Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk

BackgroundThe close association of abdominal obesity rather than general obesity with colorectal cancer (CRC) risk might be mediated by IR and inflammation, which has never been systematically explored in large-scale prospective studies.MethodsWe prospectively examined the mediation effects of the f...
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Autor*in:	Wenqiang Li [verfasserIn] Tong Liu [verfasserIn] Liang Qian [verfasserIn] Yiming Wang [verfasserIn] Xiangming Ma [verfasserIn] Liying Cao [verfasserIn] Qingsong Zhang [verfasserIn] Jun Qu [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	insulin resistance inflammation colorectal cancer obesity mediation

Übergeordnetes Werk:	In: Frontiers in Endocrinology - Frontiers Media S.A., 2011, 13(2022)
Übergeordnetes Werk:	volume:13 ; year:2022

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fendo.2022.983160

Katalog-ID:	DOAJ079657990

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520			\|a BackgroundThe close association of abdominal obesity rather than general obesity with colorectal cancer (CRC) risk might be mediated by IR and inflammation, which has never been systematically explored in large-scale prospective studies.MethodsWe prospectively examined the mediation effects of the fasting triglyceride-glucose (TyG) index and C-reactive protein (CRP) on the associations of obesity (general and abdominal) with CRC risk among 93,659 participants. We used the Cox proportional hazards regression models and subgroup analyses to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. The CAUSALMED procedure was used to perform the mediation analyses.ResultsDuring 13.02 years of follow-up, a total of 586 CRC cases were verified. Male participants with general obesity and abdominal obesity had a 1.29-fold and a 1.28-fold increased risk of CRC. However, a significant association was only observed among female individuals with abdominal obesity. Both TyG index and CRP were associated with an elevated risk of CRC, and A significant interaction between the TyG index and CRP was found for the risk of CRC (P for interaction<0.05). CRP and the TyG index significantly mediated the positive association between abdominal obesity and CRC risk.ConclusionCRP and TyG index increased the risk of CRC independently and synergistically. Mediation effects of CRP and the TyG index were found for the association between abdominal obesity and CRC risk.
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650		4	\|a inflammation
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700	0		\|a Liying Cao \|e verfasserin \|4 aut
700	0		\|a Qingsong Zhang \|e verfasserin \|4 aut
700	0		\|a Jun Qu \|e verfasserin \|4 aut
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allfields	10.3389/fendo.2022.983160 doi (DE-627)DOAJ079657990 (DE-599)DOAJ93b99ed738034cf28558387ee4fe1fe7 DE-627 ger DE-627 rakwb eng RC648-665 Wenqiang Li verfasserin aut Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundThe close association of abdominal obesity rather than general obesity with colorectal cancer (CRC) risk might be mediated by IR and inflammation, which has never been systematically explored in large-scale prospective studies.MethodsWe prospectively examined the mediation effects of the fasting triglyceride-glucose (TyG) index and C-reactive protein (CRP) on the associations of obesity (general and abdominal) with CRC risk among 93,659 participants. We used the Cox proportional hazards regression models and subgroup analyses to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. The CAUSALMED procedure was used to perform the mediation analyses.ResultsDuring 13.02 years of follow-up, a total of 586 CRC cases were verified. Male participants with general obesity and abdominal obesity had a 1.29-fold and a 1.28-fold increased risk of CRC. However, a significant association was only observed among female individuals with abdominal obesity. Both TyG index and CRP were associated with an elevated risk of CRC, and A significant interaction between the TyG index and CRP was found for the risk of CRC (P for interaction<0.05). CRP and the TyG index significantly mediated the positive association between abdominal obesity and CRC risk.ConclusionCRP and TyG index increased the risk of CRC independently and synergistically. Mediation effects of CRP and the TyG index were found for the association between abdominal obesity and CRC risk. insulin resistance inflammation colorectal cancer obesity mediation Diseases of the endocrine glands. Clinical endocrinology Tong Liu verfasserin aut Liang Qian verfasserin aut Yiming Wang verfasserin aut Xiangming Ma verfasserin aut Liying Cao verfasserin aut Qingsong Zhang verfasserin aut Jun Qu verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 13(2022) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:13 year:2022 https://doi.org/10.3389/fendo.2022.983160 kostenfrei https://doaj.org/article/93b99ed738034cf28558387ee4fe1fe7 kostenfrei https://www.frontiersin.org/articles/10.3389/fendo.2022.983160/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
