In Vivo Analgesic Potential in Swiss Albino Mice and in Vitro Thrombolytic and Membrane Stabilizing Activities of Methanolic Extract From Suaeda Maritima Whole Plant
Objective: Cold methanolic extract of Suaeda maritima have been considered to screen their biological properties such as analgesic, membrane stabilizing and thrombolytic activity. Although some investigations have previously been reported with this plant, the whole plant was not studied yet to date....
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mamunur Rashid [verfasserIn] Saddam Hussain [verfasserIn] Mamun Or Rashid [verfasserIn] Abdul Halim [verfasserIn] Niloy Sen [verfasserIn] Shalahuddin Millat [verfasserIn] Al-Amin Sarker [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Übergeordnetes Werk: |
In: Bagcilar Medical Bulletin - Galenos Yayinevi, 2022, 2(2017), 1, Seite 13-18 |
|---|---|
| Übergeordnetes Werk: |
volume:2 ; year:2017 ; number:1 ; pages:13-18 |
| Links: |
|---|
| DOI / URN: |
10.5350/BMB20170306094829 |
|---|
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DOAJ080171230 |
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| 520 | |a Objective: Cold methanolic extract of Suaeda maritima have been considered to screen their biological properties such as analgesic, membrane stabilizing and thrombolytic activity. Although some investigations have previously been reported with this plant, the whole plant was not studied yet to date. In the present study we aimed to investigate in vivo and in vitro bioactivities of Suaeda maritima.Material and Methods: The pharmacological analgesic activity was studied by acetic acid induced writhing method in vivo in a mouse model. Membrane stabilizing activity was assessed by inhibition of haemolysis at hypotonic solution induced condition in vitro, and thrombolytic activity was evaluated by employing Streptokinase as standard in vitro.Results: Extract of Suaeda maritima at a dose of 500 mg/kg body weight showed most significant inhibition of writhing at a rate of 82.25% in mice. Among all the fractions, crude methanol extract (ME) showed maximum effect with a value of 61.01% inhibition of hemolysis at 10 mg/ml dose, when standard acetyl salicylic acid (0.10 mg/mL) revealed 66.37% inhibition of hemolysis. When clots were treated with 100 μl, moderate clot lysis activity observed with each of the test sample, however highest effect was found at 10 mg/ml dose (49.13%).Conclusion: The Suaeda maritima extract showed a remarkable analgesic effect on a mouse model and membrane stabilizing and trombolytic activities in vivo models. It may introduce a new dimension in human model in analgesic, membrane stabilizing and antitrombolytic activities. | ||
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10.5350/BMB20170306094829 doi (DE-627)DOAJ080171230 (DE-599)DOAJbccaa6fa3c0142918f80806a6c7c68d6 DE-627 ger DE-627 rakwb eng Mamunur Rashid verfasserin aut In Vivo Analgesic Potential in Swiss Albino Mice and in Vitro Thrombolytic and Membrane Stabilizing Activities of Methanolic Extract From Suaeda Maritima Whole Plant 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Cold methanolic extract of Suaeda maritima have been considered to screen their biological properties such as analgesic, membrane stabilizing and thrombolytic activity. Although some investigations have previously been reported with this plant, the whole plant was not studied yet to date. In the present study we aimed to investigate in vivo and in vitro bioactivities of Suaeda maritima.Material and Methods: The pharmacological analgesic activity was studied by acetic acid induced writhing method in vivo in a mouse model. Membrane stabilizing activity was assessed by inhibition of haemolysis at hypotonic solution induced condition in vitro, and thrombolytic activity was evaluated by employing Streptokinase as standard in vitro.Results: Extract of Suaeda maritima at a dose of 500 mg/kg body weight showed most significant inhibition of writhing at a rate of 82.25% in mice. Among all the fractions, crude methanol extract (ME) showed maximum effect with a value of 61.01% inhibition of hemolysis at 10 mg/ml dose, when standard acetyl salicylic acid (0.10 mg/mL) revealed 66.37% inhibition of hemolysis. When clots were treated with 100 μl, moderate clot lysis activity observed with each of the test sample, however highest effect was found at 10 mg/ml dose (49.13%).Conclusion: The Suaeda maritima extract showed a remarkable