Electroretinogram Changes in the Sound Eye of Subjects with Unilateral Necrotizing Herpetic Retinitis

Purpose: To evaluate electroretinogram (ERG) changes in the contralateral normal appearing eye of patients with unilateral acute necrotizing herpetic retinitis (NHR). Methods: This interventional case series includes subjects with acute unilateral NHR. All patients were treated with intravenous foll...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Mohsen Azarmina [verfasserIn] Masoud Soheilian [verfasserIn] Hamid Ahmadieh [verfasserIn] Hossein Azarmina [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	Necrotizing Herpetic Retinitis; Acute Retinal Necrosis; Electroretinography

Übergeordnetes Werk:	In: Journal of Ophthalmic & Vision Research - Knowledge E, 2009, 9(2014), 2, Seite 195-203
Übergeordnetes Werk:	volume:9 ; year:2014 ; number:2 ; pages:195-203

Links:	Link aufrufen Link aufrufen Journal toc

Katalog-ID:	DOAJ079672523

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520			\|a Purpose: To evaluate electroretinogram (ERG) changes in the contralateral normal appearing eye of patients with unilateral acute necrotizing herpetic retinitis (NHR). Methods: This interventional case series includes subjects with acute unilateral NHR. All patients were treated with intravenous followed by oral acyclovir and systemic steroids. Main outcome measures were changes in a- and b-wave amplitudes of scotopic and photopic full-field ERG in the sound eye, 1 and 3 months after therapy as compared to baseline. Twenty normal subjects served as controls. Results: Forty eyes of 20 patients including 12 male and 8 female subjects with mean age of 44.1±11.5 (range 22 to 66) years were studied. Twenty unaffected eyes were the subject of the current study. The retina in all of these eyes remained intact during the course of the study. In the sound eyes, mean b-wave amplitude of the maximal combined response ERG before initiation of treatment was 229.5±38.8 microvolts which increased to 356.1±34.0 (P<0.001) and 365.8±32.7 (P<0.001) microvolts 1 and 3 months after treatment, respectively. Corresponding figures for b-wave amplitudes of the cone response ERG were 24.9±6.0, 47.0±12.9 (P<0.001) and 52.8±12.7 (P<0.001) microvolts, respectively. Visual acuity of all sound eyes remained unchanged throughout the study. Conclusion: Despite normal retinal appearance and intact visual acuity in the sound eyes of patients with NHR, electrophysiological changes were observed. Prompt diagnosis and management of NHR and continuation of medication for 3 months may reverse subclinical ERG changes and reduce the risk of progression to overt clinical disease.
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allfields	(DE-627)DOAJ079672523 (DE-599)DOAJ201c79e15e014724ae1bc3cf6fb36533 DE-627 ger DE-627 rakwb eng RE1-994 Mohsen Azarmina verfasserin aut Electroretinogram Changes in the Sound Eye of Subjects with Unilateral Necrotizing Herpetic Retinitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To evaluate electroretinogram (ERG) changes in the contralateral normal appearing eye of patients with unilateral acute necrotizing herpetic retinitis (NHR). Methods: This interventional case series includes subjects with acute unilateral NHR. All patients were treated with intravenous followed by oral acyclovir and systemic steroids. Main outcome measures were changes in a- and b-wave amplitudes of scotopic and photopic full-field ERG in the sound eye, 1 and 3 months after therapy as compared to baseline. Twenty normal subjects served as controls. Results: Forty eyes of 20 patients including 12 male and 8 female subjects with mean age of 44.1±11.5 (range 22 to 66) years were studied. Twenty unaffected eyes were the subject of the current study. The retina in all of these eyes remained intact during the course of the study. In the sound eyes, mean b-wave amplitude of the maximal combined response ERG before initiation of treatment was 229.5±38.8 microvolts which increased to 356.1±34.0 (P<0.001) and 365.8±32.7 (P<0.001) microvolts 1 and 3 months after treatment, respectively. Corresponding figures for b-wave amplitudes of the cone response ERG were 24.9±6.0, 47.0±12.9 (P<0.001) and 52.8±12.7 (P<0.001) microvolts, respectively. Visual acuity of all sound eyes remained unchanged throughout