spelling	10.3389/fendo.2022.983160 doi (DE-627)DOAJ079657990 (DE-599)DOAJ93b99ed738034cf28558387ee4fe1fe7 DE-627 ger DE-627 rakwb eng RC648-665 Wenqiang Li verfasserin aut Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundThe close association of abdominal obesity rather than general obesity with colorectal cancer (CRC) risk might be mediated by IR and inflammation, which has never been systematically explored in large-scale prospective studies.MethodsWe prospectively examined the mediation effects of the fasting triglyceride-glucose (TyG) index and C-reactive protein (CRP) on the associations of obesity (general and abdominal) with CRC risk among 93,659 participants. We used the Cox proportional hazards regression models and subgroup analyses to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. The CAUSALMED procedure was used to perform the mediation analyses.ResultsDuring 13.02 years of follow-up, a total of 586 CRC cases were verified. Male participants with general obesity and abdominal obesity had a 1.29-fold and a 1.28-fold increased risk of CRC. However, a significant association was only observed among female individuals with abdominal obesity. Both TyG index and CRP were associated with an elevated risk of CRC, and A significant interaction between the TyG index and CRP was found for the risk of CRC (P for interaction<0.05). CRP and the TyG index significantly mediated the positive association between abdominal obesity and CRC risk.ConclusionCRP and TyG index increased the risk of CRC independently and synergistically. Mediation effects of CRP and the TyG index were found for the association between abdominal obesity and CRC risk. insulin resistance inflammation colorectal cancer obesity mediation Diseases of the endocrine glands. Clinical endocrinology Tong Liu verfasserin aut Liang Qian verfasserin aut Yiming Wang verfasserin aut Xiangming Ma verfasserin aut Liying Cao verfasserin aut Qingsong Zhang verfasserin aut Jun Qu verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 13(2022) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:13 year:2022 https://doi.org/10.3389/fendo.2022.983160 kostenfrei https://doaj.org/article/93b99ed738034cf28558387ee4fe1fe7 kostenfrei https://www.frontiersin.org/articles/10.3389/fendo.2022.983160/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfields_unstemmed	10.3389/fendo.2022.983160 doi (DE-627)DOAJ079657990 (DE-599)DOAJ93b99ed738034cf28558387ee4fe1fe7 DE-627 ger DE-627 rakwb eng RC648-665 Wenqiang Li verfasserin aut Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundThe close association of abdominal obesity rather than general obesity with colorectal cancer (CRC) risk might be mediated by IR and inflammation, which has never been systematically explored in large-scale prospective studies.MethodsWe prospectively examined the mediation effects of the fasting triglyceride-glucose (TyG) index and C-reactive protein (CRP) on the associations of obesity (general and abdominal) with CRC risk among 93,659 participants. We used the Cox proportional hazards regression models and subgroup analyses to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. The CAUSALMED procedure was used to perform the mediation analyses.ResultsDuring 13.02 years of follow-up, a total of 586 CRC cases were verified. Male participants with general obesity and abdominal obesity had a 1.29-fold and a 1.28-fold increased risk of CRC. However, a significant association was only observed among female individuals with abdominal obesity. Both TyG index and CRP were associated with an elevated risk of CRC, and A significant interaction between the TyG index and CRP was found for the risk of CRC (P for interaction<0.05). CRP and the TyG index significantly mediated the positive association between abdominal obesity and CRC risk.ConclusionCRP and TyG index increased the risk of CRC independently and synergistically. Mediation effects of CRP and the TyG index were found for the association between abdominal obesity and CRC risk. insulin resistance inflammation colorectal cancer obesity mediation Diseases of the endocrine glands. Clinical endocrinology Tong Liu verfasserin aut Liang Qian verfasserin aut Yiming Wang verfasserin aut Xiangming Ma verfasserin aut Liying Cao verfasserin aut Qingsong Zhang verfasserin aut Jun Qu verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 13(2022) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:13 year:2022 https://doi.org/10.3389/fendo.2022.983160 kostenfrei https://doaj.org/article/93b99ed738034cf28558387ee4fe1fe7 kostenfrei