CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection

Abstract Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. Recent advances in CRISPR/Cas9 gene editing tec...
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Autor*in:	Jenna Kropp Schmidt [verfasserIn] Matthew R. Reynolds [verfasserIn] Thaddeus G. Golos [verfasserIn] Igor I. Slukvin [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Nonhuman primates HIV SIV CRISPR/Cas9 CCR5 HSC transplantation

Übergeordnetes Werk:	In: Retrovirology - BMC, 2004, 19(2022), 1, Seite 12
Übergeordnetes Werk:	volume:19 ; year:2022 ; number:1 ; pages:12

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1186/s12977-022-00604-5

Katalog-ID:	DOAJ079321887

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520			\|a Abstract Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. Recent advances in CRISPR/Cas9 gene editing technologies present opportunities to refine NHP HIV models for investigating genetic factors that affect HIV replication and designing cellular therapies that exploit genetic barriers to HIV infections, including engineering mutations into CCR5 and conferring resistance to HIV/simian immunodeficiency virus (SIV) infections. In this report, we provide an overview of recent advances and challenges in gene editing NHP embryos and discuss the value of genetically engineered animal models for developing novel stem cell-based therapies for curing HIV.
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allfields	10.1186/s12977-022-00604-5 doi (DE-627)DOAJ079321887 (DE-599)DOAJe31a5b9cd7574fc99593277ca7ef0841 DE-627 ger DE-627 rakwb eng RC581-607 Jenna Kropp Schmidt verfasserin aut CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. Recent advances in CRISPR/Cas9 gene editing technologies present opportunities to refine NHP HIV models for investigating genetic factors that affect HIV replication and designing cellular therapies that exploit genetic barriers to HIV infections, including engineering mutations into CCR5 and conferring resistance to HIV/simian immunodeficiency virus (SIV) infections. In this report, we provide an overview of recent advances and challenges in gene editing NHP embryos and discuss the value of genetically engineered animal models for developing novel stem cell-based therapies for curing HIV. Nonhuman primates HIV SIV CRISPR/Cas9 CCR5 HSC transplantation Immunologic diseases. Allergy Matthew R. Reynolds verfasserin aut Thaddeus G. Golos verfasserin aut Igor I. Slukvin verfasserin aut In Retrovirology BMC, 2004 19(2022), 1, Seite 12 (DE-627)385612931 (DE-600)2142602-8 17424690 nnns volume:19 year:2022 number:1 pages:12 https://doi.org/10.1186/s12977-022-00604-5 kostenfrei https://doaj.org/article/e31a5b9cd7574fc99593277ca7ef0841 kostenfrei https://doi.org/10.1186/s12977-022-00604-5 kostenfrei https://doaj.org/toc/1742-4690 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 12
spelling	10.1186/s12977-022-00604-5 doi (DE-627)DOAJ079321887 (DE-599)DOAJe31a5b9cd7574fc99593277ca7ef0841 DE-627 ger DE-627 rakwb eng RC581-607 Jenna Kropp Schmidt verfasserin aut CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. Recent advances in CRISPR/Cas9 gene editing technologies present opportunities to refine NHP HIV models for investigating genetic factors that affect HIV replication and designing cellular therapies that exploit genetic barriers to HIV infections, including engineering mutations into CCR5 and conferring resistance to HIV/simian immunodeficiency virus (SIV) infections. In this report, we provide an overview of recent advances and challenges in gene editing NHP embryos and discuss the value of genetically engineered animal models for developing novel stem cell-based therapies for curing HIV. Nonhuman primates HIV SIV CRISPR/Cas9 CCR5 HSC transplantation Immunologic diseases. Allergy Matthew R. Reynolds verfasserin aut Thaddeus G. Golos verfasserin aut Igor I. Slukvin verfasserin aut In Retrovirology BMC, 2004 19(2022), 1, Seite 12 (DE-627)385612931 (DE-600)2142602-8 17424690 nnns volume:19 year:2022 number:1 pages:12 https://doi.org/10.1186/s12977-022-00604-5 kostenfrei https://doaj.org/article/e31a5b9cd7574fc99593277ca7ef0841 kostenfrei https://doi.org/10.1186/s12977-022-00604-5 kostenfrei https://doaj.org/toc/1742-4690 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 12
allfields_unstemmed	10.1186/s12977-022-00604-5 doi (DE-627)DOAJ079321887 (DE-599)DOAJe31a5b9cd7574fc99593277ca7ef0841 DE-627 ger DE-627 rakwb eng RC581-607 Jenna Kropp Schmidt verfasserin aut CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. Recent advances in CRISPR/Cas9 gene editing technologies present opportunities to refine NHP HIV models for investigating genetic factors that affect HIV replication and designing cellular therapies that exploit genetic barriers to HIV infections, including engineering mutations into CCR5 and conferring resistance to HIV/simian immunodeficiency virus (SIV) infections. In this report, we provide an overview of recent advances and challenges in gene editing NHP embryos and discuss the value of genetically engineered animal models for developing novel stem cell-based therapies for curing HIV. Nonhuman primates HIV SIV CRISPR/Cas9 CCR5 HSC transplantation Immunologic diseases. Allergy Matthew R. Reynolds verfasserin aut Thaddeus G. Golos verfasserin aut Igor I. Slukvin verfasserin aut In Retrovirology BMC, 2004 19(2022), 1, Seite 12 (DE-627)385612931 (DE-600)2142602-8 17424690 nnns volume:19 year:2022 number:1 pages:12 https://doi.org/10.1186/s12977-022-00604-5 kostenfrei https://doaj.org/article/e31a5b9cd7574fc99593277ca7ef0841 kostenfrei https://doi.org/10.1186/s12977-022-00604-5 kostenfrei https://doaj.org/toc/1742-4690 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 12
