Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection

Bone tissue inflammation, <i<osteomyelitis</i<, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against <i<Staphylococcus aureus</i< for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against <i<Staphylococcus aureus</i< (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against <i<S. aureus</i< and the highest cytocompatibility to human osteoblasts in vitro. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Adrianna Skwira [verfasserIn] Adrian Szewczyk [verfasserIn] Agnieszka Konopacka [verfasserIn] Monika Górska [verfasserIn] Dorota Majda [verfasserIn] Rafał Sądej [verfasserIn] Magdalena Prokopowicz [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2019

Schlagwörter:	drug delivery system mesoporous silica silica-polymer ciprofloxacin polydimethylsiloxane composites coating blend

Übergeordnetes Werk:	In: Pharmaceutics - MDPI AG, 2010, 12(2019), 1, p 28
Übergeordnetes Werk:	volume:12 ; year:2019 ; number:1, p 28

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/pharmaceutics12010028

Katalog-ID:	DOAJ079316794

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allfields	10.3390/pharmaceutics12010028 doi (DE-627)DOAJ079316794 (DE-599)DOAJ5db497f8c3f1474fbbff271d08eb57cf DE-627 ger DE-627 rakwb eng RS1-441 Adrianna Skwira verfasserin aut Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bone tissue inflammation, <i<osteomyelitis</i<, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against <i<Staphylococcus aureus</i< for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against <i<Staphylococcus aureus</i< (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against <i<S. aureus</i< and the highest cytocompatibility to human osteoblasts in vitro. drug delivery system mesoporous silica silica-polymer ciprofloxacin polydimethylsiloxane composites coating blend Pharmacy and materia medica Adrian Szewczyk verfasserin aut Agnieszka Konopacka verfasserin aut Monika Górska verfasserin aut Dorota Majda verfasserin aut Rafał Sądej verfasserin aut Magdalena Prokopowicz verfasserin aut In Pharmaceutics MDPI AG, 2010 12(2019), 1, p 28 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:12 year:2019 number:1, p 28 https://doi.org/10.3390/pharmaceutics12010028 kostenfrei https://doaj.org/article/5db497f8c3f1474fbbff271d08eb57cf kostenfrei https://www.mdpi.com/1999-4923/12/1/28 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1, p 28
spelling	10.3390/pharmaceutics12010028 doi (DE-627)DOAJ079316794 (DE-599)DOAJ5db497f8c3f1474fbbff271d08eb57cf DE-627 ger DE-627 rakwb eng RS1-441 Adrianna Skwira verfasserin aut Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bone tissue inflammation, <i<osteomyelitis</i<, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against <i<Staphylococcus aureus</i< for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against <i<Staphylococcus aureus</i< (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against <i<S. aureus</i< and the highest cytocompatibility to human osteoblasts in vitro. drug delivery system mesoporous silica silica-polymer ciprofloxacin polydimethylsiloxane composites coating blend Pharmacy and materia medica Adrian Szewczyk verfasserin aut Agnieszka Konopacka verfasserin aut Monika Górska verfasserin aut Dorota Majda verfasserin aut Rafał Sądej verfasserin aut Magdalena Prokopowicz verfasserin aut In Pharmaceutics MDPI AG, 2010 12(2019), 1, p 28 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:12 year:2019 number:1, p 28 https://doi.org/10.3390/pharmaceutics12010028 kostenfrei https://doaj.org/article/5db497f8c3f1474fbbff271d08eb57cf kostenfrei https://www.mdpi.com/1999-4923/12/1/28 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1, p 28
allfields_unstemmed	10.3390/pharmaceutics12010028 doi (DE-627)DOAJ079316794 (DE-599)DOAJ5db497f8c3f1474fbbff271d08eb57cf DE-627 ger DE-627 rakwb eng RS1-441 Adrianna Skwira verfasserin aut Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bone tissue inflammation, <i<osteomyelitis</i<, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against <i<Staphylococcus aureus</i< for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against <i<Staphylococcus aureus</i< (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against <i<S. aureus</i< and the highest cytocompatibility to human osteoblasts in vitro. drug delivery system mesoporous silica silica-polymer ciprofloxacin polydimethylsiloxane composites coating blend Pharmacy and materia medica Adrian Szewczyk verfasserin aut Agnieszka Konopacka verfasserin aut Monika Górska verfasserin aut Dorota Majda verfasserin aut Rafał Sądej verfasserin aut Magdalena Prokopowicz verfasserin aut In Pharmaceutics MDPI AG, 2010 12(2019), 1, p 28 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:12 year:2019 number:1, p 28 https://doi.org/10.3390/pharmaceutics12010028 kostenfrei https://doaj.org/article/5db497f8c3f1474fbbff271d08eb57cf kostenfrei https://www.mdpi.com/1999-4923/12/1/28 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1, p 28
