Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study

Magnesium (Mg) plays a key role in infections. However, its role in coronavirus disease 2019 (COVID-19) is still underexplored, particularly in long-term sequelae. The aim of the present study was to examine the prognostic value of serum Mg levels in older people affected by COVID-19. Patients were...
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Autor*in:	Anna La Carrubba [verfasserIn] Nicola Veronese [verfasserIn] Giovanna Di Bella [verfasserIn] Claudia Cusumano [verfasserIn] Agnese Di Prazza [verfasserIn] Stefano Ciriminna [verfasserIn] Antonina Ganci [verfasserIn] Liliana Naro [verfasserIn] Ligia J. Dominguez [verfasserIn] Mario Barbagallo [verfasserIn] on behalf of the COMEPA Group [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	magnesium COVID-19 mortality prognosis long COVID COMEPA

Übergeordnetes Werk:	In: Nutrients - MDPI AG, 2009, 15(2023), 4, p 830
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:4, p 830

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/nu15040830

Katalog-ID:	DOAJ080010512

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520			\|a Magnesium (Mg) plays a key role in infections. However, its role in coronavirus disease 2019 (COVID-19) is still underexplored, particularly in long-term sequelae. The aim of the present study was to examine the prognostic value of serum Mg levels in older people affected by COVID-19. Patients were divided into those with serum Mg levels ≤1.96 vs. <1.96 mg/dL, according to the Youden index. A total of 260 participants (mean age 65 years, 53.8% males) had valid Mg measurements. Serum Mg had a good accuracy in predicting in-hospital mortality (area under the curve = 0.83; 95% CI: 0.74–0.91). Low serum Mg at admission significantly predicted in-hospital death (HR = 1.29; 95% CI: 1.03–2.68) after adjusting for several confounders. A value of Mg ≤ 1.96 mg/dL was associated with a longer mean length of stay compared to those with a serum Mg < 1.96 (15.2 vs. 12.7 days). Low serum Mg was associated with a higher incidence of long COVID symptomatology (OR = 2.14; 95% CI: 1.30–4.31), particularly post-traumatic stress disorder (OR = 2.00; 95% CI: 1.24–16.40). In conclusion, low serum Mg levels were significant predictors of mortality, length of stay, and onset of long COVID symptoms, indicating that measuring serum Mg in COVID-19 may be helpful in the prediction of complications related to the disease.
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allfields	10.3390/nu15040830 doi (DE-627)DOAJ080010512 (DE-599)DOAJcb2369bf3eaa4a319def490fc0617eb9 DE-627 ger DE-627 rakwb eng TX341-641 Anna La Carrubba verfasserin aut Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Magnesium (Mg) plays a key role in infections. However, its role in coronavirus disease 2019 (COVID-19) is still underexplored, particularly in long-term sequelae. The aim of the present study was to examine the prognostic value of serum Mg levels in older people affected by COVID-19. Patients were divided into those with serum Mg levels ≤1.96 vs. <1.96 mg/dL, according to the Youden index. A total of 260 participants (mean age 65 years, 53.8% males) had valid Mg measurements. Serum Mg had a good accuracy in predicting in-hospital mortality (area under the curve = 0.83; 95% CI: 0.74–0.91). Low serum Mg at admission significantly predicted in-hospital death (HR = 1.29; 95% CI: 1.03–2.68) after adjusting for several confounders. A value of Mg ≤ 1.96 mg/dL was associated with a longer mean length of stay compared to those with a serum Mg < 1.96 (15.2 vs. 12.7 days). Low serum Mg was associated with a higher incidence of long COVID symptomatology (OR = 2.14; 95% CI: 1.30–4.31), particularly post-traumatic stress disorder (OR = 2.00; 95% CI: 1.24–16.40). In conclusion, low serum Mg levels were significant predictors of mortality, length of stay, and onset of long COVID symptoms, indicating that measuring serum Mg in COVID-19 may be helpful in the prediction of complications related to the disease. magnesium COVID-19 mortality prognosis long COVID COMEPA Nutrition. Foods and food supply Nicola Veronese