Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study

Non-motor symptoms (NMS) characterize the Parkinson’s disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF). The aim of this observational study was to investigate the presence of NMS and NMF in patients with PD using the recently va...
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Autor*in:	Matteo Carpi [verfasserIn] Mariangela Pierantozzi [verfasserIn] Stefano Cofano [verfasserIn] Mariana Fernandes [verfasserIn] Rocco Cerroni [verfasserIn] Francesca De Cillis [verfasserIn] Nicola Biagio Mercuri [verfasserIn] Alessandro Stefani [verfasserIn] Claudio Liguori [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Parkinson’s disease non-motor fluctuations non-motor symptoms motor impairment

Übergeordnetes Werk:	In: Journal of Personalized Medicine - MDPI AG, 2012, 13(2023), 2, p 242
Übergeordnetes Werk:	volume:13 ; year:2023 ; number:2, p 242

Links:	Link aufrufen Link aufrufen Link aufrufen Journal toc

DOI / URN:	10.3390/jpm13020242

Katalog-ID:	DOAJ080238025

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allfields	10.3390/jpm13020242 doi (DE-627)DOAJ080238025 (DE-599)DOAJdb9ff8d5925747a4962862078d2ea7d1 DE-627 ger DE-627 rakwb eng Matteo Carpi verfasserin aut Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Non-motor symptoms (NMS) characterize the Parkinson’s disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF). The aim of this observational study was to investigate the presence of NMS and NMF in patients with PD using the recently validated Non-Motor Fluctuation Assessment questionnaire (NoMoFa) and to evaluate their associations with disease characteristics and motor impairment. Patients with PD were consecutively recruited, and NMS, NMF, motor impairment, motor fluctuations, levodopa-equivalent daily dose, and motor performance were evaluated. One-third of the 25 patients included in the study (10 females, 15 males, mean age: 69.9 ± 10.3) showed NMF, and patients with NMF presented a higher number of NMS (<i<p</i< < 0.01). Static NMS and NoMoFa total score were positively associated with motor performance assessed with the Global Mobility Task (<i<p</i< < 0.01 and <i<p</i< < 0.001), and the latter was also correlated with motor impairment (<i<p</i< < 0.05) but not with motor fluctuations. Overall, this study shows evidence that NMF are frequently reported by mild-to-moderate PD patients and associated with an increased number of NMS. The relationship between NoMoFa total score and motor functioning highlights the importance of understanding the clinical role of NMS and NMF in the management of PD patients. Parkinson’s disease non-motor fluctuations non-motor symptoms motor impairment Medicine R Mariangela Pierantozzi verfasserin aut Stefano Cofano verfasserin aut Mariana Fernandes verfasserin aut Rocco Cerroni verfasserin aut Francesca De Cillis verfasserin aut Nicola Biagio Mercuri verfasserin aut Alessandro Stefani verfasserin aut Claudio Liguori verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 2, p 242 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:2, p 242 https://doi.org/10.3390/jpm13020242 kostenfrei https://doaj.org/article/db9ff8d5925747a4962862078d2ea7d1 kostenfrei https://www.mdpi.com/2075-4426/13/2/242 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 2, p 242
spelling	10.3390/jpm13020242 doi (DE-627)DOAJ080238025 (DE-599)DOAJdb9ff8d5925747a4962862078d2ea7d1 DE-627 ger DE-627 rakwb eng Matteo Carpi verfasserin aut Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Non-motor symptoms (NMS) characterize the Parkinson’s disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF). The aim of this observational study was to investigate the presence of NMS and NMF in patients with PD using the recently validated Non-Motor Fluctuation Assessment questionnaire (NoMoFa) and to evaluate their associations with disease characteristics and motor impairment. Patients with PD were consecutively recruited, and NMS, NMF, motor impairment, motor fluctuations, levodopa-equivalent daily dose, and motor performance were evaluated. One-third of the 25 patients included in the study (10 females, 15 males, mean age: 69.9 ± 10.3) showed NMF, and patients with NMF presented a higher number of NMS (<i<p</i< < 0.01). Static NMS and NoMoFa total score were positively associated with motor performance assessed with the Global Mobility Task (<i<p</i< < 0.01 and <i<p</i< < 0.001), and the latter was also correlated with motor impairment (<i<p</i< < 0.05) but not with motor fluctuations. Overall, this study shows evidence that NMF are