Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice

Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2) in pregnancy induced vascular and metabolic adaptation using...
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Autor*in:	Chandra Yallampalli [verfasserIn] Ancizar Betancourt [verfasserIn] Akansha Mishra [verfasserIn] Kathleen A. Pennington [verfasserIn] Simone Hernandez Ruano [verfasserIn] Moises Tacam [verfasserIn] Madhu Chauhan [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Adrenomedullin2 intermedin pregnancy vascular-adaptation metabolic-adaptation

Übergeordnetes Werk:	In: Frontiers in Physiology - Frontiers Media S.A., 2011, 14(2023)
Übergeordnetes Werk:	volume:14 ; year:2023

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3389/fphys.2023.1116042

Katalog-ID:	DOAJ080073921

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520			\|a Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2) in pregnancy induced vascular and metabolic adaptation using AM2 knockout mice (AM2−/−).Method: The AM2−/− mice were successfully generated using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Nuclease Cas nine system. Phenotype of pregnant AM2−/− mice was assessed with respect to its fertility, blood pressure regulation, vascular health and metabolic adaptations and compared to the wild type littermates (AM2+/+).Results: Current data shows that AM2−/− females are fertile with no significant difference in number of pups/litter compared to the AM2+/+. However, ablation of AM2 decreases the gestational length and the total number of pups born dead or that die after birth is greater in AM2−/− mice compared to AM2+/+ mice (p < 0.05). Further AM2−/− mice exhibit elevated blood pressure and elevated vascular sensitivity for the contractile responses to angiotensin two and higher serum sFLT-1 trigylcerides levels compared to AM2+/+(p < 0.05). In addition, AM2−/− mice develop glucose intolerance with elevated serum levels of Insulin during pregnancy compared to the AM2+/+mice.Discussion: Current data suggests a physiological role for AM2 in pregnancy induced vascular and metabolic adaptations in mice.
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allfields	10.3389/fphys.2023.1116042 doi (DE-627)DOAJ080073921 (DE-599)DOAJ8a659094aecf40158b63e63ff5d65e10 DE-627 ger DE-627 rakwb eng QP1-981 Chandra Yallampalli verfasserin aut Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2) in pregnancy induced vascular and metabolic adaptation using AM2 knockout mice (AM2−/−).Method: The AM2−/− mice were successfully generated using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Nuclease Cas nine system. Phenotype of pregnant AM2−/− mice was assessed with respect to its fertility, blood pressure regulation, vascular health and metabolic adaptations and compared to the wild type littermates (AM2+/+).Results: Current data shows that AM2−/− females are fertile with no significant difference in number of pups/litter compared to the AM2+/+. However, ablation of AM2 decreases the gestational length and the total number of pups born dead or that die after birth is greater in AM2−/− mice compared to AM2+/+ mice (p < 0.05). Further AM2−/− mice exhibit elevated blood pressure and elevated vascular sensitivity for the contractile responses to angiotensin two and higher serum sFLT-1 trigylcerides levels compared to AM2+/+(p < 0.05). In addition, AM2−/− mice develop glucose intolerance with elevated serum levels of Insulin during pregnancy compared to the AM2+/+mice.Discussion: Current data suggests a physiological role for AM2 in pregnancy induced vascular and metabolic adaptations in mice. Adrenomedullin2 intermedin pregnancy vascular-adaptation metabolic-adaptation Physiology Ancizar Betancourt verfasserin aut Akansha Mishra verfasserin aut Kathleen A. Pennington verfasserin aut Simone Hernandez Ruano verfasserin aut Moises Tacam verfasserin aut Madhu Chauhan verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 14(2023) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:14 year:2023 https://doi.org/10.3389/fphys.2023.1116042 kostenfrei https://doaj.org/article/8a659094aecf40158b63e63ff5d65e10 kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2023.1116042/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
spelling	10.3389/fphys.2023.1116042 doi (DE-627)DOAJ080073921 (DE-599)DOAJ8a659094aecf40158b63e63ff5d65e10 DE-627 ger DE-627 rakwb eng QP1-981 Chandra Yallampalli verfasserin aut Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2) in pregnancy induced vascular and metabolic adaptation using AM2 knockout mice (AM2−/−).Method: The AM2−/− mice were successfully generated using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Nuclease Cas nine system. Phenotype of pregnant AM2−/− mice was assessed with respect to its fertility, blood pressure regulation, vascular health and metabolic adaptations and compared to the wild type littermates (AM2+/+).Results: Current data shows that AM2−/− females are fertile with no significant difference in number of pups/litter compared to the AM2+/+. However, ablation of AM2 decreases the gestational length and the total number of pups born dead or that die after birth is greater in AM2−/− mice compared to AM2+/+ mice (p < 0.05). Further AM2−/− mice exhibit elevated blood pressure and elevated vascular sensitivity for the contractile responses to angiotensin two and higher serum sFLT-1 trigylcerides levels compared