<i<Porphyromonas</i< <i<gingivalis</i< Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases
<i<Porphyromonas gingivalis</i< is a gram-negative, anaerobic bacterium that lives in the oral cavity. It is an integral part of the oral microbiome, which includes more than 500 types of bacteria. Under certain circumstances, as a consequence of virulence factors, it can become very des...
Ausführliche Beschreibung
Autor*in: |
Lorena Horvat Aleksijević [verfasserIn] Marko Aleksijević [verfasserIn] Ivana Škrlec [verfasserIn] Marko Šram [verfasserIn] Miroslav Šram [verfasserIn] Jasminka Talapko [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2022 |
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Schlagwörter: |
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Übergeordnetes Werk: |
In: Pathogens - MDPI AG, 2012, 11(2022), 10, p 1173 |
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Übergeordnetes Werk: |
volume:11 ; year:2022 ; number:10, p 1173 |
Links: |
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DOI / URN: |
10.3390/pathogens11101173 |
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Katalog-ID: |
DOAJ079431496 |
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10.3390/pathogens11101173 doi (DE-627)DOAJ079431496 (DE-599)DOAJb280e86e07594eefb99e42883a104d8d DE-627 ger DE-627 rakwb eng Lorena Horvat Aleksijević verfasserin aut <i<Porphyromonas</i< <i<gingivalis</i< Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Porphyromonas gingivalis</i< is a gram-negative, anaerobic bacterium that lives in the oral cavity. It is an integral part of the oral microbiome, which includes more than 500 types of bacteria. Under certain circumstances, as a consequence of virulence factors, it can become very destructive and proliferate to many cells in periodontal lesions. It is one of the causative agents present extremely often in dental plaque and is the main etiological factor in the development of periodontal disease. During various therapeutic procedures, <i<P. gingivalis</i< can enter the blood and disseminate through it to distant organs. This primarily refers to the influence of periodontal agents on the development of subacute endocarditis and can facilitate the development of coronary heart disease, atherosclerosis, and ischemic infarction. The action of <i<P. gingivalis</i< is facilitated by numerous factors of virulence and pathogenicity such as fimbriae, hemolysin, hemagglutinin, capsules, outer membrane vesicles, lipopolysaccharides, and gingipains. A special problem is the possibility of biofilm formation. <i<P. gingivalis</i< in a biofilm is 500 to 1000 times less sensitive to antimicrobial drugs than planktonic cells, which represents a significant problem in the treatment of infections caused by this pathogen. atherosclerosis cardiology periodontitis <i<Porphyromonas gingivalis</i< virulence factors Medicine R Marko Aleksijević verfasserin aut Ivana Škrlec verfasserin aut Marko Šram verfasserin aut Miroslav Šram verfasserin aut Jasminka Talapko verfasserin aut In Pathogens MDPI AG, 2012 11(2022), 10, p 1173 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:11 year:2022 number:10, p 1173 https://doi.org/10.3390/pathogens11101173 kostenfrei https://doaj.org/article/b280e86e07594eefb99e42883a104d8d kostenfrei https://www.mdpi.com/2076-0817/11/10/1173 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 10, p 1173 |
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10.3390/pathogens11101173 doi (DE-627)DOAJ079431496 (DE-599)DOAJb280e86e07594eefb99e42883a104d8d DE-627 ger DE-627 rakwb eng Lorena Horvat Aleksijević verfasserin aut <i<Porphyromonas</i< <i<gingivalis</i< Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Porphyromonas gingivalis</i< is a gram-negative, anaerobic bacterium that lives in the oral cavity. It is an integral part of the oral microbiome, which includes more than 500 types of bacteria. Under certain circumstances, as a consequence of virulence factors, it can become very destructive and proliferate to many cells in periodontal lesions. It is one of the causative agents present extremely often in dental plaque and is the main etiological factor in the development of periodontal disease. During various therapeutic procedures, <i<P. gingivalis</i< can enter the blood and disseminate through it to distant organs. This primarily refers to the influence of periodontal agents on the development of subacute endocarditis and can facilitate the development of coronary heart disease, atherosclerosis, and ischemic infarction. The action of <i<P. gingivalis</i< is facilitated by numerous factors of virulence and pathogenicity such as fimbriae, hemolysin, hemagglutinin, capsules, outer membrane vesicles, lipopolysaccharides, and gingipains. A special problem is the possibility of biofilm formation. <i<P. gingivalis</i< in a biofilm is 500 to 1000 times less sensitive to antimicrobial drugs than planktonic cells, which represents a significant problem in the treatment of infections caused by this pathogen. atherosclerosis cardiology periodontitis <i<Porphyromonas gingivalis</i< virulence factors Medicine R Marko Aleksijević verfasserin aut Ivana Škrlec verfasserin aut Marko Šram verfasserin aut Miroslav Šram verfasserin aut Jasminka Talapko verfasserin aut In Pathogens MDPI AG, 2012 11(2022), 10, p 1173 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:11 year:2022 number:10, p 1173 https://doi.org/10.3390/pathogens11101173 kostenfrei https://doaj.org/article/b280e86e07594eefb99e42883a104d8d kostenfrei https://www.mdpi.com/2076-0817/11/10/1173 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 10, p 1173 |