verfasserin aut Giovanna Di Bella verfasserin aut Claudia Cusumano verfasserin aut Agnese Di Prazza verfasserin aut Stefano Ciriminna verfasserin aut Antonina Ganci verfasserin aut Liliana Naro verfasserin aut Ligia J. Dominguez verfasserin aut Mario Barbagallo verfasserin aut on behalf of the COMEPA Group verfasserin aut In Nutrients MDPI AG, 2009 15(2023), 4, p 830 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:15 year:2023 number:4, p 830 https://doi.org/10.3390/nu15040830 kostenfrei https://doaj.org/article/cb2369bf3eaa4a319def490fc0617eb9 kostenfrei https://www.mdpi.com/2072-6643/15/4/830 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 4, p 830
spelling	10.3390/nu15040830 doi (DE-627)DOAJ080010512 (DE-599)DOAJcb2369bf3eaa4a319def490fc0617eb9 DE-627 ger DE-627 rakwb eng TX341-641 Anna La Carrubba verfasserin aut Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Magnesium (Mg) plays a key role in infections. However, its role in coronavirus disease 2019 (COVID-19) is still underexplored, particularly in long-term sequelae. The aim of the present study was to examine the prognostic value of serum Mg levels in older people affected by COVID-19. Patients were divided into those with serum Mg levels ≤1.96 vs. <1.96 mg/dL, according to the Youden index. A total of 260 participants (mean age 65 years, 53.8% males) had valid Mg measurements. Serum Mg had a good accuracy in predicting in-hospital mortality (area under the curve = 0.83; 95% CI: 0.74–0.91). Low serum Mg at admission significantly predicted in-hospital death (HR = 1.29; 95% CI: 1.03–2.68) after adjusting for several confounders. A value of Mg ≤ 1.96 mg/dL was associated with a longer mean length of stay compared to those with a serum Mg < 1.96 (15.2 vs. 12.7 days). Low serum Mg was associated with a higher incidence of long COVID symptomatology (OR = 2.14; 95% CI: 1.30–4.31), particularly post-traumatic stress disorder (OR = 2.00; 95% CI: 1.24–16.40). In conclusion, low serum Mg levels were significant predictors of mortality, length of stay, and onset of long COVID symptoms, indicating that measuring serum Mg in COVID-19 may be helpful in the prediction of complications related to the disease. magnesium COVID-19 mortality prognosis long COVID COMEPA Nutrition. Foods and food supply Nicola Veronese verfasserin aut Giovanna Di Bella verfasserin aut Claudia Cusumano verfasserin aut Agnese Di Prazza verfasserin aut Stefano Ciriminna verfasserin aut Antonina Ganci verfasserin aut Liliana Naro verfasserin aut Ligia J. Dominguez verfasserin aut Mario Barbagallo verfasserin aut on behalf of the COMEPA Group verfasserin aut In Nutrients MDPI AG, 2009 15(2023), 4, p 830 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:15 year:2023 number:4, p 830 https://doi.org/10.3390/nu15040830 kostenfrei https://doaj.org/article/cb2369bf3eaa4a319def490fc0617eb9 kostenfrei https://www.mdpi.com/2072-6643/15/4/830 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 4, p 830
allfields_unstemmed	10.3390/nu15040830 doi (DE-627)DOAJ080010512 (DE-599)DOAJcb2369bf3eaa4a319def490fc0617eb9 DE-627 ger DE-627 rakwb eng TX341-641 Anna La Carrubba verfasserin aut Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Magnesium (Mg) plays a key role in infections. However, its role in coronavirus disease 2019 (COVID-19) is still underexplored, particularly in long-term sequelae. The aim of the present study was to examine the prognostic value of serum Mg levels in older people affected by COVID-19. Patients were divided into those with serum Mg levels ≤1.96 vs. <1.96 mg/dL, according to the Youden index. A total of 260 participants (mean age 65 years, 53.8% males) had valid Mg measurements. Serum Mg had a good accuracy in predicting in-hospital mortality (area under the curve = 0.83; 95% CI: 0.74–0.91). Low serum Mg at admission significantly predicted in-hospital death (HR = 1.29; 95% CI: 1.03–2.68) after adjusting for several confounders. A value of Mg ≤ 1.96 mg/dL was associated with a longer mean length of stay compared to those with a serum Mg < 1.96 (15.2 vs. 12.7 days). Low serum Mg was associated with a higher incidence of long COVID symptomatology (OR = 2.14; 95% CI: 1.30–4.31), particularly post-traumatic stress disorder (OR = 2.00; 95% CI: 1.24–16.40). In conclusion, low serum Mg levels were significant predictors of mortality, length of stay, and onset of long COVID symptoms, indicating that measuring serum Mg in COVID-19 may be helpful in the prediction of complications related to the disease. magnesium COVID-19 mortality prognosis long COVID COMEPA Nutrition. Foods and food supply Nicola Veronese verfasserin aut Giovanna Di Bella verfasserin aut Claudia Cusumano verfasserin aut Agnese Di Prazza verfasserin aut Stefano Ciriminna verfasserin aut Antonina Ganci verfasserin aut Liliana Naro verfasserin aut Ligia J. Dominguez verfasserin aut Mario Barbagallo verfasserin aut on behalf of the COMEPA Group verfasserin aut In Nutrients MDPI AG, 2009 15(2023), 4, p 830 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:15 year:2023 number:4, p 830 https://doi.org/10.3390/nu15040830 kostenfrei https://doaj.org/article/cb2369bf3eaa4a319def490fc0617eb9 kostenfrei https://www.mdpi.com/2072-6643/15/4/830 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 4, p 830
allfieldsGer	10.3390/nu15040830 doi (DE-627)DOAJ080010512 (DE-599)DOAJcb2369bf3eaa4a319def490fc0617eb9 DE-627 ger DE-627 rakwb eng TX341-641 Anna La Carrubba verfasserin aut Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Magnesium (Mg) plays a key role in infections. However, its role in coronavirus disease 2019 (COVID-19) is still underexplored, particularly in long-term sequelae. The aim of the present study was to examine the prognostic value of serum Mg levels in older people affected by COVID-19. Patients were divided into those with serum Mg levels ≤1.96 vs. <1.96 mg/dL, according to the Youden index. A total of 260 participants (mean age 65 years, 53.8% males) had valid Mg measurements. Serum Mg had a good accuracy in predicting in-hospital mortality (area under the curve = 0.83; 95% CI: 0.74–0.91). Low serum Mg at admission significantly predicted in-hospital death (HR = 1.29; 95% CI: 1.03–2.68) after adjusting for several confounders. A value of Mg ≤ 1.96 mg/dL was associated with a longer mean length of stay compared to those with a serum Mg < 1.96 (15.2 vs. 12.7 days). Low serum Mg was associated with a higher incidence of long COVID symptomatology (OR = 2.14; 95% CI: 1.30–4.31), particularly post-traumatic stress disorder (OR = 2.00; 95% CI: 1.24–16.40). In conclusion, low serum Mg levels were significant predictors of mortality, length of stay, and onset of long COVID symptoms, indicating that measuring serum Mg in COVID-19 may be helpful in the prediction of complications related to the disease. magnesium COVID-19 mortality prognosis long COVID COMEPA Nutrition. Foods and food supply Nicola Veronese verfasserin aut Giovanna Di Bella verfasserin aut Claudia Cusumano verfasserin aut Agnese Di Prazza verfasserin aut Stefano Ciriminna verfasserin aut Antonina Ganci verfasserin aut Liliana Naro verfasserin aut Ligia J. Dominguez verfasserin aut Mario Barbagallo verfasserin aut on behalf of the COMEPA Group verfasserin aut In Nutrients MDPI AG, 2009 15(2023), 4, p 830 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:15 year:2023 number:4, p 830 https://doi.org/10.3390/nu15040830 kostenfrei https://doaj.org/article/cb2369bf3eaa4a319def490fc0617eb9 kostenfrei https://www.mdpi.com/2072-6643/15/4/830 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 4, p 830
allfieldsSound	10.3390/nu15040830 doi (DE-627)DOAJ080010512 (DE-599)DOAJcb2369bf3eaa4a319def490fc0617eb9 DE-627 ger DE-627 rakwb eng TX341-641 Anna La Carrubba verfasserin aut Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Magnesium (Mg) plays a key role in infections. However, its role in coronavirus disease 2019 (COVID-19) is still underexplored, particularly in long-term sequelae. The aim of the present study was to examine the prognostic value of serum Mg levels in older people affected by COVID-19. Patients were divided into those with serum Mg levels ≤1.96 vs. <1.96 mg/dL, according to the Youden index. A total of 260 participants (mean age 65 years, 53.8% males) had valid Mg measurements. Serum Mg had a