S100, CD68, and MHC class II molecule expression in cervical high- and low-grade HPV-induced lesions

INTRODUCTION: Some human papillomavirus (HPV) types are involved in malignant processes in the cervical epithelium, with 99% of cases attributed to oncogenic HPV infection. This study aimed to detect S100, CD68, and major histocompatibility complex class II (MHC-II) molecules in cervical uterine epi...
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Autor*in:	Fernanda Cassandri [verfasserIn] Inês Aparecida Tozetti [verfasserIn] Carlos Eurico dos Santos Fernandes [verfasserIn] Flávia Gatto de Almeida [verfasserIn] Gustavo Ribeiro Falcão [verfasserIn] Ilzia Doraci Lins Scapulatempo [verfasserIn] Thiago Theodoro Martins Prata [verfasserIn] Cacilda Tezelli Junqueira Padovani [verfasserIn] Daniella Borges Alves [verfasserIn] Alda Teixeira Ferreira [verfasserIn] Maria Auxiliadora Gomes Sandim Abdo [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Schlagwörter:	Papilomavírus humano Resposta immune Imunohistoquímica

Übergeordnetes Werk:	In: Revista da Sociedade Brasileira de Medicina Tropical - Sociedade Brasileira de Medicina Tropical (SBMT), 2004, 45(2012), 1, Seite 3-8
Übergeordnetes Werk:	volume:45 ; year:2012 ; number:1 ; pages:3-8

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.1590/S0037-86822012000100002

Katalog-ID:	DOAJ079751660

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520			\|a INTRODUCTION: Some human papillomavirus (HPV) types are involved in malignant processes in the cervical epithelium, with 99% of cases attributed to oncogenic HPV infection. This study aimed to detect S100, CD68, and major histocompatibility complex class II (MHC-II) molecules in cervical uterine epithelial samples in patients with high- and low-grade lesions induced by HPV. METHODS: Fifty-eight samples from patients who were confirmed positive or negative for high-risk oncogenic HPV DNA, had histopathological diagnosis of cervical intraepithelial neoplasia (CIN) of grades I, II, or III, or were negative for intraepithelial lesion or malignancy were subjected to immunohistochemistry reaction to S100 protein, CD68, and MHC-II (HLA-DR alpha chain). RESULTS: The presence of MHC-II predominated in samples exhibiting histopathological alterations (p < 0.05). S100 detection was more numerous in carcinoma samples (CIN III) (75%). Presence of this protein correlated significantly (p < 0.05) with histopathological findings and viral load. CONCLUSIONS: A small expression of CD68 was observed, which may be explained by the observation in our study having been made on random microscopic fields and not on specific areas. The findings, such as the presence of S100 protein and MHC-II expression in samples with histological alterations, could suggest that the immune system fails to control HPV replication at the early stages of infection. Further studies with larger prospective data are necessary to confirm this result.
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allfields	10.1590/S0037-86822012000100002 doi (DE-627)DOAJ079751660 (DE-599)DOAJdae18cedf4dd4bb6afed381e9006356e DE-627 ger DE-627 rakwb eng RC955-962 Fernanda Cassandri verfasserin aut S100, CD68, and MHC class II molecule expression in cervical high- and low-grade HPV-induced lesions 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier INTRODUCTION: Some human papillomavirus (HPV) types are involved in malignant processes in the cervical epithelium, with 99% of cases attributed to oncogenic HPV infection. This study aimed to detect S100, CD68, and major histocompatibility complex class II (MHC-II) molecules in cervical uterine epithelial samples in patients with high- and low-grade lesions induced by HPV. METHODS: Fifty-eight samples from patients who were confirmed positive or negative for high-risk oncogenic HPV DNA, had histopathological diagnosis of cervical intraepithelial neoplasia (CIN) of grades I, II, or III, or were negative for intraepithelial lesion or malignancy were subjected to immunohistochemistry reaction to S100 protein, CD68, and MHC-II (HLA-DR alpha chain). RESULTS: The presence of MHC-II predominated in samples exhibiting histopathological alterations (p < 0.05). S100 detection was more numerous in carcinoma samples (CIN III) (75%). Presence of this protein