https://www.frontiersin.org/articles/10.3389/fendo.2022.983160/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsGer	10.3389/fendo.2022.983160 doi (DE-627)DOAJ079657990 (DE-599)DOAJ93b99ed738034cf28558387ee4fe1fe7 DE-627 ger DE-627 rakwb eng RC648-665 Wenqiang Li verfasserin aut Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundThe close association of abdominal obesity rather than general obesity with colorectal cancer (CRC) risk might be mediated by IR and inflammation, which has never been systematically explored in large-scale prospective studies.MethodsWe prospectively examined the mediation effects of the fasting triglyceride-glucose (TyG) index and C-reactive protein (CRP) on the associations of obesity (general and abdominal) with CRC risk among 93,659 participants. We used the Cox proportional hazards regression models and subgroup analyses to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. The CAUSALMED procedure was used to perform the mediation analyses.ResultsDuring 13.02 years of follow-up, a total of 586 CRC cases were verified. Male participants with general obesity and abdominal obesity had a 1.29-fold and a 1.28-fold increased risk of CRC. However, a significant association was only observed among female individuals with abdominal obesity. Both TyG index and CRP were associated with an elevated risk of CRC, and A significant interaction between the TyG index and CRP was found for the risk of CRC (P for interaction<0.05). CRP and the TyG index significantly mediated the positive association between abdominal obesity and CRC risk.ConclusionCRP and TyG index increased the risk of CRC independently and synergistically. Mediation effects of CRP and the TyG index were found for the association between abdominal obesity and CRC risk. insulin resistance inflammation colorectal cancer obesity mediation Diseases of the endocrine glands. Clinical endocrinology Tong Liu verfasserin aut Liang Qian verfasserin aut Yiming Wang verfasserin aut Xiangming Ma verfasserin aut Liying Cao verfasserin aut Qingsong Zhang verfasserin aut Jun Qu verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 13(2022) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:13 year:2022 https://doi.org/10.3389/fendo.2022.983160 kostenfrei https://doaj.org/article/93b99ed738034cf28558387ee4fe1fe7 kostenfrei https://www.frontiersin.org/articles/10.3389/fendo.2022.983160/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
allfieldsSound	10.3389/fendo.2022.983160 doi (DE-627)DOAJ079657990 (DE-599)DOAJ93b99ed738034cf28558387ee4fe1fe7 DE-627 ger DE-627 rakwb eng RC648-665 Wenqiang Li verfasserin aut Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier BackgroundThe close association of abdominal obesity rather than general obesity with colorectal cancer (CRC) risk might be mediated by IR and inflammation, which has never been systematically explored in large-scale prospective studies.MethodsWe prospectively examined the mediation effects of the fasting triglyceride-glucose (TyG) index and C-reactive protein (CRP) on the associations of obesity (general and abdominal) with CRC risk among 93,659 participants. We used the Cox proportional hazards regression models and subgroup analyses to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. The CAUSALMED procedure was used to perform the mediation analyses.ResultsDuring 13.02 years of follow-up, a total of 586 CRC cases were verified. Male participants with general obesity and abdominal obesity had a 1.29-fold and a 1.28-fold increased risk of CRC. However, a significant association was only observed among female individuals with abdominal obesity. Both TyG index and CRP were associated with an elevated risk of CRC, and A significant interaction between the TyG index and CRP was found for the risk of CRC (P for interaction<0.05). CRP and the TyG index significantly mediated the positive association between abdominal obesity and CRC risk.ConclusionCRP and TyG index increased the risk of CRC independently and synergistically. Mediation effects of CRP and the TyG index were found for the association between abdominal obesity and CRC risk. insulin resistance inflammation colorectal cancer obesity mediation Diseases of the endocrine glands. Clinical endocrinology Tong Liu verfasserin aut Liang Qian verfasserin aut Yiming Wang verfasserin aut Xiangming Ma verfasserin aut Liying Cao verfasserin aut Qingsong Zhang verfasserin aut Jun Qu verfasserin aut In Frontiers in Endocrinology Frontiers Media S.A., 2011 13(2022) (DE-627)645090948 (DE-600)2592084-4 16642392 nnns volume:13 year:2022 https://doi.org/10.3389/fendo.2022.983160 kostenfrei https://doaj.org/article/93b99ed738034cf28558387ee4fe1fe7 kostenfrei https://www.frontiersin.org/articles/10.3389/fendo.2022.983160/full kostenfrei https://doaj.org/toc/1664-2392 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2022