the study. Conclusion: Despite normal retinal appearance and intact visual acuity in the sound eyes of patients with NHR, electrophysiological changes were observed. Prompt diagnosis and management of NHR and continuation of medication for 3 months may reverse subclinical ERG changes and reduce the risk of progression to overt clinical disease. Necrotizing Herpetic Retinitis; Acute Retinal Necrosis; Electroretinography Ophthalmology Masoud Soheilian verfasserin aut Hamid Ahmadieh verfasserin aut Hossein Azarmina verfasserin aut In Journal of Ophthalmic & Vision Research Knowledge E, 2009 9(2014), 2, Seite 195-203 (DE-627)638066077 (DE-600)2578268-X 2008322X nnns volume:9 year:2014 number:2 pages:195-203 https://doaj.org/article/201c79e15e014724ae1bc3cf6fb36533 kostenfrei http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=2;spage=195;epage=203;aulast=Azarmina kostenfrei https://doaj.org/toc/2008-322X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 2 195-203
spelling	(DE-627)DOAJ079672523 (DE-599)DOAJ201c79e15e014724ae1bc3cf6fb36533 DE-627 ger DE-627 rakwb eng RE1-994 Mohsen Azarmina verfasserin aut Electroretinogram Changes in the Sound Eye of Subjects with Unilateral Necrotizing Herpetic Retinitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To evaluate electroretinogram (ERG) changes in the contralateral normal appearing eye of patients with unilateral acute necrotizing herpetic retinitis (NHR). Methods: This interventional case series includes subjects with acute unilateral NHR. All patients were treated with intravenous followed by oral acyclovir and systemic steroids. Main outcome measures were changes in a- and b-wave amplitudes of scotopic and photopic full-field ERG in the sound eye, 1 and 3 months after therapy as compared to baseline. Twenty normal subjects served as controls. Results: Forty eyes of 20 patients including 12 male and 8 female subjects with mean age of 44.1±11.5 (range 22 to 66) years were studied. Twenty unaffected eyes were the subject of the current study. The retina in all of these eyes remained intact during the course of the study. In the sound eyes, mean b-wave amplitude of the maximal combined response ERG before initiation of treatment was 229.5±38.8 microvolts which increased to 356.1±34.0 (P<0.001) and 365.8±32.7 (P<0.001) microvolts 1 and 3 months after treatment, respectively. Corresponding figures for b-wave amplitudes of the cone response ERG were 24.9±6.0, 47.0±12.9 (P<0.001) and 52.8±12.7 (P<0.001) microvolts, respectively. Visual acuity of all sound eyes remained unchanged throughout the study. Conclusion: Despite normal retinal appearance and intact visual acuity in the sound eyes of patients with NHR, electrophysiological changes were observed. Prompt diagnosis and management of NHR and continuation of medication for 3 months may reverse subclinical ERG changes and reduce the risk of progression to overt clinical disease. Necrotizing Herpetic Retinitis; Acute Retinal Necrosis; Electroretinography Ophthalmology Masoud Soheilian verfasserin aut Hamid Ahmadieh verfasserin aut Hossein Azarmina verfasserin aut In Journal of Ophthalmic & Vision Research Knowledge E, 2009 9(2014), 2, Seite 195-203 (DE-627)638066077 (DE-600)2578268-X 2008322X nnns volume:9 year:2014 number:2 pages:195-203 https://doaj.org/article/201c79e15e014724ae1bc3cf6fb36533 kostenfrei http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=2;spage=195;epage=203;aulast=Azarmina kostenfrei https://doaj.org/toc/2008-322X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 2 195-203
allfields_unstemmed	(DE-627)DOAJ079672523 (DE-599)DOAJ201c79e15e014724ae1bc3cf6fb36533 DE-627 ger DE-627 rakwb eng RE1-994 Mohsen Azarmina verfasserin aut Electroretinogram Changes in the Sound Eye of Subjects with Unilateral Necrotizing Herpetic Retinitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To evaluate electroretinogram (ERG) changes in the contralateral normal appearing eye of patients with unilateral acute necrotizing herpetic retinitis (NHR). Methods: This interventional case series includes subjects with acute unilateral NHR. All patients were treated with intravenous followed by oral acyclovir and systemic steroids. Main outcome measures were changes in a- and b-wave amplitudes of scotopic and photopic full-field ERG in the sound