Line-Monitoring, Hyperspectral Fluorescence Setup for Simultaneous Multi-Analyte Biosensing

Conventional fluorescence scanners utilize multiple filters to distinguish different fluorescent labels, and problems arise because of this filter-based mechanism. In this work we propose a line-monitoring, hyperspectral fluorescence technique which is designed and optimized for applications in mult...
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Autor*in:	Yanhong Ji [verfasserIn] Sunan Deng [verfasserIn] Le Liu [verfasserIn] Heng Shi [verfasserIn] Zhiyi Liu [verfasserIn] Suihua Ma [verfasserIn] Hui Ma [verfasserIn] Yonghong He [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	hyperspectral fluorescence detection microfluidic system biosensor

Übergeordnetes Werk:	In: Sensors - MDPI AG, 2003, 11(2011), 11, Seite 10038-10047
Übergeordnetes Werk:	volume:11 ; year:2011 ; number:11 ; pages:10038-10047

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/s111110038

Katalog-ID:	DOAJ079293239

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allfields	10.3390/s111110038 doi (DE-627)DOAJ079293239 (DE-599)DOAJd402f131643e4495b8ce7f9983522953 DE-627 ger DE-627 rakwb eng TP1-1185 Yanhong Ji verfasserin aut Line-Monitoring, Hyperspectral Fluorescence Setup for Simultaneous Multi-Analyte Biosensing 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Conventional fluorescence scanners utilize multiple filters to distinguish different fluorescent labels, and problems arise because of this filter-based mechanism. In this work we propose a line-monitoring, hyperspectral fluorescence technique which is designed and optimized for applications in multi-channel microfluidic systems. In contrast to the filter-based mechanism, which only records fluorescent intensities, the hyperspectral technique records the full spectrum for every point on the sample plane. Multivariate data exploitation is then applied to spectra analysis to determine ratios of different fluorescent labels and eliminate unwanted artifacts. This sensor is designed to monitor multiple fluidic channels simultaneously, providing the potential for multi-analyte biosensing. The detection sensitivity is approximately 0.81 fluors/μm2, and this sensor is proved to act with a good homogeneity. Finally, a model experiment of detecting short oligonucleotides has demonstrated the biomedical application of this hyperspectral fluorescence biosensor. hyperspectral fluorescence detection microfluidic system biosensor Chemical technology Sunan Deng verfasserin aut Le Liu verfasserin aut Heng Shi verfasserin aut Zhiyi Liu verfasserin aut Suihua Ma verfasserin aut Hui Ma verfasserin aut Yonghong He verfasserin aut In Sensors MDPI AG, 2003 11(2011), 11, Seite 10038-10047 (DE-627)331640910 (DE-600)2052857-7 14248220 nnns volume:11 year:2011 number:11 pages:10038-10047 https://doi.org/10.3390/s111110038 kostenfrei https://doaj.org/article/d402f131643e4495b8ce7f9983522953 kostenfrei http://www.mdpi.com/1424-8220/11/11/10038/ kostenfrei https://doaj.org/toc/1424-8220 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2111 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2011 11 10038-10047
spelling	10.3390/s111110038 doi (DE-627)DOAJ079293239 (DE-599)DOAJd402f131643e4495b8ce7f9983522953 DE-627 ger DE-627 rakwb eng TP1-1185 Yanhong Ji verfasserin aut Line-Monitoring, Hyperspectral Fluorescence Setup for Simultaneous Multi-Analyte Biosensing 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Conventional fluorescence scanners utilize multiple filters to distinguish different fluorescent labels, and problems arise because of this filter-based mechanism. In this work we propose a line-monitoring, hyperspectral fluorescence technique which is designed and optimized for applications in multi-channel microfluidic systems. In contrast to the filter-based mechanism, which only records fluorescent intensities, the hyperspectral technique records the full spectrum for every point on the sample plane. Multivariate data exploitation is then applied to spectra analysis to determine ratios of different fluorescent labels and eliminate unwanted artifacts. This sensor is designed to monitor multiple fluidic channels simultaneously, providing the potential for multi-analyte biosensing. The detection sensitivity