frequently reported by mild-to-moderate PD patients and associated with an increased number of NMS. The relationship between NoMoFa total score and motor functioning highlights the importance of understanding the clinical role of NMS and NMF in the management of PD patients. Parkinson’s disease non-motor fluctuations non-motor symptoms motor impairment Medicine R Mariangela Pierantozzi verfasserin aut Stefano Cofano verfasserin aut Mariana Fernandes verfasserin aut Rocco Cerroni verfasserin aut Francesca De Cillis verfasserin aut Nicola Biagio Mercuri verfasserin aut Alessandro Stefani verfasserin aut Claudio Liguori verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 2, p 242 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:2, p 242 https://doi.org/10.3390/jpm13020242 kostenfrei https://doaj.org/article/db9ff8d5925747a4962862078d2ea7d1 kostenfrei https://www.mdpi.com/2075-4426/13/2/242 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 2, p 242
allfields_unstemmed	10.3390/jpm13020242 doi (DE-627)DOAJ080238025 (DE-599)DOAJdb9ff8d5925747a4962862078d2ea7d1 DE-627 ger DE-627 rakwb eng Matteo Carpi verfasserin aut Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Non-motor symptoms (NMS) characterize the Parkinson’s disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF). The aim of this observational study was to investigate the presence of NMS and NMF in patients with PD using the recently validated Non-Motor Fluctuation Assessment questionnaire (NoMoFa) and to evaluate their associations with disease characteristics and motor impairment. Patients with PD were consecutively recruited, and NMS, NMF, motor impairment, motor fluctuations, levodopa-equivalent daily dose, and motor performance were evaluated. One-third of the 25 patients included in the study (10 females, 15 males, mean age: 69.9 ± 10.3) showed NMF, and patients with NMF presented a higher number of NMS (<i<p</i< < 0.01). Static NMS and NoMoFa total score were positively associated with motor performance assessed with the Global Mobility Task (<i<p</i< < 0.01 and <i<p</i< < 0.001), and the latter was also correlated with motor impairment (<i<p</i< < 0.05) but not with motor fluctuations. Overall, this study shows evidence that NMF are frequently reported by mild-to-moderate PD patients and associated with an increased number of NMS. The relationship between NoMoFa total score and motor functioning highlights the importance of understanding the clinical role of NMS and NMF in the management of PD patients. Parkinson’s disease non-motor fluctuations non-motor symptoms motor impairment Medicine R Mariangela Pierantozzi verfasserin aut Stefano Cofano verfasserin aut Mariana Fernandes verfasserin aut Rocco Cerroni verfasserin aut Francesca De Cillis verfasserin aut Nicola Biagio Mercuri verfasserin aut Alessandro Stefani verfasserin aut Claudio Liguori verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 2, p 242 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:2, p 242 https://doi.org/10.3390/jpm13020242 kostenfrei https://doaj.org/article/db9ff8d5925747a4962862078d2ea7d1 kostenfrei https://www.mdpi.com/2075-4426/13/2/242 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 2, p 242
allfieldsGer	10.3390/jpm13020242 doi (DE-627)DOAJ080238025 (DE-599)DOAJdb9ff8d5925747a4962862078d2ea7d1 DE-627 ger DE-627 rakwb eng Matteo Carpi verfasserin aut Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Non-motor symptoms (NMS) characterize the Parkinson’s disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF). The aim of this observational study was to investigate the presence of NMS and NMF in patients with PD using the recently validated Non-Motor Fluctuation Assessment questionnaire (NoMoFa) and to evaluate their associations with disease characteristics and motor impairment. Patients with PD were consecutively recruited, and NMS, NMF, motor impairment, motor fluctuations, levodopa-equivalent daily dose, and motor performance were evaluated. One-third of the 25 patients included in the study (10 females, 15 males, mean age: 69.9 ± 10.3) showed NMF, and patients with NMF presented a higher number of NMS (<i<p</i< < 0.01). Static NMS and NoMoFa total score were positively associated with motor performance assessed with the Global Mobility Task (<i<p</i< < 0.01 and <i<p</i< < 0.001), and the latter was also correlated with motor impairment (<i<p</i< < 0.05) but not with motor fluctuations. Overall, this study shows evidence that NMF are frequently reported by mild-to-moderate PD patients and associated with an increased number of NMS. The relationship