analgesic effect on a mouse model and membrane stabilizing and trombolytic activities in vivo models. It may introduce a new dimension in human model in analgesic, membrane stabilizing and antitrombolytic activities. suaeda maritima writhing membrane stabilizing thrombolytic Medicine R Saddam Hussain verfasserin aut Mamun Or Rashid verfasserin aut Abdul Halim verfasserin aut Niloy Sen verfasserin aut Shalahuddin Millat verfasserin aut Al-Amin Sarker verfasserin aut In Bagcilar Medical Bulletin Galenos Yayinevi, 2022 2(2017), 1, Seite 13-18 (DE-627)1830482793 25479431 nnns volume:2 year:2017 number:1 pages:13-18 https://doi.org/10.5350/BMB20170306094829 kostenfrei https://doaj.org/article/bccaa6fa3c0142918f80806a6c7c68d6 kostenfrei http://behmedicalbulletin.org/archives/archive-detail/article-preview/n-vivo-analgesic-potential-in-swiss-albino-mice-an/23450 kostenfrei https://doaj.org/toc/2547-9431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2017 1 13-18 |
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10.5350/BMB20170306094829 doi (DE-627)DOAJ080171230 (DE-599)DOAJbccaa6fa3c0142918f80806a6c7c68d6 DE-627 ger DE-627 rakwb eng Mamunur Rashid verfasserin aut In Vivo Analgesic Potential in Swiss Albino Mice and in Vitro Thrombolytic and Membrane Stabilizing Activities of Methanolic Extract From Suaeda Maritima Whole Plant 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Cold methanolic extract of Suaeda maritima have been considered to screen their biological properties such as analgesic, membrane stabilizing and thrombolytic activity. Although some investigations have previously been reported with this plant, the whole plant was not studied yet to date. In the present study we aimed to investigate in vivo and in vitro bioactivities of Suaeda maritima.Material and Methods: The pharmacological analgesic activity was studied by acetic acid induced writhing method in vivo in a mouse model. Membrane stabilizing activity was assessed by inhibition of haemolysis at hypotonic solution induced condition in vitro, and thrombolytic activity was evaluated by employing Streptokinase as standard in vitro.Results: Extract of Suaeda maritima at a dose of 500 mg/kg body weight showed most significant inhibition of writhing at a rate of 82.25% in mice. Among all the fractions, crude methanol extract (ME) showed maximum effect with a value of 61.01% inhibition of hemolysis at 10 mg/ml dose, when standard acetyl salicylic acid (0.10 mg/mL) revealed 66.37% inhibition of hemolysis. When clots were treated with 100 μl, moderate clot lysis activity observed with each of the test sample, however highest effect was found at 10 mg/ml dose (49.13%).Conclusion: The Suaeda maritima extract showed a remarkable analgesic effect on a mouse model and membrane stabilizing and trombolytic activities in vivo models. It may introduce a new dimension in human model in analgesic, membrane stabilizing and antitrombolytic activities. suaeda maritima writhing membrane stabilizing thrombolytic Medicine R Saddam Hussain verfasserin aut Mamun Or Rashid verfasserin aut Abdul Halim verfasserin aut Niloy Sen verfasserin aut Shalahuddin Millat verfasserin aut Al-Amin Sarker verfasserin aut In Bagcilar Medical Bulletin Galenos Yayinevi, 2022 2(2017), 1, Seite 13-18 (DE-627)1830482793 25479431 nnns volume:2 year:2017 number:1 pages:13-18 https://doi.org/10.5350/BMB20170306094829 kostenfrei https://doaj.org/article/bccaa6fa3c0142918f80806a6c7c68d6 kostenfrei http://behmedicalbulletin.org/archives/archive-detail/article-preview/n-vivo-analgesic-potential-in-swiss-albino-mice-an/23450 kostenfrei https://doaj.org/toc/2547-9431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2017 1 13-18 |
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10.5350/BMB20170306094829 doi (DE-627)DOAJ080171230 (DE-599)DOAJbccaa6fa3c0142918f80806a6c7c68d6 DE-627 ger DE-627 rakwb eng Mamunur Rashid verfasserin aut In Vivo Analgesic Potential in Swiss Albino Mice and in Vitro Thrombolytic and Membrane Stabilizing Activities of Methanolic Extract From Suaeda Maritima Whole Plant 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Cold methanolic extract of Suaeda maritima have been considered to screen their biological properties such as analgesic, membrane stabilizing and thrombolytic activity. Although some investigations have previously been reported with this plant, the whole plant was not studied yet to date. In the present study we aimed to investigate in vivo and