correlated significantly (p < 0.05) with histopathological findings and viral load. CONCLUSIONS: A small expression of CD68 was observed, which may be explained by the observation in our study having been made on random microscopic fields and not on specific areas. The findings, such as the presence of S100 protein and MHC-II expression in samples with histological alterations, could suggest that the immune system fails to control HPV replication at the early stages of infection. Further studies with larger prospective data are necessary to confirm this result. Papilomavírus humano Resposta immune Imunohistoquímica Arctic medicine. Tropical medicine Inês Aparecida Tozetti verfasserin aut Carlos Eurico dos Santos Fernandes verfasserin aut Flávia Gatto de Almeida verfasserin aut Gustavo Ribeiro Falcão verfasserin aut Ilzia Doraci Lins Scapulatempo verfasserin aut Thiago Theodoro Martins Prata verfasserin aut Cacilda Tezelli Junqueira Padovani verfasserin aut Daniella Borges Alves verfasserin aut Alda Teixeira Ferreira verfasserin aut Maria Auxiliadora Gomes Sandim Abdo verfasserin aut In Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT), 2004 45(2012), 1, Seite 3-8 (DE-627)324614918 (DE-600)2028921-2 16789849 nnns volume:45 year:2012 number:1 pages:3-8 https://doi.org/10.1590/S0037-86822012000100002 kostenfrei https://doaj.org/article/dae18cedf4dd4bb6afed381e9006356e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100002&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-9849 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2012 1 3-8
spelling	10.1590/S0037-86822012000100002 doi (DE-627)DOAJ079751660 (DE-599)DOAJdae18cedf4dd4bb6afed381e9006356e DE-627 ger DE-627 rakwb eng RC955-962 Fernanda Cassandri verfasserin aut S100, CD68, and MHC class II molecule expression in cervical high- and low-grade HPV-induced lesions 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier INTRODUCTION: Some human papillomavirus (HPV) types are involved in malignant processes in the cervical epithelium, with 99% of cases attributed to oncogenic HPV infection. This study aimed to detect S100, CD68, and major histocompatibility complex class II (MHC-II) molecules in cervical uterine epithelial samples in patients with high- and low-grade lesions induced by HPV. METHODS: Fifty-eight samples from patients who were confirmed positive or negative for high-risk oncogenic HPV DNA, had histopathological diagnosis of cervical intraepithelial neoplasia (CIN) of grades I, II, or III, or were negative for intraepithelial lesion or malignancy were subjected to immunohistochemistry reaction to S100 protein, CD68, and MHC-II (HLA-DR alpha chain). RESULTS: The presence of MHC-II predominated in samples exhibiting histopathological alterations (p < 0.05). S100 detection was more numerous in carcinoma samples (CIN III) (75%). Presence of this protein correlated significantly (p < 0.05) with histopathological findings and viral load. CONCLUSIONS: A small expression of CD68 was observed, which may be explained by the observation in our study having been made on random microscopic fields and not on specific areas. The findings, such as the presence of S100 protein and MHC-II expression in samples with histological alterations, could suggest that the immune system fails to control HPV replication at the early stages of infection. Further studies with larger prospective data are necessary to confirm this result. Papilomavírus humano Resposta immune Imunohistoquímica Arctic medicine. Tropical medicine Inês Aparecida Tozetti verfasserin aut Carlos Eurico dos Santos Fernandes verfasserin aut Flávia Gatto de Almeida verfasserin aut Gustavo Ribeiro Falcão verfasserin aut Ilzia Doraci Lins Scapulatempo verfasserin aut Thiago Theodoro Martins Prata verfasserin aut Cacilda Tezelli Junqueira Padovani verfasserin aut Daniella Borges Alves verfasserin aut Alda Teixeira Ferreira verfasserin aut Maria Auxiliadora Gomes Sandim Abdo verfasserin aut In Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT), 2004 45(2012), 1, Seite 3-8 (DE-627)324614918 (DE-600)2028921-2 16789849 nnns volume:45 year:2012 number:1 pages:3-8 https://doi.org/10.1590/S0037-86822012000100002 kostenfrei https://doaj.org/article/dae18cedf4dd4bb6afed381e9006356e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100002&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-9849 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2012 1 3-8