between NoMoFa total score and motor functioning highlights the importance of understanding the clinical role of NMS and NMF in the management of PD patients. Parkinson’s disease non-motor fluctuations non-motor symptoms motor impairment Medicine R Mariangela Pierantozzi verfasserin aut Stefano Cofano verfasserin aut Mariana Fernandes verfasserin aut Rocco Cerroni verfasserin aut Francesca De Cillis verfasserin aut Nicola Biagio Mercuri verfasserin aut Alessandro Stefani verfasserin aut Claudio Liguori verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 2, p 242 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:2, p 242 https://doi.org/10.3390/jpm13020242 kostenfrei https://doaj.org/article/db9ff8d5925747a4962862078d2ea7d1 kostenfrei https://www.mdpi.com/2075-4426/13/2/242 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 2, p 242
allfieldsSound	10.3390/jpm13020242 doi (DE-627)DOAJ080238025 (DE-599)DOAJdb9ff8d5925747a4962862078d2ea7d1 DE-627 ger DE-627 rakwb eng Matteo Carpi verfasserin aut Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Non-motor symptoms (NMS) characterize the Parkinson’s disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF). The aim of this observational study was to investigate the presence of NMS and NMF in patients with PD using the recently validated Non-Motor Fluctuation Assessment questionnaire (NoMoFa) and to evaluate their associations with disease characteristics and motor impairment. Patients with PD were consecutively recruited, and NMS, NMF, motor impairment, motor fluctuations, levodopa-equivalent daily dose, and motor performance were evaluated. One-third of the 25 patients included in the study (10 females, 15 males, mean age: 69.9 ± 10.3) showed NMF, and patients with NMF presented a higher number of NMS (<i<p</i< < 0.01). Static NMS and NoMoFa total score were positively associated with motor performance assessed with the Global Mobility Task (<i<p</i< < 0.01 and <i<p</i< < 0.001), and the latter was also correlated with motor impairment (<i<p</i< < 0.05) but not with motor fluctuations. Overall, this study shows evidence that NMF are frequently reported by mild-to-moderate PD patients and associated with an increased number of NMS. The relationship between NoMoFa total score and motor functioning highlights the importance of understanding the clinical role of NMS and NMF in the management of PD patients. Parkinson’s disease non-motor fluctuations non-motor symptoms motor impairment Medicine R Mariangela Pierantozzi verfasserin aut Stefano Cofano verfasserin aut Mariana Fernandes verfasserin aut Rocco Cerroni verfasserin aut Francesca De Cillis verfasserin aut Nicola Biagio Mercuri verfasserin aut Alessandro Stefani verfasserin aut Claudio Liguori verfasserin aut In Journal of Personalized Medicine MDPI AG, 2012 13(2023), 2, p 242 (DE-627)71862713X (DE-600)2662248-8 20754426 nnns volume:13 year:2023 number:2, p 242 https://doi.org/10.3390/jpm13020242 kostenfrei https://doaj.org/article/db9ff8d5925747a4962862078d2ea7d1 kostenfrei https://www.mdpi.com/2075-4426/13/2/242 kostenfrei https://doaj.org/toc/2075-4426 Journal toc kostenfrei GBV_USEFLAG_A SYSFLAG_A GBV_DOAJ GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 13 2023 2, p 242
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author	Matteo Carpi
spellingShingle	Matteo Carpi misc Parkinson’s disease misc non-motor fluctuations misc non-motor symptoms misc motor impairment misc Medicine misc R Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study
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topic_title	Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study Parkinson’s disease non-motor fluctuations non-motor symptoms motor impairment
topic	misc Parkinson’s disease misc non-motor fluctuations misc non-motor symptoms misc motor impairment misc Medicine misc R
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title	Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study
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title_full	Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study
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author_browse	Matteo Carpi Mariangela Pierantozzi Stefano Cofano Mariana Fernandes Rocco Cerroni Francesca De Cillis Nicola Biagio Mercuri Alessandro Stefani Claudio Liguori
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title_sort	both motor and non-motor fluctuations matter in the clinical management of patients with parkinson’s disease: an exploratory study
title_auth	Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study