in vitro bioactivities of Suaeda maritima.Material and Methods: The pharmacological analgesic activity was studied by acetic acid induced writhing method in vivo in a mouse model. Membrane stabilizing activity was assessed by inhibition of haemolysis at hypotonic solution induced condition in vitro, and thrombolytic activity was evaluated by employing Streptokinase as standard in vitro.Results: Extract of Suaeda maritima at a dose of 500 mg/kg body weight showed most significant inhibition of writhing at a rate of 82.25% in mice. Among all the fractions, crude methanol extract (ME) showed maximum effect with a value of 61.01% inhibition of hemolysis at 10 mg/ml dose, when standard acetyl salicylic acid (0.10 mg/mL) revealed 66.37% inhibition of hemolysis. When clots were treated with 100 μl, moderate clot lysis activity observed with each of the test sample, however highest effect was found at 10 mg/ml dose (49.13%).Conclusion: The Suaeda maritima extract showed a remarkable analgesic effect on a mouse model and membrane stabilizing and trombolytic activities in vivo models. It may introduce a new dimension in human model in analgesic, membrane stabilizing and antitrombolytic activities. suaeda maritima writhing membrane stabilizing thrombolytic Medicine R Saddam Hussain verfasserin aut Mamun Or Rashid verfasserin aut Abdul Halim verfasserin aut Niloy Sen verfasserin aut Shalahuddin Millat verfasserin aut Al-Amin Sarker verfasserin aut In Bagcilar Medical Bulletin Galenos Yayinevi, 2022 2(2017), 1, Seite 13-18 (DE-627)1830482793 25479431 nnns volume:2 year:2017 number:1 pages:13-18 https://doi.org/10.5350/BMB20170306094829 kostenfrei https://doaj.org/article/bccaa6fa3c0142918f80806a6c7c68d6 kostenfrei http://behmedicalbulletin.org/archives/archive-detail/article-preview/n-vivo-analgesic-potential-in-swiss-albino-mice-an/23450 kostenfrei https://doaj.org/toc/2547-9431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2017 1 13-18 |
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10.5350/BMB20170306094829 doi (DE-627)DOAJ080171230 (DE-599)DOAJbccaa6fa3c0142918f80806a6c7c68d6 DE-627 ger DE-627 rakwb eng Mamunur Rashid verfasserin aut In Vivo Analgesic Potential in Swiss Albino Mice and in Vitro Thrombolytic and Membrane Stabilizing Activities of Methanolic Extract From Suaeda Maritima Whole Plant 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Cold methanolic extract of Suaeda maritima have been considered to screen their biological properties such as analgesic, membrane stabilizing and thrombolytic activity. Although some investigations have previously been reported with this plant, the whole plant was not studied yet to date. In the present study we aimed to investigate in vivo and in vitro bioactivities of Suaeda maritima.Material and Methods: The pharmacological analgesic activity was studied by acetic acid induced writhing method in vivo in a mouse model. Membrane stabilizing activity was assessed by inhibition of haemolysis at hypotonic solution induced condition in vitro, and thrombolytic activity was evaluated by employing Streptokinase as standard in vitro.Results: Extract of Suaeda maritima at a dose of 500 mg/kg body weight showed most significant inhibition of writhing at a rate of 82.25% in mice. Among all the fractions, crude methanol extract (ME) showed maximum effect with a value of 61.01% inhibition of hemolysis at 10 mg/ml dose, when standard acetyl salicylic acid (0.10 mg/mL) revealed 66.37% inhibition of hemolysis. When clots were treated with 100 μl, moderate clot lysis activity observed with each of the test sample, however highest effect was found at 10 mg/ml dose (49.13%).Conclusion: The Suaeda maritima extract showed a remarkable analgesic effect on a mouse model and membrane stabilizing and trombolytic activities in vivo models. It may introduce a new dimension in human model in analgesic, membrane stabilizing and antitrombolytic activities. suaeda maritima writhing membrane stabilizing thrombolytic Medicine R Saddam Hussain verfasserin aut Mamun Or Rashid verfasserin aut Abdul Halim verfasserin aut Niloy Sen verfasserin aut Shalahuddin Millat verfasserin aut Al-Amin Sarker verfasserin aut In Bagcilar Medical Bulletin Galenos Yayinevi, 2022 2(2017), 1, Seite 13-18 (DE-627)1830482793 25479431 nnns volume:2 year:2017 number:1 pages:13-18 https://doi.org/10.5350/BMB20170306094829 kostenfrei https://doaj.org/article/bccaa6fa3c0142918f80806a6c7c68d6 kostenfrei http://behmedicalbulletin.org/archives/archive-detail/article-preview/n-vivo-analgesic-potential-in-swiss-albino-mice-an/23450 kostenfrei https://doaj.org/toc/2547-9431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2017 1 13-18 |
