p53 mutation and deletion contribute to tumor immune evasion

TP53 (or p53) is widely accepted to be a tumor suppressor. Upon various cellular stresses, p53 mediates cell cycle arrest and apoptosis to maintain genomic stability. p53 is also discovered to suppress tumor growth through regulating metabolism and ferroptosis. However, p53 is always lost or mutated...
Ausführliche Beschreibung

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Autor*in:	Siyang Liu [verfasserIn] Tianyao Liu [verfasserIn] Jiaxuan Jiang [verfasserIn] Hongqian Guo [verfasserIn] Rong Yang [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	p53 mutation p53 deletion tumor immune evasion tumor immune microenvironment MHC

Übergeordnetes Werk:	In: Frontiers in Genetics - Frontiers Media S.A., 2011, 14(2023)
Übergeordnetes Werk:	volume:14 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fgene.2023.1088455

Katalog-ID:	DOAJ079884814

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520			\|a TP53 (or p53) is widely accepted to be a tumor suppressor. Upon various cellular stresses, p53 mediates cell cycle arrest and apoptosis to maintain genomic stability. p53 is also discovered to suppress tumor growth through regulating metabolism and ferroptosis. However, p53 is always lost or mutated in human and the loss or mutation of p53 is related to a high risk of tumors. Although the link between p53 and cancer has been well established, how the different p53 status of tumor cells help themselves evade immune response remains largely elusive. Understanding the molecular mechanisms of different status of p53 and tumor immune evasion can help optimize the currently used therapies. In this context, we discussed the how the antigen presentation and tumor antigen expression mode altered and described how the tumor cells shape a suppressive tumor immune microenvironment to facilitate its proliferation and metastasis.
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allfieldsSound	10.3389/fgene.2023.1088455 doi (DE-627)DOAJ079884814 (DE-599)DOAJ2f152c04bafc4f61a90dcbebb91a1e6e DE-627 ger DE-627 rakwb eng QH426-470 Siyang Liu verfasserin aut p53 mutation and deletion contribute to tumor immune evasion 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier TP53 (or p53) is widely accepted to be a tumor suppressor. Upon various cellular stresses, p53 mediates cell cycle arrest and apoptosis to maintain genomic stability. p53 is also discovered to suppress tumor growth through regulating metabolism and ferroptosis. However, p53 is always lost or mutated in human and the loss or mutation of p53 is related to a high risk of tumors. Although the link between p53 and cancer has been well established, how the different p53 status of tumor cells help themselves evade immune response remains largely elusive. Understanding the molecular mechanisms of different status of p53 and tumor immune evasion can help optimize the currently used therapies. In this context, we discussed the how the antigen presentation and tumor antigen expression mode altered and described how the tumor cells shape a suppressive tumor immune microenvironment to facilitate its proliferation and metastasis. p53 mutation p53 deletion tumor immune evasion tumor immune microenvironment MHC Genetics Tianyao Liu verfasserin aut Jiaxuan Jiang verfasserin aut Hongqian Guo verfasserin aut Rong Yang verfasserin aut In Frontiers in Genetics Frontiers Media S.A., 2011 14(2023) (DE-627)65799829X (DE-600)2606823-0 16648021 nnns volume:14 year:2023 https://doi.org/10.3389/fgene.2023.1088455 kostenfrei https://doaj.org/article/2f152c04bafc4f61a90dcbebb91a1e6e kostenfrei https://www.frontiersin.org/articles/10.3389/fgene.2023.1088455/full kostenfrei https://doaj.org/toc/1664-8021 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
language	English
source	In Frontiers in Genetics 14(2023) volume:14 year:2023
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topic_facet	p53 mutation p53 deletion tumor immune evasion tumor immune microenvironment MHC Genetics
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container_title	Frontiers in Genetics
authorswithroles_txt_mv	Siyang Liu @@aut@@ Tianyao Liu @@aut@@ Jiaxuan Jiang @@aut@@ Hongqian Guo @@aut@@ Rong Yang @@aut@@
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callnumber-first	Q - Science
author	Siyang Liu
spellingShingle	Siyang Liu misc QH426-470 misc p53 mutation misc p53 deletion misc tumor immune evasion misc tumor immune microenvironment misc MHC misc Genetics p53 mutation and deletion contribute to tumor immune evasion
