Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology

5-aminolevulinic acid (ALA) is a clinically approved prodrug involved in intracellular Heme biosynthesis to produce the natural photosensitizer (PS) Protoporphyrin IX (PpIX). ALA based photodynamic therapy (PDT) has been used to treat various malignant and non-malignant diseases. However, natural AL...
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Autor*in:	Liang Lou [verfasserIn] Shizhe Zhou [verfasserIn] Sijia Tan [verfasserIn] Menghua Xiang [verfasserIn] Wei Wang [verfasserIn] Chuang Yuan [verfasserIn] Liqian Gao [verfasserIn] Qicai Xiao [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	5-aminolevulinic acid biotransformation photodynamic therapy prodrug nanotechnology

Übergeordnetes Werk:	In: Frontiers in Pharmacology - Frontiers Media S.A., 2010, 14(2023)
Übergeordnetes Werk:	volume:14 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphar.2023.1137707

Katalog-ID:	DOAJ079819370

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callnumber-first	R - Medicine
author	Liang Lou
spellingShingle	Liang Lou misc RM1-950 misc 5-aminolevulinic acid misc biotransformation misc photodynamic therapy misc prodrug misc nanotechnology misc Therapeutics. Pharmacology Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology
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topic_title	RM1-950 Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology 5-aminolevulinic acid biotransformation photodynamic therapy prodrug nanotechnology
topic	misc RM1-950 misc 5-aminolevulinic acid misc biotransformation misc photodynamic therapy misc prodrug misc nanotechnology misc Therapeutics. Pharmacology
topic_unstemmed	misc RM1-950 misc 5-aminolevulinic acid misc biotransformation misc photodynamic therapy misc prodrug misc nanotechnology misc Therapeutics. Pharmacology
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title	Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology
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title_sort	amplifying the efficacy of ala-based prodrugs for photodynamic therapy using nanotechnology
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title_auth	Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology
abstract	5-aminolevulinic acid (ALA) is a clinically approved prodrug involved in intracellular Heme biosynthesis to produce the natural photosensitizer (PS) Protoporphyrin IX (PpIX). ALA based photodynamic therapy (PDT) has been used to treat various malignant and non-malignant diseases. However, natural ALA has disadvantages such as weak lipophilicity, low stability and poor bioavailability, greatly reducing its clinical performance. The emerging nanotechnology is expected to address these limitations and thus improve the therapeutic outcomes. Herein, we summarized important recent advances in the design of ALA-based prodrugs using nanotechnology to improve the efficacy of PDT. The potential limitations and future perspectives of ALA-based nanomedicines are also briefly presented and discussed.
abstractGer	5-aminolevulinic acid (ALA) is a clinically approved prodrug involved in intracellular Heme biosynthesis to produce the natural photosensitizer (PS) Protoporphyrin IX (PpIX). ALA based photodynamic therapy (PDT) has been used to treat various malignant and non-malignant diseases. However, natural ALA has disadvantages such as weak lipophilicity, low stability and poor bioavailability, greatly reducing its clinical performance. The emerging nanotechnology is expected to address these limitations and thus improve the therapeutic outcomes. Herein, we summarized important recent advances in the design of ALA-based prodrugs using nanotechnology to improve the efficacy of PDT. The potential limitations and future perspectives of ALA-based nanomedicines are also briefly presented and discussed.
abstract_unstemmed	5-aminolevulinic acid (ALA) is a clinically approved prodrug involved in intracellular Heme biosynthesis to produce the natural photosensitizer (PS) Protoporphyrin IX (PpIX). ALA based photodynamic therapy (PDT) has been used to treat various malignant and non-malignant diseases. However, natural ALA has disadvantages such as weak lipophilicity, low stability and poor bioavailability, greatly reducing its clinical performance. The emerging nanotechnology is expected to address these limitations and thus improve the therapeutic outcomes. Herein, we summarized important recent advances in the design of ALA-based prodrugs using nanotechnology to improve the efficacy of PDT. The potential limitations and future perspectives of ALA-based nanomedicines are also briefly presented and discussed.
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title_short	Amplifying the efficacy of ALA-based prodrugs for photodynamic therapy using nanotechnology
url	https://doi.org/10.3389/fphar.2023.1137707 https://doaj.org/article/eff54de5c2dc491494e8b2f310b0cbb1 https://www.frontiersin.org/articles/10.3389/fphar.2023.1137707/full https://doaj.org/toc/1663-9812
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