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10.5350/BMB20170306094829 doi (DE-627)DOAJ080171230 (DE-599)DOAJbccaa6fa3c0142918f80806a6c7c68d6 DE-627 ger DE-627 rakwb eng Mamunur Rashid verfasserin aut In Vivo Analgesic Potential in Swiss Albino Mice and in Vitro Thrombolytic and Membrane Stabilizing Activities of Methanolic Extract From Suaeda Maritima Whole Plant 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Objective: Cold methanolic extract of Suaeda maritima have been considered to screen their biological properties such as analgesic, membrane stabilizing and thrombolytic activity. Although some investigations have previously been reported with this plant, the whole plant was not studied yet to date. In the present study we aimed to investigate in vivo and in vitro bioactivities of Suaeda maritima.Material and Methods: The pharmacological analgesic activity was studied by acetic acid induced writhing method in vivo in a mouse model. Membrane stabilizing activity was assessed by inhibition of haemolysis at hypotonic solution induced condition in vitro, and thrombolytic activity was evaluated by employing Streptokinase as standard in vitro.Results: Extract of Suaeda maritima at a dose of 500 mg/kg body weight showed most significant inhibition of writhing at a rate of 82.25% in mice. Among all the fractions, crude methanol extract (ME) showed maximum effect with a value of 61.01% inhibition of hemolysis at 10 mg/ml dose, when standard acetyl salicylic acid (0.10 mg/mL) revealed 66.37% inhibition of hemolysis. When clots were treated with 100 μl, moderate clot lysis activity observed with each of the test sample, however highest effect was found at 10 mg/ml dose (49.13%).Conclusion: The Suaeda maritima extract showed a remarkable analgesic effect on a mouse model and membrane stabilizing and trombolytic activities in vivo models. It may introduce a new dimension in human model in analgesic, membrane stabilizing and antitrombolytic activities. suaeda maritima writhing membrane stabilizing thrombolytic Medicine R Saddam Hussain verfasserin aut Mamun Or Rashid verfasserin aut Abdul Halim verfasserin aut Niloy Sen verfasserin aut Shalahuddin Millat verfasserin aut Al-Amin Sarker verfasserin aut In Bagcilar Medical Bulletin Galenos Yayinevi, 2022 2(2017), 1, Seite 13-18 (DE-627)1830482793 25479431 nnns volume:2 year:2017 number:1 pages:13-18 https://doi.org/10.5350/BMB20170306094829 kostenfrei https://doaj.org/article/bccaa6fa3c0142918f80806a6c7c68d6 kostenfrei http://behmedicalbulletin.org/archives/archive-detail/article-preview/n-vivo-analgesic-potential-in-swiss-albino-mice-an/23450 kostenfrei https://doaj.org/toc/2547-9431 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 2 2017 1 13-18 |
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Mamunur Rashid @@aut@@ Saddam Hussain @@aut@@ Mamun Or Rashid @@aut@@ Abdul Halim @@aut@@ Niloy Sen @@aut@@ Shalahuddin Millat @@aut@@ Al-Amin Sarker @@aut@@ |
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In Vivo Analgesic Potential in Swiss Albino Mice and in Vitro Thrombolytic and Membrane Stabilizing Activities of Methanolic Extract From Suaeda Maritima Whole Plant suaeda maritima writhing membrane stabilizing thrombolytic |
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in vivo analgesic potential in swiss albino mice and in vitro thrombolytic and membrane stabilizing activities of methanolic extract from suaeda maritima whole plant |
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In Vivo Analgesic Potential in Swiss Albino Mice and in Vitro Thrombolytic and Membrane Stabilizing Activities of Methanolic Extract From Suaeda Maritima Whole Plant |