to AM2+/+(p < 0.05). In addition, AM2−/− mice develop glucose intolerance with elevated serum levels of Insulin during pregnancy compared to the AM2+/+mice.Discussion: Current data suggests a physiological role for AM2 in pregnancy induced vascular and metabolic adaptations in mice. Adrenomedullin2 intermedin pregnancy vascular-adaptation metabolic-adaptation Physiology Ancizar Betancourt verfasserin aut Akansha Mishra verfasserin aut Kathleen A. Pennington verfasserin aut Simone Hernandez Ruano verfasserin aut Moises Tacam verfasserin aut Madhu Chauhan verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 14(2023) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:14 year:2023 https://doi.org/10.3389/fphys.2023.1116042 kostenfrei https://doaj.org/article/8a659094aecf40158b63e63ff5d65e10 kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2023.1116042/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
allfields_unstemmed	10.3389/fphys.2023.1116042 doi (DE-627)DOAJ080073921 (DE-599)DOAJ8a659094aecf40158b63e63ff5d65e10 DE-627 ger DE-627 rakwb eng QP1-981 Chandra Yallampalli verfasserin aut Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2) in pregnancy induced vascular and metabolic adaptation using AM2 knockout mice (AM2−/−).Method: The AM2−/− mice were successfully generated using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Nuclease Cas nine system. Phenotype of pregnant AM2−/− mice was assessed with respect to its fertility, blood pressure regulation, vascular health and metabolic adaptations and compared to the wild type littermates (AM2+/+).Results: Current data shows that AM2−/− females are fertile with no significant difference in number of pups/litter compared to the AM2+/+. However, ablation of AM2 decreases the gestational length and the total number of pups born dead or that die after birth is greater in AM2−/− mice compared to AM2+/+ mice (p < 0.05). Further AM2−/− mice exhibit elevated blood pressure and elevated vascular sensitivity for the contractile responses to angiotensin two and higher serum sFLT-1 trigylcerides levels compared to AM2+/+(p < 0.05). In addition, AM2−/− mice develop glucose intolerance with elevated serum levels of Insulin during pregnancy compared to the AM2+/+mice.Discussion: Current data suggests a physiological role for AM2 in pregnancy induced vascular and metabolic adaptations in mice. Adrenomedullin2 intermedin pregnancy vascular-adaptation metabolic-adaptation Physiology Ancizar Betancourt verfasserin aut Akansha Mishra verfasserin aut Kathleen A. Pennington verfasserin aut Simone Hernandez Ruano verfasserin aut Moises Tacam verfasserin aut Madhu Chauhan verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 14(2023) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:14 year:2023 https://doi.org/10.3389/fphys.2023.1116042 kostenfrei https://doaj.org/article/8a659094aecf40158b63e63ff5d65e10 kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2023.1116042/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
allfieldsGer	10.3389/fphys.2023.1116042 doi (DE-627)DOAJ080073921 (DE-599)DOAJ8a659094aecf40158b63e63ff5d65e10 DE-627 ger DE-627 rakwb eng QP1-981 Chandra Yallampalli verfasserin aut Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2) in pregnancy induced vascular and metabolic adaptation using AM2 knockout mice (AM2−/−).Method: The AM2−/− mice were successfully generated using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Nuclease Cas nine system. Phenotype of pregnant AM2−/− mice was assessed with respect to its fertility, blood pressure regulation, vascular health and metabolic adaptations and compared to the wild type littermates (AM2+/+).Results: Current data shows that AM2−/− females are fertile with no significant difference in number of pups/litter compared to the AM2+/+. However, ablation of AM2 decreases the gestational length and the total number of pups born dead or that die after birth is greater in AM2−/− mice compared to AM2+/+ mice (p < 0.05). Further AM2−/− mice exhibit elevated blood pressure and elevated vascular sensitivity for the contractile responses to angiotensin two and higher serum sFLT-1 trigylcerides levels compared to AM2+/+(p < 0.05). In addition, AM2−/− mice develop glucose intolerance with elevated serum levels of Insulin during pregnancy compared to the AM2+/+mice.Discussion: Current data suggests a physiological role for AM2 in pregnancy induced vascular and metabolic adaptations in mice. Adrenomedullin2 intermedin pregnancy vascular-adaptation metabolic-adaptation Physiology Ancizar Betancourt verfasserin aut Akansha Mishra verfasserin aut Kathleen A. Pennington verfasserin aut Simone Hernandez Ruano verfasserin aut Moises Tacam verfasserin aut Madhu Chauhan verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 14(2023) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:14 year:2023 https://doi.org/10.3389/fphys.2023.1116042 kostenfrei https://doaj.org/article/8a659094aecf40158b63e63ff5d65e10 kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2023.1116042/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
