Comprehensive Study of Lung Cancer Proton Therapy with Injection of GNPs

The application of radiation therapy (RT) in lung cancer has shown some exciting and sometimes disappointing advances in recent years. Protons compared with photons interact differently with human tissues, and can be used to improve patient care for suffering from lung cancer. A new strategy is the...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Seyedehnasrin Hosseinimotlagh [verfasserIn] Reza Khoramdel [verfasserIn] Zohreh Parang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Lung Nanoparticles proton relativistic simulation

Übergeordnetes Werk:	In: Basic & Clinical Cancer Research - Tehran University of Medical Sciences, 2021, 13(2023), 4
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:4

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ079878687

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allfields	(DE-627)DOAJ079878687 (DE-599)DOAJ7f0a8fed4de84ee4b9db1546600dd2a3 DE-627 ger DE-627 rakwb eng Seyedehnasrin Hosseinimotlagh verfasserin aut Comprehensive Study of Lung Cancer Proton Therapy with Injection of GNPs 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The application of radiation therapy (RT) in lung cancer has shown some exciting and sometimes disappointing advances in recent years. Protons compared with photons interact differently with human tissues, and can be used to improve patient care for suffering from lung cancer. A new strategy is the simultaneous injection of nanoparticles with proton radiation into the tumor which has been given over a decade to improve conventional RT. In this work, proton beam therapy (PBT) with gold nanoparticles (GNPs) is used as a part of a combination program to treat advanced localized lung cancers. This paper aims to develop the complex Geant4 model on the human lung and predict the distribution of absorbed dose in lung tumors during proton therapy without and with a high-Z injection of GNPs. Thus, the absorbed dose distribution in lung tumors for four modes such as (i) Bethe-Bloch’s relativistic quantum theory, (ii) GEANT4/ GATE7 simulation model, (iii) Hartree-Fock-Roothaan(HFR) wave functions, and the(vi) Bortfeld theoretical model without and with the injection of GNPs in predicted lung phantom are compared. Lung Nanoparticles proton relativistic simulation Medicine R Reza Khoramdel verfasserin aut Zohreh Parang verfasserin aut In Basic & Clinical Cancer Research Tehran University of Medical Sciences, 2021 13(2023), 4 (DE-627)737703458 (DE-600)2705811-6 22285466 nnns volume:13 year:2023 number:4 https://doaj.org/article/7f0a8fed4de84ee4b9db1546600dd2a3 kostenfrei https://bccr.tums.ac.ir/index.php/bccrj/article/view/413 kostenfrei https://doaj.org/toc/2228-6527 Journal toc kostenfrei https://doaj.org/toc/2228-5466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 4
spelling	(DE-627)DOAJ079878687 (DE-599)DOAJ7f0a8fed4de84ee4b9db1546600dd2a3 DE-627 ger DE-627 rakwb eng Seyedehnasrin Hosseinimotlagh verfasserin aut Comprehensive Study of Lung Cancer Proton Therapy with Injection of GNPs 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The application of radiation therapy (RT) in lung cancer has shown some exciting and sometimes disappointing advances in recent years. Protons compared with photons interact differently with human tissues, and can be used to improve patient care for suffering from lung cancer. A new strategy is the simultaneous injection of nanoparticles with proton radiation into the tumor which has been given over a decade to improve conventional RT. In this work, proton beam therapy (PBT) with gold nanoparticles (GNPs) is used as a part of a combination program to treat advanced localized lung cancers. This paper aims to develop the complex Geant4 model on the human lung and predict the distribution of absorbed dose in lung tumors during proton therapy without and with a high-Z injection of GNPs. Thus, the absorbed dose distribution in lung tumors for four modes such as (i) Bethe-Bloch’s relativistic quantum theory, (ii) GEANT4/ GATE7 simulation model, (iii) Hartree-Fock-Roothaan(HFR) wave functions, and the(vi) Bortfeld theoretical model without and with the injection of GNPs in predicted lung phantom are compared. Lung Nanoparticles proton relativistic simulation Medicine R Reza Khoramdel verfasserin aut Zohreh Parang verfasserin aut In Basic & Clinical Cancer Research Tehran University of Medical Sciences, 2021 13(2023), 4 (DE-627)737703458 (DE-600)2705811-6 22285466 nnns volume:13 year:2023 number:4 https://doaj.org/article/7f0a8fed4de84ee4b9db1546600dd2a3 kostenfrei https://bccr.tums.ac.ir/index.php/bccrj/article/view/413 kostenfrei https://doaj.org/toc/2228-6527 Journal toc kostenfrei https://doaj.org/toc/2228-5466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 4
