Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas

While recurrence is frequent in ependymoma, the underlying molecular mechanisms remain to be explored. Here, the authors investigate epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses over 13 years and identify distinct patterns of DNA methylation.

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Autor*in:	Sibo Zhao [verfasserIn] Jia Li [verfasserIn] Huiyuan Zhang [verfasserIn] Lin Qi [verfasserIn] Yuchen Du [verfasserIn] Mari Kogiso [verfasserIn] Frank K. Braun [verfasserIn] Sophie Xiao [verfasserIn] Yulun Huang [verfasserIn] Jianfang Li [verfasserIn] Wan-Yee Teo [verfasserIn] Holly Lindsay [verfasserIn] Patricia Baxter [verfasserIn] Jack M. F. Su [verfasserIn] Adekunle Adesina [verfasserIn] Miklós Laczik [verfasserIn] Paola Genevini [verfasserIn] Anne-Clemence Veillard [verfasserIn] Sol Schvartzman [verfasserIn] Geoffrey Berguet [verfasserIn] Shi-Rong Ding [verfasserIn] Liping Du [verfasserIn] Clifford Stephan [verfasserIn] Jianhua Yang [verfasserIn] Peter J. A. Davies [verfasserIn] Xinyan Lu [verfasserIn] Murali Chintagumpala [verfasserIn] Donald William Parsons [verfasserIn] Laszlo Perlaky [verfasserIn] Yun-Fei Xia [verfasserIn] Tsz-Kwong Man [verfasserIn] Yun Huang [verfasserIn] Deqiang Sun [verfasserIn] Xiao-Nan Li [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Übergeordnetes Werk:	In: Nature Communications - Nature Portfolio, 2016, 13(2022), 1, Seite 16
Übergeordnetes Werk:	volume:13 ; year:2022 ; number:1 ; pages:16

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1038/s41467-022-34514-z

Katalog-ID:	DOAJ079448054

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source	In Nature Communications 13(2022), 1, Seite 16 volume:13 year:2022 number:1 pages:16
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title	Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas
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title_sort	epigenetic alterations of repeated relapses in patient-matched childhood ependymomas
title_auth	Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas
abstract	While recurrence is frequent in ependymoma, the underlying molecular mechanisms remain to be explored. Here, the authors investigate epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses over 13 years and identify distinct patterns of DNA methylation.
abstractGer	While recurrence is frequent in ependymoma, the underlying molecular mechanisms remain to be explored. Here, the authors investigate epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses over 13 years and identify distinct patterns of DNA methylation.
abstract_unstemmed	While recurrence is frequent in ependymoma, the underlying molecular mechanisms remain to be explored. Here, the authors investigate epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses over 13 years and identify distinct patterns of DNA methylation.
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title_short	Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas
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Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas

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