good accuracy in predicting in-hospital mortality (area under the curve = 0.83; 95% CI: 0.74–0.91). Low serum Mg at admission significantly predicted in-hospital death (HR = 1.29; 95% CI: 1.03–2.68) after adjusting for several confounders. A value of Mg ≤ 1.96 mg/dL was associated with a longer mean length of stay compared to those with a serum Mg < 1.96 (15.2 vs. 12.7 days). Low serum Mg was associated with a higher incidence of long COVID symptomatology (OR = 2.14; 95% CI: 1.30–4.31), particularly post-traumatic stress disorder (OR = 2.00; 95% CI: 1.24–16.40). In conclusion, low serum Mg levels were significant predictors of mortality, length of stay, and onset of long COVID symptoms, indicating that measuring serum Mg in COVID-19 may be helpful in the prediction of complications related to the disease. magnesium COVID-19 mortality prognosis long COVID COMEPA Nutrition. Foods and food supply Nicola Veronese verfasserin aut Giovanna Di Bella verfasserin aut Claudia Cusumano verfasserin aut Agnese Di Prazza verfasserin aut Stefano Ciriminna verfasserin aut Antonina Ganci verfasserin aut Liliana Naro verfasserin aut Ligia J. Dominguez verfasserin aut Mario Barbagallo verfasserin aut on behalf of the COMEPA Group verfasserin aut In Nutrients MDPI AG, 2009 15(2023), 4, p 830 (DE-627)610604155 (DE-600)2518386-2 20726643 nnns volume:15 year:2023 number:4, p 830 https://doi.org/10.3390/nu15040830 kostenfrei https://doaj.org/article/cb2369bf3eaa4a319def490fc0617eb9 kostenfrei https://www.mdpi.com/2072-6643/15/4/830 kostenfrei https://doaj.org/toc/2072-6643 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 4, p 830
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author	Anna La Carrubba
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topic_title	TX341-641 Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study magnesium COVID-19 mortality prognosis long COVID COMEPA
topic	misc TX341-641 misc magnesium misc COVID-19 misc mortality misc prognosis misc long COVID misc COMEPA misc Nutrition. Foods and food supply
topic_unstemmed	misc TX341-641 misc magnesium misc COVID-19 misc mortality misc prognosis misc long COVID misc COMEPA misc Nutrition. Foods and food supply
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title	Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study
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author_browse	Anna La Carrubba Nicola Veronese Giovanna Di Bella Claudia Cusumano Agnese Di Prazza Stefano Ciriminna Antonina Ganci Liliana Naro Ligia J. Dominguez Mario Barbagallo on behalf of the COMEPA Group
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title_sort	prognostic value of magnesium in covid-19: findings from the comepa study
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title_auth	Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study
abstract	Magnesium (Mg) plays a key role in infections. However, its role in coronavirus disease 2019 (COVID-19) is still underexplored, particularly in long-term sequelae. The aim of the present study was to examine the prognostic value of serum Mg levels in older people affected by COVID-19. Patients were divided into those with serum Mg levels ≤1.96 vs. <1.96 mg/dL, according to the Youden index. A total of 260 participants (mean age 65 years, 53.8% males) had valid Mg measurements. Serum Mg had a good accuracy in predicting in-hospital mortality (area under the curve = 0.83; 95% CI: 0.74–0.91). Low serum Mg at admission significantly predicted in-hospital death (HR = 1.29; 95% CI: 1.03–2.68) after adjusting for several confounders. A value of Mg ≤ 1.96 mg/dL was associated with a longer mean length of stay compared to those with a serum Mg < 1.96 (15.2 vs. 12.7 days). Low serum Mg was associated with a higher incidence of long COVID symptomatology (OR = 2.14; 95% CI: 1.30–4.31), particularly post-traumatic stress disorder (OR = 2.00; 95% CI: 1.24–16.40). In conclusion, low serum Mg levels were significant predictors of mortality, length of stay, and onset of long COVID symptoms, indicating that measuring serum Mg in COVID-19 may be helpful in the prediction of complications related to the disease.