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10.3390/pathogens11101173 doi (DE-627)DOAJ079431496 (DE-599)DOAJb280e86e07594eefb99e42883a104d8d DE-627 ger DE-627 rakwb eng Lorena Horvat Aleksijević verfasserin aut <i<Porphyromonas</i< <i<gingivalis</i< Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Porphyromonas gingivalis</i< is a gram-negative, anaerobic bacterium that lives in the oral cavity. It is an integral part of the oral microbiome, which includes more than 500 types of bacteria. Under certain circumstances, as a consequence of virulence factors, it can become very destructive and proliferate to many cells in periodontal lesions. It is one of the causative agents present extremely often in dental plaque and is the main etiological factor in the development of periodontal disease. During various therapeutic procedures, <i<P. gingivalis</i< can enter the blood and disseminate through it to distant organs. This primarily refers to the influence of periodontal agents on the development of subacute endocarditis and can facilitate the development of coronary heart disease, atherosclerosis, and ischemic infarction. The action of <i<P. gingivalis</i< is facilitated by numerous factors of virulence and pathogenicity such as fimbriae, hemolysin, hemagglutinin, capsules, outer membrane vesicles, lipopolysaccharides, and gingipains. A special problem is the possibility of biofilm formation. <i<P. gingivalis</i< in a biofilm is 500 to 1000 times less sensitive to antimicrobial drugs than planktonic cells, which represents a significant problem in the treatment of infections caused by this pathogen. atherosclerosis cardiology periodontitis <i<Porphyromonas gingivalis</i< virulence factors Medicine R Marko Aleksijević verfasserin aut Ivana Škrlec verfasserin aut Marko Šram verfasserin aut Miroslav Šram verfasserin aut Jasminka Talapko verfasserin aut In Pathogens MDPI AG, 2012 11(2022), 10, p 1173 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:11 year:2022 number:10, p 1173 https://doi.org/10.3390/pathogens11101173 kostenfrei https://doaj.org/article/b280e86e07594eefb99e42883a104d8d kostenfrei https://www.mdpi.com/2076-0817/11/10/1173 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 10, p 1173 |
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10.3390/pathogens11101173 doi (DE-627)DOAJ079431496 (DE-599)DOAJb280e86e07594eefb99e42883a104d8d DE-627 ger DE-627 rakwb eng Lorena Horvat Aleksijević verfasserin aut <i<Porphyromonas</i< <i<gingivalis</i< Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Porphyromonas gingivalis</i< is a gram-negative, anaerobic bacterium that lives in the oral cavity. It is an integral part of the oral microbiome, which includes more than 500 types of bacteria. Under certain circumstances, as a consequence of virulence factors, it can become very destructive and proliferate to many cells in periodontal lesions. It is one of the causative agents present extremely often in dental plaque and is the main etiological factor in the development of periodontal disease. During various therapeutic procedures, <i<P. gingivalis</i< can enter the blood and disseminate through it to distant organs. This primarily refers to the influence of periodontal agents on the development of subacute endocarditis and can facilitate the development of coronary heart disease, atherosclerosis, and ischemic infarction. The action of <i<P. gingivalis</i< is facilitated by numerous factors of virulence and pathogenicity such as fimbriae, hemolysin, hemagglutinin, capsules, outer membrane vesicles, lipopolysaccharides, and gingipains. A special problem is the possibility of biofilm formation. <i<P. gingivalis</i< in a biofilm is 500 to 1000 times less sensitive to antimicrobial drugs than planktonic cells, which represents a significant problem in the treatment of infections caused by this pathogen. atherosclerosis cardiology periodontitis <i<Porphyromonas gingivalis</i< virulence factors Medicine R Marko Aleksijević verfasserin aut Ivana Škrlec verfasserin aut Marko Šram verfasserin aut Miroslav Šram verfasserin aut Jasminka Talapko verfasserin aut In Pathogens MDPI AG, 2012 11(2022), 10, p 1173 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:11 year:2022 number:10, p 1173 https://doi.org/10.3390/pathogens11101173 kostenfrei https://doaj.org/article/b280e86e07594eefb99e42883a104d8d kostenfrei https://www.mdpi.com/2076-0817/11/10/1173 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 10, p 1173 |
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10.3390/pathogens11101173 doi (DE-627)DOAJ079431496 (DE-599)DOAJb280e86e07594eefb99e42883a104d8d DE-627 ger DE-627 rakwb eng Lorena Horvat Aleksijević verfasserin aut <i<Porphyromonas</i< <i<gingivalis</i< Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <i<Porphyromonas gingivalis</i< is a gram-negative, anaerobic bacterium that lives in the oral cavity. It is an integral part of the oral microbiome, which includes more than 500 types of bacteria. Under certain circumstances, as a consequence of virulence factors, it can become very destructive and proliferate to many cells in periodontal lesions. It is one of the causative agents present extremely often in dental plaque and is the main etiological factor in the development of periodontal disease. During various therapeutic procedures, <i<P. gingivalis</i< can enter the blood and disseminate through it to distant organs. This primarily refers to the influence of periodontal agents on the development of subacute endocarditis and can