allfieldsGer	10.3390/pharmaceutics12010028 doi (DE-627)DOAJ079316794 (DE-599)DOAJ5db497f8c3f1474fbbff271d08eb57cf DE-627 ger DE-627 rakwb eng RS1-441 Adrianna Skwira verfasserin aut Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bone tissue inflammation, <i<osteomyelitis</i<, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against <i<Staphylococcus aureus</i< for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against <i<Staphylococcus aureus</i< (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against <i<S. aureus</i< and the highest cytocompatibility to human osteoblasts in vitro. drug delivery system mesoporous silica silica-polymer ciprofloxacin polydimethylsiloxane composites coating blend Pharmacy and materia medica Adrian Szewczyk verfasserin aut Agnieszka Konopacka verfasserin aut Monika Górska verfasserin aut Dorota Majda verfasserin aut Rafał Sądej verfasserin aut Magdalena Prokopowicz verfasserin aut In Pharmaceutics MDPI AG, 2010 12(2019), 1, p 28 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:12 year:2019 number:1, p 28 https://doi.org/10.3390/pharmaceutics12010028 kostenfrei https://doaj.org/article/5db497f8c3f1474fbbff271d08eb57cf kostenfrei https://www.mdpi.com/1999-4923/12/1/28 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1, p 28
allfieldsSound	10.3390/pharmaceutics12010028 doi (DE-627)DOAJ079316794 (DE-599)DOAJ5db497f8c3f1474fbbff271d08eb57cf DE-627 ger DE-627 rakwb eng RS1-441 Adrianna Skwira verfasserin aut Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection 2019 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Bone tissue inflammation, <i<osteomyelitis</i<, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against <i<Staphylococcus aureus</i< for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against <i<Staphylococcus aureus</i< (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against <i<S. aureus</i< and the highest cytocompatibility to human osteoblasts in vitro. drug delivery system mesoporous silica silica-polymer ciprofloxacin polydimethylsiloxane composites coating blend Pharmacy and materia medica Adrian Szewczyk verfasserin aut Agnieszka Konopacka verfasserin aut Monika Górska verfasserin aut Dorota Majda verfasserin aut Rafał Sądej verfasserin aut Magdalena Prokopowicz verfasserin aut In Pharmaceutics MDPI AG, 2010 12(2019), 1, p 28 (DE-627)614096529 (DE-600)2527217-2 19994923 nnns volume:12 year:2019 number:1, p 28 https://doi.org/10.3390/pharmaceutics12010028 kostenfrei https://doaj.org/article/5db497f8c3f1474fbbff271d08eb57cf kostenfrei https://www.mdpi.com/1999-4923/12/1/28 kostenfrei https://doaj.org/toc/1999-4923 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2019 1, p 28
language	English
source	In Pharmaceutics 12(2019), 1, p 28 volume:12 year:2019 number:1, p 28
sourceStr	In Pharmaceutics 12(2019), 1, p 28 volume:12 year:2019 number:1, p 28
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	drug delivery system mesoporous silica silica-polymer ciprofloxacin polydimethylsiloxane composites coating blend Pharmacy and materia medica
isfreeaccess_bool	true
container_title	Pharmaceutics
authorswithroles_txt_mv	Adrianna Skwira @@aut@@ Adrian Szewczyk @@aut@@ Agnieszka Konopacka @@aut@@ Monika Górska @@aut@@ Dorota Majda @@aut@@ Rafał Sądej @@aut@@ Magdalena Prokopowicz @@aut@@
publishDateDaySort_date	2019-01-01T00:00:00Z
hierarchy_top_id	614096529
id	DOAJ079316794
language_de	englisch
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callnumber-first	R - Medicine
author	Adrianna Skwira
spellingShingle	Adrianna Skwira misc RS1-441 misc drug delivery system misc mesoporous silica misc silica-polymer misc ciprofloxacin misc polydimethylsiloxane misc composites misc coating blend misc Pharmacy and materia medica Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection
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topic_title	RS1-441 Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection drug delivery system mesoporous silica silica-polymer ciprofloxacin polydimethylsiloxane composites coating blend
topic	misc RS1-441 misc drug delivery system misc mesoporous silica misc silica-polymer misc ciprofloxacin misc polydimethylsiloxane misc composites misc coating blend misc Pharmacy and materia medica
topic_unstemmed	misc RS1-441 misc drug delivery system misc mesoporous silica misc silica-polymer misc ciprofloxacin misc polydimethylsiloxane misc composites misc coating blend misc Pharmacy and materia medica
topic_browse	misc RS1-441 misc drug delivery system misc mesoporous silica misc silica-polymer misc ciprofloxacin misc polydimethylsiloxane misc composites misc coating blend misc Pharmacy and materia medica
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title	Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection
ctrlnum	(DE-627)DOAJ079316794 (DE-599)DOAJ5db497f8c3f1474fbbff271d08eb57cf
title_full	Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection
author_sort	Adrianna Skwira
journal	Pharmaceutics
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author_browse	Adrianna Skwira Adrian Szewczyk Agnieszka Konopacka Monika Górska Dorota Majda Rafał Sądej Magdalena Prokopowicz
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title_sort	silica-polymer composites as the novel antibiotic delivery systems for bone tissue infection
callnumber	RS1-441
title_auth	Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection
abstract	Bone tissue inflammation, <i<osteomyelitis</i<, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against <i<Staphylococcus aureus</i< for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against <i<Staphylococcus aureus</i< (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against <i<S. aureus</i< and the highest cytocompatibility to human osteoblasts in vitro.
abstractGer	Bone tissue inflammation, <i<osteomyelitis</i<, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against <i<Staphylococcus aureus</i< for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against <i<Staphylococcus aureus</i< (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against <i<S. aureus</i< and the highest cytocompatibility to human osteoblasts in vitro.
abstract_unstemmed	Bone tissue inflammation, <i<osteomyelitis</i<, is commonly caused by bacterial invasion and requires prolonged antibiotic therapy for weeks or months. Thus, the aim of this study was to develop novel silica-polymer local bone antibiotic delivery systems characterized by a sustained release of ciprofloxacin (CIP) which remain active against <i<Staphylococcus aureus</i< for a few weeks, and do not have a toxic effect towards human osteoblasts. Four formulations composed of ethylcellulose (EC), polydimethylsiloxane (PDMS), freeze-dried CIP, and CIP-adsorbed mesoporous silica materials (MCM-41-CIP) were prepared via solvent-evaporation blending method. All obtained composites were characterized in terms of molecular structure, morphological, and structural properties by using Fourier Transform Infrared Spectroscopy (FTIR), scanning electron microscopy equipped with energy-dispersive X-ray spectroscopy (SEM/EDX), and X-ray diffraction (XRD), thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC), and in vitro antibiotic release. The antibacterial activity against <i<Staphylococcus aureus</i< (ATCC 6538) as well as the in vitro cytocompatibility to human osteoblasts of obtained composites were also examined. Physicochemical results confirmed the presence of particular components (FTIR), formation of continuous polymer phase onto the surface of freeze-dried CIP or MCM-41-CIP (SEM/EDX), and semi-crystalline (composites containing freeze-dried CIP) or amorphous (composites containing MCM-41-CIP) structure (XRD). TGA and DSC analysis indicated the high thermal stability of CIP adsorbed onto the MCM-41, and higher after MCM-41-CIP coating with polymer blend. The release study revealed the significant reduction in initial burst of CIP for the composites which contained MCM-41-CIP instead of freeze-dried CIP. These composites were also characterized by the 30-day activity against <i<S. aureus</i< and the highest cytocompatibility to human osteoblasts in vitro.
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title_short	Silica-Polymer Composites as the Novel Antibiotic Delivery Systems for Bone Tissue Infection
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