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Objective: Cold methanolic extract of Suaeda maritima have been considered to screen their biological properties such as analgesic, membrane stabilizing and thrombolytic activity. Although some investigations have previously been reported with this plant, the whole plant was not studied yet to date. In the present study we aimed to investigate in vivo and in vitro bioactivities of Suaeda maritima.Material and Methods: The pharmacological analgesic activity was studied by acetic acid induced writhing method in vivo in a mouse model. Membrane stabilizing activity was assessed by inhibition of haemolysis at hypotonic solution induced condition in vitro, and thrombolytic activity was evaluated by employing Streptokinase as standard in vitro.Results: Extract of Suaeda maritima at a dose of 500 mg/kg body weight showed most significant inhibition of writhing at a rate of 82.25% in mice. Among all the fractions, crude methanol extract (ME) showed maximum effect with a value of 61.01% inhibition of hemolysis at 10 mg/ml dose, when standard acetyl salicylic acid (0.10 mg/mL) revealed 66.37% inhibition of hemolysis. When clots were treated with 100 μl, moderate clot lysis activity observed with each of the test sample, however highest effect was found at 10 mg/ml dose (49.13%).Conclusion: The Suaeda maritima extract showed a remarkable analgesic effect on a mouse model and membrane stabilizing and trombolytic activities in vivo models. It may introduce a new dimension in human model in analgesic, membrane stabilizing and antitrombolytic activities. |
| abstractGer |
Objective: Cold methanolic extract of Suaeda maritima have been considered to screen their biological properties such as analgesic, membrane stabilizing and thrombolytic activity. Although some investigations have previously been reported with this plant, the whole plant was not studied yet to date. In the present study we aimed to investigate in vivo and in vitro bioactivities of Suaeda maritima.Material and Methods: The pharmacological analgesic activity was studied by acetic acid induced writhing method in vivo in a mouse model. Membrane stabilizing activity was assessed by inhibition of haemolysis at hypotonic solution induced condition in vitro, and thrombolytic activity was evaluated by employing Streptokinase as standard in vitro.Results: Extract of Suaeda maritima at a dose of 500 mg/kg body weight showed most significant inhibition of writhing at a rate of 82.25% in mice. Among all the fractions, crude methanol extract (ME) showed maximum effect with a value of 61.01% inhibition of hemolysis at 10 mg/ml dose, when standard acetyl salicylic acid (0.10 mg/mL) revealed 66.37% inhibition of hemolysis. When clots were treated with 100 μl, moderate clot lysis activity observed with each of the test sample, however highest effect was found at 10 mg/ml dose (49.13%).Conclusion: The Suaeda maritima extract showed a remarkable analgesic effect on a mouse model and membrane stabilizing and trombolytic activities in vivo models. It may introduce a new dimension in human model in analgesic, membrane stabilizing and antitrombolytic activities. |
| abstract_unstemmed |
Objective: Cold methanolic extract of Suaeda maritima have been considered to screen their biological properties such as analgesic, membrane stabilizing and thrombolytic activity. Although some investigations have previously been reported with this plant, the whole plant was not studied yet to date. In the present study we aimed to investigate in vivo and in vitro bioactivities of Suaeda maritima.Material and Methods: The pharmacological analgesic activity was studied by acetic acid induced writhing method in vivo in a mouse model. Membrane stabilizing activity was assessed by inhibition of haemolysis at hypotonic solution induced condition in vitro, and thrombolytic activity was evaluated by employing Streptokinase as standard in vitro.Results: Extract of Suaeda maritima at a dose of 500 mg/kg body weight showed most significant inhibition of writhing at a rate of 82.25% in mice. Among all the fractions, crude methanol extract (ME) showed maximum effect with a value of 61.01% inhibition of hemolysis at 10 mg/ml dose, when standard acetyl salicylic acid (0.10 mg/mL) revealed 66.37% inhibition of hemolysis. When clots were treated with 100 μl, moderate clot lysis activity observed with each of the test sample, however highest effect was found at 10 mg/ml dose (49.13%).Conclusion: The Suaeda maritima extract showed a remarkable analgesic effect on a mouse model and membrane stabilizing and trombolytic activities in vivo models. It may introduce a new dimension in human model in analgesic, membrane stabilizing and antitrombolytic activities. |
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In Vivo Analgesic Potential in Swiss Albino Mice and in Vitro Thrombolytic and Membrane Stabilizing Activities of Methanolic Extract From Suaeda Maritima Whole Plant |
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