eye, 1 and 3 months after therapy as compared to baseline. Twenty normal subjects served as controls. Results: Forty eyes of 20 patients including 12 male and 8 female subjects with mean age of 44.1±11.5 (range 22 to 66) years were studied. Twenty unaffected eyes were the subject of the current study. The retina in all of these eyes remained intact during the course of the study. In the sound eyes, mean b-wave amplitude of the maximal combined response ERG before initiation of treatment was 229.5±38.8 microvolts which increased to 356.1±34.0 (P<0.001) and 365.8±32.7 (P<0.001) microvolts 1 and 3 months after treatment, respectively. Corresponding figures for b-wave amplitudes of the cone response ERG were 24.9±6.0, 47.0±12.9 (P<0.001) and 52.8±12.7 (P<0.001) microvolts, respectively. Visual acuity of all sound eyes remained unchanged throughout the study. Conclusion: Despite normal retinal appearance and intact visual acuity in the sound eyes of patients with NHR, electrophysiological changes were observed. Prompt diagnosis and management of NHR and continuation of medication for 3 months may reverse subclinical ERG changes and reduce the risk of progression to overt clinical disease. Necrotizing Herpetic Retinitis; Acute Retinal Necrosis; Electroretinography Ophthalmology Masoud Soheilian verfasserin aut Hamid Ahmadieh verfasserin aut Hossein Azarmina verfasserin aut In Journal of Ophthalmic & Vision Research Knowledge E, 2009 9(2014), 2, Seite 195-203 (DE-627)638066077 (DE-600)2578268-X 2008322X nnns volume:9 year:2014 number:2 pages:195-203 https://doaj.org/article/201c79e15e014724ae1bc3cf6fb36533 kostenfrei http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=2;spage=195;epage=203;aulast=Azarmina kostenfrei https://doaj.org/toc/2008-322X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 2 195-203
allfieldsGer	(DE-627)DOAJ079672523 (DE-599)DOAJ201c79e15e014724ae1bc3cf6fb36533 DE-627 ger DE-627 rakwb eng RE1-994 Mohsen Azarmina verfasserin aut Electroretinogram Changes in the Sound Eye of Subjects with Unilateral Necrotizing Herpetic Retinitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To evaluate electroretinogram (ERG) changes in the contralateral normal appearing eye of patients with unilateral acute necrotizing herpetic retinitis (NHR). Methods: This interventional case series includes subjects with acute unilateral NHR. All patients were treated with intravenous followed by oral acyclovir and systemic steroids. Main outcome measures were changes in a- and b-wave amplitudes of scotopic and photopic full-field ERG in the sound eye, 1 and 3 months after therapy as compared to baseline. Twenty normal subjects served as controls. Results: Forty eyes of 20 patients including 12 male and 8 female subjects with mean age of 44.1±11.5 (range 22 to 66) years were studied. Twenty unaffected eyes were the subject of the current study. The retina in all of these eyes remained intact during the course of the study. In the sound eyes, mean b-wave amplitude of the maximal combined response ERG before initiation of treatment was 229.5±38.8 microvolts which increased to 356.1±34.0 (P<0.001) and 365.8±32.7 (P<0.001) microvolts 1 and 3 months after treatment, respectively. Corresponding figures for b-wave amplitudes of the cone response ERG were 24.9±6.0, 47.0±12.9 (P<0.001) and 52.8±12.7 (P<0.001) microvolts, respectively. Visual acuity of all sound eyes remained unchanged throughout the study. Conclusion: Despite normal retinal appearance and intact visual acuity in the sound eyes of patients with NHR, electrophysiological changes were observed. Prompt diagnosis and management of NHR and continuation of medication for 3 months may reverse subclinical ERG changes and reduce the risk of progression to overt clinical disease. Necrotizing Herpetic Retinitis; Acute Retinal Necrosis; Electroretinography Ophthalmology Masoud Soheilian verfasserin aut Hamid Ahmadieh verfasserin aut Hossein Azarmina verfasserin aut In Journal of Ophthalmic & Vision Research Knowledge E, 2009 9(2014), 2, Seite 195-203 (DE-627)638066077 (DE-600)2578268-X 2008322X nnns volume:9 year:2014 number:2 pages:195-203 https://doaj.org/article/201c79e15e014724ae1bc3cf6fb36533 kostenfrei http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=2;spage=195;epage=203;aulast=Azarmina kostenfrei https://doaj.org/toc/2008-322X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 2 195-203