is approximately 0.81 fluors/μm2, and this sensor is proved to act with a good homogeneity. Finally, a model experiment of detecting short oligonucleotides has demonstrated the biomedical application of this hyperspectral fluorescence biosensor. hyperspectral fluorescence detection microfluidic system biosensor Chemical technology Sunan Deng verfasserin aut Le Liu verfasserin aut Heng Shi verfasserin aut Zhiyi Liu verfasserin aut Suihua Ma verfasserin aut Hui Ma verfasserin aut Yonghong He verfasserin aut In Sensors MDPI AG, 2003 11(2011), 11, Seite 10038-10047 (DE-627)331640910 (DE-600)2052857-7 14248220 nnns volume:11 year:2011 number:11 pages:10038-10047 https://doi.org/10.3390/s111110038 kostenfrei https://doaj.org/article/d402f131643e4495b8ce7f9983522953 kostenfrei http://www.mdpi.com/1424-8220/11/11/10038/ kostenfrei https://doaj.org/toc/1424-8220 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2111 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2011 11 10038-10047
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allfieldsSound	10.3390/s111110038 doi (DE-627)DOAJ079293239 (DE-599)DOAJd402f131643e4495b8ce7f9983522953 DE-627 ger DE-627 rakwb eng TP1-1185 Yanhong Ji verfasserin aut Line-Monitoring, Hyperspectral Fluorescence Setup for Simultaneous Multi-Analyte Biosensing 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Conventional fluorescence scanners utilize multiple filters to distinguish different fluorescent labels, and problems arise because of this filter-based mechanism. In this work we propose a line-monitoring, hyperspectral fluorescence technique which is designed and optimized for applications in multi-channel microfluidic systems. In contrast to the filter-based mechanism, which only records fluorescent intensities, the hyperspectral technique records the full spectrum for every point on the sample plane. Multivariate data exploitation is then applied to spectra analysis to determine ratios of different fluorescent labels and eliminate unwanted artifacts. This sensor is designed to monitor multiple fluidic channels simultaneously, providing the potential for multi-analyte biosensing. The detection sensitivity is approximately 0.81 fluors/μm2, and this sensor is proved to act with a good homogeneity. Finally, a model experiment of detecting short oligonucleotides has demonstrated the biomedical application of this hyperspectral fluorescence biosensor. hyperspectral fluorescence detection microfluidic system biosensor Chemical technology Sunan Deng verfasserin aut Le Liu verfasserin aut Heng Shi verfasserin aut Zhiyi Liu verfasserin aut Suihua Ma verfasserin aut Hui Ma verfasserin aut Yonghong He verfasserin aut In Sensors MDPI AG, 2003 11(2011), 11, Seite 10038-10047 (DE-627)331640910 (DE-600)2052857-7 14248220 nnns volume:11 year:2011 number:11 pages:10038-10047 https://doi.org/10.3390/s111110038 kostenfrei https://doaj.org/article/d402f131643e4495b8ce7f9983522953 kostenfrei http://www.mdpi.com/1424-8220/11/11/10038/ kostenfrei https://doaj.org/toc/1424-8220 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2111 GBV_ILN_2507 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2011 11 10038-10047
language	English
source	In Sensors 11(2011), 11, Seite 10038-10047 volume:11 year:2011 number:11 pages:10038-10047
sourceStr	In Sensors 11(2011), 11, Seite 10038-10047 volume:11 year:2011 number:11 pages:10038-10047
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	hyperspectral fluorescence detection microfluidic system biosensor Chemical technology
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container_title	Sensors
authorswithroles_txt_mv	Yanhong Ji @@aut@@ Sunan Deng @@aut@@ Le Liu @@aut@@ Heng Shi @@aut@@ Zhiyi Liu @@aut@@ Suihua Ma @@aut@@ Hui Ma @@aut@@ Yonghong He @@aut@@
publishDateDaySort_date	2011-01-01T00:00:00Z
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callnumber-first	T - Technology
author	Yanhong Ji
spellingShingle	Yanhong Ji misc TP1-1185 misc hyperspectral fluorescence detection misc microfluidic system misc biosensor misc Chemical technology Line-Monitoring, Hyperspectral Fluorescence Setup for Simultaneous Multi-Analyte Biosensing
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topic_title	TP1-1185 Line-Monitoring, Hyperspectral Fluorescence Setup for Simultaneous Multi-Analyte Biosensing hyperspectral fluorescence detection microfluidic system biosensor
