The importance of studying inherited hematological disorders in ancient Anatolian populations

Before analysis of DNA from ancient remains was possible, anthropologists studied evolution and migration patterns using data obtained from population genetic studies on modern populations combined with data obtained from morphological evaluations of ancient remains. Currently, DNA analysis of ancie...
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Autor*in:	Yeşim Doğan Alakoç [verfasserIn] Nejat Akar [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Schlagwörter:	DNA population genetics molecular anthropology factor V G1691A (Leiden) beta-thalassemia sickle cell anemia Anatolia

Übergeordnetes Werk:	In: Turkish Journal of Hematology - Galenos Yayinevi, 2004, 28(2011), 04, Seite 257-263
Übergeordnetes Werk:	volume:28 ; year:2011 ; number:04 ; pages:257-263

Links:	Link aufrufen Link aufrufen Journal toc Journal toc

Katalog-ID:	DOAJ080215858

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source	In Turkish Journal of Hematology 28(2011), 04, Seite 257-263 volume:28 year:2011 number:04 pages:257-263
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topic_facet	DNA population genetics molecular anthropology factor V G1691A (Leiden) beta-thalassemia sickle cell anemia Anatolia Diseases of the blood and blood-forming organs
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spellingShingle	Yeşim Doğan Alakoç misc RC633-647.5 misc DNA misc population genetics misc molecular anthropology misc factor V G1691A (Leiden) misc beta-thalassemia misc sickle cell anemia misc Anatolia misc Diseases of the blood and blood-forming organs The importance of studying inherited hematological disorders in ancient Anatolian populations
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topic_title	RC633-647.5 The importance of studying inherited hematological disorders in ancient Anatolian populations DNA population genetics molecular anthropology factor V G1691A (Leiden) beta-thalassemia sickle cell anemia Anatolia
topic	misc RC633-647.5 misc DNA misc population genetics misc molecular anthropology misc factor V G1691A (Leiden) misc beta-thalassemia misc sickle cell anemia misc Anatolia misc Diseases of the blood and blood-forming organs
topic_unstemmed	misc RC633-647.5 misc DNA misc population genetics misc molecular anthropology misc factor V G1691A (Leiden) misc beta-thalassemia misc sickle cell anemia misc Anatolia misc Diseases of the blood and blood-forming organs
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title	The importance of studying inherited hematological disorders in ancient Anatolian populations
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title_full	The importance of studying inherited hematological disorders in ancient Anatolian populations
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title_sort	importance of studying inherited hematological disorders in ancient anatolian populations
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title_auth	The importance of studying inherited hematological disorders in ancient Anatolian populations
abstract	Before analysis of DNA from ancient remains was possible, anthropologists studied evolution and migration patterns using data obtained from population genetic studies on modern populations combined with data obtained from morphological evaluations of ancient remains. Currently, DNA analysis of ancient populations is making a valuable contribution to these efforts. Researchers that perform ancient DNA analysis prefer to study polymorphisms on the Y chromosome or mitochondrial DNA because the results are easier to statistically evaluate. To evaluate polymorphisms on diploid genomes, which are more informative, only mutations that have been extensively examined in modern populations should be chosen. The most extensively evaluated mutations are those related to prevalent inherited disorders. As such, beta-thalassemia, sickle cell anemia, FVL mutation of globin and the factor V genes are good candidates for DNA studies in ancient populations. These mutations are common in Anatolia, host to many civilizations since the Paleolithic period. This history makes Anatolia a good place for conducting research that could enhance our understanding of human evolution and migration patterns.
abstractGer	Before analysis of DNA from ancient remains was possible, anthropologists studied evolution and migration patterns using data obtained from population genetic studies on modern populations combined with data obtained from morphological evaluations of ancient remains. Currently, DNA analysis of ancient populations is making a valuable contribution to these efforts. Researchers that perform ancient DNA analysis prefer to study polymorphisms on the Y chromosome or mitochondrial DNA because the results are easier to statistically evaluate. To evaluate polymorphisms on diploid genomes, which are more informative, only mutations that have been extensively examined in modern populations should be chosen. The most extensively evaluated mutations are those related to prevalent inherited disorders. As such, beta-thalassemia, sickle cell anemia, FVL mutation of globin and the factor V genes are good candidates for DNA studies in ancient populations. These mutations are common in Anatolia, host to many civilizations since the Paleolithic period. This history makes Anatolia a good place for conducting research that could enhance our understanding of human evolution and migration patterns.
abstract_unstemmed	Before analysis of DNA from ancient remains was possible, anthropologists studied evolution and migration patterns using data obtained from population genetic studies on modern populations combined with data obtained from morphological evaluations of ancient remains. Currently, DNA analysis of ancient populations is making a valuable contribution to these efforts. Researchers that perform ancient DNA analysis prefer to study polymorphisms on the Y chromosome or mitochondrial DNA because the results are easier to statistically evaluate. To evaluate polymorphisms on diploid genomes, which are more informative, only mutations that have been extensively examined in modern populations should be chosen. The most extensively evaluated mutations are those related to prevalent inherited disorders. As such, beta-thalassemia, sickle cell anemia, FVL mutation of globin and the factor V genes are good candidates for DNA studies in ancient populations. These mutations are common in Anatolia, host to many civilizations since the Paleolithic period. This history makes Anatolia a good place for conducting research that could enhance our understanding of human evolution and migration patterns.
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The importance of studying inherited hematological disorders in ancient Anatolian populations

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