Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study

(1) Background: Favipiravir (FVP) is a new antiviral drug used to treat COVID-19. It has been authorized to be used in the kingdom of Saudi Arabia in the treatment of COVID-19. The mechanism of action of FVP is working as a specific inhibitor for the RNA-dependent RNA polymerase of the RNA chain vir...
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Autor*in:	Amal Oweid Almutairi [verfasserIn] Mahmoud Zaki El-Readi [verfasserIn] Mohammad Althubiti [verfasserIn] Yosra Zakariyya Alhindi [verfasserIn] Nahla Ayoub [verfasserIn] Abdullah R. Alzahrani [verfasserIn] Saeed S. Al-Ghamdi [verfasserIn] Safaa Yehia Eid [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	COVID-19 favipiravir liver injury

Übergeordnetes Werk:	In: Tropical Medicine and Infectious Disease - MDPI AG, 2017, 8(2023), 2, p 129
Übergeordnetes Werk:	volume:8 ; year:2023 ; number:2, p 129

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/tropicalmed8020129

Katalog-ID:	DOAJ079957714

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520			\|a (1) Background: Favipiravir (FVP) is a new antiviral drug used to treat COVID-19. It has been authorized to be used in the kingdom of Saudi Arabia in the treatment of COVID-19. The mechanism of action of FVP is working as a specific inhibitor for the RNA-dependent RNA polymerase of the RNA chain virus. FVP has the potential to be hepatotoxic because of the structure similarity with pyrazinamide. This retrospective study aimed to determine the prevalence of liver injury in FVP-treated COVID-19 patients in General East Jeddah Hospital, Saudi Arabia, during the COVID-19 pandemic. (2) Methods: A total of 6000 patients infected with COVID-19 and treated at the East Jeddah Hospital were included, with a sample size of 362 patients. The participants ranged from 18 to 70 years of age, both males and females, with normal hepatic and renal function and had a confirmed diagnosis of COVID-19 infection. Patients who had gouty arthritis, hepatic and renal dysfunction, dead patients, pregnant women, and breastfeeding mothers were all excluded from this study. A retrospective cohort study compared two groups of patients treated with and without FVP and who followed the Saudi Ministry of Health protocol to manage COVID-19 infection. (3) Results: An adverse effect of FVP on the liver was found that ranged from mild to severe. Stopping treatment with FVP was associated with an observed important increase in the levels of liver enzymes AST (<i<p</i< < 0.001), ALT (<i<p</i< < 0.001), alkaline phosphatase (<i<p</i< < 0.03), total bilirubin (<i<p</i< < 0.001), and direct bilirubin (<i<p</i< < 0.001) in the treated compared with the untreated group. (4) Conclusion: This study showed a significant difference between the treated and the untreated groups with FVP in liver injury. FVP influences the liver, increasing the blood levels of the liver function parameters.
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allfields	10.3390/tropicalmed8020129 doi (DE-627)DOAJ079957714 (DE-599)DOAJ206af45773d24cacbf66f5d84cd730e8 DE-627 ger DE-627 rakwb eng Amal Oweid Almutairi verfasserin aut Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Favipiravir (FVP) is a new antiviral drug used to treat COVID-19. It has been authorized to be used in the kingdom of Saudi Arabia in the treatment of COVID-19. The mechanism of action of FVP is working as a specific inhibitor for the RNA-dependent RNA polymerase of the RNA chain virus. FVP has the potential to be hepatotoxic because of the structure similarity with pyrazinamide. This retrospective study aimed to determine the prevalence of liver injury in FVP-treated COVID-19 patients in General East Jeddah Hospital, Saudi Arabia, during the COVID-19 pandemic. (2) Methods: A total of 6000 patients infected with COVID-19 and treated at the East Jeddah Hospital were included, with a sample size of 362 patients. The participants ranged from 18 to 70 years of age, both males and