abstract	Non-motor symptoms (NMS) characterize the Parkinson’s disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF). The aim of this observational study was to investigate the presence of NMS and NMF in patients with PD using the recently validated Non-Motor Fluctuation Assessment questionnaire (NoMoFa) and to evaluate their associations with disease characteristics and motor impairment. Patients with PD were consecutively recruited, and NMS, NMF, motor impairment, motor fluctuations, levodopa-equivalent daily dose, and motor performance were evaluated. One-third of the 25 patients included in the study (10 females, 15 males, mean age: 69.9 ± 10.3) showed NMF, and patients with NMF presented a higher number of NMS (<i<p</i< < 0.01). Static NMS and NoMoFa total score were positively associated with motor performance assessed with the Global Mobility Task (<i<p</i< < 0.01 and <i<p</i< < 0.001), and the latter was also correlated with motor impairment (<i<p</i< < 0.05) but not with motor fluctuations. Overall, this study shows evidence that NMF are frequently reported by mild-to-moderate PD patients and associated with an increased number of NMS. The relationship between NoMoFa total score and motor functioning highlights the importance of understanding the clinical role of NMS and NMF in the management of PD patients.
abstractGer	Non-motor symptoms (NMS) characterize the Parkinson’s disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF). The aim of this observational study was to investigate the presence of NMS and NMF in patients with PD using the recently validated Non-Motor Fluctuation Assessment questionnaire (NoMoFa) and to evaluate their associations with disease characteristics and motor impairment. Patients with PD were consecutively recruited, and NMS, NMF, motor impairment, motor fluctuations, levodopa-equivalent daily dose, and motor performance were evaluated. One-third of the 25 patients included in the study (10 females, 15 males, mean age: 69.9 ± 10.3) showed NMF, and patients with NMF presented a higher number of NMS (<i<p</i< < 0.01). Static NMS and NoMoFa total score were positively associated with motor performance assessed with the Global Mobility Task (<i<p</i< < 0.01 and <i<p</i< < 0.001), and the latter was also correlated with motor impairment (<i<p</i< < 0.05) but not with motor fluctuations. Overall, this study shows evidence that NMF are frequently reported by mild-to-moderate PD patients and associated with an increased number of NMS. The relationship between NoMoFa total score and motor functioning highlights the importance of understanding the clinical role of NMS and NMF in the management of PD patients.
abstract_unstemmed	Non-motor symptoms (NMS) characterize the Parkinson’s disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF). The aim of this observational study was to investigate the presence of NMS and NMF in patients with PD using the recently validated Non-Motor Fluctuation Assessment questionnaire (NoMoFa) and to evaluate their associations with disease characteristics and motor impairment. Patients with PD were consecutively recruited, and NMS, NMF, motor impairment, motor fluctuations, levodopa-equivalent daily dose, and motor performance were evaluated. One-third of the 25 patients included in the study (10 females, 15 males, mean age: 69.9 ± 10.3) showed NMF, and patients with NMF presented a higher number of NMS (<i<p</i< < 0.01). Static NMS and NoMoFa total score were positively associated with motor performance assessed with the Global Mobility Task (<i<p</i< < 0.01 and <i<p</i< < 0.001), and the latter was also correlated with motor impairment (<i<p</i< < 0.05) but not with motor fluctuations. Overall, this study shows evidence that NMF are frequently reported by mild-to-moderate PD patients and associated with an increased number of NMS. The relationship between NoMoFa total score and motor functioning highlights the importance of understanding the clinical role of NMS and NMF in the management of PD patients.
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title_short	Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study
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author2	Mariangela Pierantozzi Stefano Cofano Mariana Fernandes Rocco Cerroni Francesca De Cillis Nicola Biagio Mercuri Alessandro Stefani Claudio Liguori
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up_date	2024-07-03T13:33:25.852Z
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Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study

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