facilitate the development of coronary heart disease, atherosclerosis, and ischemic infarction. The action of <i<P. gingivalis</i< is facilitated by numerous factors of virulence and pathogenicity such as fimbriae, hemolysin, hemagglutinin, capsules, outer membrane vesicles, lipopolysaccharides, and gingipains. A special problem is the possibility of biofilm formation. <i<P. gingivalis</i< in a biofilm is 500 to 1000 times less sensitive to antimicrobial drugs than planktonic cells, which represents a significant problem in the treatment of infections caused by this pathogen. atherosclerosis cardiology periodontitis <i<Porphyromonas gingivalis</i< virulence factors Medicine R Marko Aleksijević verfasserin aut Ivana Škrlec verfasserin aut Marko Šram verfasserin aut Miroslav Šram verfasserin aut Jasminka Talapko verfasserin aut In Pathogens MDPI AG, 2012 11(2022), 10, p 1173 (DE-627)732627885 (DE-600)2695572-6 20760817 nnns volume:11 year:2022 number:10, p 1173 https://doi.org/10.3390/pathogens11101173 kostenfrei https://doaj.org/article/b280e86e07594eefb99e42883a104d8d kostenfrei https://www.mdpi.com/2076-0817/11/10/1173 kostenfrei https://doaj.org/toc/2076-0817 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2022 10, p 1173 |
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Lorena Horvat Aleksijević |
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<i<Porphyromonas</i< <i<gingivalis</i< Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery Diseases |
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<i<Porphyromonas gingivalis</i< is a gram-negative, anaerobic bacterium that lives in the oral cavity. It is an integral part of the oral microbiome, which includes more than 500 types of bacteria. Under certain circumstances, as a consequence of virulence factors, it can become very destructive and proliferate to many cells in periodontal lesions. It is one of the causative agents present extremely often in dental plaque and is the main etiological factor in the development of periodontal disease. During various therapeutic procedures, <i<P. gingivalis</i< can enter the blood and disseminate through it to distant organs. This primarily refers to the influence of periodontal agents on the development of subacute endocarditis and can facilitate the development of coronary heart disease, atherosclerosis, and ischemic infarction. The action of <i<P. gingivalis</i< is facilitated by numerous factors of virulence and pathogenicity such as fimbriae, hemolysin, hemagglutinin, capsules, outer membrane vesicles, lipopolysaccharides, and gingipains. A special problem is the possibility of biofilm formation. <i<P. gingivalis</i< in a biofilm is 500 to 1000 times less sensitive to antimicrobial drugs than planktonic cells, which represents a significant problem in the treatment of infections caused by this pathogen. |
abstractGer |
<i<Porphyromonas gingivalis</i< is a gram-negative, anaerobic bacterium that lives in the oral cavity. It is an integral part of the oral microbiome, which includes more than 500 types of bacteria. Under certain circumstances, as a consequence of virulence factors, it can become very destructive and proliferate to many cells in periodontal lesions. It is one of the causative agents present extremely often in dental plaque and is the main etiological factor in the development of periodontal disease. During various therapeutic procedures, <i<P. gingivalis</i< can enter the blood and disseminate through it to distant organs. This primarily refers to the influence of periodontal agents on the development of subacute endocarditis and can facilitate the development of coronary heart disease, atherosclerosis, and ischemic infarction. The action of <i<P. gingivalis</i< is facilitated by numerous factors of virulence and pathogenicity such as fimbriae, hemolysin, hemagglutinin, capsules, outer membrane vesicles, lipopolysaccharides, and gingipains. A special problem is the possibility of biofilm formation. <i<P. gingivalis</i< in a biofilm is 500 to 1000 times less sensitive to antimicrobial drugs than planktonic cells, which represents a significant problem in the treatment of infections caused by this pathogen. |
abstract_unstemmed |
<i<Porphyromonas gingivalis</i< is a gram-negative, anaerobic bacterium that lives in the oral cavity. It is an integral part of the oral microbiome, which includes more than 500 types of bacteria. Under certain circumstances, as a consequence of virulence factors, it can become very destructive and proliferate to many cells in periodontal lesions. It is one of the causative agents present extremely often in dental plaque and is the main etiological factor in the development of periodontal disease. During various therapeutic procedures, <i<P. gingivalis</i< can enter the blood and disseminate through it to distant organs. This primarily refers to the influence of periodontal agents on the development of subacute endocarditis and can facilitate the development of coronary heart disease, atherosclerosis, and ischemic infarction. The action of <i<P. gingivalis</i< is facilitated by numerous factors of virulence and pathogenicity such as fimbriae, hemolysin, hemagglutinin, capsules, outer membrane vesicles, lipopolysaccharides, and gingipains. A special problem is the possibility of biofilm formation. <i<P. gingivalis</i< in a biofilm is 500 to 1000 times less sensitive to antimicrobial drugs than planktonic cells, which represents a significant problem in the treatment of infections caused by this pathogen. |
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