females, with normal hepatic and renal function and had a confirmed diagnosis of COVID-19 infection. Patients who had gouty arthritis, hepatic and renal dysfunction, dead patients, pregnant women, and breastfeeding mothers were all excluded from this study. A retrospective cohort study compared two groups of patients treated with and without FVP and who followed the Saudi Ministry of Health protocol to manage COVID-19 infection. (3) Results: An adverse effect of FVP on the liver was found that ranged from mild to severe. Stopping treatment with FVP was associated with an observed important increase in the levels of liver enzymes AST (<i<p</i< < 0.001), ALT (<i<p</i< < 0.001), alkaline phosphatase (<i<p</i< < 0.03), total bilirubin (<i<p</i< < 0.001), and direct bilirubin (<i<p</i< < 0.001) in the treated compared with the untreated group. (4) Conclusion: This study showed a significant difference between the treated and the untreated groups with FVP in liver injury. FVP influences the liver, increasing the blood levels of the liver function parameters. COVID-19 favipiravir liver injury Medicine R Mahmoud Zaki El-Readi verfasserin aut Mohammad Althubiti verfasserin aut Yosra Zakariyya Alhindi verfasserin aut Nahla Ayoub verfasserin aut Abdullah R. Alzahrani verfasserin aut Saeed S. Al-Ghamdi verfasserin aut Safaa Yehia Eid verfasserin aut In Tropical Medicine and Infectious Disease MDPI AG, 2017 8(2023), 2, p 129 (DE-627)102556488X 24146366 nnns volume:8 year:2023 number:2, p 129 https://doi.org/10.3390/tropicalmed8020129 kostenfrei https://doaj.org/article/206af45773d24cacbf66f5d84cd730e8 kostenfrei https://www.mdpi.com/2414-6366/8/2/129 kostenfrei https://doaj.org/toc/2414-6366 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2023 2, p 129
spelling	10.3390/tropicalmed8020129 doi (DE-627)DOAJ079957714 (DE-599)DOAJ206af45773d24cacbf66f5d84cd730e8 DE-627 ger DE-627 rakwb eng Amal Oweid Almutairi verfasserin aut Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Favipiravir (FVP) is a new antiviral drug used to treat COVID-19. It has been authorized to be used in the kingdom of Saudi Arabia in the treatment of COVID-19. The mechanism of action of FVP is working as a specific inhibitor for the RNA-dependent RNA polymerase of the RNA chain virus. FVP has the potential to be hepatotoxic because of the structure similarity with pyrazinamide. This retrospective study aimed to determine the prevalence of liver injury in FVP-treated COVID-19 patients in General East Jeddah Hospital, Saudi Arabia, during the COVID-19 pandemic. (2) Methods: A total of 6000 patients infected with COVID-19 and treated at the East Jeddah Hospital were included, with a sample size of 362 patients. The participants ranged from 18 to 70 years of age, both males and females, with normal hepatic and renal function and had a confirmed diagnosis of COVID-19 infection. Patients who had gouty arthritis, hepatic and renal dysfunction, dead patients, pregnant women, and breastfeeding mothers were all excluded from this study. A retrospective cohort study compared two groups of patients treated with and without FVP and who followed the Saudi Ministry of Health protocol to manage COVID-19 infection. (3) Results: An adverse effect of FVP on the liver was found that ranged from mild to severe. Stopping treatment with FVP was associated with an observed important increase in the levels of liver enzymes AST (<i<p</i< < 0.001), ALT (<i<p</i< < 0.001), alkaline phosphatase (<i<p</i< < 0.03), total bilirubin (<i<p</i< < 0.001), and direct bilirubin (<i<p</i< < 0.001) in the treated compared with the untreated group. (4) Conclusion: This study showed a significant difference between the treated and the untreated groups with FVP in liver injury. FVP influences the liver, increasing the blood levels of the liver function parameters. COVID-19 favipiravir liver injury Medicine R Mahmoud Zaki El-Readi verfasserin aut Mohammad Althubiti verfasserin aut Yosra Zakariyya Alhindi verfasserin aut Nahla Ayoub verfasserin aut Abdullah R. Alzahrani verfasserin aut Saeed S. Al-Ghamdi verfasserin aut Safaa Yehia Eid verfasserin aut In Tropical Medicine and Infectious Disease MDPI AG, 2017 8(2023), 2, p 129 (DE-627)102556488X 24146366 nnns volume:8 year:2023 number:2, p 129 https://doi.org/10.3390/tropicalmed8020129 kostenfrei https://doaj.org/article/206af45773d24cacbf66f5d84cd730e8 kostenfrei https://www.mdpi.com/2414-6366/8/2/129 kostenfrei https://doaj.org/toc/2414-6366 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2023 2, p 129