allfields_unstemmed	10.1590/S0037-86822012000100002 doi (DE-627)DOAJ079751660 (DE-599)DOAJdae18cedf4dd4bb6afed381e9006356e DE-627 ger DE-627 rakwb eng RC955-962 Fernanda Cassandri verfasserin aut S100, CD68, and MHC class II molecule expression in cervical high- and low-grade HPV-induced lesions 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier INTRODUCTION: Some human papillomavirus (HPV) types are involved in malignant processes in the cervical epithelium, with 99% of cases attributed to oncogenic HPV infection. This study aimed to detect S100, CD68, and major histocompatibility complex class II (MHC-II) molecules in cervical uterine epithelial samples in patients with high- and low-grade lesions induced by HPV. METHODS: Fifty-eight samples from patients who were confirmed positive or negative for high-risk oncogenic HPV DNA, had histopathological diagnosis of cervical intraepithelial neoplasia (CIN) of grades I, II, or III, or were negative for intraepithelial lesion or malignancy were subjected to immunohistochemistry reaction to S100 protein, CD68, and MHC-II (HLA-DR alpha chain). RESULTS: The presence of MHC-II predominated in samples exhibiting histopathological alterations (p < 0.05). S100 detection was more numerous in carcinoma samples (CIN III) (75%). Presence of this protein correlated significantly (p < 0.05) with histopathological findings and viral load. CONCLUSIONS: A small expression of CD68 was observed, which may be explained by the observation in our study having been made on random microscopic fields and not on specific areas. The findings, such as the presence of S100 protein and MHC-II expression in samples with histological alterations, could suggest that the immune system fails to control HPV replication at the early stages of infection. Further studies with larger prospective data are necessary to confirm this result. Papilomavírus humano Resposta immune Imunohistoquímica Arctic medicine. Tropical medicine Inês Aparecida Tozetti verfasserin aut Carlos Eurico dos Santos Fernandes verfasserin aut Flávia Gatto de Almeida verfasserin aut Gustavo Ribeiro Falcão verfasserin aut Ilzia Doraci Lins Scapulatempo verfasserin aut Thiago Theodoro Martins Prata verfasserin aut Cacilda Tezelli Junqueira Padovani verfasserin aut Daniella Borges Alves verfasserin aut Alda Teixeira Ferreira verfasserin aut Maria Auxiliadora Gomes Sandim Abdo verfasserin aut In Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT), 2004 45(2012), 1, Seite 3-8 (DE-627)324614918 (DE-600)2028921-2 16789849 nnns volume:45 year:2012 number:1 pages:3-8 https://doi.org/10.1590/S0037-86822012000100002 kostenfrei https://doaj.org/article/dae18cedf4dd4bb6afed381e9006356e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100002&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-9849 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2012 1 3-8
allfieldsGer	10.1590/S0037-86822012000100002 doi (DE-627)DOAJ079751660 (DE-599)DOAJdae18cedf4dd4bb6afed381e9006356e DE-627 ger DE-627 rakwb eng RC955-962 Fernanda Cassandri verfasserin aut S100, CD68, and MHC class II molecule expression in cervical high- and low-grade HPV-induced lesions 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier INTRODUCTION: Some human papillomavirus (HPV) types are involved in malignant processes in the cervical epithelium, with 99% of cases attributed to oncogenic HPV infection. This study aimed to detect S100, CD68, and major histocompatibility complex class II (MHC-II) molecules in cervical uterine epithelial samples in patients with high- and low-grade lesions induced by HPV. METHODS: Fifty-eight samples from patients who were confirmed positive or negative for high-risk oncogenic HPV DNA, had histopathological diagnosis of cervical intraepithelial neoplasia (CIN) of grades I, II, or III, or were negative for intraepithelial lesion or malignancy were subjected to immunohistochemistry reaction to S100 protein, CD68, and MHC-II (HLA-DR alpha chain). RESULTS: The presence of MHC-II predominated in samples exhibiting histopathological alterations (p < 0.05). S100 detection was more numerous in carcinoma samples (CIN III) (75%). Presence of this protein