Prevention and management of CMV infection in pediatric solid organ transplant recipients

Human cytomegalovirus (CMV) remains one of the most common opportunistic infections following solid organ transplantation in children. CMV causes morbidity and mortality through direct tissue-invasive disease and indirect immunomodulatory effects. In recent years, several new agents have emerged for...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Shanthi S. Balani [verfasserIn] Sanober Sadiq [verfasserIn] Chelsey J. Jensen [verfasserIn] Sarah J. Kizilbash [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	opportunistic infections pediatric solid organ transplant cytomegalovirus treatment cytomegalovirus prevention cytomegalovirus emerging treatment

Übergeordnetes Werk:	In: Frontiers in Pediatrics - Frontiers Media S.A., 2013, 11(2023)
Übergeordnetes Werk:	volume:11 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fped.2023.1098434

Katalog-ID:	DOAJ07988427X

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520			\|a Human cytomegalovirus (CMV) remains one of the most common opportunistic infections following solid organ transplantation in children. CMV causes morbidity and mortality through direct tissue-invasive disease and indirect immunomodulatory effects. In recent years, several new agents have emerged for the prevention and treatment of CMV disease in solid organ transplant recipients. However, pediatric data remain scarce, and many of the treatments are extrapolated from the adult literature. Controversies exist about the type and duration of prophylactic therapies and the optimal dosing of antiviral agents. This review provides an up-to-date overview of treatment modalities used to prevent and treat CMV disease in solid organ transplant (SOT) recipients.
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allfieldsSound	10.3389/fped.2023.1098434 doi (DE-627)DOAJ07988427X (DE-599)DOAJ5f3cb6ad51764b31b2b2545d7e224aa8 DE-627 ger DE-627 rakwb eng RJ1-570 Shanthi S. Balani verfasserin aut Prevention and management of CMV infection in pediatric solid organ transplant recipients 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Human cytomegalovirus (CMV) remains one of the most common opportunistic infections following solid organ transplantation in children. CMV causes morbidity and mortality through direct tissue-invasive disease and indirect immunomodulatory effects. In recent years, several new agents have emerged for the prevention and treatment of CMV disease in solid organ transplant recipients. However, pediatric data remain scarce, and many of the treatments are extrapolated from the adult literature. Controversies exist about the type and duration of prophylactic therapies and the optimal dosing of antiviral agents. This review provides an up-to-date overview of treatment modalities used to prevent and treat CMV disease in solid organ transplant (SOT) recipients. opportunistic infections pediatric solid organ transplant cytomegalovirus treatment cytomegalovirus prevention cytomegalovirus emerging treatment Pediatrics Sanober Sadiq verfasserin aut Chelsey J. Jensen verfasserin aut Sarah J. Kizilbash verfasserin aut In Frontiers in Pediatrics Frontiers Media S.A., 2013 11(2023) (DE-627)742738744 (DE-600)2711999-3 22962360 nnns volume:11 year:2023 https://doi.org/10.3389/fped.2023.1098434 kostenfrei https://doaj.org/article/5f3cb6ad51764b31b2b2545d7e224aa8 kostenfrei https://www.frontiersin.org/articles/10.3389/fped.2023.1098434/full kostenfrei https://doaj.org/toc/2296-2360 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 11 2023
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callnumber-first	R - Medicine
author	Shanthi S. Balani
spellingShingle	Shanthi S. Balani misc RJ1-570 misc opportunistic infections misc pediatric solid organ transplant misc cytomegalovirus treatment misc cytomegalovirus prevention misc cytomegalovirus emerging treatment misc Pediatrics Prevention and management of CMV infection in pediatric solid organ transplant recipients
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topic_title	RJ1-570 Prevention and management of CMV infection in pediatric solid organ transplant recipients opportunistic infections pediatric solid organ transplant cytomegalovirus treatment cytomegalovirus prevention cytomegalovirus emerging treatment
topic	misc RJ1-570 misc opportunistic infections misc pediatric solid organ transplant misc cytomegalovirus treatment misc cytomegalovirus prevention misc cytomegalovirus emerging treatment misc Pediatrics
topic_unstemmed	misc RJ1-570 misc opportunistic infections misc pediatric solid organ transplant misc cytomegalovirus treatment misc cytomegalovirus prevention misc cytomegalovirus emerging treatment misc Pediatrics
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title	Prevention and management of CMV infection in pediatric solid organ transplant recipients
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title_full	Prevention and management of CMV infection in pediatric solid organ transplant recipients
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author_browse	Shanthi S. Balani Sanober Sadiq Chelsey J. Jensen Sarah J. Kizilbash
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title_sort	prevention and management of cmv infection in pediatric solid organ transplant recipients
callnumber	RJ1-570
title_auth	Prevention and management of CMV infection in pediatric solid organ transplant recipients
abstract	Human cytomegalovirus (CMV) remains one of the most common opportunistic infections following solid organ transplantation in children. CMV causes morbidity and mortality through direct tissue-invasive disease and indirect immunomodulatory effects. In recent years, several new agents have emerged for the prevention and treatment of CMV disease in solid organ transplant recipients. However, pediatric data remain scarce, and many of the treatments are extrapolated from the adult literature. Controversies exist about the type and duration of prophylactic therapies and the optimal dosing of antiviral agents. This review provides an up-to-date overview of treatment modalities used to prevent and treat CMV disease in solid organ transplant (SOT) recipients.
abstractGer	Human cytomegalovirus (CMV) remains one of the most common opportunistic infections following solid organ transplantation in children. CMV causes morbidity and mortality through direct tissue-invasive disease and indirect immunomodulatory effects. In recent years, several new agents have emerged for the prevention and treatment of CMV disease in solid organ transplant recipients. However, pediatric data remain scarce, and many of the treatments are extrapolated from the adult literature. Controversies exist about the type and duration of prophylactic therapies and the optimal dosing of antiviral agents. This review provides an up-to-date overview of treatment modalities used to prevent and treat CMV disease in solid organ transplant (SOT) recipients.
abstract_unstemmed	Human cytomegalovirus (CMV) remains one of the most common opportunistic infections following solid organ transplantation in children. CMV causes morbidity and mortality through direct tissue-invasive disease and indirect immunomodulatory effects. In recent years, several new agents have emerged for the prevention and treatment of CMV disease in solid organ transplant recipients. However, pediatric data remain scarce, and many of the treatments are extrapolated from the adult literature. Controversies exist about the type and duration of prophylactic therapies and the optimal dosing of antiviral agents. This review provides an up-to-date overview of treatment modalities used to prevent and treat CMV disease in solid organ transplant (SOT) recipients.
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title_short	Prevention and management of CMV infection in pediatric solid organ transplant recipients
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