allfieldsSound	(DE-627)DOAJ079672523 (DE-599)DOAJ201c79e15e014724ae1bc3cf6fb36533 DE-627 ger DE-627 rakwb eng RE1-994 Mohsen Azarmina verfasserin aut Electroretinogram Changes in the Sound Eye of Subjects with Unilateral Necrotizing Herpetic Retinitis 2014 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Purpose: To evaluate electroretinogram (ERG) changes in the contralateral normal appearing eye of patients with unilateral acute necrotizing herpetic retinitis (NHR). Methods: This interventional case series includes subjects with acute unilateral NHR. All patients were treated with intravenous followed by oral acyclovir and systemic steroids. Main outcome measures were changes in a- and b-wave amplitudes of scotopic and photopic full-field ERG in the sound eye, 1 and 3 months after therapy as compared to baseline. Twenty normal subjects served as controls. Results: Forty eyes of 20 patients including 12 male and 8 female subjects with mean age of 44.1±11.5 (range 22 to 66) years were studied. Twenty unaffected eyes were the subject of the current study. The retina in all of these eyes remained intact during the course of the study. In the sound eyes, mean b-wave amplitude of the maximal combined response ERG before initiation of treatment was 229.5±38.8 microvolts which increased to 356.1±34.0 (P<0.001) and 365.8±32.7 (P<0.001) microvolts 1 and 3 months after treatment, respectively. Corresponding figures for b-wave amplitudes of the cone response ERG were 24.9±6.0, 47.0±12.9 (P<0.001) and 52.8±12.7 (P<0.001) microvolts, respectively. Visual acuity of all sound eyes remained unchanged throughout the study. Conclusion: Despite normal retinal appearance and intact visual acuity in the sound eyes of patients with NHR, electrophysiological changes were observed. Prompt diagnosis and management of NHR and continuation of medication for 3 months may reverse subclinical ERG changes and reduce the risk of progression to overt clinical disease. Necrotizing Herpetic Retinitis; Acute Retinal Necrosis; Electroretinography Ophthalmology Masoud Soheilian verfasserin aut Hamid Ahmadieh verfasserin aut Hossein Azarmina verfasserin aut In Journal of Ophthalmic & Vision Research Knowledge E, 2009 9(2014), 2, Seite 195-203 (DE-627)638066077 (DE-600)2578268-X 2008322X nnns volume:9 year:2014 number:2 pages:195-203 https://doaj.org/article/201c79e15e014724ae1bc3cf6fb36533 kostenfrei http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=2;spage=195;epage=203;aulast=Azarmina kostenfrei https://doaj.org/toc/2008-322X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2014 2 195-203
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source	In Journal of Ophthalmic & Vision Research 9(2014), 2, Seite 195-203 volume:9 year:2014 number:2 pages:195-203
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topic_facet	Necrotizing Herpetic Retinitis; Acute Retinal Necrosis; Electroretinography Ophthalmology
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Methods: This interventional case series includes subjects with acute unilateral NHR. All patients were treated with intravenous followed by oral acyclovir and systemic steroids. Main outcome measures were changes in a- and b-wave amplitudes of scotopic and photopic full-field ERG in the sound eye, 1 and 3 months after therapy as compared to baseline. Twenty normal subjects served as controls. Results: Forty eyes of 20 patients including 12 male and 8 female subjects with mean age of 44.1±11.5 (range 22 to 66) years were studied. Twenty unaffected eyes were the subject of the current study. The retina in all of these eyes remained intact during the course of the study. In the sound eyes, mean b-wave amplitude of the maximal combined response ERG before initiation of treatment was 229.5±38.8 microvolts which increased to 356.1±34.0 (P<0.001) and 365.8±32.7 (P<0.001) microvolts 1 and 3 months after treatment, respectively. Corresponding figures for b-wave amplitudes of the cone response ERG were 24.9±6.0, 47.0±12.9 (P<0.001) and 52.8±12.7 (P<0.001) microvolts, respectively. Visual acuity of all sound eyes remained unchanged throughout the study. Conclusion: Despite normal retinal appearance and intact visual acuity in the sound eyes of patients with NHR, electrophysiological changes were observed. Prompt diagnosis and management of NHR and continuation of medication for 3 months may reverse subclinical ERG changes and reduce the risk of progression to overt clinical disease.