allfields_unstemmed	(DE-627)DOAJ079878687 (DE-599)DOAJ7f0a8fed4de84ee4b9db1546600dd2a3 DE-627 ger DE-627 rakwb eng Seyedehnasrin Hosseinimotlagh verfasserin aut Comprehensive Study of Lung Cancer Proton Therapy with Injection of GNPs 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The application of radiation therapy (RT) in lung cancer has shown some exciting and sometimes disappointing advances in recent years. Protons compared with photons interact differently with human tissues, and can be used to improve patient care for suffering from lung cancer. A new strategy is the simultaneous injection of nanoparticles with proton radiation into the tumor which has been given over a decade to improve conventional RT. In this work, proton beam therapy (PBT) with gold nanoparticles (GNPs) is used as a part of a combination program to treat advanced localized lung cancers. This paper aims to develop the complex Geant4 model on the human lung and predict the distribution of absorbed dose in lung tumors during proton therapy without and with a high-Z injection of GNPs. Thus, the absorbed dose distribution in lung tumors for four modes such as (i) Bethe-Bloch’s relativistic quantum theory, (ii) GEANT4/ GATE7 simulation model, (iii) Hartree-Fock-Roothaan(HFR) wave functions, and the(vi) Bortfeld theoretical model without and with the injection of GNPs in predicted lung phantom are compared. Lung Nanoparticles proton relativistic simulation Medicine R Reza Khoramdel verfasserin aut Zohreh Parang verfasserin aut In Basic & Clinical Cancer Research Tehran University of Medical Sciences, 2021 13(2023), 4 (DE-627)737703458 (DE-600)2705811-6 22285466 nnns volume:13 year:2023 number:4 https://doaj.org/article/7f0a8fed4de84ee4b9db1546600dd2a3 kostenfrei https://bccr.tums.ac.ir/index.php/bccrj/article/view/413 kostenfrei https://doaj.org/toc/2228-6527 Journal toc kostenfrei https://doaj.org/toc/2228-5466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 4
allfieldsGer	(DE-627)DOAJ079878687 (DE-599)DOAJ7f0a8fed4de84ee4b9db1546600dd2a3 DE-627 ger DE-627 rakwb eng Seyedehnasrin Hosseinimotlagh verfasserin aut Comprehensive Study of Lung Cancer Proton Therapy with Injection of GNPs 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The application of radiation therapy (RT) in lung cancer has shown some exciting and sometimes disappointing advances in recent years. Protons compared with photons interact differently with human tissues, and can be used to improve patient care for suffering from lung cancer. A new strategy is the simultaneous injection of nanoparticles with proton radiation into the tumor which has been given over a decade to improve conventional RT. In this work, proton beam therapy (PBT) with gold nanoparticles (GNPs) is used as a part of a combination program to treat advanced localized lung cancers. This paper aims to develop the complex Geant4 model on the human lung and predict the distribution of absorbed dose in lung tumors during proton therapy without and with a high-Z injection of GNPs. Thus, the absorbed dose distribution in lung tumors for four modes such as (i) Bethe-Bloch’s relativistic quantum theory, (ii) GEANT4/ GATE7 simulation model, (iii) Hartree-Fock-Roothaan(HFR) wave functions, and the(vi) Bortfeld theoretical model without and with the injection of GNPs in predicted lung phantom are compared. Lung Nanoparticles proton relativistic simulation Medicine R Reza Khoramdel verfasserin aut Zohreh Parang verfasserin aut In Basic & Clinical Cancer Research Tehran University of Medical Sciences, 2021 13(2023), 4 (DE-627)737703458 (DE-600)2705811-6 22285466 nnns volume:13 year:2023 number:4 https://doaj.org/article/7f0a8fed4de84ee4b9db1546600dd2a3 kostenfrei https://bccr.tums.ac.ir/index.php/bccrj/article/view/413 kostenfrei https://doaj.org/toc/2228-6527 Journal toc kostenfrei https://doaj.org/toc/2228-5466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 4
allfieldsSound	(DE-627)DOAJ079878687 (DE-599)DOAJ7f0a8fed4de84ee4b9db1546600dd2a3 DE-627 ger DE-627 rakwb eng Seyedehnasrin Hosseinimotlagh verfasserin aut Comprehensive Study of Lung Cancer Proton Therapy with Injection of GNPs 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier The application of radiation therapy (RT) in lung cancer has shown some exciting and sometimes disappointing advances in recent years. Protons compared with photons interact differently with human tissues, and can be used to improve patient care for suffering from lung cancer. A new strategy is the simultaneous injection of nanoparticles with proton radiation into the tumor which has been given over a decade to improve conventional RT. In this work, proton beam therapy (PBT) with gold nanoparticles (GNPs) is used as a part of a combination program to treat advanced localized lung cancers. This paper aims to develop the complex Geant4 model on the human lung and predict the distribution of absorbed dose in lung tumors during proton therapy without and with a high-Z injection of GNPs. Thus, the absorbed dose distribution in lung tumors for four modes such as (i) Bethe-Bloch’s relativistic quantum theory, (ii) GEANT4/ GATE7 simulation model, (iii) Hartree-Fock-Roothaan(HFR) wave functions, and the(vi) Bortfeld theoretical model without and with the injection of GNPs in predicted lung phantom are compared. Lung Nanoparticles proton relativistic simulation Medicine R Reza Khoramdel verfasserin aut Zohreh Parang verfasserin aut In Basic & Clinical Cancer Research Tehran University of Medical Sciences, 2021 13(2023), 4 (DE-627)737703458 (DE-600)2705811-6 22285466 nnns volume:13 year:2023 number:4 https://doaj.org/article/7f0a8fed4de84ee4b9db1546600dd2a3 kostenfrei https://bccr.tums.ac.ir/index.php/bccrj/article/view/413 kostenfrei https://doaj.org/toc/2228-6527 Journal toc kostenfrei https://doaj.org/toc/2228-5466 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 4