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authorswithroles_txt_mv	Wenqiang Li @@aut@@ Tong Liu @@aut@@ Liang Qian @@aut@@ Yiming Wang @@aut@@ Xiangming Ma @@aut@@ Liying Cao @@aut@@ Qingsong Zhang @@aut@@ Jun Qu @@aut@@
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We used the Cox proportional hazards regression models and subgroup analyses to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. The CAUSALMED procedure was used to perform the mediation analyses.ResultsDuring 13.02 years of follow-up, a total of 586 CRC cases were verified. Male participants with general obesity and abdominal obesity had a 1.29-fold and a 1.28-fold increased risk of CRC. However, a significant association was only observed among female individuals with abdominal obesity. Both TyG index and CRP were associated with an elevated risk of CRC, and A significant interaction between the TyG index and CRP was found for the risk of CRC (P for interaction&lt;0.05). CRP and the TyG index significantly mediated the positive association between abdominal obesity and CRC risk.ConclusionCRP and TyG index increased the risk of CRC independently and synergistically. Mediation effects of CRP and the TyG index were found for the association between abdominal obesity and CRC risk.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">insulin resistance</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">inflammation</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">colorectal cancer</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">obesity</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">mediation</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Diseases of the endocrine glands. 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callnumber-first	R - Medicine
author	Wenqiang Li
spellingShingle	Wenqiang Li misc RC648-665 misc insulin resistance misc inflammation misc colorectal cancer misc obesity misc mediation misc Diseases of the endocrine glands. Clinical endocrinology Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk
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topic_title	RC648-665 Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk insulin resistance inflammation colorectal cancer obesity mediation
topic	misc RC648-665 misc insulin resistance misc inflammation misc colorectal cancer misc obesity misc mediation misc Diseases of the endocrine glands. Clinical endocrinology
topic_unstemmed	misc RC648-665 misc insulin resistance misc inflammation misc colorectal cancer misc obesity misc mediation misc Diseases of the endocrine glands. Clinical endocrinology
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title	Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk
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title_full	Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk
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journal	Frontiers in Endocrinology
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author_browse	Wenqiang Li Tong Liu Liang Qian Yiming Wang Xiangming Ma Liying Cao Qingsong Zhang Jun Qu
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doi_str_mv	10.3389/fendo.2022.983160
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title_sort	insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk
callnumber	RC648-665
title_auth	Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk
abstract	BackgroundThe close association of abdominal obesity rather than general obesity with colorectal cancer (CRC) risk might be mediated by IR and inflammation, which has never been systematically explored in large-scale prospective studies.MethodsWe prospectively examined the mediation effects of the fasting triglyceride-glucose (TyG) index and C-reactive protein (CRP) on the associations of obesity (general and abdominal) with CRC risk among 93,659 participants. We used the Cox proportional hazards regression models and subgroup analyses to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. The CAUSALMED procedure was used to perform the mediation analyses.ResultsDuring 13.02 years of follow-up, a total of 586 CRC cases were verified. Male participants with general obesity and abdominal obesity had a 1.29-fold and a 1.28-fold increased risk of CRC. However, a significant association was only observed among female individuals with abdominal obesity. Both TyG index and CRP were associated with an elevated risk of CRC, and A significant interaction between the TyG index and CRP was found for the risk of CRC (P for interaction<0.05). CRP and the TyG index significantly mediated the positive association between abdominal obesity and CRC risk.ConclusionCRP and TyG index increased the risk of CRC independently and synergistically. Mediation effects of CRP and the TyG index were found for the association between abdominal obesity and CRC risk.