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topic_title	QH426-470 p53 mutation and deletion contribute to tumor immune evasion p53 mutation p53 deletion tumor immune evasion tumor immune microenvironment MHC
topic	misc QH426-470 misc p53 mutation misc p53 deletion misc tumor immune evasion misc tumor immune microenvironment misc MHC misc Genetics
topic_unstemmed	misc QH426-470 misc p53 mutation misc p53 deletion misc tumor immune evasion misc tumor immune microenvironment misc MHC misc Genetics
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title	p53 mutation and deletion contribute to tumor immune evasion
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title_full	p53 mutation and deletion contribute to tumor immune evasion
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title_sort	p53 mutation and deletion contribute to tumor immune evasion
callnumber	QH426-470
title_auth	p53 mutation and deletion contribute to tumor immune evasion
abstract	TP53 (or p53) is widely accepted to be a tumor suppressor. Upon various cellular stresses, p53 mediates cell cycle arrest and apoptosis to maintain genomic stability. p53 is also discovered to suppress tumor growth through regulating metabolism and ferroptosis. However, p53 is always lost or mutated in human and the loss or mutation of p53 is related to a high risk of tumors. Although the link between p53 and cancer has been well established, how the different p53 status of tumor cells help themselves evade immune response remains largely elusive. Understanding the molecular mechanisms of different status of p53 and tumor immune evasion can help optimize the currently used therapies. In this context, we discussed the how the antigen presentation and tumor antigen expression mode altered and described how the tumor cells shape a suppressive tumor immune microenvironment to facilitate its proliferation and metastasis.
abstractGer	TP53 (or p53) is widely accepted to be a tumor suppressor. Upon various cellular stresses, p53 mediates cell cycle arrest and apoptosis to maintain genomic stability. p53 is also discovered to suppress tumor growth through regulating metabolism and ferroptosis. However, p53 is always lost or mutated in human and the loss or mutation of p53 is related to a high risk of tumors. Although the link between p53 and cancer has been well established, how the different p53 status of tumor cells help themselves evade immune response remains largely elusive. Understanding the molecular mechanisms of different status of p53 and tumor immune evasion can help optimize the currently used therapies. In this context, we discussed the how the antigen presentation and tumor antigen expression mode altered and described how the tumor cells shape a suppressive tumor immune microenvironment to facilitate its proliferation and metastasis.
abstract_unstemmed	TP53 (or p53) is widely accepted to be a tumor suppressor. Upon various cellular stresses, p53 mediates cell cycle arrest and apoptosis to maintain genomic stability. p53 is also discovered to suppress tumor growth through regulating metabolism and ferroptosis. However, p53 is always lost or mutated in human and the loss or mutation of p53 is related to a high risk of tumors. Although the link between p53 and cancer has been well established, how the different p53 status of tumor cells help themselves evade immune response remains largely elusive. Understanding the molecular mechanisms of different status of p53 and tumor immune evasion can help optimize the currently used therapies. In this context, we discussed the how the antigen presentation and tumor antigen expression mode altered and described how the tumor cells shape a suppressive tumor immune microenvironment to facilitate its proliferation and metastasis.
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title_short	p53 mutation and deletion contribute to tumor immune evasion
url	https://doi.org/10.3389/fgene.2023.1088455 https://doaj.org/article/2f152c04bafc4f61a90dcbebb91a1e6e https://www.frontiersin.org/articles/10.3389/fgene.2023.1088455/full https://doaj.org/toc/1664-8021
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author2	Tianyao Liu Jiaxuan Jiang Hongqian Guo Rong Yang
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p53 mutation and deletion contribute to tumor immune evasion

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Zugang & Verfügbarkeit

Vorhandene Bände

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