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Necrotizing Herpetic Retinitis; Acute Retinal Necrosis; Electroretinography</subfield></datafield><datafield tag="653" ind1=" " ind2="0"><subfield code="a">Ophthalmology</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Masoud Soheilian</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hamid Ahmadieh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="0" ind2=" "><subfield code="a">Hossein Azarmina</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" 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callnumber-first	R - Medicine
author	Mohsen Azarmina
spellingShingle	Mohsen Azarmina misc RE1-994 misc Necrotizing Herpetic Retinitis; Acute Retinal Necrosis; Electroretinography misc Ophthalmology Electroretinogram Changes in the Sound Eye of Subjects with Unilateral Necrotizing Herpetic Retinitis
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topic_title	RE1-994 Electroretinogram Changes in the Sound Eye of Subjects with Unilateral Necrotizing Herpetic Retinitis Necrotizing Herpetic Retinitis; Acute Retinal Necrosis; Electroretinography
topic	misc RE1-994 misc Necrotizing Herpetic Retinitis; Acute Retinal Necrosis; Electroretinography misc Ophthalmology
topic_unstemmed	misc RE1-994 misc Necrotizing Herpetic Retinitis; Acute Retinal Necrosis; Electroretinography misc Ophthalmology
topic_browse	misc RE1-994 misc Necrotizing Herpetic Retinitis; Acute Retinal Necrosis; Electroretinography misc Ophthalmology
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title	Electroretinogram Changes in the Sound Eye of Subjects with Unilateral Necrotizing Herpetic Retinitis
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title_full	Electroretinogram Changes in the Sound Eye of Subjects with Unilateral Necrotizing Herpetic Retinitis
author_sort	Mohsen Azarmina
journal	Journal of Ophthalmic & Vision Research
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author_browse	Mohsen Azarmina Masoud Soheilian Hamid Ahmadieh Hossein Azarmina
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author-letter	Mohsen Azarmina
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title_sort	electroretinogram changes in the sound eye of subjects with unilateral necrotizing herpetic retinitis
callnumber	RE1-994
title_auth	Electroretinogram Changes in the Sound Eye of Subjects with Unilateral Necrotizing Herpetic Retinitis
abstract	Purpose: To evaluate electroretinogram (ERG) changes in the contralateral normal appearing eye of patients with unilateral acute necrotizing herpetic retinitis (NHR). Methods: This interventional case series includes subjects with acute unilateral NHR. All patients were treated with intravenous followed by oral acyclovir and systemic steroids. Main outcome measures were changes in a- and b-wave amplitudes of scotopic and photopic full-field ERG in the sound eye, 1 and 3 months after therapy as compared to baseline. Twenty normal subjects served as controls. Results: Forty eyes of 20 patients including 12 male and 8 female subjects with mean age of 44.1±11.5 (range 22 to 66) years were studied. Twenty unaffected eyes were the subject of the current study. The retina in all of these eyes remained intact during the course of the study. In the sound eyes, mean b-wave amplitude of the maximal combined response ERG before initiation of treatment was 229.5±38.8 microvolts which increased to 356.1±34.0 (P<0.001) and 365.8±32.7 (P<0.001) microvolts 1 and 3 months after treatment, respectively. Corresponding figures for b-wave amplitudes of the cone response ERG were 24.9±6.0, 47.0±12.9 (P<0.001) and 52.8±12.7 (P<0.001) microvolts, respectively. Visual acuity of all sound eyes remained unchanged throughout the study. Conclusion: Despite normal retinal appearance and intact visual acuity in the sound eyes of patients with NHR, electrophysiological changes were observed. Prompt diagnosis and management of NHR and continuation of medication for 3 months may reverse subclinical ERG changes and reduce the risk of progression to overt clinical disease.