allfieldsGer	10.1186/s12977-022-00604-5 doi (DE-627)DOAJ079321887 (DE-599)DOAJe31a5b9cd7574fc99593277ca7ef0841 DE-627 ger DE-627 rakwb eng RC581-607 Jenna Kropp Schmidt verfasserin aut CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. Recent advances in CRISPR/Cas9 gene editing technologies present opportunities to refine NHP HIV models for investigating genetic factors that affect HIV replication and designing cellular therapies that exploit genetic barriers to HIV infections, including engineering mutations into CCR5 and conferring resistance to HIV/simian immunodeficiency virus (SIV) infections. In this report, we provide an overview of recent advances and challenges in gene editing NHP embryos and discuss the value of genetically engineered animal models for developing novel stem cell-based therapies for curing HIV. Nonhuman primates HIV SIV CRISPR/Cas9 CCR5 HSC transplantation Immunologic diseases. Allergy Matthew R. Reynolds verfasserin aut Thaddeus G. Golos verfasserin aut Igor I. Slukvin verfasserin aut In Retrovirology BMC, 2004 19(2022), 1, Seite 12 (DE-627)385612931 (DE-600)2142602-8 17424690 nnns volume:19 year:2022 number:1 pages:12 https://doi.org/10.1186/s12977-022-00604-5 kostenfrei https://doaj.org/article/e31a5b9cd7574fc99593277ca7ef0841 kostenfrei https://doi.org/10.1186/s12977-022-00604-5 kostenfrei https://doaj.org/toc/1742-4690 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 12
allfieldsSound	10.1186/s12977-022-00604-5 doi (DE-627)DOAJ079321887 (DE-599)DOAJe31a5b9cd7574fc99593277ca7ef0841 DE-627 ger DE-627 rakwb eng RC581-607 Jenna Kropp Schmidt verfasserin aut CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Abstract Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. Recent advances in CRISPR/Cas9 gene editing technologies present opportunities to refine NHP HIV models for investigating genetic factors that affect HIV replication and designing cellular therapies that exploit genetic barriers to HIV infections, including engineering mutations into CCR5 and conferring resistance to HIV/simian immunodeficiency virus (SIV) infections. In this report, we provide an overview of recent advances and challenges in gene editing NHP embryos and discuss the value of genetically engineered animal models for developing novel stem cell-based therapies for curing HIV. Nonhuman primates HIV SIV CRISPR/Cas9 CCR5 HSC transplantation Immunologic diseases. Allergy Matthew R. Reynolds verfasserin aut Thaddeus G. Golos verfasserin aut Igor I. Slukvin verfasserin aut In Retrovirology BMC, 2004 19(2022), 1, Seite 12 (DE-627)385612931 (DE-600)2142602-8 17424690 nnns volume:19 year:2022 number:1 pages:12 https://doi.org/10.1186/s12977-022-00604-5 kostenfrei https://doaj.org/article/e31a5b9cd7574fc99593277ca7ef0841 kostenfrei https://doi.org/10.1186/s12977-022-00604-5 kostenfrei https://doaj.org/toc/1742-4690 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 19 2022 1 12
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author	Jenna Kropp Schmidt
spellingShingle	Jenna Kropp Schmidt misc RC581-607 misc Nonhuman primates misc HIV misc SIV misc CRISPR/Cas9 misc CCR5 misc HSC transplantation misc Immunologic diseases. Allergy CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection
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topic_title	RC581-607 CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection Nonhuman primates HIV SIV CRISPR/Cas9 CCR5 HSC transplantation
topic	misc RC581-607 misc Nonhuman primates misc HIV misc SIV misc CRISPR/Cas9 misc CCR5 misc HSC transplantation misc Immunologic diseases. Allergy
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title	CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection
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title_auth	CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection
abstract	Abstract Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. Recent advances in CRISPR/Cas9 gene editing technologies present opportunities to refine NHP HIV models for investigating genetic factors that affect HIV replication and designing cellular therapies that exploit genetic barriers to HIV infections, including engineering mutations into CCR5 and conferring resistance to HIV/simian immunodeficiency virus (SIV) infections. In this report, we provide an overview of recent advances and challenges in gene editing NHP embryos and discuss the value of genetically engineered animal models for developing novel stem cell-based therapies for curing HIV.
abstractGer	Abstract Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. Recent advances in CRISPR/Cas9 gene editing technologies present opportunities to refine NHP HIV models for investigating genetic factors that affect HIV replication and designing cellular therapies that exploit genetic barriers to HIV infections, including engineering mutations into CCR5 and conferring resistance to HIV/simian immunodeficiency virus (SIV) infections. In this report, we provide an overview of recent advances and challenges in gene editing NHP embryos and discuss the value of genetically engineered animal models for developing novel stem cell-based therapies for curing HIV.
abstract_unstemmed	Abstract Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. Recent advances in CRISPR/Cas9 gene editing technologies present opportunities to refine NHP HIV models for investigating genetic factors that affect HIV replication and designing cellular therapies that exploit genetic barriers to HIV infections, including engineering mutations into CCR5 and conferring resistance to HIV/simian immunodeficiency virus (SIV) infections. In this report, we provide an overview of recent advances and challenges in gene editing NHP embryos and discuss the value of genetically engineered animal models for developing novel stem cell-based therapies for curing HIV.
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title_short	CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection
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CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection

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