allfields_unstemmed	10.3390/tropicalmed8020129 doi (DE-627)DOAJ079957714 (DE-599)DOAJ206af45773d24cacbf66f5d84cd730e8 DE-627 ger DE-627 rakwb eng Amal Oweid Almutairi verfasserin aut Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Favipiravir (FVP) is a new antiviral drug used to treat COVID-19. It has been authorized to be used in the kingdom of Saudi Arabia in the treatment of COVID-19. The mechanism of action of FVP is working as a specific inhibitor for the RNA-dependent RNA polymerase of the RNA chain virus. FVP has the potential to be hepatotoxic because of the structure similarity with pyrazinamide. This retrospective study aimed to determine the prevalence of liver injury in FVP-treated COVID-19 patients in General East Jeddah Hospital, Saudi Arabia, during the COVID-19 pandemic. (2) Methods: A total of 6000 patients infected with COVID-19 and treated at the East Jeddah Hospital were included, with a sample size of 362 patients. The participants ranged from 18 to 70 years of age, both males and females, with normal hepatic and renal function and had a confirmed diagnosis of COVID-19 infection. Patients who had gouty arthritis, hepatic and renal dysfunction, dead patients, pregnant women, and breastfeeding mothers were all excluded from this study. A retrospective cohort study compared two groups of patients treated with and without FVP and who followed the Saudi Ministry of Health protocol to manage COVID-19 infection. (3) Results: An adverse effect of FVP on the liver was found that ranged from mild to severe. Stopping treatment with FVP was associated with an observed important increase in the levels of liver enzymes AST (<i<p</i< < 0.001), ALT (<i<p</i< < 0.001), alkaline phosphatase (<i<p</i< < 0.03), total bilirubin (<i<p</i< < 0.001), and direct bilirubin (<i<p</i< < 0.001) in the treated compared with the untreated group. (4) Conclusion: This study showed a significant difference between the treated and the untreated groups with FVP in liver injury. FVP influences the liver, increasing the blood levels of the liver function parameters. COVID-19 favipiravir liver injury Medicine R Mahmoud Zaki El-Readi verfasserin aut Mohammad Althubiti verfasserin aut Yosra Zakariyya Alhindi verfasserin aut Nahla Ayoub verfasserin aut Abdullah R. Alzahrani verfasserin aut Saeed S. Al-Ghamdi verfasserin aut Safaa Yehia Eid verfasserin aut In Tropical Medicine and Infectious Disease MDPI AG, 2017 8(2023), 2, p 129 (DE-627)102556488X 24146366 nnns volume:8 year:2023 number:2, p 129 https://doi.org/10.3390/tropicalmed8020129 kostenfrei https://doaj.org/article/206af45773d24cacbf66f5d84cd730e8 kostenfrei https://www.mdpi.com/2414-6366/8/2/129 kostenfrei https://doaj.org/toc/2414-6366 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2023 2, p 129
allfieldsGer	10.3390/tropicalmed8020129 doi (DE-627)DOAJ079957714 (DE-599)DOAJ206af45773d24cacbf66f5d84cd730e8 DE-627 ger DE-627 rakwb eng Amal Oweid Almutairi verfasserin aut Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Favipiravir (FVP) is a new antiviral drug used to treat COVID-19. It has been authorized to be used in the kingdom of Saudi Arabia in the treatment of COVID-19. The mechanism of action of FVP is working as a specific inhibitor for the RNA-dependent RNA polymerase of the RNA chain virus. FVP has the potential to be hepatotoxic because of the structure similarity with pyrazinamide. This retrospective study aimed to determine the prevalence of liver injury in FVP-treated COVID-19 