together with three known compounds—tryptophan (2), kynurenic acid (3), and 4-amino-3-methoxy benzoic acid (4)—were isolated and identified from the broth culture of Nocardiopsis sp. UR67 strain associated with the marine sponge Cally...
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Autor*in:	Alyaa Hatem Ibrahim [verfasserIn] Eman Zekry Attia [verfasserIn] Dina Hajjar [verfasserIn] Mohamed A. Anany [verfasserIn] Samar Yehia Desoukey [verfasserIn] Mostafa Ahmed Fouad [verfasserIn] Mohamed Salah Kamel [verfasserIn] Harald Wajant [verfasserIn] Tobias A. M. Gulder [verfasserIn] Usama Ramadan Abdelmohsen [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2018

Schlagwörter:	Nocardiopsis cyclic hexapeptide cytotoxicity marine actinomycetes sponges

Übergeordnetes Werk:	In: Marine Drugs - MDPI AG, 2005, 16(2018), 9, p 290
Übergeordnetes Werk:	volume:16 ; year:2018 ; number:9, p 290

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/md16090290

Katalog-ID:	DOAJ079287174

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authorswithroles_txt_mv	Alyaa Hatem Ibrahim @@aut@@ Eman Zekry Attia @@aut@@ Dina Hajjar @@aut@@ Mohamed A. Anany @@aut@@ Samar Yehia Desoukey @@aut@@ Mostafa Ahmed Fouad @@aut@@ Mohamed Salah Kamel @@aut@@ Harald Wajant @@aut@@ Tobias A. M. Gulder @@aut@@ Usama Ramadan Abdelmohsen @@aut@@
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callnumber-first	Q - Science
author	Alyaa Hatem Ibrahim
spellingShingle	Alyaa Hatem Ibrahim misc QH301-705.5 misc Nocardiopsis misc cyclic hexapeptide misc cytotoxicity misc marine actinomycetes misc sponges misc Biology (General) New Cytotoxic Cyclic Peptide from the Marine Sponge-Associated Nocardiopsis sp. UR67
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topic_title	QH301-705.5 New Cytotoxic Cyclic Peptide from the Marine Sponge-Associated Nocardiopsis sp. UR67 Nocardiopsis cyclic hexapeptide cytotoxicity marine actinomycetes sponges
topic	misc QH301-705.5 misc Nocardiopsis misc cyclic hexapeptide misc cytotoxicity misc marine actinomycetes misc sponges misc Biology (General)
topic_unstemmed	misc QH301-705.5 misc Nocardiopsis misc cyclic hexapeptide misc cytotoxicity misc marine actinomycetes misc sponges misc Biology (General)
topic_browse	misc QH301-705.5 misc Nocardiopsis misc cyclic hexapeptide misc cytotoxicity misc marine actinomycetes misc sponges misc Biology (General)
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title	New Cytotoxic Cyclic Peptide from the Marine Sponge-Associated Nocardiopsis sp. UR67
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title_full	New Cytotoxic Cyclic Peptide from the Marine Sponge-Associated Nocardiopsis sp. UR67
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author_browse	Alyaa Hatem Ibrahim Eman Zekry Attia Dina Hajjar Mohamed A. Anany Samar Yehia Desoukey Mostafa Ahmed Fouad Mohamed Salah Kamel Harald Wajant Tobias A. M. Gulder Usama Ramadan Abdelmohsen
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title_sort	new cytotoxic cyclic peptide from the marine sponge-associated nocardiopsis sp. ur67
callnumber	QH301-705.5
title_auth	New Cytotoxic Cyclic Peptide from the Marine Sponge-Associated Nocardiopsis sp. UR67
abstract	A new cyclic hexapeptide, nocardiotide A (1), together with three known compounds—tryptophan (2), kynurenic acid (3), and 4-amino-3-methoxy benzoic acid (4)—were isolated and identified from the broth culture of Nocardiopsis sp. UR67 strain associated with the marine sponge Callyspongia sp. from the Red Sea. The structure elucidation of the isolated compounds were determined based on detailed spectroscopic data including 1D and 2D nuclear magnetic resonance (NMR) experimental analyses in combination with high resolution electrospray ionization mass spectrometry (HR-ESI-MS), while the absolute stereochemistry of all amino acids components of nocardiotide A (1) was deduced using Marfey’s method. Additionally, ten known metabolites were dereplicated using HR-ESI-MS analysis. Nocardiotide A (1) displayed significant cytotoxic effects towards the murine CT26 colon carcinoma, human HeLa cervix carcinoma, and human MM.1S multiple myeloma cell lines. The results obtained revealed sponge-associated Nocardiopsis as a substantial source of lead natural products with pronounced pharmacological activities.
abstractGer	A new cyclic hexapeptide, nocardiotide A (1), together with three known compounds—tryptophan (2), kynurenic acid (3), and 4-amino-3-methoxy benzoic acid (4)—were isolated and identified from the broth culture of Nocardiopsis sp. UR67 strain associated with the marine sponge Callyspongia sp. from the Red Sea. The structure elucidation of the isolated compounds were determined based on detailed spectroscopic data including 1D and 2D nuclear magnetic resonance (NMR) experimental analyses in combination with high resolution electrospray ionization mass spectrometry (HR-ESI-MS), while the absolute stereochemistry of all amino acids components of nocardiotide A (1) was deduced using Marfey’s method. Additionally, ten known metabolites were dereplicated using HR-ESI-MS analysis. Nocardiotide A (1) displayed significant cytotoxic effects towards the murine CT26 colon carcinoma, human HeLa cervix carcinoma, and human MM.1S multiple myeloma cell lines. The results obtained revealed sponge-associated Nocardiopsis as a substantial source of lead natural products with pronounced pharmacological activities.
abstract_unstemmed	A new cyclic hexapeptide, nocardiotide A (1), together with three known compounds—tryptophan (2), kynurenic acid (3), and 4-amino-3-methoxy benzoic acid (4)—were isolated and identified from the broth culture of Nocardiopsis sp. UR67 strain associated with the marine sponge Callyspongia sp. from the Red Sea. The structure elucidation of the isolated compounds were determined based on detailed spectroscopic data including 1D and 2D nuclear magnetic resonance (NMR) experimental analyses in combination with high resolution electrospray ionization mass spectrometry (HR-ESI-MS), while the absolute stereochemistry of all amino acids components of nocardiotide A (1) was deduced using Marfey’s method. Additionally, ten known metabolites were dereplicated using HR-ESI-MS analysis. Nocardiotide A (1) displayed significant cytotoxic effects towards the murine CT26 colon carcinoma, human HeLa cervix carcinoma, and human MM.1S multiple myeloma cell lines. The results obtained revealed sponge-associated Nocardiopsis as a substantial source of lead natural products with pronounced pharmacological activities.
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container_issue	9, p 290
title_short	New Cytotoxic Cyclic Peptide from the Marine Sponge-Associated Nocardiopsis sp. UR67
url	https://doi.org/10.3390/md16090290 https://doaj.org/article/57c98dcde588445d8da8df4a1cd35e56 http://www.mdpi.com/1660-3397/16/9/290 https://doaj.org/toc/1660-3397
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author2	Eman Zekry Attia Dina Hajjar Mohamed A. Anany Samar Yehia Desoukey Mostafa Ahmed Fouad Mohamed Salah Kamel Harald Wajant Tobias A. M. Gulder Usama Ramadan Abdelmohsen
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up_date	2024-07-03T22:42:19.438Z
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New Cytotoxic Cyclic Peptide from the Marine Sponge-Associated Nocardiopsis sp. UR67

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