correlated significantly (p < 0.05) with histopathological findings and viral load. CONCLUSIONS: A small expression of CD68 was observed, which may be explained by the observation in our study having been made on random microscopic fields and not on specific areas. The findings, such as the presence of S100 protein and MHC-II expression in samples with histological alterations, could suggest that the immune system fails to control HPV replication at the early stages of infection. Further studies with larger prospective data are necessary to confirm this result. Papilomavírus humano Resposta immune Imunohistoquímica Arctic medicine. Tropical medicine Inês Aparecida Tozetti verfasserin aut Carlos Eurico dos Santos Fernandes verfasserin aut Flávia Gatto de Almeida verfasserin aut Gustavo Ribeiro Falcão verfasserin aut Ilzia Doraci Lins Scapulatempo verfasserin aut Thiago Theodoro Martins Prata verfasserin aut Cacilda Tezelli Junqueira Padovani verfasserin aut Daniella Borges Alves verfasserin aut Alda Teixeira Ferreira verfasserin aut Maria Auxiliadora Gomes Sandim Abdo verfasserin aut In Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT), 2004 45(2012), 1, Seite 3-8 (DE-627)324614918 (DE-600)2028921-2 16789849 nnns volume:45 year:2012 number:1 pages:3-8 https://doi.org/10.1590/S0037-86822012000100002 kostenfrei https://doaj.org/article/dae18cedf4dd4bb6afed381e9006356e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100002&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-9849 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2012 1 3-8
allfieldsSound	10.1590/S0037-86822012000100002 doi (DE-627)DOAJ079751660 (DE-599)DOAJdae18cedf4dd4bb6afed381e9006356e DE-627 ger DE-627 rakwb eng RC955-962 Fernanda Cassandri verfasserin aut S100, CD68, and MHC class II molecule expression in cervical high- and low-grade HPV-induced lesions 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier INTRODUCTION: Some human papillomavirus (HPV) types are involved in malignant processes in the cervical epithelium, with 99% of cases attributed to oncogenic HPV infection. This study aimed to detect S100, CD68, and major histocompatibility complex class II (MHC-II) molecules in cervical uterine epithelial samples in patients with high- and low-grade lesions induced by HPV. METHODS: Fifty-eight samples from patients who were confirmed positive or negative for high-risk oncogenic HPV DNA, had histopathological diagnosis of cervical intraepithelial neoplasia (CIN) of grades I, II, or III, or were negative for intraepithelial lesion or malignancy were subjected to immunohistochemistry reaction to S100 protein, CD68, and MHC-II (HLA-DR alpha chain). RESULTS: The presence of MHC-II predominated in samples exhibiting histopathological alterations (p < 0.05). S100 detection was more numerous in carcinoma samples (CIN III) (75%). Presence of this protein correlated significantly (p < 0.05) with histopathological findings and viral load. CONCLUSIONS: A small expression of CD68 was observed, which may be explained by the observation in our study having been made on random microscopic fields and not on specific areas. The findings, such as the presence of S100 protein and MHC-II expression in samples with histological alterations, could suggest that the immune system fails to control HPV replication at the early stages of infection. Further studies with larger prospective data are necessary to confirm this result. Papilomavírus humano Resposta immune Imunohistoquímica Arctic medicine. Tropical medicine Inês Aparecida Tozetti verfasserin aut Carlos Eurico dos Santos Fernandes verfasserin aut Flávia Gatto de Almeida verfasserin aut Gustavo Ribeiro Falcão verfasserin aut Ilzia Doraci Lins Scapulatempo verfasserin aut Thiago Theodoro Martins Prata verfasserin aut Cacilda Tezelli Junqueira Padovani verfasserin aut Daniella Borges Alves verfasserin aut Alda Teixeira Ferreira verfasserin aut Maria Auxiliadora Gomes Sandim Abdo verfasserin aut In Revista da Sociedade Brasileira de Medicina Tropical Sociedade Brasileira de Medicina Tropical (SBMT), 2004 45(2012), 1, Seite 3-8 (DE-627)324614918 (DE-600)2028921-2 16789849 nnns volume:45 year:2012 number:1 pages:3-8 https://doi.org/10.1590/S0037-86822012000100002 kostenfrei https://doaj.org/article/dae18cedf4dd4bb6afed381e9006356e kostenfrei http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100002&lng=en&tlng=en kostenfrei https://doaj.org/toc/1678-9849 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 45 2012 1 3-8
