Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury
Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investiga...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Oguz Kayiran [verfasserIn] Suat Sedat Cuzdan [verfasserIn] Afsin Uysal [verfasserIn] Ugur Kocer [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Indian Journal of Medical Research - Wolters Kluwer Medknow Publications, 2005, 146(2017), 3, Seite 369-374 |
|---|---|
| Übergeordnetes Werk: |
volume:146 ; year:2017 ; number:3 ; pages:369-374 |
| Links: |
|---|
| DOI / URN: |
10.4103/ijmr.IJMR_1428_14 |
|---|
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DOAJ079633838 |
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| 520 | |a Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly. Interpretation & conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings. | ||
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10.4103/ijmr.IJMR_1428_14 doi (DE-627)DOAJ079633838 (DE-599)DOAJa42b6c32e7454c2281f3af7fd2ee53ba DE-627 ger DE-627 rakwb eng Oguz Kayiran verfasserin aut Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly. Interpretation & conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings. Ethyl pyruvate - ischaemia - reperfusion injury - skin flap Medicine R Suat Sedat Cuzdan verfasserin aut Afsin Uysal verfasserin aut Ugur Kocer verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 146(2017), 3, Seite 369-374 (DE-627)DOAJ000026956 09715916 nnns volume:146 year:2017 number:3 pages:369-374 https://doi.org/10.4103/ijmr.IJMR_1428_14 kostenfrei https://doaj.org/article/a42b6c32e7454c2281f3af7fd2ee53ba kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2017;volume=146;issue=3;spage=369;epage=374;aulast=Kayiran kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 146 2017 3 369-374 |
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10.4103/ijmr.IJMR_1428_14 doi (DE-627)DOAJ079633838 (DE-599)DOAJa42b6c32e7454c2281f3af7fd2ee53ba DE-627 ger DE-627 rakwb eng Oguz Kayiran verfasserin aut Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly. Interpretation & conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings. Ethyl pyruvate - ischaemia - reperfusion injury - skin flap Medicine R Suat Sedat Cuzdan verfasserin aut Afsin Uysal verfasserin aut Ugur Kocer verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 146(2017), 3, Seite 369-374 (DE-627)DOAJ000026956 09715916 nnns volume:146 year:2017 number:3 pages:369-374 https://doi.org/10.4103/ijmr.IJMR_1428_14 kostenfrei https://doaj.org/article/a42b6c32e7454c2281f3af7fd2ee53ba kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2017;volume=146;issue=3;spage=369;epage=374;aulast=Kayiran kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 146 2017 3 369-374 |
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10.4103/ijmr.IJMR_1428_14 doi (DE-627)DOAJ079633838 (DE-599)DOAJa42b6c32e7454c2281f3af7fd2ee53ba DE-627 ger DE-627 rakwb eng Oguz Kayiran verfasserin aut Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly. Interpretation & conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings. Ethyl pyruvate - ischaemia - reperfusion injury - skin flap Medicine R Suat Sedat Cuzdan verfasserin aut Afsin Uysal verfasserin aut Ugur Kocer verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 146(2017), 3, Seite 369-374 (DE-627)DOAJ000026956 09715916 nnns volume:146 year:2017 number:3 pages:369-374 https://doi.org/10.4103/ijmr.IJMR_1428_14 kostenfrei https://doaj.org/article/a42b6c32e7454c2281f3af7fd2ee53ba kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2017;volume=146;issue=3;spage=369;epage=374;aulast=Kayiran kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 146 2017 3 369-374 |
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10.4103/ijmr.IJMR_1428_14 doi (DE-627)DOAJ079633838 (DE-599)DOAJa42b6c32e7454c2281f3af7fd2ee53ba DE-627 ger DE-627 rakwb eng Oguz Kayiran verfasserin aut Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly. Interpretation & conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings. Ethyl pyruvate - ischaemia - reperfusion injury - skin flap Medicine R Suat Sedat Cuzdan verfasserin aut Afsin Uysal verfasserin aut Ugur Kocer verfasserin aut In Indian Journal of Medical Research Wolters Kluwer Medknow Publications, 2005 146(2017), 3, Seite 369-374 (DE-627)DOAJ000026956 09715916 nnns volume:146 year:2017 number:3 pages:369-374 https://doi.org/10.4103/ijmr.IJMR_1428_14 kostenfrei https://doaj.org/article/a42b6c32e7454c2281f3af7fd2ee53ba kostenfrei http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2017;volume=146;issue=3;spage=369;epage=374;aulast=Kayiran kostenfrei https://doaj.org/toc/0971-5916 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ AR 146 2017 3 369-374 |
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Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury |
| abstract |
Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly. Interpretation & conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings. |
| abstractGer |
Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly. Interpretation & conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings. |
| abstract_unstemmed |
Background & objectives: Reperfusion after ischaemia is detrimental to the tissues. The oxidative stress created and cytokines released are mostly responsible in this process. In this study, ethyl pyruvate, a known agent for its anti-inflammatory and antioxidant properties, was used to investigate the effects on ischaemia/reperfusion injury on skin island flaps in rats. Methods: Sixty rats were randomly distributed in three groups (non-ischaemic, ischaemic and medication groups). Ethyl pyruvate was administered in the medication group with a dose of 50 mg/kg. After 24 h and one week, the animals were sacrificed, and the flaps were analyzed macroscopically, histopathologically, biochemically (total nitrite, malondialdehyde and myeloperoxidase). Results: Biochemical markers indicating oxidative stress, were found elevated in ischaemic group, whereas medication with ethyl pyruvate significantly reduced these values. There was a significant reduction (P<0.05) in the levels of these markers between ischaemic and medication groups. Ethyl pyruvate improved all the parameters significantly. Interpretation & conclusion: Ethyl pyruvate showed strong scavenger activity against reactive oxygen species. It could be a potential candidate to improve the flap viability in reconstructive microsurgery, especially in free tissue transfers. However, more studies are warranted in experimental models to confirm these findings. |
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Ethyl pyruvate improves skin flap survival after ischaemia reperfusion injury |
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https://doi.org/10.4103/ijmr.IJMR_1428_14 https://doaj.org/article/a42b6c32e7454c2281f3af7fd2ee53ba http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2017;volume=146;issue=3;spage=369;epage=374;aulast=Kayiran https://doaj.org/toc/0971-5916 |
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Suat Sedat Cuzdan Afsin Uysal Ugur Kocer |
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Suat Sedat Cuzdan Afsin Uysal Ugur Kocer |
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10.4103/ijmr.IJMR_1428_14 |
| up_date |
2024-07-04T00:15:37.550Z |
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