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author	Seyedehnasrin Hosseinimotlagh
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topic_title	Comprehensive Study of Lung Cancer Proton Therapy with Injection of GNPs Lung Nanoparticles proton relativistic simulation
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title	Comprehensive Study of Lung Cancer Proton Therapy with Injection of GNPs
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title_full	Comprehensive Study of Lung Cancer Proton Therapy with Injection of GNPs
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title_sort	comprehensive study of lung cancer proton therapy with injection of gnps
title_auth	Comprehensive Study of Lung Cancer Proton Therapy with Injection of GNPs
abstract	The application of radiation therapy (RT) in lung cancer has shown some exciting and sometimes disappointing advances in recent years. Protons compared with photons interact differently with human tissues, and can be used to improve patient care for suffering from lung cancer. A new strategy is the simultaneous injection of nanoparticles with proton radiation into the tumor which has been given over a decade to improve conventional RT. In this work, proton beam therapy (PBT) with gold nanoparticles (GNPs) is used as a part of a combination program to treat advanced localized lung cancers. This paper aims to develop the complex Geant4 model on the human lung and predict the distribution of absorbed dose in lung tumors during proton therapy without and with a high-Z injection of GNPs. Thus, the absorbed dose distribution in lung tumors for four modes such as (i) Bethe-Bloch’s relativistic quantum theory, (ii) GEANT4/ GATE7 simulation model, (iii) Hartree-Fock-Roothaan(HFR) wave functions, and the(vi) Bortfeld theoretical model without and with the injection of GNPs in predicted lung phantom are compared.
abstractGer	The application of radiation therapy (RT) in lung cancer has shown some exciting and sometimes disappointing advances in recent years. Protons compared with photons interact differently with human tissues, and can be used to improve patient care for suffering from lung cancer. A new strategy is the simultaneous injection of nanoparticles with proton radiation into the tumor which has been given over a decade to improve conventional RT. In this work, proton beam therapy (PBT) with gold nanoparticles (GNPs) is used as a part of a combination program to treat advanced localized lung cancers. This paper aims to develop the complex Geant4 model on the human lung and predict the distribution of absorbed dose in lung tumors during proton therapy without and with a high-Z injection of GNPs. Thus, the absorbed dose distribution in lung tumors for four modes such as (i) Bethe-Bloch’s relativistic quantum theory, (ii) GEANT4/ GATE7 simulation model, (iii) Hartree-Fock-Roothaan(HFR) wave functions, and the(vi) Bortfeld theoretical model without and with the injection of GNPs in predicted lung phantom are compared.
abstract_unstemmed	The application of radiation therapy (RT) in lung cancer has shown some exciting and sometimes disappointing advances in recent years. Protons compared with photons interact differently with human tissues, and can be used to improve patient care for suffering from lung cancer. A new strategy is the simultaneous injection of nanoparticles with proton radiation into the tumor which has been given over a decade to improve conventional RT. In this work, proton beam therapy (PBT) with gold nanoparticles (GNPs) is used as a part of a combination program to treat advanced localized lung cancers. This paper aims to develop the complex Geant4 model on the human lung and predict the distribution of absorbed dose in lung tumors during proton therapy without and with a high-Z injection of GNPs. Thus, the absorbed dose distribution in lung tumors for four modes such as (i) Bethe-Bloch’s relativistic quantum theory, (ii) GEANT4/ GATE7 simulation model, (iii) Hartree-Fock-Roothaan(HFR) wave functions, and the(vi) Bortfeld theoretical model without and with the injection of GNPs in predicted lung phantom are compared.
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title_short	Comprehensive Study of Lung Cancer Proton Therapy with Injection of GNPs
url	https://doaj.org/article/7f0a8fed4de84ee4b9db1546600dd2a3 https://bccr.tums.ac.ir/index.php/bccrj/article/view/413 https://doaj.org/toc/2228-6527 https://doaj.org/toc/2228-5466
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