abstractGer	Magnesium (Mg) plays a key role in infections. However, its role in coronavirus disease 2019 (COVID-19) is still underexplored, particularly in long-term sequelae. The aim of the present study was to examine the prognostic value of serum Mg levels in older people affected by COVID-19. Patients were divided into those with serum Mg levels ≤1.96 vs. <1.96 mg/dL, according to the Youden index. A total of 260 participants (mean age 65 years, 53.8% males) had valid Mg measurements. Serum Mg had a good accuracy in predicting in-hospital mortality (area under the curve = 0.83; 95% CI: 0.74–0.91). Low serum Mg at admission significantly predicted in-hospital death (HR = 1.29; 95% CI: 1.03–2.68) after adjusting for several confounders. A value of Mg ≤ 1.96 mg/dL was associated with a longer mean length of stay compared to those with a serum Mg < 1.96 (15.2 vs. 12.7 days). Low serum Mg was associated with a higher incidence of long COVID symptomatology (OR = 2.14; 95% CI: 1.30–4.31), particularly post-traumatic stress disorder (OR = 2.00; 95% CI: 1.24–16.40). In conclusion, low serum Mg levels were significant predictors of mortality, length of stay, and onset of long COVID symptoms, indicating that measuring serum Mg in COVID-19 may be helpful in the prediction of complications related to the disease.
abstract_unstemmed	Magnesium (Mg) plays a key role in infections. However, its role in coronavirus disease 2019 (COVID-19) is still underexplored, particularly in long-term sequelae. The aim of the present study was to examine the prognostic value of serum Mg levels in older people affected by COVID-19. Patients were divided into those with serum Mg levels ≤1.96 vs. <1.96 mg/dL, according to the Youden index. A total of 260 participants (mean age 65 years, 53.8% males) had valid Mg measurements. Serum Mg had a good accuracy in predicting in-hospital mortality (area under the curve = 0.83; 95% CI: 0.74–0.91). Low serum Mg at admission significantly predicted in-hospital death (HR = 1.29; 95% CI: 1.03–2.68) after adjusting for several confounders. A value of Mg ≤ 1.96 mg/dL was associated with a longer mean length of stay compared to those with a serum Mg < 1.96 (15.2 vs. 12.7 days). Low serum Mg was associated with a higher incidence of long COVID symptomatology (OR = 2.14; 95% CI: 1.30–4.31), particularly post-traumatic stress disorder (OR = 2.00; 95% CI: 1.24–16.40). In conclusion, low serum Mg levels were significant predictors of mortality, length of stay, and onset of long COVID symptoms, indicating that measuring serum Mg in COVID-19 may be helpful in the prediction of complications related to the disease.
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title_short	Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study
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Prognostic Value of Magnesium in COVID-19: Findings from the COMEPA Study

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