patients in General East Jeddah Hospital, Saudi Arabia, during the COVID-19 pandemic. (2) Methods: A total of 6000 patients infected with COVID-19 and treated at the East Jeddah Hospital were included, with a sample size of 362 patients. The participants ranged from 18 to 70 years of age, both males and females, with normal hepatic and renal function and had a confirmed diagnosis of COVID-19 infection. Patients who had gouty arthritis, hepatic and renal dysfunction, dead patients, pregnant women, and breastfeeding mothers were all excluded from this study. A retrospective cohort study compared two groups of patients treated with and without FVP and who followed the Saudi Ministry of Health protocol to manage COVID-19 infection. (3) Results: An adverse effect of FVP on the liver was found that ranged from mild to severe. Stopping treatment with FVP was associated with an observed important increase in the levels of liver enzymes AST (<i<p</i< < 0.001), ALT (<i<p</i< < 0.001), alkaline phosphatase (<i<p</i< < 0.03), total bilirubin (<i<p</i< < 0.001), and direct bilirubin (<i<p</i< < 0.001) in the treated compared with the untreated group. (4) Conclusion: This study showed a significant difference between the treated and the untreated groups with FVP in liver injury. FVP influences the liver, increasing the blood levels of the liver function parameters. COVID-19 favipiravir liver injury Medicine R Mahmoud Zaki El-Readi verfasserin aut Mohammad Althubiti verfasserin aut Yosra Zakariyya Alhindi verfasserin aut Nahla Ayoub verfasserin aut Abdullah R. Alzahrani verfasserin aut Saeed S. Al-Ghamdi verfasserin aut Safaa Yehia Eid verfasserin aut In Tropical Medicine and Infectious Disease MDPI AG, 2017 8(2023), 2, p 129 (DE-627)102556488X 24146366 nnns volume:8 year:2023 number:2, p 129 https://doi.org/10.3390/tropicalmed8020129 kostenfrei https://doaj.org/article/206af45773d24cacbf66f5d84cd730e8 kostenfrei https://www.mdpi.com/2414-6366/8/2/129 kostenfrei https://doaj.org/toc/2414-6366 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2023 2, p 129
allfieldsSound	10.3390/tropicalmed8020129 doi (DE-627)DOAJ079957714 (DE-599)DOAJ206af45773d24cacbf66f5d84cd730e8 DE-627 ger DE-627 rakwb eng Amal Oweid Almutairi verfasserin aut Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier (1) Background: Favipiravir (FVP) is a new antiviral drug used to treat COVID-19. It has been authorized to be used in the kingdom of Saudi Arabia in the treatment of COVID-19. The mechanism of action of FVP is working as a specific inhibitor for the RNA-dependent RNA polymerase of the RNA chain virus. FVP has the potential to be hepatotoxic because of the structure similarity with pyrazinamide. This retrospective study aimed to determine the prevalence of liver injury in FVP-treated COVID-19 patients in General East Jeddah Hospital, Saudi Arabia, during the COVID-19 pandemic. (2) Methods: A total of 6000 patients infected with COVID-19 and treated at the East Jeddah Hospital were included, with a sample size of 362 patients. The participants ranged from 18 to 70 years of age, both males and females, with normal hepatic and renal function and had a confirmed diagnosis of COVID-19 infection. Patients who had gouty arthritis, hepatic and renal dysfunction, dead patients, pregnant women, and breastfeeding mothers were all excluded from this study. A retrospective cohort study compared two groups of patients treated with and without FVP and who followed the Saudi Ministry of Health protocol to manage COVID-19 infection. (3) Results: An adverse effect of FVP on the liver was found that ranged from mild to severe. Stopping treatment with FVP was associated with an observed important increase in the levels of liver enzymes AST (<i<p</i< < 0.001), ALT (<i<p</i< < 0.001), alkaline phosphatase (<i<p</i< < 0.03), total bilirubin (<i<p</i< < 0.001), and direct bilirubin (<i<p</i< < 0.001) in the treated compared with the untreated group. (4) Conclusion: This study showed a significant difference