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source	In Revista da Sociedade Brasileira de Medicina Tropical 45(2012), 1, Seite 3-8 volume:45 year:2012 number:1 pages:3-8
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authorswithroles_txt_mv	Fernanda Cassandri @@aut@@ Inês Aparecida Tozetti @@aut@@ Carlos Eurico dos Santos Fernandes @@aut@@ Flávia Gatto de Almeida @@aut@@ Gustavo Ribeiro Falcão @@aut@@ Ilzia Doraci Lins Scapulatempo @@aut@@ Thiago Theodoro Martins Prata @@aut@@ Cacilda Tezelli Junqueira Padovani @@aut@@ Daniella Borges Alves @@aut@@ Alda Teixeira Ferreira @@aut@@ Maria Auxiliadora Gomes Sandim Abdo @@aut@@
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topic_title	RC955-962 S100, CD68, and MHC class II molecule expression in cervical high- and low-grade HPV-induced lesions Papilomavírus humano Resposta immune Imunohistoquímica
topic	misc RC955-962 misc Papilomavírus humano misc Resposta immune misc Imunohistoquímica misc Arctic medicine. Tropical medicine
topic_unstemmed	misc RC955-962 misc Papilomavírus humano misc Resposta immune misc Imunohistoquímica misc Arctic medicine. Tropical medicine
topic_browse	misc RC955-962 misc Papilomavírus humano misc Resposta immune misc Imunohistoquímica misc Arctic medicine. Tropical medicine
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title	S100, CD68, and MHC class II molecule expression in cervical high- and low-grade HPV-induced lesions
ctrlnum	(DE-627)DOAJ079751660 (DE-599)DOAJdae18cedf4dd4bb6afed381e9006356e
title_full	S100, CD68, and MHC class II molecule expression in cervical high- and low-grade HPV-induced lesions
author_sort	Fernanda Cassandri
journal	Revista da Sociedade Brasileira de Medicina Tropical
journalStr	Revista da Sociedade Brasileira de Medicina Tropical
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author_browse	Fernanda Cassandri Inês Aparecida Tozetti Carlos Eurico dos Santos Fernandes Flávia Gatto de Almeida Gustavo Ribeiro Falcão Ilzia Doraci Lins Scapulatempo Thiago Theodoro Martins Prata Cacilda Tezelli Junqueira Padovani Daniella Borges Alves Alda Teixeira Ferreira Maria Auxiliadora Gomes Sandim Abdo
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author-letter	Fernanda Cassandri
doi_str_mv	10.1590/S0037-86822012000100002
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title_sort	s100, cd68, and mhc class ii molecule expression in cervical high- and low-grade hpv-induced lesions
callnumber	RC955-962
title_auth	S100, CD68, and MHC class II molecule expression in cervical high- and low-grade HPV-induced lesions
abstract	INTRODUCTION: Some human papillomavirus (HPV) types are involved in malignant processes in the cervical epithelium, with 99% of cases attributed to oncogenic HPV infection. This study aimed to detect S100, CD68, and major histocompatibility complex class II (MHC-II) molecules in cervical uterine epithelial samples in patients with high- and low-grade lesions induced by HPV. METHODS: Fifty-eight samples from patients who were confirmed positive or negative for high-risk oncogenic HPV DNA, had histopathological diagnosis of cervical intraepithelial neoplasia (CIN) of grades I, II, or III, or were negative for intraepithelial lesion or malignancy were subjected to immunohistochemistry reaction to S100 protein, CD68, and MHC-II (HLA-DR alpha chain). RESULTS: The presence of MHC-II predominated in samples exhibiting histopathological alterations (p < 0.05). S100 detection was more numerous in carcinoma samples (CIN III) (75%). Presence of this protein correlated significantly (p < 0.05) with histopathological findings and viral load. CONCLUSIONS: A small expression of CD68 was observed, which may be explained by the observation in our study having been made on random microscopic fields and not on specific areas. The findings, such as the presence of S100 protein and MHC-II expression in samples with histological alterations, could suggest that the immune system fails to control HPV replication at the early stages of infection. Further studies with larger prospective data are necessary to confirm this result.