topic	misc TP1-1185 misc hyperspectral fluorescence detection misc microfluidic system misc biosensor misc Chemical technology
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title	Line-Monitoring, Hyperspectral Fluorescence Setup for Simultaneous Multi-Analyte Biosensing
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title_sort	line-monitoring, hyperspectral fluorescence setup for simultaneous multi-analyte biosensing
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title_auth	Line-Monitoring, Hyperspectral Fluorescence Setup for Simultaneous Multi-Analyte Biosensing
abstract	Conventional fluorescence scanners utilize multiple filters to distinguish different fluorescent labels, and problems arise because of this filter-based mechanism. In this work we propose a line-monitoring, hyperspectral fluorescence technique which is designed and optimized for applications in multi-channel microfluidic systems. In contrast to the filter-based mechanism, which only records fluorescent intensities, the hyperspectral technique records the full spectrum for every point on the sample plane. Multivariate data exploitation is then applied to spectra analysis to determine ratios of different fluorescent labels and eliminate unwanted artifacts. This sensor is designed to monitor multiple fluidic channels simultaneously, providing the potential for multi-analyte biosensing. The detection sensitivity is approximately 0.81 fluors/μm2, and this sensor is proved to act with a good homogeneity. Finally, a model experiment of detecting short oligonucleotides has demonstrated the biomedical application of this hyperspectral fluorescence biosensor.
abstractGer	Conventional fluorescence scanners utilize multiple filters to distinguish different fluorescent labels, and problems arise because of this filter-based mechanism. In this work we propose a line-monitoring, hyperspectral fluorescence technique which is designed and optimized for applications in multi-channel microfluidic systems. In contrast to the filter-based mechanism, which only records fluorescent intensities, the hyperspectral technique records the full spectrum for every point on the sample plane. Multivariate data exploitation is then applied to spectra analysis to determine ratios of different fluorescent labels and eliminate unwanted artifacts. This sensor is designed to monitor multiple fluidic channels simultaneously, providing the potential for multi-analyte biosensing. The detection sensitivity is approximately 0.81 fluors/μm2, and this sensor is proved to act with a good homogeneity. Finally, a model experiment of detecting short oligonucleotides has demonstrated the biomedical application of this hyperspectral fluorescence biosensor.
abstract_unstemmed	Conventional fluorescence scanners utilize multiple filters to distinguish different fluorescent labels, and problems arise because of this filter-based mechanism. In this work we propose a line-monitoring, hyperspectral fluorescence technique which is designed and optimized for applications in multi-channel microfluidic systems. In contrast to the filter-based mechanism, which only records fluorescent intensities, the hyperspectral technique records the full spectrum for every point on the sample plane. Multivariate data exploitation is then applied to spectra analysis to determine ratios of different fluorescent labels and eliminate unwanted artifacts. This sensor is designed to monitor multiple fluidic channels simultaneously, providing the potential for multi-analyte biosensing. The detection sensitivity is approximately 0.81 fluors/μm2, and this sensor is proved to act with a good homogeneity. Finally, a model experiment of detecting short oligonucleotides has demonstrated the biomedical application of this hyperspectral fluorescence biosensor.
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title_short	Line-Monitoring, Hyperspectral Fluorescence Setup for Simultaneous Multi-Analyte Biosensing
url	https://doi.org/10.3390/s111110038 https://doaj.org/article/d402f131643e4495b8ce7f9983522953 http://www.mdpi.com/1424-8220/11/11/10038/ https://doaj.org/toc/1424-8220
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