allfieldsSound	10.3389/fphys.2023.1116042 doi (DE-627)DOAJ080073921 (DE-599)DOAJ8a659094aecf40158b63e63ff5d65e10 DE-627 ger DE-627 rakwb eng QP1-981 Chandra Yallampalli verfasserin aut Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2) in pregnancy induced vascular and metabolic adaptation using AM2 knockout mice (AM2−/−).Method: The AM2−/− mice were successfully generated using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Nuclease Cas nine system. Phenotype of pregnant AM2−/− mice was assessed with respect to its fertility, blood pressure regulation, vascular health and metabolic adaptations and compared to the wild type littermates (AM2+/+).Results: Current data shows that AM2−/− females are fertile with no significant difference in number of pups/litter compared to the AM2+/+. However, ablation of AM2 decreases the gestational length and the total number of pups born dead or that die after birth is greater in AM2−/− mice compared to AM2+/+ mice (p < 0.05). Further AM2−/− mice exhibit elevated blood pressure and elevated vascular sensitivity for the contractile responses to angiotensin two and higher serum sFLT-1 trigylcerides levels compared to AM2+/+(p < 0.05). In addition, AM2−/− mice develop glucose intolerance with elevated serum levels of Insulin during pregnancy compared to the AM2+/+mice.Discussion: Current data suggests a physiological role for AM2 in pregnancy induced vascular and metabolic adaptations in mice. Adrenomedullin2 intermedin pregnancy vascular-adaptation metabolic-adaptation Physiology Ancizar Betancourt verfasserin aut Akansha Mishra verfasserin aut Kathleen A. Pennington verfasserin aut Simone Hernandez Ruano verfasserin aut Moises Tacam verfasserin aut Madhu Chauhan verfasserin aut In Frontiers in Physiology Frontiers Media S.A., 2011 14(2023) (DE-627)631498788 (DE-600)2564217-0 1664042X nnns volume:14 year:2023 https://doi.org/10.3389/fphys.2023.1116042 kostenfrei https://doaj.org/article/8a659094aecf40158b63e63ff5d65e10 kostenfrei https://www.frontiersin.org/articles/10.3389/fphys.2023.1116042/full kostenfrei https://doaj.org/toc/1664-042X Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 14 2023
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Goal of this study was to assess the specific role of Adrenomedullin2 (AM2) in pregnancy induced vascular and metabolic adaptation using AM2 knockout mice (AM2−/−).Method: The AM2−/− mice were successfully generated using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Nuclease Cas nine system. Phenotype of pregnant AM2−/− mice was assessed with respect to its fertility, blood pressure regulation, vascular health and metabolic adaptations and compared to the wild type littermates (AM2+/+).Results: Current data shows that AM2−/− females are fertile with no significant difference in number of pups/litter compared to the AM2+/+. However, ablation of AM2 decreases the gestational length and the total number of pups born dead or that die after birth is greater in AM2−/− mice compared to AM2+/+ mice (p &lt; 0.05). 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author	Chandra Yallampalli
spellingShingle	Chandra Yallampalli misc QP1-981 misc Adrenomedullin2 misc intermedin misc pregnancy misc vascular-adaptation misc metabolic-adaptation misc Physiology Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice
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topic_title	QP1-981 Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice Adrenomedullin2 intermedin pregnancy vascular-adaptation metabolic-adaptation
topic	misc QP1-981 misc Adrenomedullin2 misc intermedin misc pregnancy misc vascular-adaptation misc metabolic-adaptation misc Physiology
topic_unstemmed	misc QP1-981 misc Adrenomedullin2 misc intermedin misc pregnancy misc vascular-adaptation misc metabolic-adaptation misc Physiology
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title	Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice
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title_full	Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice
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author_browse	Chandra Yallampalli Ancizar Betancourt Akansha Mishra Kathleen A. Pennington Simone Hernandez Ruano Moises Tacam Madhu Chauhan
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title_sort	role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice
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title_auth	Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice
abstract	Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2) in pregnancy induced vascular and metabolic adaptation using AM2 knockout mice (AM2−/−).Method: The AM2−/− mice were successfully generated using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Nuclease Cas nine system. Phenotype of pregnant AM2−/− mice was assessed with respect to its fertility, blood pressure regulation, vascular health and metabolic adaptations and compared to the wild type littermates (AM2+/+).Results: Current data shows that AM2−/− females are fertile with no significant difference in number of pups/litter compared to the AM2+/+. However, ablation of AM2 decreases the gestational length and the total number of pups born dead or that die after birth is greater in AM2−/− mice compared to AM2+/+ mice (p < 0.05). Further AM2−/− mice exhibit elevated blood pressure and elevated vascular sensitivity for the contractile responses to angiotensin two and higher serum sFLT-1 trigylcerides levels compared to AM2+/+(p < 0.05). In addition, AM2−/− mice develop glucose intolerance with elevated serum levels of Insulin during pregnancy compared to the AM2+/+mice.Discussion: Current data suggests a physiological role for AM2 in pregnancy induced vascular and metabolic adaptations in mice.