abstractGer	INTRODUCTION: Some human papillomavirus (HPV) types are involved in malignant processes in the cervical epithelium, with 99% of cases attributed to oncogenic HPV infection. This study aimed to detect S100, CD68, and major histocompatibility complex class II (MHC-II) molecules in cervical uterine epithelial samples in patients with high- and low-grade lesions induced by HPV. METHODS: Fifty-eight samples from patients who were confirmed positive or negative for high-risk oncogenic HPV DNA, had histopathological diagnosis of cervical intraepithelial neoplasia (CIN) of grades I, II, or III, or were negative for intraepithelial lesion or malignancy were subjected to immunohistochemistry reaction to S100 protein, CD68, and MHC-II (HLA-DR alpha chain). RESULTS: The presence of MHC-II predominated in samples exhibiting histopathological alterations (p < 0.05). S100 detection was more numerous in carcinoma samples (CIN III) (75%). Presence of this protein correlated significantly (p < 0.05) with histopathological findings and viral load. CONCLUSIONS: A small expression of CD68 was observed, which may be explained by the observation in our study having been made on random microscopic fields and not on specific areas. The findings, such as the presence of S100 protein and MHC-II expression in samples with histological alterations, could suggest that the immune system fails to control HPV replication at the early stages of infection. Further studies with larger prospective data are necessary to confirm this result.
abstract_unstemmed	INTRODUCTION: Some human papillomavirus (HPV) types are involved in malignant processes in the cervical epithelium, with 99% of cases attributed to oncogenic HPV infection. This study aimed to detect S100, CD68, and major histocompatibility complex class II (MHC-II) molecules in cervical uterine epithelial samples in patients with high- and low-grade lesions induced by HPV. METHODS: Fifty-eight samples from patients who were confirmed positive or negative for high-risk oncogenic HPV DNA, had histopathological diagnosis of cervical intraepithelial neoplasia (CIN) of grades I, II, or III, or were negative for intraepithelial lesion or malignancy were subjected to immunohistochemistry reaction to S100 protein, CD68, and MHC-II (HLA-DR alpha chain). RESULTS: The presence of MHC-II predominated in samples exhibiting histopathological alterations (p < 0.05). S100 detection was more numerous in carcinoma samples (CIN III) (75%). Presence of this protein correlated significantly (p < 0.05) with histopathological findings and viral load. CONCLUSIONS: A small expression of CD68 was observed, which may be explained by the observation in our study having been made on random microscopic fields and not on specific areas. The findings, such as the presence of S100 protein and MHC-II expression in samples with histological alterations, could suggest that the immune system fails to control HPV replication at the early stages of infection. Further studies with larger prospective data are necessary to confirm this result.
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container_issue	1
title_short	S100, CD68, and MHC class II molecule expression in cervical high- and low-grade HPV-induced lesions
url	https://doi.org/10.1590/S0037-86822012000100002 https://doaj.org/article/dae18cedf4dd4bb6afed381e9006356e http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100002&lng=en&tlng=en https://doaj.org/toc/1678-9849
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author2	Inês Aparecida Tozetti Carlos Eurico dos Santos Fernandes Flávia Gatto de Almeida Gustavo Ribeiro Falcão Ilzia Doraci Lins Scapulatempo Thiago Theodoro Martins Prata Cacilda Tezelli Junqueira Padovani Daniella Borges Alves Alda Teixeira Ferreira Maria Auxiliadora Gomes Sandim Abdo
author2Str	Inês Aparecida Tozetti Carlos Eurico dos Santos Fernandes Flávia Gatto de Almeida Gustavo Ribeiro Falcão Ilzia Doraci Lins Scapulatempo Thiago Theodoro Martins Prata Cacilda Tezelli Junqueira Padovani Daniella Borges Alves Alda Teixeira Ferreira Maria Auxiliadora Gomes Sandim Abdo
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up_date	2024-07-04T00:41:53.144Z
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