abstractGer	BackgroundThe close association of abdominal obesity rather than general obesity with colorectal cancer (CRC) risk might be mediated by IR and inflammation, which has never been systematically explored in large-scale prospective studies.MethodsWe prospectively examined the mediation effects of the fasting triglyceride-glucose (TyG) index and C-reactive protein (CRP) on the associations of obesity (general and abdominal) with CRC risk among 93,659 participants. We used the Cox proportional hazards regression models and subgroup analyses to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. The CAUSALMED procedure was used to perform the mediation analyses.ResultsDuring 13.02 years of follow-up, a total of 586 CRC cases were verified. Male participants with general obesity and abdominal obesity had a 1.29-fold and a 1.28-fold increased risk of CRC. However, a significant association was only observed among female individuals with abdominal obesity. Both TyG index and CRP were associated with an elevated risk of CRC, and A significant interaction between the TyG index and CRP was found for the risk of CRC (P for interaction<0.05). CRP and the TyG index significantly mediated the positive association between abdominal obesity and CRC risk.ConclusionCRP and TyG index increased the risk of CRC independently and synergistically. Mediation effects of CRP and the TyG index were found for the association between abdominal obesity and CRC risk.
abstract_unstemmed	BackgroundThe close association of abdominal obesity rather than general obesity with colorectal cancer (CRC) risk might be mediated by IR and inflammation, which has never been systematically explored in large-scale prospective studies.MethodsWe prospectively examined the mediation effects of the fasting triglyceride-glucose (TyG) index and C-reactive protein (CRP) on the associations of obesity (general and abdominal) with CRC risk among 93,659 participants. We used the Cox proportional hazards regression models and subgroup analyses to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. The CAUSALMED procedure was used to perform the mediation analyses.ResultsDuring 13.02 years of follow-up, a total of 586 CRC cases were verified. Male participants with general obesity and abdominal obesity had a 1.29-fold and a 1.28-fold increased risk of CRC. However, a significant association was only observed among female individuals with abdominal obesity. Both TyG index and CRP were associated with an elevated risk of CRC, and A significant interaction between the TyG index and CRP was found for the risk of CRC (P for interaction<0.05). CRP and the TyG index significantly mediated the positive association between abdominal obesity and CRC risk.ConclusionCRP and TyG index increased the risk of CRC independently and synergistically. Mediation effects of CRP and the TyG index were found for the association between abdominal obesity and CRC risk.
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title_short	Insulin resistance and inflammation mediate the association of abdominal obesity with colorectal cancer risk
url	https://doi.org/10.3389/fendo.2022.983160 https://doaj.org/article/93b99ed738034cf28558387ee4fe1fe7 https://www.frontiersin.org/articles/10.3389/fendo.2022.983160/full https://doaj.org/toc/1664-2392
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author2	Tong Liu Liang Qian Yiming Wang Xiangming Ma Liying Cao Qingsong Zhang Jun Qu
author2Str	Tong Liu Liang Qian Yiming Wang Xiangming Ma Liying Cao Qingsong Zhang Jun Qu
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up_date	2024-07-04T00:21:04.715Z
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We used the Cox proportional hazards regression models and subgroup analyses to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of CRC. The CAUSALMED procedure was used to perform the mediation analyses.ResultsDuring 13.02 years of follow-up, a total of 586 CRC cases were verified. Male participants with general obesity and abdominal obesity had a 1.29-fold and a 1.28-fold increased risk of CRC. However, a significant association was only observed among female individuals with abdominal obesity. Both TyG index and CRP were associated with an elevated risk of CRC, and A significant interaction between the TyG index and CRP was found for the risk of CRC (P for interaction&lt;0.05). CRP and the TyG index significantly mediated the positive association between abdominal obesity and CRC risk.ConclusionCRP and TyG index increased the risk of CRC independently and synergistically. 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