abstractGer	Purpose: To evaluate electroretinogram (ERG) changes in the contralateral normal appearing eye of patients with unilateral acute necrotizing herpetic retinitis (NHR). Methods: This interventional case series includes subjects with acute unilateral NHR. All patients were treated with intravenous followed by oral acyclovir and systemic steroids. Main outcome measures were changes in a- and b-wave amplitudes of scotopic and photopic full-field ERG in the sound eye, 1 and 3 months after therapy as compared to baseline. Twenty normal subjects served as controls. Results: Forty eyes of 20 patients including 12 male and 8 female subjects with mean age of 44.1±11.5 (range 22 to 66) years were studied. Twenty unaffected eyes were the subject of the current study. The retina in all of these eyes remained intact during the course of the study. In the sound eyes, mean b-wave amplitude of the maximal combined response ERG before initiation of treatment was 229.5±38.8 microvolts which increased to 356.1±34.0 (P<0.001) and 365.8±32.7 (P<0.001) microvolts 1 and 3 months after treatment, respectively. Corresponding figures for b-wave amplitudes of the cone response ERG were 24.9±6.0, 47.0±12.9 (P<0.001) and 52.8±12.7 (P<0.001) microvolts, respectively. Visual acuity of all sound eyes remained unchanged throughout the study. Conclusion: Despite normal retinal appearance and intact visual acuity in the sound eyes of patients with NHR, electrophysiological changes were observed. Prompt diagnosis and management of NHR and continuation of medication for 3 months may reverse subclinical ERG changes and reduce the risk of progression to overt clinical disease.
abstract_unstemmed	Purpose: To evaluate electroretinogram (ERG) changes in the contralateral normal appearing eye of patients with unilateral acute necrotizing herpetic retinitis (NHR). Methods: This interventional case series includes subjects with acute unilateral NHR. All patients were treated with intravenous followed by oral acyclovir and systemic steroids. Main outcome measures were changes in a- and b-wave amplitudes of scotopic and photopic full-field ERG in the sound eye, 1 and 3 months after therapy as compared to baseline. Twenty normal subjects served as controls. Results: Forty eyes of 20 patients including 12 male and 8 female subjects with mean age of 44.1±11.5 (range 22 to 66) years were studied. Twenty unaffected eyes were the subject of the current study. The retina in all of these eyes remained intact during the course of the study. In the sound eyes, mean b-wave amplitude of the maximal combined response ERG before initiation of treatment was 229.5±38.8 microvolts which increased to 356.1±34.0 (P<0.001) and 365.8±32.7 (P<0.001) microvolts 1 and 3 months after treatment, respectively. Corresponding figures for b-wave amplitudes of the cone response ERG were 24.9±6.0, 47.0±12.9 (P<0.001) and 52.8±12.7 (P<0.001) microvolts, respectively. Visual acuity of all sound eyes remained unchanged throughout the study. Conclusion: Despite normal retinal appearance and intact visual acuity in the sound eyes of patients with NHR, electrophysiological changes were observed. Prompt diagnosis and management of NHR and continuation of medication for 3 months may reverse subclinical ERG changes and reduce the risk of progression to overt clinical disease.
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title_short	Electroretinogram Changes in the Sound Eye of Subjects with Unilateral Necrotizing Herpetic Retinitis
url	https://doaj.org/article/201c79e15e014724ae1bc3cf6fb36533 http://www.jovr.org/article.asp?issn=2008-322X;year=2014;volume=9;issue=2;spage=195;epage=203;aulast=Azarmina https://doaj.org/toc/2008-322X
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author2	Masoud Soheilian Hamid Ahmadieh Hossein Azarmina
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Electroretinogram Changes in the Sound Eye of Subjects with Unilateral Necrotizing Herpetic Retinitis

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