between the treated and the untreated groups with FVP in liver injury. FVP influences the liver, increasing the blood levels of the liver function parameters. COVID-19 favipiravir liver injury Medicine R Mahmoud Zaki El-Readi verfasserin aut Mohammad Althubiti verfasserin aut Yosra Zakariyya Alhindi verfasserin aut Nahla Ayoub verfasserin aut Abdullah R. Alzahrani verfasserin aut Saeed S. Al-Ghamdi verfasserin aut Safaa Yehia Eid verfasserin aut In Tropical Medicine and Infectious Disease MDPI AG, 2017 8(2023), 2, p 129 (DE-627)102556488X 24146366 nnns volume:8 year:2023 number:2, p 129 https://doi.org/10.3390/tropicalmed8020129 kostenfrei https://doaj.org/article/206af45773d24cacbf66f5d84cd730e8 kostenfrei https://www.mdpi.com/2414-6366/8/2/129 kostenfrei https://doaj.org/toc/2414-6366 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 8 2023 2, p 129
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author	Amal Oweid Almutairi
spellingShingle	Amal Oweid Almutairi misc COVID-19 misc favipiravir misc liver injury misc Medicine misc R Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study
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topic_title	Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study COVID-19 favipiravir liver injury
topic	misc COVID-19 misc favipiravir misc liver injury misc Medicine misc R
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title	Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study
ctrlnum	(DE-627)DOAJ079957714 (DE-599)DOAJ206af45773d24cacbf66f5d84cd730e8
title_full	Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study
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author_browse	Amal Oweid Almutairi Mahmoud Zaki El-Readi Mohammad Althubiti Yosra Zakariyya Alhindi Nahla Ayoub Abdullah R. Alzahrani Saeed S. Al-Ghamdi Safaa Yehia Eid
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doi_str_mv	10.3390/tropicalmed8020129
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title_sort	liver injury in favipiravir-treated covid-19 patients: retrospective single-center cohort study
title_auth	Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study
abstract	(1) Background: Favipiravir (FVP) is a new antiviral drug used to treat COVID-19. It has been authorized to be used in the kingdom of Saudi Arabia in the treatment of COVID-19. The mechanism of action of FVP is working as a specific inhibitor for the RNA-dependent RNA polymerase of the RNA chain virus. FVP has the potential to be hepatotoxic because of the structure similarity with pyrazinamide. This retrospective study aimed to determine the prevalence of liver injury in FVP-treated COVID-19 patients in General East Jeddah Hospital, Saudi Arabia, during the COVID-19 pandemic. (2) Methods: A total of 6000 patients infected with COVID-19 and treated at the East Jeddah Hospital were included, with a sample size of 362 patients. The participants ranged from 18 to 70 years of age, both males and females, with normal hepatic and renal function and had a confirmed diagnosis of COVID-19 infection. Patients who had gouty arthritis, hepatic and renal dysfunction, dead patients, pregnant women, and breastfeeding mothers were all excluded from this study. A retrospective cohort study compared two groups of patients treated with and without FVP and who followed the Saudi Ministry of Health protocol to manage COVID-19 infection. (3) Results: An adverse effect of FVP on the liver was found that ranged from mild to severe. Stopping treatment with FVP was associated with an observed important increase in the levels of liver enzymes AST (<i<p</i< < 0.001), ALT (<i<p</i< < 0.001), alkaline phosphatase (<i<p</i< < 0.03), total bilirubin (<i<p</i< < 0.001), and direct bilirubin (<i<p</i< < 0.001) in the treated compared with the untreated group. (4) Conclusion: This study showed a significant difference between the treated and the untreated groups with FVP in liver injury. FVP influences the liver, increasing the blood levels of the liver function parameters.