abstractGer	Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2) in pregnancy induced vascular and metabolic adaptation using AM2 knockout mice (AM2−/−).Method: The AM2−/− mice were successfully generated using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Nuclease Cas nine system. Phenotype of pregnant AM2−/− mice was assessed with respect to its fertility, blood pressure regulation, vascular health and metabolic adaptations and compared to the wild type littermates (AM2+/+).Results: Current data shows that AM2−/− females are fertile with no significant difference in number of pups/litter compared to the AM2+/+. However, ablation of AM2 decreases the gestational length and the total number of pups born dead or that die after birth is greater in AM2−/− mice compared to AM2+/+ mice (p < 0.05). Further AM2−/− mice exhibit elevated blood pressure and elevated vascular sensitivity for the contractile responses to angiotensin two and higher serum sFLT-1 trigylcerides levels compared to AM2+/+(p < 0.05). In addition, AM2−/− mice develop glucose intolerance with elevated serum levels of Insulin during pregnancy compared to the AM2+/+mice.Discussion: Current data suggests a physiological role for AM2 in pregnancy induced vascular and metabolic adaptations in mice.
abstract_unstemmed	Introduction: Adrenomedullin2 (AM2) shares its receptor with Calcitonin gene related peptide and adrenomedullin with overlapping but distinct biological functions. Goal of this study was to assess the specific role of Adrenomedullin2 (AM2) in pregnancy induced vascular and metabolic adaptation using AM2 knockout mice (AM2−/−).Method: The AM2−/− mice were successfully generated using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Nuclease Cas nine system. Phenotype of pregnant AM2−/− mice was assessed with respect to its fertility, blood pressure regulation, vascular health and metabolic adaptations and compared to the wild type littermates (AM2+/+).Results: Current data shows that AM2−/− females are fertile with no significant difference in number of pups/litter compared to the AM2+/+. However, ablation of AM2 decreases the gestational length and the total number of pups born dead or that die after birth is greater in AM2−/− mice compared to AM2+/+ mice (p < 0.05). Further AM2−/− mice exhibit elevated blood pressure and elevated vascular sensitivity for the contractile responses to angiotensin two and higher serum sFLT-1 trigylcerides levels compared to AM2+/+(p < 0.05). In addition, AM2−/− mice develop glucose intolerance with elevated serum levels of Insulin during pregnancy compared to the AM2+/+mice.Discussion: Current data suggests a physiological role for AM2 in pregnancy induced vascular and metabolic adaptations in mice.
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title_short	Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice
url	https://doi.org/10.3389/fphys.2023.1116042 https://doaj.org/article/8a659094aecf40158b63e63ff5d65e10 https://www.frontiersin.org/articles/10.3389/fphys.2023.1116042/full https://doaj.org/toc/1664-042X
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author2	Ancizar Betancourt Akansha Mishra Kathleen A. Pennington Simone Hernandez Ruano Moises Tacam Madhu Chauhan
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up_date	2024-07-04T01:56:59.009Z
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Further AM2−/− mice exhibit elevated blood pressure and elevated vascular sensitivity for the contractile responses to angiotensin two and higher serum sFLT-1 trigylcerides levels compared to AM2+/+(p &lt; 0.05). 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Role of adrenomedullin2/ intermedin in pregnancy induced vascular and metabolic adaptation in mice

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