abstractGer	(1) Background: Favipiravir (FVP) is a new antiviral drug used to treat COVID-19. It has been authorized to be used in the kingdom of Saudi Arabia in the treatment of COVID-19. The mechanism of action of FVP is working as a specific inhibitor for the RNA-dependent RNA polymerase of the RNA chain virus. FVP has the potential to be hepatotoxic because of the structure similarity with pyrazinamide. This retrospective study aimed to determine the prevalence of liver injury in FVP-treated COVID-19 patients in General East Jeddah Hospital, Saudi Arabia, during the COVID-19 pandemic. (2) Methods: A total of 6000 patients infected with COVID-19 and treated at the East Jeddah Hospital were included, with a sample size of 362 patients. The participants ranged from 18 to 70 years of age, both males and females, with normal hepatic and renal function and had a confirmed diagnosis of COVID-19 infection. Patients who had gouty arthritis, hepatic and renal dysfunction, dead patients, pregnant women, and breastfeeding mothers were all excluded from this study. A retrospective cohort study compared two groups of patients treated with and without FVP and who followed the Saudi Ministry of Health protocol to manage COVID-19 infection. (3) Results: An adverse effect of FVP on the liver was found that ranged from mild to severe. Stopping treatment with FVP was associated with an observed important increase in the levels of liver enzymes AST (<i<p</i< < 0.001), ALT (<i<p</i< < 0.001), alkaline phosphatase (<i<p</i< < 0.03), total bilirubin (<i<p</i< < 0.001), and direct bilirubin (<i<p</i< < 0.001) in the treated compared with the untreated group. (4) Conclusion: This study showed a significant difference between the treated and the untreated groups with FVP in liver injury. FVP influences the liver, increasing the blood levels of the liver function parameters.
abstract_unstemmed	(1) Background: Favipiravir (FVP) is a new antiviral drug used to treat COVID-19. It has been authorized to be used in the kingdom of Saudi Arabia in the treatment of COVID-19. The mechanism of action of FVP is working as a specific inhibitor for the RNA-dependent RNA polymerase of the RNA chain virus. FVP has the potential to be hepatotoxic because of the structure similarity with pyrazinamide. This retrospective study aimed to determine the prevalence of liver injury in FVP-treated COVID-19 patients in General East Jeddah Hospital, Saudi Arabia, during the COVID-19 pandemic. (2) Methods: A total of 6000 patients infected with COVID-19 and treated at the East Jeddah Hospital were included, with a sample size of 362 patients. The participants ranged from 18 to 70 years of age, both males and females, with normal hepatic and renal function and had a confirmed diagnosis of COVID-19 infection. Patients who had gouty arthritis, hepatic and renal dysfunction, dead patients, pregnant women, and breastfeeding mothers were all excluded from this study. A retrospective cohort study compared two groups of patients treated with and without FVP and who followed the Saudi Ministry of Health protocol to manage COVID-19 infection. (3) Results: An adverse effect of FVP on the liver was found that ranged from mild to severe. Stopping treatment with FVP was associated with an observed important increase in the levels of liver enzymes AST (<i<p</i< < 0.001), ALT (<i<p</i< < 0.001), alkaline phosphatase (<i<p</i< < 0.03), total bilirubin (<i<p</i< < 0.001), and direct bilirubin (<i<p</i< < 0.001) in the treated compared with the untreated group. (4) Conclusion: This study showed a significant difference between the treated and the untreated groups with FVP in liver injury. FVP influences the liver, increasing the blood levels of the liver function parameters.
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container_issue	2, p 129
title_short	Liver Injury in Favipiravir-Treated COVID-19 Patients: Retrospective Single-Center Cohort Study
url	https://doi.org/10.3390/tropicalmed8020129 https://doaj.org/article/206af45773d24cacbf66f5d84cd730e8 https://www.mdpi.com/2414-6366/8/2/129 https://doaj.org/toc/2414-6366
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author2	Mahmoud Zaki El-Readi Mohammad Althubiti Yosra Zakariyya Alhindi Nahla Ayoub Abdullah R. Alzahrani Saeed S. Al-Ghamdi Safaa Yehia Eid
author2Str	Mahmoud Zaki El-Readi Mohammad Althubiti Yosra Zakariyya Alhindi Nahla Ayoub Abdullah R. Alzahrani Saeed S. Al-Ghamdi Safaa Yehia Eid
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doi_str	10.3390/tropicalmed8020129
up_date	2024-07-04T01:30:30.666Z
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